Maria Waldhoer on why endpoint GPCR assays miss most of what ligands do — and what kinetic pharmacological fingerprints reveal instead. << Back to podcast list Strategic Partner(s) Maria Waldhoer: Pharmacological biology modeling of receptor signaling pathways Pharmacological fingerprints as multi-parameter compound InterAx treats GPCR pharmacology the way engineers treat aircraft design: build the mathematical model GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

. << Back to podcast list Strategic Partner(s) Silvio Gutkind: When GPCRs Drive Cancer GPCRs are the Silvio Gutkind is Professor of Pharmacology and Associate Director of Basic Science at the UC San Diego His lab combines classical pharmacology with cancer genomics, bioinformatics, and synthetic lethality pharmacology Key Insights from the Conversation 1. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

Terry Hebert is a Professor of Pharmacology and Therapeutics at McGill University. in receptor pharmacology. an untapped pharmacological frontier, and caged ligands offer a route to drugging them selectively. Patient-Derived iPSCs Open the Door to Personalized GPCR Pharmacology Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

The conversation moves across discoveries that shaped a generation of GPCR pharmacology: the GABA-B heterodimer pharmacology of receptor families implicated in neuroscience, immunology, and metabolism. failure Orphan GPCRs and the missing pharmacology of ~100 unassigned receptors GPCRs in oncology, immunology GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

research from what still depends on pharmacological judgment. pharmacology Orphan receptor deorphanization and the limits of learning from known peptides Generative Using the terms interchangeably blurs what each approach can realistically deliver in a pharmacology Most pharmacology datasets aren't useless for ML; they're incomplete. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

receptor pharmacology and drug discovery. << Back to podcast list Strategic Partner(s) David Gloriam : Orphan Receptors, GPCRDB, and the Data Revolution in GPCR Pharmacology GPCRs represent the largest and most pharmacologically important family of membrane receptors, yet a significant portion remain orphans The Bottleneck Has Flipped For most of the history of pharmacological research, generating reliable data GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

This raises one of the most consequential questions in current GPCR pharmacology: can biased signaling The discussion ranges across four decades of receptor pharmacology — from the era when the field debated Louis University and trained in pharmacology at NIH and in molecular biology and psychiatry at Stanford Bryan Roth on the web UNC School of Medicine / Pharmacology Roth Lab Roth Leads $26.9 Million Project GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

A Class D GPCR dimer with no prior blueprint The first solved structure of a Class D GPCR - a yeast receptor Subsequent work has focused on understanding the molecular basis of GPCR pharmacology through structure GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

For Schulte, the scarcity of pharmacological tools is not just a technical inconvenience — it is the Each frizzled receptor is its own pharmacological entity The frizzled family is commonly discussed as section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. , British Journal of Pharmacology, Pharmacological Reviews, and The Journal of Biological Chemistry. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

A quantitative model can turn an artifact into pharmacology. Early in her postdoc, Dr. Graciela Pineyro’s love for GPCR pharmacology started in Uruguay where she first worked on the serotonin GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

protein families in pharmacology and drug discovery, yet many receptors remain poorly characterized discovery and pharmacological characterization. in computational pharmacology Deorphanization strategies for poorly characterized GPCRs Structural determinants pharmacology. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

pharmacology and drug discovery. , and the evolving role of computational pharmacology in modern drug discovery. dynamics to pharmacological outcomes relevant for drug discovery. subtype selectivity Integrating computational pharmacology with experimental GPCR biology Translating GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

build a productive, independent scientific research career in adhesion G protein-coupled receptor (aGPCR a basis for understanding aGPCR biology in the nervous system. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

validation, thrombosis pharmacology, and metabolic disease biology, with contributions to multiple clinical He has led mechanistic pharmacology operations and served as interim head of a 70-person cross-functional research organization spanning mechanistic pharmacology, compound management, and core automation. About this episode Brian Arey is Senior Director of Mechanistic Pharmacology within Leads Discovery and GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

in pharmacology - and Masha Niv has spent her career building the tools to change that. motifs, more prone to activation, and resistant to pharmacological blockade - and why those properties The conversation also covers what happens when taste pharmacology intersects with drug development - resist antagonists - structural architecture and pharmacological consequences 41:58 - Taste GPCRs as GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

Advance your GPCR research career with Dr. GPCR University. GPCR University Your professional home in GPCR science. Marsha Pierce | Midewestern University Introduction to GLP-1 pharmacology Translational Pharmacology field GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform Also super-valuable for those of us learning how to teach pharmacology GPCR researcher Dr.

GPCR About Dr. Trejo joined the faculty in the Department of Pharmacology at the University of North Carolina in 2000 and then moved to UC San Diego School Medicine, Department of Pharmacology in 2008, where she quickly In 2014, she was appointed Vice-Chair of the Department of Pharmacology. The long-term goal of Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

This gap is one of the defining bottlenecks in receptor pharmacology, and closing it one receptor at cannot be studied pharmacologically in a cell-based setting. Bender frames this not as a replacement for bench pharmacology but as the only realistic path to coverage Brian is involved in organizing the GRC/GRS Molecular Pharmacology meeting, which has been postponed GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

To answer this, his work integrates GPCR molecular pharmacology with computational biology, population His research integrates GPCR molecular pharmacology, computational biology, and pharmacoepidemiology The approach treats the evolutionary record as a pharmacological hypothesis generator. 3. This is the argument for keeping computational pharmacologists embedded in pharmacological communities GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

Explore Martin Marro’s impact on GPCR drug discovery, assay innovation, and translational pharmacology Martin Marro, currently Executive Director and Head of Cell Pharmacology at Eli Lilly’s Obesity Research What learning from “failed” screens can reveal about receptor pharmacology and species selectivity. pharmacology. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

Your One-Stop-Shop for GPCR Drug Discovery and Development Researchers developing GPCR-targeted therapeutics These assays enable complete pharmacological profiling across cAMP, β-arrestin, and internalization. Together, these datasets exemplify the depth of pharmacological insight enabled by Eurofins DiscoverX Access GPCR Obesity and Diabetes Solutions and Key Resources Discover GPCR Obesity and Diabetes Product Eurofins Discovery GPCR services provides the industry's most extensive collection of validated GPCR

parathyroid hormone receptor sits at the intersection of calcium homeostasis, bone metabolism, and a set of pharmacological His work has demonstrated that nanobody-ligand conjugates can rescue pharmacologically weak peptides, The pharmacological logic is sound, and the engineering framework to test it exists. Work in his independent laboratory is focused on developing new pharmacological tools via chemistry and GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

Ajay Yekkirala is a GPCR pharmacologist, biotech entrepreneur, and co-founder of Superluminal Medicines strategic leaders seeking new drug development models Anyone curious about where AI meets molecular pharmacology rejection letter pivoted him into a PhD program at the University of Iowa, where he studied opioid pharmacology GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

GPCR University. ​ than $10/week Join Premium Below👇 Team Access for Discovery Groups Full University Premium + Terry's Pharmacology Built for teams aligning pharmacology across programs — so everyone works from the same expert-led foundation . $2,249.25/year Per person, min 5 seats ( 25% team discount ) Get Team Access Premium + Terry's Pharmacology Terry Kenakin's pharmacology access with monthly AMA's — the complete GPCR learning experience in one

GPCR Ecosystem. in a competitive manner and in a short time (<3 months), customized fluorescent ligands with optimal pharmacological Chemistry and Technology from the University of Bari and completed her PhD in Biomolecular Sciences in Pharmacology measurement of binding displacement, delivering robust pIC₅₀ and pKᵢ values that align with established pharmacology Probes Innovative fluorescent probes that de-risk the pre-clinical drug discovery phase with optimal pharmacological

GPCR pharmacologist Dr. are nature's own biased receptors, and building a structural pharmacology lab in India. << Back to podcast proteins orchestrate such functional diversity across an entire receptor superfamily remains one of pharmacology's Arun Shukla leads a structural pharmacology lab in the Department of Biological Sciences and Bioengineering GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

ABOUT THE GUEST Qing Fan is an associate professor of pharmacology and pathology and cell biology at Disease-associated mutations in the GABA-B transmembrane domain and what they suggest about precision pharmacology limitations and the case for allosteric and biased approaches Cryo-EM as a catalyst for structural pharmacology Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses

System Sensitivity: Revealing True Drug Activity Through Functional Volume Control The pharmacology Terry Kenakin Professor of Pharmacology and Pharmacology Course Coordinator Department of Pharmacology , University of North Carolina School of Medicine, Chapel Hill Head Instructor, Terry's Pharmacology Kenakin trained in chemistry and pharmacology at the University of Alberta and completed postdoctoral GPCR Dr.

Michelle earned her PhD in Molecular Pharmacology at Monash University, then trained in single-cell biology How GPCR Collaboration Built an Innovation Engine 🎓 Want more like this? GPCR Premium . GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.

training at the University of New South Wales (UNSW) Sydney, Australia in 2016 with first class Honours in Pharmacology This project aims to characterise the molecular pharmacology of GPR146 and to validate the proposed ligands GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses GPCR Podcast? Leave a Review.