collaborative chemistry enabled in designing receptor-targeted fluorescent ligands The moment when structural tissue-specific engagement Who should listen Navigated complex datasets where interpretation depended on biological Robert Turner Professor of Diabetic Medicine at the University of Oxford , working within the Oxford Centre His group develops imaging and chemical biology tools to reveal how GLP-1 and GIP receptors operate within David Hodson on the Web Radcliffe Department of Medicine Islet Biology Lab University of Birmingham Unlock

constraint on pharmacological interpretation Equilibrium vs. dynamic frameworks for studying receptor biology An assay measures a specific thing - not the biology you assume it measures One of Livingston's most Academia and industry are structurally complementary - not competing versions of the same thing Academia Livingston argues these structural constraints make the two sectors dependent on each other - and notes moving - and then to flip it on its head again and say the receptor at the surface might not be the center

GPCR webinars are free, live online scientific sessions focused on G protein-coupled receptor biology Whether you're deep in receptor biology or evaluating assay tools, these sessions are built for you. GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design Every session is grounded in receptor biology with a focus on what's practical and applicable. A working understanding of GPCR biology helps you get the most from each session.

She developed expertise over the past two decades studying structure/function relationships of GPCRs me to shape a swiss start-up company from a scientifc idea to a thriving Biotech focusing on Systems Biology Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology network and biocomputing services, served on the Steering Committee of the San Diego Supercomputer Center

that mastering a technique isn’t enough—true scientific breakthroughs come from formulating the right biological Membrane Proteins and Receptors (COMPARE), University of Nottingham, where he provides leadership in structural He joined the MRC Centre for Protein Engineering and later at the MRC Laboratory of Molecular Biology group leader at the Paul Scherrer Institute and ETH Zürich in Switzerland, changing his attention to structural In 2017 Dmitry became a full professor at the Centre of Membrane Proteins and Receptors, COMPARE, a joined

Radioligand binding and the first demonstration of GPCR structure — The methodological progression from The cloning race and the serendipity of the intronless gene — Competing against Genentech's molecular biology When Brian Kobilka proposed screening a genomic library, Merck's molecular biology collaborators called The discovery that it was structurally homologous to rhodopsin was a complete surprise. of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University Medical Center

Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience Operational Discipline I instill structure and consistency across every phase of your discovery process Yamina brings the clarity, rigor, and structured decision-making that keeps programs on track. Therapeutics Before working with Yamina, we had solid internal momentum but needed to better align our biology Her input helped us structure the screening funnel, define clear go/no-go criteria, and integrate ADME

Since returning to Europe, her research has centered on receptor biology at the intersection of basic It is a small detail, but it marks something real about the state of adhesion GPCR biology in insects : these receptors exist in a space where the biology precedes the vocabulary. For receptor biology that requires iterative genetic manipulation - knocking out, tagging, rescuing, Some journals are beginning to accept negative data, and both agree this matters structurally.

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain biology discovery, he later co-founded Superluminal Medicines, a company using machine learning to explore GPCR structure-function Ajay’s work sits at the intersection of GPCR biology, AI, and translational medicine.

the GPCR research community — bridging wet-lab experimentation, open-access tools, and computational biology GPCR superfamily , building a digital and physical toolkit to systematically investigate GPCR-RAMP biology The system is modular and adaptable, opening doors for systems biology and context-specific interaction As the field advances, the computational layer — including AlphaFold and structural prediction tools Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of

Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane protein biology—plus observed signaling outcomes, providing a bridge between structural biology and pharmacology. Nivedha reflects on how her career in GPCR biology began unexpectedly during her postdoctoral work. I was always interested in biology, especially studying anatomy. At the time, I didn’t realize the full scope of GPCR biology.

Nikolaus Heveker's lab at the CHU Sainte-Justine Research Center on chemokine receptor structure–function Splice variants aren't just structural — they signal differently. career 06:30 An empty lab and the chemokine redundancy problem 09:00 A master's, old-school molecular biology During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships

Gloriam on orphan GPCR biology, GPCRDB, biased signaling, and how the data analysis bottleneck is reshaping This conversation explores the intersection of computational biology, cheminformatics, and structural biology. His primary research focus is orphan GPCR biology, with particular emphasis on identifying endogenous for experimentalists, but as the primary constraint to overcome in advancing receptor biology.

Di Pizio — who leads the computational pharmacology group at the Leibniz Institute for Food Systems Biology biology lab in Marburg. Antonella Di Pizio, an independent research group leader at the Leibniz Institute for Food Systems Biology biology. Antonella Di Pizio on the web Leibniz-Institute for Food Systems Biology at the Technical University

signaling — one of the most fundamental pathways in vertebrate development, stem cell renewal, and tumor biology pharmacologically accessible binding pocket — a conclusion that was not obvious from the initial frizzled 4 crystal structure Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Biology is on Frizzled signaling and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology

His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors , cyclic AMP regulation, and receptor biology across tissue systems. Biology runs on opposing forces, and good pharmacology learns to see them. 07:40 Expanding the hypothesis — PAR1, PAR4, and upstream pathobiology 11:00 Gas pedals and brakes — biology's Paul Insel "Almost most biological systems are all about gas pedals and brakes.

<< Back to podcast list Strategic Partner(s) Translating computational approaches to GPCR biologists He earned his PhD in Physics at the same university, focusing on in silico structural vaccinology and Now in a tenure-track position, his research spans the development of computational methods such as structure-based Scholar ResearchGate Bysky App : @ riccardocapelli.bsky.social Twitter X : @ ric_capelli Computational Structural Biology Unlock the Full Dr.

Structural biologist Qing Fan describes a decade of GABA-B receptor research at Columbia - from obligate ABOUT THE GUEST Qing Fan is an associate professor of pharmacology and pathology and cell biology at A structural biologist by training, her research focuses on the three-dimensional architecture of class findings to receptor function and disease-relevant biology. Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University

Communications, which she joined in April 2020, following three years on the editorial teams of Nature Structural and Molecular Biology and Nature Biotechnology. Katarzyna handles submissions in structural biology, biophysics and biochemistry, with a particular focus

Initially driven by a general passion for biology and a childhood dream of being an astronaut, he began “The goal is to smash all the amazing biology together and make a drug.” team aims to understand how and where these compounds interact with the receptor, paving the way for structure-based Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing

At the center of that problem is biased agonism: the differential engagement of downstream pathways by Zhao is a Research Fellow at the Monash Institute of Pharmaceutical Sciences (MIPS), Drug Discovery Biology Working alongside structural biologists, computational pharmacologists, and receptor scientists working 32:30 From PAR2 to GLP-1 - building the mechanistic picture one step at a time 37:01 GLP-1 receptor biology

Transform your biotech idea or data into a clear, strategic roadmap with aligned biology, timelines, Welcome Biotech Growth Wherever You Are in Discovery—Let’s Build a Plan That Moves You Forward Align your biology Confidence Decisions, Not More Data We'll define what matters, when to decide, and how to act—based on your biology guides program momentum Focus resources where they’ll change outcomes No More Strategy Swirl I build structure up clear deliverables across internal and CRO teams Keep cross-functional teams moving with shared structure

This conversation explores the biology, diversity, and unexpected reach of human taste GPCRs, beginning Niv describes how bitter taste receptors differ structurally from most other GPCRs - missing conserved matchmaking - applying recommendation system logic to the bitter taste receptor family Sweet taste receptor biology Bitter taste receptors are built to activate, not to be blocked Bitter taste GPCRs are structurally unusual consequences 41:58 - Taste GPCRs as drug targets - asthma, cardiac physiology, and early signals in cancer biology

What emerges is a quiet argument that the structural shifts the pandemic forced — project planning in Experimental planning under uncertainty — Structuring projects into self-contained blocks so a lab can Civic responsibility in returning to the bench — Deconfining a research center slowly, with planning research center closed again, the team would still have something to analyze, something to write. The research center was deconfining at 20% capacity the week of the recording. Dr.

signaling mechanisms employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. begun studying GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure Prior to that, Ben received his Ph.D. from UCSF in 2008, where he worked with David Julius on the structure

Pradhan returns to often: that organisms in chronic pain are fundamentally different biological systems Professor of Psychiatry at the University of Illinois at Chicago, where her lab studies opioid receptor biology the same family produce opposite clinical outcomes Chronic disease states as fundamentally altered biological Pradhan turns to the structural weight carried by women and scientists of color in academia — the cumulative

Ray Stevens in 2013 solving several GPCR crystal structures, including that of the first serotonin receptor Bryan Roth where I established GPCR structural biology and learned the ins and outs of molecular pharmacology started my own lab at the Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function

biology to delineate mechanisms of action. The structure was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models Our mission is to understand the mechanism and structural bases for ligand binding and efficacy to help One example of our recent work surrounds a structure-based effort to develop ligands that specifically changes in G protein structure.

Eurofins DiscoverX scientists on physiological relevance, the GPCRs that refuse to work, and why obesity biology list Strategic Partner(s) Jane Lamerdin and Gaurav Agrawal: Building GPCR Assays That Reflect Real Biology Obesity and GLP-1 biology changed that, and the largest target class is once again at the front of drug Her background spans high-throughput, molecular, and systems biology research, which lets her speak to The easy readout drifts away from the biology researchers actually want to measure.

Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke the AudetLab located at the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters.