📰 GPCR Weekly News, July 31 to August 6, 2023

Greetings, GPCR fellows! Prepare for the latest GPCR updates.

This week's highlights:

• Dr. Randy Hall's study: GPR37L1's role in shaping cortical astrocytes during development

• Dr. Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease treatment

• Drs. Devki D Sukhtankar and Pina M Cardarelli's research: Burixafor Hydrobromide (GPC-100) effects on hematopoietic cells in mice and humans

Mark your calendar! The Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' is set for September 22nd. Want to share your project informally? Submit a 1-minute abstract video using this form. Join us for a discussion session on Kumospace, replacing the poster session.

Stay updated with the Dr. GPCR Newsletter for confirmed speaker announcements.

Remember to catch up on the Classified GPCR News from July 31st to August 6th, 2023.

Adhesion GPCRs

• Functional partnerships between GPI-anchored proteins and adhesion GPCRs

GPCR Activation and Signaling

• GPCR activation and GRK2 assembly by a biased intracellular agonist

• Conserved class B GPCR activation by a biased intracellular agonist

• The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

• The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

• To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from inactive conformation using molecular dynamic simulations

• Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84

GPCR Binders, Drugs, and more

• Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors

• Development of an Affinity-Based Probe to Profile Endogenous Human Adenosine A3 Receptor Expression

• Pharmacokinetics and Pharmacodynamics of Burixafor Hydrobromide (GPC-100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells, in Mice and Healthy Subjects

GPCRs in Cardiology, Endocrinology, and Taste

• Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease

GPCRs in Neuroscience

• Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimers

• GPR37L1 controls maturation and organization of cortical astrocytes during development

GPCRs in Oncology and Immunology

• GPCRs and fibroblast heterogeneity in fibroblast-associated diseases

• Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model

Methods & Updates in GPCR Research

• Current and emerging methods for probing neuropeptide transmission

• Nanowire Biosensors with Olfactory Proteins: Towards a genuine electronic nose with single molecule sensitivity and high selectivity

Reviews, GPCRs, and more

• GPR84 in physiology - many functions in many tissues

• Bispecific Monoclonal Antibodies in Multiple Myeloma: Data from ASH 2022: A Podcast

Structural and Molecular Insights into GPCR Function

• Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar

Industry News

• Addex GABAb Positive Allosteric Modulator Program To Receive Additional Chf 2.7 Million From Indivior In Extended Substance Use Disorder Research Collaboration

• Addex Therapeutics To Release Half-Year 2023 Financial Results And Host Conference Call On August 10, 2023

• X4 Pharmaceuticals Closes $115 Million Loan Facility with Hercules Capital

• Gene-to-structure and Europe give Proteros customers a winning hand

• Sosei Heptares Operational Highlights and Consolidated Results for the Second Quarter and First Half of 2023

• Septerna: $150 Million Raised To Discover And Advance Novel Oral Small Molecule Medicines Targeting G Protein-Coupled Receptors

• Novo Nordisk A/S: Semaglutide 2.4 mg reduces the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity in the SELECT trial

• Crinetics Pharmaceuticals Reports Second Quarter 2023 Financial Results And Provides Corporate Update

• X4 Pharmaceuticals Announces Industry Veteran Dr. Christophe Arbet-Engels to Join as Chief Medical Officer

GPCR Events, Meetings, and Webinars

• ONCORNET2.0 Final Symposium (August 31 - September 1, 2023)

• 3rd Transatlantic ECI GPCR Symposium (September 7 - 8, 2023)

• Discovery On Target - DOT (September 25 - 28, 2023)

• Training Seminar "The Renaissance in GPCRs as Drug Targets: Allosteric Function and Biased Signaling" at the DOT (September 27 - 28, 2023)

• 3rd Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023)

• GPCR Retreat (November 2 - 4, 2023)

• MPGPCR Conference (November 15 -17, 2023)

• ASCEPT Annual Scientific Meeting (November 20 -23, 2023)

• Structure, Mechanism, and Drug Interactions of GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024)

GPCR Jobs

• NEW Director, Regulatory Affairs

• NEW Research Scientist/Senior Scientist I - Molecular Pharmacology

• NEW Director, Clinical Data Management

• Director, Discovery Toxicology

• Postdoc Fellow - Dr. Robert Lefkowitz Lab

• Postdoc Fellow - Dr. Robert Lefkowitz Lab

• Senior Research Specialist - Natural Sciences - Surgery

• Senior Scientist- Membrane Technologies

Explore Dr. GPCR Ecosystem