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Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes

Remulate is the receptor she secured funding to study, the one her first PhD student built an entire discuss the cost of unpublished negative data - particularly for PhD students working within three-year funding

Track My Discovery The wrong CRO—or wrong experiments—can burn months and millions You're not here to fund

The "unknown unknowns" should change how we fund and train scientists Dr. GPR68 and the feedback loop in pancreatic cancer 19:46 Challenges of targeting GPCRs in oncology — funding

design for GPCR biology Academic entrepreneurship and the path from bench to phase 2 clinical trials Funding The spin-out - how a discovery became a phase 2 clinical trial in kidney disease 16:56 Why grant-only funding

endogenous agonist is known, it may be a large peptide or lipidated compound that cannot be practically dosed

downregulation and tolerance, while low-internalizing agonists uncouple the receptor from ion channels without losing migraine — a path through four labs 04:19 Why mu worsens migraine and delta relieves it 09:27 What chronic dosing

Why This Matters How GPCR tools lose impact when distribution and access aren’t planned from the start scientific activities, from proprietary technology development to international collaborations and funded

The "brain always wins" problem is solved by isoform selectivity, not by dose.

dosage and length of treatment in a mouse model and suggested using a biosensor-based assay to examine dose-response

Tissue-specific targeting as a strategy for reframing side effects The primary dose-limiting side effect

To date, she has successfully led seven funded projects.

primarily nausea and vomiting - remain among the main barriers to broader clinical use and optimal dosing

“When we saw dose-dependent internalization in endogenous GLP1R cells—without microscopy—that was the

They highlighted the strategic importance of planning in the biotech sector due to limited funds and

Jan Nedergaard, pioneers in thermogenesis research. Fundamental Limitation Traditional β₂-adrenergic agonists can stimulate muscle growth and fat loss but lose But traditional β₂ agonists lose effectiveness over time because the receptor becomes desensitized. The body adapts, requiring higher doses. That makes them unsuitable as long-term therapeutic drugs.

John suggested building milestones and landmarks into a postdoc, such as applying for funding opportunities

Arthur shared his insights into the unique grant funding system in Australia, the importance of impact

Arthur shared his insights into the unique grant funding system in Australia, the importance of impact

from concept to systematic mutation screen From academic discovery to co-founding Heptares: decision, funding

GPCR ecosystem 32:28 Q&A — preparing an episode, funding, and what's next 46:53 Recording Brian Roth

In a funding environment that rewards the opposite, the advice is harder to take than it sounds — and

before his group was large enough to require it - acting on advice from mentors who recognized that funding And that's the fun part." "I walked in there and I did the best performance ever.

and to work on projects that they're passionate about and not simply projects that may attract more funding

you, Joe, to the podcast today. Joe Kim, welcome to the Dr. GPCR podcast. Dr. Joseph Kim: Thank you, Yamina. I go by Joe. So Joe, tell me a little bit about how you ended up working on GPCRs in Ashish’s lab. There’s that saying that the difference between drugs and poisons is often just the dose.

His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs He has developed novel tools and methodologies to study fungal GPCRs which allowed the determination of the first structures of the prototypical fungal GPCR Ste2.

Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins in the lungs seemingly naïve idea at the dinner table led to a side project by which I characterized the impact of a fungal A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and