What If the Most Important Part of Your Drug Isn’t What It Binds—But What It Does?

Picture this: two compounds bind to the same receptor. One sparks a firestorm of cellular activity. The other? Silence.

Why? The answer lies in a misunderstood property called efficacy—the power of a drug to trigger a response after binding. In Terry Kenakin’s latest lesson, you’ll uncover why efficacy is the unsung hero of drug discovery and how its effects depend entirely on the biological system it’s tested in.

This isn’t just a theory class. Terry walks you through real-world experiments, decades of receptor pharmacology wisdom, and the cutting-edge operational model used to quantify efficacy. You'll learn why some agonists succeed in sensitive tissues but fail elsewhere—and how this knowledge can dramatically shift your screening strategy.

If you’re stuck trying to figure out why your lead compound looks promising in vitro but flops in vivo, you need this lesson.

Ready to think beyond binding?

🔓 Find the lesson in Terry’s Pharmacology Vault: “Efficacy and System Sensitivity

Unlock "Agonism & Efficacy" now