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References Kumar V, Chunchagatta Lakshman PK, Prasad TK, Manjunath K, Bairy S, Vasu AS, Ganavi B, Jasti S, Kamariah N.

APRIL 06 - 09, 2022 | | SNOWBIRD RESORT, UTAH, UNITED STATES The superfamily of G protein-coupled receptors

involving interaction between neurotrophic factor-α1 (NF-α1/carboxypeptidase E, CPE) and human 5-HTR1E, a G

Avoid costly blind spots:  Discover how G protein stoichiometry can dictate whether your assay informs—or

Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.

behaviors in Sapap3 knockout mice Methods & Updates in GPCR Research Genome-wide identification of 769 G

These changes can alter how the receptor talks to G proteins, arrestins, or other receptors.

Adrenergic receptors on B cells and intracellular β2-ADR downstream molecules (G protein-coupled receptor

potential RNA interference target for control of the fall webworm Hyphantria cunea Background: Insect G

molecular weight proteins that their functional activities are achieved by binding to the cell surface G

Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors

sphingosine-1-phosphate receptor selectivity Industry News Sosei Heptares and Verily Nominate First G-protein-coupled

There is excitement about combining pHSense with other HTRF assays for multi-pathway mapping—G protein

We demonstrate that the chemoreceptor genes, srg-36 and srg-37, which encode G protein-coupled receptors

Previously, we had identified a novel pyrazole-based agonist 1 ((S)-N-(1-(cyclobutylamino)-1-oxo-5-(piperidin

Interpret multi-phase binding curves correctly , recognizing G-protein coupling and kinetic effects rather

Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv .

treatment of pSS. β-arrestin2 is a key protein that mediates desensitization and internalization of G

Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune

appears to be a second high-affinity site may simply reflect kinetic factors—such as ligand-receptor-G

μg/L in C. elegans The aim of this study was to identify Gα proteins mediating function of neuronal G

Methods & Updates in GPCR Research A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled

This joint effort by both associations is repeated every year, with 2026’s being in Dublin, Ireland.

GPCR Activation and Signaling β-Arrestin-dependent and -independent endosomal G protein activation by

GPCRs in Neuroscience Heterotrimeric G proteins regulate planarian regeneration and behavior.

GPCR Function AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G

These data will be shared as an oral presentation by Ron S.

References Brogi, S., Corelli, F., Di Marzo, V., Ligresti, A., Mugnaini, C., Pasquini, S., & Tafi, A.

Source: Way GP, Sailem H, Shave S, Kasprowicz R, Carragher NO. Lin S, Schorpp K, Rothenaigner I, Hadian K. Image-based high-content screening in drug discovery.

heterodimer is a potent neutrophil chemoattractant Methods & Updates in GPCR Research GproteinDb in 2024: new G