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The Overlooked Step in Every Discovery Program So what does that mean for discovery scientists designing the next generation of GPCR ligands? Your Membership Includes: Frameworks proven in real discovery programs On-demand lessons  designed for trusted by biotech, pharma, and academia 💎 $2999/year — one conference cost = a full year of expert training Kenakin with your own enzyme or GPCR interaction puzzles.

Watch Episode 175 From failed assays to breakthroughs in GPCR modeling , Dr. At that point, very few GPCR crystal structures had been determined. For Carlsson, this marked a shift in how his lab approached GPCR research. This perspective influences how his lab trains students. protein sequences, small molecule data are often fragmented, inconsistent, or unavailable, making model training

Eric Trinquet, a veteran innovator behind functional GPCR assays like HTRF and IP-One, believes rigid If you’re building tools or careers in GPCR science, this is your playbook. It began with an unmet need: how to track Gq-coupled GPCR activity without the mess of calcium flux or GPCR   Dr. GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr. GPCR Premium Ecosystem  for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical

GPCR Ecosystem. GPCR Podcast To mark the spotlight, Dr. GPCR  invited Dr. Eric Trinquet  to the Dr. GPCR. GPCR Dr. Through our podcast, training programs, and partner content, we help scientists connect, collaborate,

GPCR Podcast: Visualizing GLP-1 & GIP Receptors in Islets and Brain Understanding incretin biology depends Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built GPCR Premium Membership Gives You an Edge Premium delivers a clear, noise-free stream of GPCR intelligence GPCR innovation is accelerating. GPCR Team

We’re also reopening our instructor program  — welcoming scientists from across the community to teach Our access program for researchers in developing countries  continues as well: eligible scientists can GPCR Ambassador Program As we grow, we want the community to grow with us. Our Ambassador Program empowers community members to share Dr. GPCR About Dr. GPCR Dr.

Unlocking the Puzzle: The Importance of Precision in GPCR Programs and the Hidden Costs of Overlooking A GPCR program can have world-class science, top-tier talent, and millions in funding — and still fail Hiring Won’t Save Your GPCR Drug Discovery Program When a drug discovery program stalls, the default A few familiar failure points: Fragmented Data: GPCR programs spew data across files, folders, and inboxes Build Precision Systems for GPCR Drug Discovery The only way out for GPCR drug discovery programs isn

partnership built on trust and curiosity — reshaped both careers and helped unlock a new generation of GPCR How a Collaboration Led to a GPCR Imaging Breakthrough JB didn’t set out to contribute to a GPCR imaging It was the start of a scientific partnership with the potential to shift how GPCRs could be visualized How Chemical Probes Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the Designing Reliable GPCR Imaging Tools for Real Biological Systems Success brought new challenges.

August 2022 "G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that serve Classically, GPCR internalization has been considered to lead to receptor desensitization. Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in , which will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets Read more at the source #DrGPCR #GPCR #IndustryNews

Johannes “JB” Broichhagen trained as a synthetic chemist — someone who trusted carbon–carbon bonds far Interdisciplinary design isn’t optional in GPCR imaging. It’s the catalyst. And the most striking validation came from in vivo GPCR imaging. Strong GPCR imaging tools come from strong interdisciplinary relationships.  🎧 Listen to the full episode https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/chemical-probes-for-gpcr-imaging-and-internalization

Why Speed Matters in GPCR Drug Discovery Nine out of ten GPCR programs stall  not because the target Programs stall. Timelines stretch. programs to advance or kill. Program Kill vs. Advance: What Real Teams Do How do large pharma teams decide whether to advance or pause a GPCR program

Hi GPCR Community, If you work on GPCR discovery, you already know: early signals can mislead, and timing across oncology, metabolic, CNS, and fibrosis programs. Track, GPCR Happy Hour, and more! GPCR innovation is accelerating. community platform to help train and inspire the next generation of scientists.

GPCR Ecosystem Directory —a centralized hub for tools, training, and technology. GPCR. GPCR Dr. GPCR is a nonprofit organization connecting the global GPCR community through training, curated news, With over 160 podcast episodes, live and on-demand educational programs, and a dynamic partner ecosystem

GPCR Virtual Cafe. This time with none other than Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

your conclusions, your experiments, and even your program’s credibility. clear framework for distinguishing these mechanisms and avoiding common pitfalls that can derail a program data interpretations that can lead to costly dead ends and missed opportunities in your drug discovery program Sharpen your discovery decisions ➤ Yamina's Consulting Corner - Building Your GPCR Program for Breakthroughs Learn how to transform your program from a series of disconnected efforts into a predictable, de-risked

Later, exposure to veterinarians working in agricultural settings inspired him to train in veterinary — the “interface” between brain and body. GPCRs Re-Enter the Story — Not as Theory, but as Tools GPCRs have always been powerful drug targets — That partnership eventually produced fluorescent GPCR tools  that allow researchers to visualize GPCR Can GPCRs act as “delivery ZIP codes” for targeted therapies?

Broichhagen aka JB, the goal was bold and elegant: Create a photo-switchable ligand to remotely control GPCR They had a tool that did bind the GPCR… but not in the light-controlled way they wanted. The Moment a Failed Tool Became a GPCR Imaging Breakthrough What the compound did reliably do was label This solved a long-standing problem in GPCR biology: You can't understand signaling if you can’t see  The Larger Lesson for Scientists and Innovators This story isn’t just about a GPCR imaging tool.

Take a look at our GPCR coverage for this week. We've got 11 GPCR papers, seven industry news pieces, a new GPCR event, and even a job ad.   with real-time kinetics Discovering new ligands and GPCR behaviors for unique drug profiles   GPCR Event Concurrent Private Placement of $130.7 Million Tectonic Therapeutic Announces US IND Clearance for Lead Program GPCR Ecosystem

And that’s exactly what carries strong discovery programs into 2026. Terry’s Corner: GPCR Binding Affinity Experiments That Hold Up Orthosteric GPCR binding affinity experiments GPCR Podcast: When GPCR Tools Scale Even the most elegant tools only matter when they scale beyond a The strongest discovery programs aren’t built on instrumentation alone—they’re built on interpretation GPCR Premium Member And Lock in The Current Rate➤ https://www.ecosystem.drgpcr.com/gpcr-university-pricing

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating Conventional GPCR drug discovery has largely focused on orthosteric sites, but recent breakthroughs in GPCR activity, enabling greater specificity and fewer side effects. allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

Exploring the Hidden Dynamics: How Kinetics Reveals What Equilibrium Conceals in GPCR Research. Hi GPCR Community, If equilibrium curves are your comfort zone, this week’s feature will challenge (and GPCR Premium: Sneak Peek Here’s a fast, high-level preview of what Premium Members are unpacking this We’ve got your GPCR Track, Happy Hour, and sessions mapped so you can extract maximum value. GPCR innovation is accelerating.

For decades, GPCRs have been the cornerstone of pharmacology. GPCR Modeling in Context: Then and Now When Carlsson entered the GPCR field in the early 2000s, structural Why Predictive GPCR Modeling Matters Now The convergence of machine learning, improved GPCR structures Want to go deeper into GPCR modeling? Dr. GPCR Podcast Push the boundaries of what's possible 👉 Join the Dr.

Terry's Corner – Designing Drugs That Anticipate Physiological Pushback Most GPCR programs don’t fail GPCR , our mission is simple but urgent: Accelerate GPCR biology and drug discovery by connecting scientists GPCR Podcast, the Revvity team built pHSense™ from the ground up by listening to what GPCR scientists GPCR innovation is accelerating. GPCR and the offered resources in my work sphere." — DrGPCR University Attendee GPCR innovation doesn

2026 GPCR Pharmacology AMA: Receptor Theory, Biased Signaling & Assay Interpretation The first GPCR Pharmacology as new videos are released: ▶️ https://www.youtube.com/@TerryPharmacologyCorner New White Paper on GPCR School of Medicine, has authored a new white paper in collaboration with Eurofins DiscoverX: Assess GPCR programs, this connects functional assay data directly to translational decision-making — moving beyond theory and mechanistic reasoning The value lies not in a single explanation, but in preserving rigor as programs

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where GPCR Podcast Listener Why Dr. GPCR Premium 🔹 What’s included? The pace of GPCR innovation is accelerating.

infrastructure, not duplicated equipment Centralized core facilities for receptor assays PhD students trained across multiple techniques, not just one pipeline Senior scientists embedded as “connectors” between programs The structure you train in often matters more than the experiment you start with. Year 2  — Core imaging and signaling platforms launched Year 4  — Pooled grants fund expansion and training programs Year 7  — International collaborations and industry partnerships take root Today  — Model continues

In GPCR drug discovery, a single mistaken assumption can derail an entire program. Why Misreading Antagonism Delays GPCR Drug Discovery If a dose-response curve shifts to the right, you Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate This is the kind of insight that makes the difference between a dead-end program and a well-informed

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Ecosystem paid membership with extra benefits? 🔬Join the #GPCR movement today! ➡️ https://www.ecosystem.drgpcr.com/plans-pricing #gpcr #drgpcr