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GPR21 expression was evaluated at gene and protein level, the signalling pathway was investigated by

Learn about his remarkable career and research in #GPCR signaling and trafficking.

Stuart Maudsley on how an aging physiological context affects #GPCR signaling #drgpcr.

proteins by G-protein coupled receptors has pro-nociceptive properties, suggesting that blockade of Gq/11 signalling

Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane

intracellular loop 2 that is subject to RNA editing, which differentially affects GPCR constitutive and agonist signaling

Our results indicated the involvement of the PLC-IP3-ORAI signaling pathway and CACCS in MRGPRB2-mediated

drug discovery create large datasets regarding ligand synthesis and screening, ligand binding assays, signaling Multi-target drug design: GPCRs are often involved in complex signaling networks. genomics, proteomics, and pharmacological data, to identify potential drug targets within the GPCR signaling With the revolution of biased signalling of GPCRs comes the possibility of designing drugs that selectively

September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted

G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological

mutagenesis experiments, we show that TM2 rearrangement is critical for the propagation of allosteric signals

Previous findings suggest that parallel pathways independently relay innate threat signals from different

Here, we review how nanobodies have been adopted to elucidate the structure, pharmacology, and signaling

We further highlight residues in transmembrane 7 (TM7) that mediate stronger signaling in mouse versus

GPCR Activation and Signaling Rules and mechanisms governing G protein coupling selectivity of GPCRs Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling

DNAJC13 is crucial to the trafficking of DOR, facilitating its downregulation and influencing cellular signaling

These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

inhibition of glutamate release from presynaptic nerve terminals and is also poised upstream of a myriad of signaling

Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest

GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,

CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling

September 2022 "Research on cancer therapies focuses on processes such as angiogenesis, cell signaling

September 2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate

by the suppression of gut IEL effector functions linked to the dampening of proximal T cell receptor signaling

describes novel findings regarding the complex biology of the preproglucagon-derived hormones, their signaling

Utilizing Single Particle Tracking: Analysis of Diffusion Modes "G protein-coupled receptors (GPCRs) are signaling

assay toolbox to characterize ligand efficacy at the level of receptor proteins instead of downstream signaling

In this aspect, our present data shed new light on the unexplored H2R signaling mechanisms.

Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure GPCR Activation and Signaling GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal

development approaches include a range of techniques leveraging structural biology, immunology, cell signaling