Discover how Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane These residues may represent potential targets for allosteric modulators that reshape receptor signaling Ligands may bind one subtype strongly but another weakly.

compounds that signal differently from the natural hormone, rather than treating such a compound as a curiosity Knock out an overexpressed kinase and a tumor may simply route around it. Scotsman who said make them drugs - 05:45 Why research is a privilege rather than a reward for good marks

on G protein hotspot mutations, why the canonical GαQ pathway fails in uveal melanoma, and how CXCR3 may protein family in medicine, but until recently their role in cancer was treated as marginal — a few curiosities believed in to a recognized driver class in oncology, and explains why chemokine receptors like CXCR3 may CXCR3 may be the hidden gatekeeper of immunotherapy response. no one believed in 10:52 The cancer genomics result that reframed GPCRs as drivers 16:45 Why CXCR3 may

For many scientists, the origin moment is this ordinary and this decisive. in India and it was during a biochemistry class where he learned about cell signaling that he became curious

That gap in care sparked a curiosity that became a career. struggling to grip mice in early animal studies to thesis delays during COVID-19, Serafini's journey is marked

The insight that G protein regulatory proteins may shape the functional selectivity of GLP-1 agonists cells and the periphery, but in neural tissue, where the downstream consequences of biased coupling may Minor offsets may occur. 00:00 Introduction and Dr. unexpected space to think, organize data, and build collaborations 57:58 Advice for trainees - staying curious

how his experiences at the University of Chicago and the University of Michigan shaped his scientific curiosity

scaffolds like thiazolidines and xanthinediones, Ben is helping define how structurally different PAMs may “It doesn’t matter how many cool, fun tools you have. With clarity, curiosity, and a collaborative spirit, Ben reminds us that impactful science isn’t just

What it felt like to see the first dose-response curves in native beta cells—and why that moment changed A mix of scientific curiosity, a tolerance for failure, and a commitment to delivering real-world impact—one

GPCRs, RAMPs, and the selectivity problem in CGRP-targeted migraine therapies - what the approved drugs may two receptor complexes, combined with the known pharmacology of CGRP at CTR-RAMP1, suggest the drug may be less target-selective than its approval label implies - and that effects attributed to one target may Burning Curiosity as the Non-Negotiable Hay's advice to junior scientists distills to a single criterion : if the curiosity isn't deep enough to outlast the failures, the career won't hold.

Falling in Love with GPCRs GPCR pharmacology captured his scientific curiosity. His unwavering dedication through these cycles became an asset—many others shifted focus, leaving a smaller

– Overcoming introversion, the importance of talking to people, and how networking (or just genuine curiosity Whether in academia or industry, success comes from curiosity, persistence, and knowing your values.

Jennifer Pluznick explains why olfactory receptors in the kidney are more than curiosities — they sense The trafficking failure itself may encode something about how tightly ORs are regulated in olfactory