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- A casual postdoc in Santiago. A bold yes during the pandemic. Now? A biotech startup solving GPCR challenges worldwide 🌎 Celtarys Research didn’t follow the script, and neither does their chemistry. 🎧 In this week’s episode, Dr. Maria Majellaro talks about trusting your gut, learning to lead, and building science that scales. ✳️Celtarys is ready to support your assay development. Get to know more: Celtarys Research | Dr. GPCR Ecosystem | Dr. GPCR Ecosystem #GPCRtools #GPCRtrainingProgram #DrGPCR #BiotechLeadership | Dr. GPCR Ecosystem
A biotech startup solving GPCR challenges worldwide 🌎 Celtarys Research didn’t follow the script, and GPCR Ecosystem | Dr. GPCR Ecosystem #GPCRtools #GPCRtrainingProgram #DrGPCR #BiotechLeadership Published on June 17, 2025 GPCR Podcast A casual postdoc in Santiago. A bold yes during the pandemic. Now? GPCR Ecosystem | Dr.
- Autoantibodies that activate GPCRs? Wild—but real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling in Ep.167 of the Dr.GPCR Podcast This episode is a must if you're thinking diagnostics. 📲 Tap to listen: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRautoantibodies #GPCRdrugdiscovery #DrGPCR #Immunology | Dr. GPCR Ecosystem
Home → Flash News → Autoantibodies that activate GPCRs? Wild—but real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling GPCR Podcast Autoantibodies that activate GPCRs? Wild—but real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling
- Dr. Bruno Giros | Dr. GPCR Ecosystem
GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! | Dr. GPCR Ecosystem
allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs Check out the latest GPCR news in the Ecosystem today! Published on October 29, 2024 Category GPCR Weekly News Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the latest GPCR news in the Ecosystem today!
- Dr. Thomas P. Sakmar | Dr. GPCR Ecosystem
made early key contributions and developed strategies to express, reconstitute and assay engineered GPCRs chemistry of spectral tuning, and to a better understanding of the molecular mechanism of activation of GPCRs GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Booklet for participants | Dr. GPCR Ecosystem
OFFICIAL BOOKLET Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF
- Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out the latest GPCR news in the Ecosystem today! #drgpcr Published on January 14, 2025 Category GPCR Weekly News Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out the latest GPCR news in the Ecosystem today!
- In case you haven’t heard, Dr. Terry Kenakin will soon start the course Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection 📖 The five-lecture series describes essential additional elements to GPCR discovery programs that extend the discovery process and increase therapeutic opportunity. | Dr. GPCR Ecosystem
Optimization of Candidate Selection 📖 The five-lecture series describes essential additional elements to GPCR GPCR Courses In case you haven’t heard, Dr. https://www.ecosystem.drgpcr.com/advanced-methods-for-the-optimization-of-candidate-selection #gpcr # uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With
- "Have a nice weekend, and I'll see you tomorrow!": RAMP-interacting GPCR Pathways
Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to : RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by
- Did you know that A2B adenosine receptor-triggered calcium mobilization varies by cell type? A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling, revealing a more complex regulation than previously thought. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity Published on March 10, 2025 Category GPCR Weekly News Did you know that GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr
- Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! #drgpcr Published on February 13, 2025 Category GPCR Weekly News Did you know that GPR20, a potential Check out the latest GPCR news in the Ecosystem today! uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With
- What can an updated profile do for you? 🔎 Personalized content, better networking, and collaboration opportunities. Fill in the blanks—update now! ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr | Dr. GPCR Ecosystem
✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Published on January 15, 2025 Category Dr. GPCR Profiles What can an updated profile do for you? ✳️Visit https://bit.ly/4fY4UHV today #gpcr #drgpcr Previous Next Recent Articles
- New insights into FPR2 signaling! GRK5 drives FPR2 endocytosis, but β-arrestin plays a pivotal role in postendocytic trafficking, plasma membrane recycling, and regulating signal transduction. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr #drgpcr Published on January 30, 2025 Category GPCR Weekly News New insights into FPR2 signaling! Check out the latest GPCR news in the Ecosystem today! receptor-activation-and-signaling/grk5-regulates-endocytosis-of-fpr2-independent-of-%CE%B2-arrestins #gpcr
- Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://buff.ly/e6gAlBv #gpcr#drgpcr | Dr. GPCR Ecosystem
Check out the latest GPCR news in the Ecosystem today! ➡️https://buff.ly/e6gAlBv #gpcr#drgpcr Published on April 21, 2025 Category GPCR Weekly News Check out Check out the latest GPCR news in the Ecosystem today! ➡️ https:// buff.ly/e6gAlBv #gpcr#drgpcr Previous Next Recent Articles
- Dr. Nyla Naim, Dr. Michael Lemieux & Dr. Jason Nasse | Dr. GPCR Ecosystem
GPCR Ecosystem About Dr. GPCR Ecosystem About Dr. Jason Nasse Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Coffee Break with pastries announcement of the aGEM award | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
- Mexico City Nocturnal Tour, Food and drinks | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program
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- ep 169 with sokhom pin some 2 | Dr. GPCR Ecosystem
GPCR Podcast Build the team you always wished you had. At Alkermes, Sokhom S. It was leadership. ✳️ Watch Ep. 169: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin
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- Dr. Kathleen Caron | Dr. GPCR Ecosystem
GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Home → Flash News → How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs barcodes influence β-arrestin binding to GPCRs? Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin # uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design
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- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with GPCR Podcast Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With
- Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep.166 of the Dr.GPCR Podcast,. The catch? It’s all about understanding the system, not replacing it. From neuromas to novel modulators, this episode is full of breakthroughs that matter for patients. 📲 Watch now: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Home → Flash News → Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep GPCR Podcast Ben Clements reveals a 10x improvement in efficacy using GPCR-targeted PAMs, in Ep.166 of uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Partners Submition Form | Dr. GPCR Ecosystem
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- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! Published on December 3, 2024 Category GPCR Weekly News Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free! ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
#gpcr #drgpcr #metabolism #obesity Published on March 3, 2025 Category GPCR Weekly News Did you know #gpcr #drgpcr #metabolism #obesity Previous Next Recent Articles Why Biotech Fundraising Fails Due to uncomfortable truth: 👉 Your biotech is already running on an operating cadence you didn’t consciously design Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With GPCR News Dec 18, 2025 Scientific Isolation: The Real Reason Early Biotechs Lose Traction The Quiet Drift
- Dr. Caron Tribute Part 2 | Dr. GPCR Ecosystem
GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
- Dr. Caron Tribute Part 1 | Dr. GPCR Ecosystem
GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks
