Search Results

Franziska M Heydenreich, Michel Bouvier, Brian Kobilka, M Madan Babu, and their team's work on Molecular

David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Abigail Alwin , Campbell Krusemark , Ezequiel Marron Fernandez de Velasco , Steven H Olson , Lauren M

M, et al. 2023).

  (5) Meldal, M.; Tornøe, C. W. Cu-Catalyzed Azide−Alkyne Cycloaddition. Chem.

Soave M, Briddon SJ, Hill SJ, Stoddart LA.

J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2024).

Sosei Heptares Acquires Idorsia’s Pharmaceuticals Business in Japan and APAC (ex-China), Accelerating

Bouvier, M., Oligomerization of G-protein-coupled transmitter receptors.  

Watch Episode 166 Pain management is broken.  And Benjamin Clements is on a mission to fix it. through how positive allosteric modulators (PAMs)  targeting the mu-opioid receptor  could preserve pain In fact, one of their recent neuroma pain studies showed a tenfold increase in methadone potency . That’s huge.” – Ben Clements By combining chronic pain models with receptor-level pharmacology, Ben is Beyond Acute Pain: Into the Chronic Unknown Opioids work well for acute pain. Chronic pain?

SMOOTHENED-PKA signaling in the Hedgehog cascade Elita Yuliantie , Arthur Christopoulos , Patrick M.

M., & Lefkowitz, R. J. (2003).

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka,

Anson, M., et al., Incidence of new onset type 2 diabetes in adults living with obesity treated with

Continuing Study Addex Therapeutics in the 23rd BioEquity Europe Conference Simon Bekker-Jensen and Mette M

Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic

Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in

Non-Peptide Small Molecule GLP-1 Receptor Agonist GSBR-1290 Crinetics Pharmaceuticals Appoints Robert M.

Nayara Braga Emidio, Ross Cheloha, Laura M Wingler, et al. for their work on Nanobody-Mediated Dualsteric

Maziarz, M., et al., Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor

insights into G protein coupling specificity at a class A GPCR Jianjun Cao, Arthur Christopoulos, Patrick M.

Burger , Arthur Christopoulos , David M.

GPCR Podcast : From Personal Pain to Scientific Purpose: Alex Serafini’s Journey We sit down with Dr. Serafini’s early struggles with chronic pain sparked a career focused on innovating where pain management His work challenges outdated targets, explores overlooked roles of GPCRs and RGS proteins in pain, and Redefine your playbook:  Why Serafini believes that pain research needs to start from clinical phenotype Explore blind spots:  The underestimated role of GPCRs and RGS proteins in chronic pain mechanisms.

genito-urinary system, the activation of ORs was shown to influence the motility of spermatozoa (Spehr M.

studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain Barcodes Shape Arrestin Engagement with ACKR3   A β-Arrestin-2-Biased NTSR1 Modulator for Non-Addictive Pain

highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L) and methionine (M)

receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain Pain may associate with inflamed tissue characterized by acidic pH. The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding

has pro-nociceptive properties, suggesting that blockade of Gq/11 signalling could be beneficial for pain Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice to painful

Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

Dysregulation of RGS proteins has been implicated in a range of diseases, including cardiovascular disease, pain Relating to pain, RGS4 in pain regulation is a topic of increasing interest because it has been identified G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.