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- 📰 GPCR Weekly News, May 22 to 28, 2023
November 2 - 4, 2023) GPCR Jobs NEW Associate Director / Director, Clinical Operations Postdoctoral Research
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
Additionally, deep mutational scanning can generate large-scale datasets, allowing researchers to determine
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
cannot adequately predict protein structure (Jumper et al., 2021) ); 3) the same limitation holds when searching Automated tools for researchers: AI solutions which bring together theoretical, computational, and experimental Instead, it complements and assists researchers in the GPCR drug discovery process.
- Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in ...
This research further clarified the underlying role of β-arrestin2 and provided an experimental foundation
- Ode to GPCRs
Therefore, the presentation of 10 or more Nobel prizes highlights the importance of research work on the primary physiological and chemical visual processes in the eye.[7–11] Through Nobel prize-winning research Prize in Physiology or Medicine went to Eric Richard Kandel, Arvid Carlsson, and Paul Greengard for research Therefore, we envision that this field will continue to produce high-impact research work that will garner
- Chemokine receptor-targeted drug discovery: progress and challenges
the notion that redundancy is not a feature of the chemokine system (Nedjai et al. 2012), but more research
- 📰 GPCR Weekly News, February 27 to March 5, 2023
Methods & Updates in GPCR Research Time- and cost-efficient bacterial expression and purification of
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior
- A robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery.
Cannabinoids as Anticancer Drugs: Current Status of Preclinical Research. Nucleic Acids Research 2021 , 49 (12), e72–e72. https://doi.org/10.1093/nar/gkab237 . (20) Degorce
- Targeting Intracellular Allosteric Sites in GPCRs
Recent advances in structural biology have allowed researchers to visualize the binding of allosteric
- 📰 GPCR Weekly News
Methods & Updates in GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking
- Odorant receptors – a bit of smell for drug discovery
Future directions Important directions in ORs research to advance drug discovery include the deorphanization
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Neurochemical research, 42(1), 166–172. https://doi.org/10.1007/s11064-016-2026-6 Mendizabal-Zubiaga,
- Overview of adhesion GPCRs self-activation
knowing the factors that determine the selectivity of coupling represents a very interesting area of research
- Glyco-sulfo hotspots in the chemokine receptor system
Further research will be needed to boost our understanding on the dynamics and biological relevance of
- Decoding β-Arrestins: from Structure to function
dissociation of crucial effector proteins within distinct subcellular locations remains a fundamental research
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
Significant resources have been invested into the search for small molecule modulators of small protein involves leaving the ‘address’ binding interface on the extracellular face of the receptor unchanged and searching A unique and important feature of Orion’s discovery process is that the initial search for potent target The Future of GPCR Research GPCRs are a very important class of drug targets, but despite historical Orion has entered a strategic research collaboration with Peptilogics, a US-based AI drug discovery company
