Inside Out: Mapping GPCRs from Membrane Codes to Market Moves

GPCR News
May 28
1 min read

Hi GPCR Enthusiasts (and Arrestin Aficionados!)

This week at Dr. GPCR, we’re decoding arrestin-driven signaling and spotlighting the tools to match.

Check out our new on-demand course on non-canonical GPCR behaviors and a podcast episode tracing 30 years of GPCR-RAMP discovery. Additionally, new studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain without the need for opioids, and a real-time lipid probe tracks early signaling events.

Significant insights—inside and out.

Dr. GPCR Updates

Advanced Methods for the Optimization of Candidate Selection – Master GPCR behavior beyond second messengers

Build sharper strategies for GPCR-targeted therapeutics with this advanced course—now available on demand for Premium members. Led by Dr. Terry Kenakin, these five modules reveal how location bias, intracellular signaling, and ligand kinetics can be leveraged to expand drug discovery horizons and fine-tune candidate selection.

Access the Course

Hacking GPCRs: A Toolkit for Systems Biology – New Podcast Episode

In Episode 167, Dr. Tom Sakmar and Dr. Ilana Kotliar share how three decades of curiosity evolved into a tech-powered platform for mapping GPCR-RAMP interactions. From dual-epitope tagging to scalable multiplex assays, this conversation dives deep into the tools now transforming receptor biology—and how they’re being used to de-orphanize GPCRs, explore autoantibodies, and uncover new therapeutic directions.