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- Anything BUT GPCRs with Dr. Mikel Garcia-Marcos | Dr. GPCR Ecosystem
Mikel Garcia-Marcos About Dr. Mikel Garcia-Marcos "I was trained as a biochemist and molecular biologist during my Ph.D (2005) in Spain Mikel Garcia-Marcos, the host Yamina explores Dr. Garcia-Marcos's academic journey, which spans training in Spain, Belgium, and a postdoctoral fellowship Mikel Garcia-Marcos on the web Boston University LinkedIn Dr. GPCR Enjoying the Dr. GPCR Podcast?
- ⏳ In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March 18th! If you’re working on GPCR drug discovery, you know that finding a promising candidate is just the start. A drug must also: ✅ Be absorbed into the body ✅ Reach the right target ✅ Stay long enough to be effective ✅ Cause no harm 📢 Spots are limited—register by March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery | Dr. GPCR Ecosystem
In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March the right target ✅ Stay long enough to be effective ✅ Cause no harm 📢 Spots are limited—register by March GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Published on March 10, 2025 Category In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March the right target✅ Stay long enough to be effective✅ Cause no harm 📢 Spots are limited—register by March
- Self-Learning, Collaboration, and Delegation in Science with Dr. Badr Sokrat | Dr. GPCR Ecosystem
Christian Baron studying bacterial secretion systems, I joined the molecular pharmacology laboratory There, I completed a PhD in biochemistry exploring the non-canonical functions and possible novel mechanisms and regulation, specifically in the context of pain and inflammation, and how his PhD research on non-canonical
- 🎯 Crack the code of GPCR ligand development! In case you haven’t heard, Dr. Terry Kenakin is hosting a 4-week course on GPCR drug development—and registration closes in 3 days! ⚠️ What you’ll learn: ✅ Drug absorption, metabolism & clearance ✅ PK-PD modeling & therapeutic profiles ✅ Early safety assessments & toxicity risks 📌 Limited spots—sign up before March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research | Dr. GPCR Ecosystem
& therapeutic profiles ✅ Early safety assessments & toxicity risks 📌 Limited spots—sign up before March GPCR Ecosystem #GPCR #DrGPCR #Pharma #Biotech #Research Published on March 15, 2025 Category Dr. modeling & therapeutic profiles✅ Early safety assessments & toxicity risks 📌 Limited spots—sign up before March
- 🚨 Exciting Opportunity for Professionals in Drug Development! 🚨 Register today for a one-of-a-kind online course at Dr. GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." 🗓 Dates: March 20 - April 10, 2025 ⏰ Time: Thursdays, 10:00 AM - 11:30 AM (EST) This advanced course is essential for anyone working in drug development and focuses on: The essentials of new drug development Key pharmacokinetic elements (absorption, distribution, clearance) Hepatic metabolism and the Cytochrome P450 system Drug safety and toxicology (including drug-drug interactions) And much more! Gain deep insights into GPCR drug candidates and learn the critical assays and techniques required to bring therapeutic molecules to life. 🚨 Only 25 spots available — register now! 💡 This is a great opportunity for both academia and industry professionals. Sessions will be live, and you’ll also have 1:1 discussion time with the instructor. Full PDFs of the slides will be available! 🔗 https://buff.ly/lVEcRUc #GPCR #DrugDevelopment #Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry | Dr. GPCR Ecosystem
." 🗓 Dates: March 20 - April 10, 2025 ⏰ Time: Thursdays, 10:00 AM - 11:30 AM (EST) This advanced course Pharmacokinetics #TherapeuticDrugs #OnlineCourse #DrGPCRUniversity #PharmaceuticalIndustry Published on March GPCR University: "Development of GPCR Ligands as Therapeutic Drugs." 🗓 Dates: March 20 - April 10, 2025
- Chloe Hicks | Dr. GPCR Ecosystem
She is currently working on her senior thesis which involves identifying the non-canonical signaling
- Dr. Katarina Nemec | Dr. GPCR Ecosystem
I aim to discover new therapeutic approaches, and druggable molecules or refine canonical drug targets
- How does nanoscale GPCR organization shape signaling? 🤔 We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, here’s the answer 😉 ✅Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr | Dr. GPCR Ecosystem
Gabriele Kockelkoren #gpcr #drgpcr Published on March 20, 2025 Category Dr.
- 📢 All 2025 Dr.GPCR Courses Are Open for Registration! Which one will you choose? 🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course for you. 💡 Bonus: Premium Members enjoy 25% off on all courses! 🔗 Explore & register today: https://www.ecosystem.drgpcr.com/gpcr-courses #GPCR #DrGPCR #Biotech #DrugDiscovery #Pharmacology | Dr. GPCR Ecosystem
www.ecosystem.drgpcr.com/gpcr-courses #GPCR #DrGPCR #Biotech #DrugDiscovery #Pharmacology Published on March
- A newly engineered biosensor reveals DNAJC13 as a key player in GPCR trafficking, shedding light on its role in DOR downregulation and endosomal regulation. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation #gpcr #drgpcr | Dr. GPCR Ecosystem
an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation #gpcr #drgpcr Published on March
- A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr | Dr. GPCR Ecosystem
large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr Published on March
- Do you remember the first time you were left alone in the lab with an experiment? 🤔 Did your experience compare to Dr. Brian Hudson’s? 😄 Tune into this week’s Dr. GPCR Podcast for great stories, GPCR insights, and a fascinating journey that led Dr. Hudson to years of groundbreaking research at the University of Glasgow. Don’t miss out! ✅Listen now https://buff.ly/aEQGUFl #gpcr #drgpcr | Dr. GPCR Ecosystem
✅Listen now https://buff.ly/aEQGUFl #gpcr #drgpcr Published on March 17, 2025 Category Dr.
- How does a superagonist activate M2 muscarinic receptors? New simulations reveal the conformational changes from inactive to active states to highlighting how ligand dynamics drive GPCR activation! Catch the full story in the Ecosystem! https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics #GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics | Dr. GPCR Ecosystem
receptor-activation-regulated-by-aromatic-ring-dynamics #GPCR #drGPCR #M2R #drugdiscovery #moleculardynamics Published on March
- 🎧 "You will always feel like you know nothing— and that’s completely fine." In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren shares: 🔬 How GPCR spatial organization shapes signaling and drug responses 🌍 His interdisciplinary journey from physics to pharmacology 💡 Why embracing the unknown is key to scientific breakthroughs A must-listen for biophysicists, pharmacologists, and drug hunters pushing the boundaries of discovery! 🎙️ Tune in now:Ep 162 with Dr. Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast | Dr. GPCR Ecosystem
Gabriele Kockelkoren #DrGPCR #GPCR #Biophysics #Pharmacology #DrugDiscovery #SciencePodcast Published on March
- 🔬 Enhance Your GPCR Expertise with Dr.GPCR University! Looking to sharpen your skills in GPCR pharmacology, drug discovery, data analysis, or project management? Dr.GPCR University offers industry-focused courses designed to help you stay ahead in the field. ✅ Comprehensive course library covering cutting-edge GPCR science ✅ Practical insights for real-world drug discovery challenges ✅ Flexible, on-demand learning to fit your schedule 🚀 Elevate your expertise today: Start learning now #GPCR #Pharmacology #DrugDiscovery #Biotech #DrGPCR | Dr. GPCR Ecosystem
expertise today: Start learning now #GPCR #Pharmacology #DrugDiscovery #Biotech #DrGPCR Published on March
- 🚀 New Workshop: Practical Quantification of Allosteric Modulation Join Dr. Terry Kenakin on May 1st, 2025, for an advanced live workshop on allosteric modulators in GPCR drug discovery. Learn how to: ✔️ Identify, measure, and quantify allosteric properties ✔️ Apply functional allosteric models to determine mechanisms of action ✔️ Confirm allostery through kinetic analysis 📅 Date: May 1st, 2025 ⏳ Registration deadline: April 18th 📍 Live on Google Meet 🔗 Register now: https://www.ecosystem.drgpcr.com/event-details-registration/practical-quantification-of-allosteric-modulation #GPCR #Allostery #DrugDiscovery #Pharmacology | Dr. GPCR Ecosystem
practical-quantification-of-allosteric-modulation #GPCR #Allostery #DrugDiscovery #Pharmacology Published on March
- Did you know that A2B adenosine receptor-triggered calcium mobilization varies by cell type? A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling, revealing a more complex regulation than previously thought. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity Published on March
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
and GAIN domains and found that this ADGR is resistant to autoproteolysis despite the presence of a canonical identified several unique structural features that are important for autoproteolytic cleavage, beyond the canonical Molecular Biochemis-try, Leipzig University, Johannisallee 30, D-04103 Leipzig" About Fabian Pohl "Mar Sträter Oct 2011 – Mar 2016 Master of Science in chemistry, University Leipzig Oct 2008 – Sep 2011 Bachelor
- 💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you’ll learn: ✅ Drug Development Basics – Absorption, metabolism, PK principles ✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling – Predicting drug behavior, non-linear PK ✅ Early Drug Safety – Toxicity risks & drug interactions 📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery | Dr. GPCR Ecosystem
GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Published on March 8, 2025 Category
- Illuminating Functional Selectivity and Allosterism at GPCRs.
The Canadian Institutes for Health Research and March of Dimes currently support his research."
- Developing new tools to uncover GPCR signaling patterns with Remi Janicot | Dr. GPCR Ecosystem
Mikel Garcia-Marcos seemed like a good fit as GPCRs are integral to the functioning of the nervous system
- Dr. Roger Sunahara | Dr. GPCR Ecosystem
We also study non-canonical sites, those outside of the native hormone, or orthosteric, binding sites
- Trainee Symposium II
Mikel Garcia-Marcos which investigates GPCR and G protein signaling" Remi Janicot on the web Boston University
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free! ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity Published on March
- Your GPCR Order Has Arrived! ❇ Feb 10 - 16, 2025 | Dr. GPCR Ecosystem
. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April Agonist Call for GPCR Papers NEW Special Issue on Adhesion GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 -
- Fresh, Fresh, GPCR News ❇ Feb 17 - 23, 2025 | Dr. GPCR Ecosystem
What’s Next Call for GPCR Papers Special Issue on Adhesion GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite - Online March
