He earned his PhD at MIT in the laboratory of Lawrence Stern, where he studied structure-function relationships antibody motifs known to bind GPCRs and inserting them at the top of the heavy chain CDR3, the library enters skipping fragment-based screening and going directly to full bivalent IgG, the team hands functional biology He looks for target classes where existing platforms have already failed — not because the biology is He earned his Ph.D. at the Massachusetts Institute of Technology, where he studied MHC class II structure-function

She developed expertise over the past two decades studying structure/function relationships of GPCRs Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Monserrat Avila Zozaya I did a PhD in cell biology at CINVESTAV, Mexico. About John Azietaku John Teye Azietaku,PhD is a trained pharmacist, holding a Ph.D. in Drug Discovery Biology

that mastering a technique isn’t enough—true scientific breakthroughs come from formulating the right biological Membrane Proteins and Receptors (COMPARE), University of Nottingham, where he provides leadership in structural He joined the MRC Centre for Protein Engineering and later at the MRC Laboratory of Molecular Biology group leader at the Paul Scherrer Institute and ETH Zürich in Switzerland, changing his attention to structural In 2017 Dmitry became a full professor at the Centre of Membrane Proteins and Receptors, COMPARE, a joined

constraint on pharmacological interpretation Equilibrium vs. dynamic frameworks for studying receptor biology An assay measures a specific thing - not the biology you assume it measures One of Livingston's most Academia and industry are structurally complementary - not competing versions of the same thing Academia Livingston argues these structural constraints make the two sectors dependent on each other - and notes moving - and then to flip it on its head again and say the receptor at the surface might not be the center

She developed expertise over the past two decades studying structure/function relationships of GPCRs me to shape a swiss start-up company from a scientifc idea to a thriving Biotech focusing on Systems Biology Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology network and biocomputing services, served on the Steering Committee of the San Diego Supercomputer Center

Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience Operational Discipline I instill structure and consistency across every phase of your discovery process Yamina brings the clarity, rigor, and structured decision-making that keeps programs on track. Therapeutics Before working with Yamina, we had solid internal momentum but needed to better align our biology Her input helped us structure the screening funnel, define clear go/no-go criteria, and integrate ADME

Radioligand binding and the first demonstration of GPCR structure — The methodological progression from The cloning race and the serendipity of the intronless gene — Competing against Genentech's molecular biology When Brian Kobilka proposed screening a genomic library, Merck's molecular biology collaborators called The discovery that it was structurally homologous to rhodopsin was a complete surprise. of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University Medical Center

Since returning to Europe, her research has centered on receptor biology at the intersection of basic It is a small detail, but it marks something real about the state of adhesion GPCR biology in insects : these receptors exist in a space where the biology precedes the vocabulary. For receptor biology that requires iterative genetic manipulation - knocking out, tagging, rescuing, Some journals are beginning to accept negative data, and both agree this matters structurally.

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain biology discovery, he later co-founded Superluminal Medicines, a company using machine learning to explore GPCR structure-function Ajay’s work sits at the intersection of GPCR biology, AI, and translational medicine.

Joseph Kim’s curiosity for science led him into GPCR research, drug discovery, and membrane protein biology—plus observed signaling outcomes, providing a bridge between structural biology and pharmacology. Nivedha reflects on how her career in GPCR biology began unexpectedly during her postdoctoral work. I was always interested in biology, especially studying anatomy. At the time, I didn’t realize the full scope of GPCR biology.

the GPCR research community — bridging wet-lab experimentation, open-access tools, and computational biology GPCR superfamily , building a digital and physical toolkit to systematically investigate GPCR-RAMP biology The system is modular and adaptable, opening doors for systems biology and context-specific interaction As the field advances, the computational layer — including AlphaFold and structural prediction tools Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of

Gloriam on orphan GPCR biology, GPCRDB, biased signaling, and how the data analysis bottleneck is reshaping This conversation explores the intersection of computational biology, cheminformatics, and structural biology. His primary research focus is orphan GPCR biology, with particular emphasis on identifying endogenous for experimentalists, but as the primary constraint to overcome in advancing receptor biology.

Di Pizio — who leads the computational pharmacology group at the Leibniz Institute for Food Systems Biology biology lab in Marburg. Antonella Di Pizio, an independent research group leader at the Leibniz Institute for Food Systems Biology biology. Antonella Di Pizio on the web Leibniz-Institute for Food Systems Biology at the Technical University

At the time, the lab chasing the first GPCR crystal structure was cutting the tail off entirely. ABOUT RANDY Randy Hall is Professor of Pharmacology and Chemical Biology at Emory University School of Recent work centers on GPR37 and GPR37L1 and on the adhesion receptors BAI1, BAI2 and GPR56, with a particular The structural effort underway at the time simply deleted them. Screening work has since produced agonists and antagonists, and the first cryo EM structure of an adhesion

fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts in GPCR biology We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each If you’re working on exciting GPCR-related research — from structural biology to drug discovery — we’ to connect, exchange, and collaborate to improve human health through a better understanding of GPCR biology We'll then engage in a conversation centered around your career and how you got introduced to GPCRs.

Nikolaus Heveker's lab at the CHU Sainte-Justine Research Center on chemokine receptor structure–function Splice variants aren't just structural — they signal differently. career 06:30 An empty lab and the chemokine redundancy problem 09:00 A master's, old-school molecular biology During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships

<< Back to podcast list Strategic Partner(s) Translating computational approaches to GPCR biologists He earned his PhD in Physics at the same university, focusing on in silico structural vaccinology and Now in a tenure-track position, his research spans the development of computational methods such as structure-based Scholar ResearchGate Bysky App : @ riccardocapelli.bsky.social Twitter X : @ ric_capelli Computational Structural Biology Unlock the Full Dr.

signaling — one of the most fundamental pathways in vertebrate development, stem cell renewal, and tumor biology pharmacologically accessible binding pocket — a conclusion that was not obvious from the initial frizzled 4 crystal structure Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Biology is on Frizzled signaling and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology

Structural biologist Qing Fan describes a decade of GABA-B receptor research at Columbia - from obligate ABOUT THE GUEST Qing Fan is an associate professor of pharmacology and pathology and cell biology at A structural biologist by training, her research focuses on the three-dimensional architecture of class findings to receptor function and disease-relevant biology. Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University

Communications, which she joined in April 2020, following three years on the editorial teams of Nature Structural and Molecular Biology and Nature Biotechnology. Katarzyna handles submissions in structural biology, biophysics and biochemistry, with a particular focus

His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors , cyclic AMP regulation, and receptor biology across tissue systems. Biology runs on opposing forces, and good pharmacology learns to see them. 07:40 Expanding the hypothesis — PAR1, PAR4, and upstream pathobiology 11:00 Gas pedals and brakes — biology's Paul Insel "Almost most biological systems are all about gas pedals and brakes.

Initially driven by a general passion for biology and a childhood dream of being an astronaut, he began “The goal is to smash all the amazing biology together and make a drug.” team aims to understand how and where these compounds interact with the receptor, paving the way for structure-based Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing

Transform your biotech idea or data into a clear, strategic roadmap with aligned biology, timelines, Welcome Biotech Growth Wherever You Are in Discovery—Let’s Build a Plan That Moves You Forward Align your biology Confidence Decisions, Not More Data We'll define what matters, when to decide, and how to act—based on your biology guides program momentum Focus resources where they’ll change outcomes No More Strategy Swirl I build structure up clear deliverables across internal and CRO teams Keep cross-functional teams moving with shared structure

What emerges is a quiet argument that the structural shifts the pandemic forced — project planning in Experimental planning under uncertainty — Structuring projects into self-contained blocks so a lab can Civic responsibility in returning to the bench — Deconfining a research center slowly, with planning research center closed again, the team would still have something to analyze, something to write. The research center was deconfining at 20% capacity the week of the recording. Dr.

This conversation explores the biology, diversity, and unexpected reach of human taste GPCRs, beginning Niv describes how bitter taste receptors differ structurally from most other GPCRs - missing conserved matchmaking - applying recommendation system logic to the bitter taste receptor family Sweet taste receptor biology Bitter taste receptors are built to activate, not to be blocked Bitter taste GPCRs are structurally unusual consequences 41:58 - Taste GPCRs as drug targets - asthma, cardiac physiology, and early signals in cancer biology

signaling mechanisms employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. begun studying GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure Prior to that, Ben received his Ph.D. from UCSF in 2008, where he worked with David Julius on the structure

Ray Stevens in 2013 solving several GPCR crystal structures, including that of the first serotonin receptor Bryan Roth where I established GPCR structural biology and learned the ins and outs of molecular pharmacology started my own lab at the Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function

Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke the AudetLab located at the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters.

biology to delineate mechanisms of action. The structure was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models Our mission is to understand the mechanism and structural bases for ligand binding and efficacy to help One example of our recent work surrounds a structure-based effort to develop ligands that specifically changes in G protein structure.

At the center of that problem is biased agonism: the differential engagement of downstream pathways by Zhao is a Research Fellow at the Monash Institute of Pharmaceutical Sciences (MIPS), Drug Discovery Biology Working alongside structural biologists, computational pharmacologists, and receptor scientists working 32:30 From PAR2 to GLP-1 - building the mechanistic picture one step at a time 37:01 GLP-1 receptor biology