The europium complex becomes increasingly fluorescent as the pH drops, enabling dynamic tracking of internalization With formats including TR-FRET, radioligand binding, cAMP, IP-One, and phospho-protein assays (ERK, AKT

Backed by more than 30 years of GPCR experience, including 20+ years of successful Integrated Drug Discovery Beyond screening, our capabilities include custom assay development, deorphanization, biophysical characterization design Rapid turnaround execution Functional Pharmacology & Binding Expertise > 2700 Human GPCR assays including

novel paradigms of drug action at GPCRs, particularly allosteric modulation and biased agonism, and incorporates Professor Christopoulos has over 360 publications, including in leading international journals such as He has also been the recipient of multiple awards, including the John J. GPCR AI Summary Quick recap Yamina and Arthur discussed Arthur's career journey in pharmacology, including Arthur shared his career journey, including his collaboration with Patrick Sexton and Jim Burch, and

) and arrestins as GPCR regulators and as mediators of distinct signaling pathways through partners including In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Instructors at the course included Marc Chabre , Harden McConnell , Richard Henderson , Martin Rodbell Institute appointment, Tom advanced a series of novel biochemical and biophysical assay platforms, including This work involved active long-term collaborators, including Richard Mathies and Fritz Siebert , and Early applications included “targeted photo-crosslinking,” and more recently, the parallel development

We focus on several aspects of metabolite-sensing GPCRs including signal transduction, intracellular Claudia suggested possible next steps, including researching review articles or articles to gain a higher

They worked on the interactome of yeast and mammalian Rab5 homologs including identification of Rab5 Tall has presented his work at 59 invited seminars including national and international meetings and

conditioning around deference, the general insecurity of early-stage training, and the fear of appearing incompetent

.” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present an incredible subtypes and very few known ligands, the structure–function relationships remain largely mysterious—and incredibly

Randy has received a number of research prizes, including the PhRMA New Investigator Award, the Distinguished

These tools are fully open to academic researchers , with wide applicability beyond just RAMPs — including As the field advances, the computational layer — including AlphaFold and structural prediction tools — will play an increasingly pivotal role. Outside of the lab, Ilana is a leader within her community, spearheading several outreach initiatives including

He describes his work on GPCR mechanotransduction in endothelial cells - including the early identification thrombosis pharmacology, and metabolic disease biology, with contributions to multiple clinical programs including He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility

Inclusion matters We welcome diverse voices, experiences, and expertise. Launched our podcast to share expert insights with the scientific community. 2021 2nd Annual Summit Increased Premium Members Include: ✔ Drug hunters at early-stage biotechs ✔ CRO leaders building assays and tools moving into translational work ✔ Teams preparing for fundraising or due diligence Expert Contributors Include Free Membership Includes: ✔ Free version of GPCR Weekly News - straight to your inbox!

Majellaro Her decisions, often made intuitively rather than analytically, have led to key inflection points—including The company works with clients from pharma, CROs, and academia, including MD Anderson and several leading

Successful GPCR research increasingly depends on close collaboration between these two domains. If the experimental data is poorly annotated or incomplete, the computational predictions will not be The terminology used in the literature is inconsistent.

His lab's contributions include the development of BRET (Bioluminescence Resonance Energy Transfer) technology In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones Michel’s scientific contributions were recognized by the attribution of many awards and distinctions including

Who Should Join To join the community, you should be actively related to the GPCR field , including: Evidence first; hype last Openness with Intent — Share to accelerate; respect boundaries Diversity & Inclusion

Enhance Client Project Delivery: Streamline workflows and improve scientific execution to increase client

pharmacology of the β₂-adrenergic receptor , a GPCR traditionally associated with bronchodilation but increasingly opportunities to design drugs that promote beneficial metabolic responses such as muscle growth and increased Later I became increasingly interested in skeletal muscle metabolism and how β₂-adrenergic signaling

As of August 2022, he has over 270 publications in scientific journals (including Science, Nature, Cell Gainetdinov was included in the Web of Science (WOS) Highly Cited Researchers (HCR) list, representing

In my role at Orion Biotechnology, I work at the intersection of science and business, which includes Caron has received numerous awards including a Burroughs Wellcome Fund Career Award in the Biomedical Slosky’s work has been recognized through several travel and research awards, including the William James Slosky is passionate about training the next generation of scientists and increasing diversity, equity , and inclusion in science.

Lamerdin and Agrawal explain why the field, and increasingly regulators, now expect assays built closer obesity and GLP-1 resurgence that returned GPCRs to the front of drug discovery De-orphanizing GPCRs, including

His experience also includes translating knowledge generated into the selection of targets, screening co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases including Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory

It is not incidental to the science; it is part of the scientific logic. 6.

Other academic interests of his include studying pharmaceutical finance & healthcare administration and developing technologies that increase healthcare access. His non-academic interests include traveling, scouting out micro-breweries, and collecting beer cans.

contributed to the identification of RAMP proteins, the GABA-B heterodimer, and ligands for orphan receptors including

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shares approaches that combine genetic manipulation (CRISPR-Cas9) and functional behavioral assays, including

quantitative imaging by FRET, BRET, and single-molecule microscopy, and signaling on internal membranes including

and therefore blood pressure; another regulates glucose handling through a transporter family that includes Pluznick's advice to early-career scientists is shaped by her own near-dismissal of an inconvenient microarray