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The community is gathering. No agenda. No presentations. Just your people, in one room. Some of the best conversations in GPCR science don't happen at the podium. They happen in the hallway between sessions, at the coffee station, or in the ten minutes after a talk when someone finally says what they actually think. The problem is those moments are rare, rushed, and easy to miss. That's why we created GPCR Happy Hour. On April 29th, the Dr. GPCR community is gathering in Boston for an informal evening of real conversation. No presentations. No panels. No agenda. Just GPCR scientists in a room together, with food, drinks, and two hours to have the discussions that conferences don't make space for. The evening takes place at Pressed Cafe, 105 Huntington Ave — steps from The Colonnade, where the 5th Annual GPCRs-Targeted Drug Discovery Summit  is bringing together 80+ senior leaders across GPCR-focused biopharma from April 28–30. If you're attending the summit, join us right after Conference Day One wraps. If you're local to Boston, this is your chance to meet the community in person. Space is limited to 50 scientists. Food and one drink ticket included. Cash bar available. Register your spot here. Why we keep it small Fifty people is a deliberate choice. It's the size where you can actually talk to everyone in the room. Where a conversation that starts with one person pulls in three others. Where you walk away with a handful of connections that actually go somewhere, not a stack of business cards you'll never follow up on. This is not a mixer. It's not a corporate reception. It's a gathering of people who already share something (a deep commitment to GPCR science) even if they're meeting for the first time. Who's making the GPCR Happy Hour evening possible GPCR Happy Hour is made possible by four companies that didn't just want to reach GPCR scientists, they wanted to be part of bringing the community together in person. NIS | Founding Co-Host NanoImaging Services (NIS) is a US-based structural biology partner offering a fully integrated gene-to-structure platform, with facilities in San Diego, CA and Woburn, MA. Through their acquisition of Proteos, NIS combines two decades of recombinant protein production expertise, across mammalian, insect, and bacterial expression systems with high-resolution cryo-EM capabilities, including epitope mapping and structure determination of challenging targets like GPCRs and membrane protein complexes. NIS is the kind of partner that understands what GPCR discovery actually requires at the structural level. Want to learn more about NIS? Watch my conversation with their CSO Giovanna Scapin Revvity | Founding Co-Host Revvity is a global leader in life science innovation, delivering tools and technologies that bridge the gap between discovery and real-world impact. With decades of expertise and an unwavering focus on precision, Revvity empowers scientists to simplify complex workflows, accelerate discovery, and drive breakthroughs in drug development, diagnostics, and disease biology. Whether you're decoding signaling pathways or designing the next generation of therapeutics, Revvity brings the kind of platform-level support that serious GPCR programs depend on. EuroscreenFast EuroscreenFast has been a pioneer in GPCR science for more than 30 years,. The first company to offer access to recombinant GPCR assays. Today, their catalogue includes over 1,000 functional assays representing more than 550 GPCR and other targets, trusted by therapeutic developers worldwide for affinity, potency, efficacy, and functional selectivity studies. Their deorphanisation track record (17 identified natural receptor-ligand pairs) speaks to the depth of their scientific investment in the field. Montana Molecular Montana Molecular is a leader in advanced GPCR assay technologies and services, combining genetically encoded fluorescent biosensors and BacMam gene delivery tools to measure the spatial and temporal signaling properties of drug candidates in living cells. Their platform delivers kinetic profiles that reliably inform decisions and reduce the risk and cost of developing new drugs, exactly the kind of intelligence GPCR programs need at the lead selection stage. Who should come This evening is open to pharma, biotech, academia, and students. If you work in GPCR science (or plan to) you belong in this room. Whether you've been following Dr. GPCR online for years or you're hearing about us for the first time, walk in. You already belong. Employees of service providers or CROs: please inquire about co-hosting and vendor options at Hello@DrGPCR.org . The details 📅 Wednesday, April 29, 2026 ⏰ 6:00 PM – 8:00 PM 📍 Pressed Cafe, 105 Huntington Ave, Boston, MA (A two-minute walk from The Colonnade) Food and one drink ticket included. Cash bar available after. Space is limited to 50 scientists — registration is required. This event is open to pharma, biotech, academia, and students. Employees of service providers or CROs: please inquire about co-hosting and vendor options. Register your spot. We'll see you April 29th.

It's spring break at Dr. GPCR — a quieter week, and a good moment to look at what this community is examining next. Five live Masterclasses are scheduled before summer break. Two Partner Webinars are lining up. And two recent sessions are moving into the on-demand library next week. Taken together, the lineup spans biophysics, kinetics, spatial biology, subcellular regulation, and program building. Five sessions examining GPCR science past the equilibrium snapshots, where and when receptors signal, how kinetics shape drug action, and how all of it translates into programs. Coming to the GPCR Masterclass On-Demand Library Two sessions from April are moving into the Premium Masterclass library next week: Bryan Roth on intracellular allosteric modulators as molecular glues — recorded April 9. Terry Hébert on iPSC-derived systems for GPCR signaling and translation — recorded April 16. Explore the library ➤ Five Live GPCR Masterclasses Before Summer All included in Premium , each one a direct scientific exchange with a leading scientist, with full replay access afterward. Sam Hoare  — How Signaling Kinetics Shapes GPCR Drug Action. May 14. Sudarshan Rajagopal  — The Spatiotemporal Revolution in GPCR Biology. May 21. Andrew Tobin  — How to Build Breakthrough GPCR Programs. June 4. Jakob Höppner  — Subcellular Regulation of PTH1R Signaling. June 11. Dmitry Veprintsev  — Biophysical Approaches to Study Orphan GPCR Ligand Binding and Signalling. June 18. More live Masterclasses coming in the fall. Learn more about Live Masterclasses ➤ Partner Webinars Eurofins DiscoverX (Dr. Terry Kenakin, invited speaker)  — Biased signaling. GeneTex (Dr. Alex Ball)  — A reagent gap that holds back the biology. Details coming soon. Next Week in Boston The Dr. GPCR community gathers in person next week. GPCRs Targeted Drug Discovery Summit  — April 28–30. What to expect and how to register ➤ GPCR Happy Hour  — April 29. Come find us ➤ About Dr. GPCR Dr. GPCR is the intelligence and community for GPCR scientists. Premium members have full access to the pre-summer Masterclass lineup, the live sessions, and the expanding on-demand library. Where to find your Premium content As a Premium member, everything is under the Premium  menu in the top navigation — Live Masterclass, Masterclass On Demand, Weekly News, Job Listings, GPCR Events, Ask the Ecosystem, Ecosystem Members, and Your Feedback. Bookmark ecosystem.drgpcr.com  and you're one click away from all of it. Join Premium ➤ Try Premium for 14 days — $49 ➤

Dr. GPCR is proud to partner with the 5th Annual GPCRs-Targeted Drug Discovery Summit.  This post is your one-stop hub — agenda highlights, who's attending, our exclusive discount code, and speaker interviews as they go live. Why the GPCR Drug Discovery Field Is Converging in Boston The GPCR field is in a genuinely exciting moment. Not hype — momentum. The human genome encodes ~800 GPCRs, yet only around 15% are currently targeted by approved drugs — leaving an enormous and largely untapped therapeutic opportunity. New structural tools, AI-driven design pipelines, and a growing number of programs moving into the clinic are redefining what's possible across modalities and indications. Pharma interest is high, as reflected in major deals across the space. The 5th Annual GPCRs-Targeted Drug Discovery Summit is the industry-led meeting dedicated entirely to GPCR drug discovery — across small molecules, peptides, and antibodies, and across indications. This year's program reflects where science is actually heading. Dr. GPCR founder Dr. Yamina Berchiche will be there — if you're attending, reach out to connect. Who's at the GPCR-Targeted Drug Discovery Summit 2026 The meeting brings together 80+ senior leaders from biotech and pharma to advance GPCR programmes from discovery through translation — experts in GPCR biology, structural biology, computational design, pharmacology, and translational strategy. Companies already confirmed to attend include: Abalone Bio  ·  AbbVie  ·  Biagon  ·  Biolexis Therapeutics  ·  Confo Therapeutics  ·  Eli Lilly  ·  GSK  ·  Nabla Bio  ·  Northeastern University  ·  Nxera Pharma  ·  OMass Therapeutics  ·  Superluminal Medicines  ·  Tectonic Therapeutics  ·  and many more. GPCR Drug Discovery Agenda Highlights: What's New in 2026 This year's summit runs across three days — an AI & ML Focus Day on April 28, followed by two conference days — and the program spans the full breadth of the field. Biased Signaling, Endosomal Pathways & GPCR Signaling Complexity How do we disentangle intrinsic, system, and kinetic bias in a way that actually predicts clinical outcomes? Sessions from InterAx Biotech, Northeastern University, and Function Therapeutics dig into this — moving beyond static potency and efficacy to mechanistic signatures that guide drug design. A panel discussion will tackle best practices for measuring GPCR signaling bias in vitro and what that means for in vivo and clinical translation. AI & ML in GPCR Drug Discovery A dedicated focus day brings together teams from Nabla Bio, Abalone Bio, Biagon, Iambic Therapeutics, Lembas, and Eli Lilly. These aren't primers on AI — they're teams presenting real workflows and real data, covering generative antibody design, dynamic conformational modeling, federated computing platforms, and predictive simulations that shorten discovery timelines. Antibodies, Cyclic Peptides & Allosteric Modulators Nine or more presentations on non-small molecule approaches — including agonistic antibodies, GPCR-directed ADCs, orally available cyclic peptides, and allosteric probes for Class B GPCRs. Companies presenting include Skymab Biotherapeutics, Confo Therapeutics, GSK, Metaphore Biotechnologies, and Abilita Therapeutics. Translational Stories & Clinical Data OMass Therapeutics on long-residence MC2R antagonists. Tectonic Therapeutics on engineering a long-acting relaxin for pulmonary hypertension. Kainova Therapeutics presenting Phase 1 outcomes for their EP4 receptor antagonist in solid tumors. Alphamol on Phase 1 results from an orphan GPCR program pursued against industry skepticism. 🎥 Speaker Spotlight: GPCR Drug Discovery Experts to Watch Dr. Will Barnes is Executive Director and Head of GPCR Biology at Iambic Therapeutics, where he leads AI-driven structural modeling for GPCR drug discovery. With a PhD studying histamine receptors and a postdoc with Bob Lefkowitz at Duke, he brings two decades of industry experience — and a GPCR program in every chapter of it. Watch our conversation below. Register for the GPCR Drug Discovery Summit — Exclusive DrGPCR Discount Use the exclusive DrGPCR discount code DRGPCR10 at checkout for 10% off registration. Early bird pricing also runs through March 6 , saving up to $600 off the door price — so don't wait.   🔗  Register here   🔗  Explore the full event guide   🔗  Contact the event team for your discount The 5th Annual GPCRs-Targeted Drug Discovery Summit takes place April 28–30, 2026 at The Colonnade, 120 Huntington Avenue, Boston, MA.

Explore GPCR signaling kinetics and temporal drug action mechanisms with Sam Hoare. Clinical insights on tachyphylaxis, tolerance, and kinetic-based therapeutics. < Back How Signaling Kinetics Shapes GPCR Drug Action May 14, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction GPCR signaling kinetics, the temporal dynamics of receptor activation and downstream signaling, directly influence therapeutic outcomes from beta-agonist tachyphylaxis to opioid tolerance. This session addresses the clinical landscape of kinetic-dependent drug action, biosensor-based measurement of signaling over time, and analytical approaches for extracting actionable kinetic parameters in drug discovery. Coverage spans tachyphylaxis mechanisms in beta-agonist therapy, tolerance development with opioid agonists, and therapeutic desensitization strategies at S1P1 and GnRH receptors. Designed for pharmacologists, drug discovery scientists, and translational researchers working on temporal aspects of GPCR therapeutics. Instructor Sam Hoare is a drug discovery consultant and founder of Pharmechanics LLC, specializing in kinetic analysis of drug action and the application of binding and signaling kinetics to therapeutic development. After completing his Ph.D. in biochemistry studying allosteric modulation of dopamine receptors at the University of Kent and postdoctoral training on Class B GPCRs at the National Institute of Mental Health, he spent 15 years as a pharmacology leader at Neurocrine Biosciences, guiding in vitro biology for numerous drug discovery campaigns. Sam is an editor at the NIH Assay Guidance Manual and regularly teaches advanced pharmacology and experimental design. His expertise in translating kinetic data from bench to bedside directly informs this Masterclass. Upcoming Live Sessions

Explore detailed information about our GPCR-focused University Courses. Learn about course content, instructors, and how to advance your expertise in drug discovery. Empower. Connect. Transform. Become part of the Dr. GPCR University Instructor community—where teaching is more than sharing knowledge; it’s about uplifting scientists and advancing GPCR discovery, together. Connecting scientists through knowledge, passion, and purpose. About Dr. GPCR University Dr. GPCR University is a global platform where scientists share their knowledge, inspire discovery, and advance GPCR research together. Our on-demand courses connect experts, students, and industry professionals through authentic, instructor-led learning—built by scientists, for scientists. Each contribution brings new perspectives and tools to advance the field. Instructors are recognized and compensated for their work, ensuring that every shared insight creates impact, visibility, and lasting value across the GPCR community. Course Formats You Can Teach At Dr. GPCR University , every instructor brings a unique voice, style, and rhythm to teaching. Our flexible course formats are designed to fit your time, depth, and teaching goals — whether you’re sharing a focused insight or leading a full exploration of GPCR science. You can also co-lead Full-Length Courses with up to three fellow instructors to share the workload and enrich the learning experience. 🧭 Full-Length Course Structure: 4 × 1-hour sessions Purpose: Deep, multi-session learning experience Best for: Comprehensive topics that require exploration and discussion ⚡ Short Course Structure: 1 session (2–4 hours of content) Purpose: Concise yet thorough coverage of key concepts Best for: Core methods, applied principles, or emerging topics 🔍 Mini Course Structure: 1 short lesson (1–2 hours of content) Purpose: Focused insights into a single theme Best for: Quick takeaways or specialized topics No matter the format, your course helps scientists learn, connect, and keep GPCR science moving forward — one discovery at a time. Instructor Benefits At Dr. GPCR University , we believe those who teach move science forward. As an instructor, you’re not just sharing knowledge — you’re shaping the next generation of GPCR scientists. We make sure your time, expertise, and contribution are recognized and supported every step of the way. 🌟 By teaching with us, you gain: ✔ Premium Membership for you and your team for one year (no credit card required) ✔ A global platform to share your expertise and reach scientists worldwide ✔ Full support with technical setup, editing, and course promotion — so you can focus on teaching We handle logistics so you can focus on what truly matters: delivering meaningful, high-quality education. To ensure lasting impact, each course becomes part of the Dr. GPCR University ecosystem — maintained, updated, and accessible to learners in the long term. Your name and expertise remain at the heart of the course, continuing to inspire scientists long after the sessions end. Together, we’re shaping the future of GPCR education — one course, one scientist, one discovery at a time. What You’ll Need to Provide to Teach a Course Welcome — we’re thrilled to have you join Dr. GPCR University . You bring the expertise; we’ll handle the setup, editing, and promotion. Here’s everything you’ll prepare to bring your course to life: 🧩 Step 1: Email us Start by emailing it us at Hello@DrGPCR.org . We will then have a short call and send you the our Instructor Intake Form — it’s how we build your profile and course page. You’ll be asked for: Instructor info – name, email, affiliation, short bio, photo, and optional social media handles. Course details – title, format (short talk / mini-course / series), audience, main objectives, expected learning outcomes, key topics (≈ 250 words), recommended readings, and any co-instructors. Preferences & agreement – communication style, access to the Premium area, and acknowledgment of the instructor agreement (you’ll receive the full version right after submission). 🧱 Step 2: Plan Your Course Structure Decide how your course will flow — number of modules, duration, and teaching style. (See Course Formats above for ideas.) 🕙 Scheduling note: Courses are typically hosted Thursdays at 10 AM EST — a sweet spot for our global community. We’ll confirm your date together once your proposal is approved. 📝 Step 3: Prepare Your Content Create your teaching materials — slides, visuals, readings, or anything that helps learners grasp your message. Don’t worry — we’ll support you with templates and review tips along the way. 🎥 Step 4: Record a Short Video Chat You’ll have a quick recorded conversation with Dr. Yamina Berchiche about your course — what it covers, why it matters, and what students can expect. It’s relaxed, engaging, and helps introduce you to the community. 💬 Step 5: Join Your Private Course Group Once live, you’ll connect with your students in a private discussion space — perfect for questions, insights, and follow-ups. 💫 Step 6: Teach & Inspire Share your expertise with scientists around the world. Enjoy the experience, the visibility, and the impact — and receive recognition and compensation for your contribution. (See Instructor Benefits for details.) ✨ Your ideas, your voice, and your course will help shape the next chapter of GPCR discovery. Share Your Expertise with the World We’re here to support you from idea to impact. Start your journey as a Dr. GPCR University Instructor and help move GPCR science forward. Email us at Hello@DrGPCR.org Live Masterclass Sessions Previous Instructors Dr. Matteo Pavan Dr. Terry Kenakin Dr. Kenneth Jacobson Dr. Yamina Berchiche Dr. Sam Hoare Dr. GPCR Courses Reviews Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere GPCR researcher Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field GPCR researcher The content had enough depth to satisfy the hunger for theory while being full of practical knowledge GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology GPCR researcher Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him GPCR researcher Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. GPCR researcher The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work GPCR researcher Contact Contact us First name* Last name Email* Write a message Submit

Advance your GPCR research career with Dr. GPCR University. Access 20+ on-demand GPCR courses, 200+ expert talks, weekly news, and a global scientist network. Join Premium today. Dr. GPCR University Your professional home in GPCR science. University is your professional home in GPCR science — premium intelligence, live Masterclasses, job listings, events, and a community of scientists who have your back. Everything you need, in one place. See what it feels like — $50 for 14 days Already know this is home? Join University — $499/year 1,400+ GPCR scientists reached 200+ Expert talks available $499 Per year — less than $10/week What's inside? The rooms in your professional home University isn't a bundle of features — it's a place where your GPCR professional life is supported. Here's what's waiting for you inside. Live Masterclass Live scientific exchanges with leading GPCR experts. You're in the room with the scientist, asking your question — not watching from the audience. Explore Live Masterclass → Job Listings GPCR-specific job opportunities curated for the community. Your next role is already here — opportunities find you when you're inside the ecosystem. Masterclass On Demand Full recordings of every session, available anytime. Revisit the science at your pace — over 200 expert talks in the library and growing. Explore Masterclass on Demand → GPCR Events A calendar of relevant conferences, meetings, and events in the GPCR field. Your next conference is already here. Premium Weekly News The complete GPCR intelligence — classified publications, industry news, job listings, and events calendar. Know what's coming before it becomes consensus. See Weekly News → Ask the Ecosystem The question you've been sitting on — someone in this ecosystem has the answer. A discussion forum where members share insights and get answers from the community. Live Masterclass In the room with the scientist, not watching from the audience Live scientific exchanges where you engage directly with leading GPCR experts. The question you've been holding — this is where you ask it. Dr. Andrew Tobin | Glasgow University How to Build Breakthrough GPCR Programs Research Strategy June 4, 2026 Dr. Sam Hoare | Pharmechanics How Signaling Kinetics Shapes GPCR Drug Action Translational Pharmacology & Disease Models May 14, 2026 Dr. Marsha Pierce | Midewestern University Introduction to GLP-1 pharmacology October 8, 2026 Dr. Sudarshan Rajagopal | Duke University The Spatiotemporal Revolution in GPCR Biology Biased Signaling & Allosteric Modulation May 21, 2026 Dr. Jakob Höppner | Harvard University | MGH Subcellular Regulation of PTH1R Signaling June 11, 2026 Explore Live Masterclasses → Who it's for? Whether you're just starting out or 20 years in — this is your place University is designed for GPCR scientists at every career stage who want to stay sharp, connected, and supported. 🎓 Early-career researchers Find your footing in the field. Access the experts, the intelligence, and the community that accelerates your growth. 🔬 Discovery scientists Stay at the frontier. Live Masterclasses and Premium Weekly News keep you ahead of the field — not chasing it. 🏆 Senior investigators Your career stage doesn't matter. Your commitment to the science does. Connect, contribute, and stay current. Explore the Masterclass On Demand Watch Now Structure-Based Design of Modulators of Purinergic GPCRs Kenneth A. Jacobson, Matteo Pavan Watch Now The Allosteric Advantage Terry Kenakin Watch Now CRC Super-User: Your Data Advantage Sam Hoare Explore Masterclasses On Demand → The comparison A society membership costs more and gives you less Most GPCR scientists belong to at least one scientific society. Here's how that compares to University. Typical Scientific Society $150 – $500+/year A journal subscription A conference discount A newsletter Occasional networking events Dr. GPCR University $499/year — less than $10 a week Live Masterclasses with leading GPCR scientists 200+ on-demand expert sessions Premium Weekly News intelligence GPCR job board and events calendar Community forum & ecosystem access Intelligence Hub dashboard Grandfather guarantee — your rate never increases "The one membership that has your back." $50 for 14 days - Strat Now What others are saying Scientists inside the ecosystem Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere GPCR researcher The content had enough depth to satisfy the hunger for theory while being full of practical knowledge GPCR researcher Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him GPCR researcher The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work GPCR researcher Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology GPCR researcher Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. GPCR researcher Common questions Thinking it over? Fair enough. Here are the concerns we hear most — and honest answers. "It's too expensive." At less than $10 a week, University gives you live access to leading GPCR scientists, 200+ on-demand talks, premium intelligence, a job board, events calendar, and a global community of peers. One insight, one connection, one 'aha' moment — can save months of research time. "I'm not sure I'll use it often." Even one Masterclass or one new collaboration can make a difference. Members often find value in ways they didn't expect — from expert feedback to career-changing introductions. That's why we offer a 14-day trial, so you can experience it first. "I already get what I need from papers." Papers inform. University helps you understand and apply that knowledge — through expert context, structured scientific exchanges, and real interaction with peers from academia and industry. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . There was a technical issue on our end. Try again or refresh. Move in. Look around. See if it's home. For 14 days, this is what it feels like to have everything in one place — intelligence, learning, community, and opportunities. Your first Masterclass is waiting. See what it feels like Already know this is home? Join University — $499/year Your 14-day trial is $50. If University feels like home, it's $499/year — less than $10 a week. Grandfather guarantee: your rate never increases. No surprise charges.