Must-read publications:  GPCRs in neurological disorders; OSTα-OSTβ structure; GPCR–G protein–β-arrestin It’s about better alignment : helping scientists, drug hunters, and decision-makers stay grounded in GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G

Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, and a G

G protein-coupled receptors (GPCRs) are critical myocardial signal transducers which regulate cardiac

Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinetic studies "G

To target hard-to-drug targets like G protein-coupled receptors (GPCRs), more libraries, including better

Gáspár Pándy-Szekeres ) will present and demonstrate the newest resources of the GPCRdb: 1) the new G

the tethered agonist-dependent activities of all 33 aGPCRs in a suite of transcriptional reporter, G PMID: 38608683 The activation profile of different G proteins by ADGRL3 is shown using a collection of

its silicon platform, announced a strategic collaboration to discover therapeutic antibodies against G

Class B G protein-coupled receptors (GPCRs) are notoriously difficult to target by small molecules because

A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled

GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence

October 2022 "While the role of G-protein-coupled receptors (GPCR) in cancer is acknowledged, their underlying

The highest scoring protective hits included the complement C3a receptor (C3aR), a G-protein coupled

G protein-coupled receptor 3 (GPR3) belongs to the class A rhodopsin-type GPCR family and is highly expressed

Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity "The adhesion family of G

forming a vicious cycle with IGF1/IGF1R signaling pathway "There is a potential correlation between G-protein-coupled

considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor, namely G

amino acids, our current understanding on how endogenous PTHrP transduces signals through its cognate G-protein

G-protein coupled receptors (GPCRs) play a paramount role in diverse brain functions.

unpredictably, the wrong interpretation doesn’t just waste time; it costs viable compounds, credibility, and millions Avoid costly blind spots:  Discover how G protein stoichiometry can dictate whether your assay informs—or GPCR scientists, translational pharmacologists, biotech discovery teams, and decision-makers who need

β-arrestins (βarrs) play multifaceted roles in the function of G protein-coupled receptors (GPCRs). βarrs

Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

These changes can alter how the receptor talks to G proteins, arrestins, or other receptors. future topics Built for discovery-phase teams, pharmacologists refining their methods, and decision-makers

receptor 2 allosterism is defined by cellular context; Conformational biosensors delineate endosomal G

X-ray crystallography, by cryo-EM has enabled insights into important drug target families such as G

Industry News OMass Therapeutics Welcomes Melissa Faris as Chief Business Officer Septerna: Revitalizing G-Protein Amgen to Discover Small Molecule Therapeutics using Artificial Intelligence Novo Nordisk Invests 42 Billion

At Discovery on Target he presents YJ-015, a G protein biased APJ agonist developed as an adjuvant to

behaviors in Sapap3 knockout mice Methods & Updates in GPCR Research Genome-wide identification of 769 G

critical component in multiple immune signaling processes and is dependent on activation by Ras and G