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collaborative chemistry enabled in designing receptor-targeted fluorescent ligands The moment when structural tissue-specific engagement Who should listen Navigated complex datasets where interpretation depended on biological Robert Turner Professor of Diabetic Medicine at the University of Oxford , working within the Oxford Centre His group develops imaging and chemical biology tools to reveal how GLP-1 and GIP receptors operate within David Hodson on the Web Radcliffe Department of Medicine Islet Biology Lab University of Birmingham Upcoming

Foord reflects on his path from academic neuroendocrinology to introducing molecular biology and molecular importance of team composition, negative data, and scientific community in navigating complex receptor biology Trained in neuroendocrinology, he helped bring molecular biology into traditionally pharmacology-driven The CGRP story illustrates how structural biology and pharmacology intersect with corporate decisions He argues that integrating structural biology, computational pharmacology, and genetics may still be

regulate over 800 receptors, why "non-canonical" GPCRs are nature's own biased receptors, and building a structural How two structurally similar proteins orchestrate such functional diversity across an entire receptor Arun Shukla leads a structural pharmacology lab in the Department of Biological Sciences and Bioengineering His research focuses on the structural and functional basis of GPCR–beta-arrestin interactions, combining Episode Timeline 00:00 Introduction 02:15 From DNA quadruplexes to GPCR structural biology 06:32 The

that mastering a technique isn’t enough—true scientific breakthroughs come from formulating the right biological Membrane Proteins and Receptors (COMPARE), University of Nottingham, where he provides leadership in structural He joined the MRC Centre for Protein Engineering and later at the MRC Laboratory of Molecular Biology group leader at the Paul Scherrer Institute and ETH Zürich in Switzerland, changing his attention to structural In 2017 Dmitry became a full professor at the Centre of Membrane Proteins and Receptors, COMPARE, a joined

GPCR webinars are free, live online scientific sessions focused on G protein-coupled receptor biology Whether you're deep in receptor biology or evaluating assay tools, these sessions are built for you. GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design Every session is grounded in receptor biology with a focus on what's practical and applicable. A working understanding of GPCR biology helps you get the most from each session.

Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke the AudetLab located at the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters.

Structural biologist Qing Fan describes a decade of GABA-B receptor research at Columbia - from obligate ABOUT THE GUEST Qing Fan is an associate professor of pharmacology and pathology and cell biology at A structural biologist by training, her research focuses on the three-dimensional architecture of class findings to receptor function and disease-relevant biology. Fan is currently an associate professor of Pharmacology and Pathology and Cell Biology at Columbia University

Her research centers on the molecular pharmacology of class B GPCRs - specifically the calcitonin receptor biology of RAMPs - allosteric modulation over direct ligand contact Reproducibility and target validation Shared structural features between the two receptor complexes, combined with the known pharmacology of RAMPs Act Allosterically - Not Through Direct Ligand Contact Structural data from the CLR and CTR receptor up to 20% of women worldwide, Hay notes, the research investment in understanding the receptor-level biology

signaling mechanisms employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. begun studying GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure Prior to that, Ben received his Ph.D. from UCSF in 2008, where he worked with David Julius on the structure

Ray Stevens in 2013 solving several GPCR crystal structures, including that of the first serotonin receptor Bryan Roth where I established GPCR structural biology and learned the ins and outs of molecular pharmacology started my own lab at the Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function

Transform your biotech idea or data into a clear, strategic roadmap with aligned biology, timelines, Welcome Biotech Growth Wherever You Are in Discovery—Let’s Build a Plan That Moves You Forward Align your biology Confidence Decisions, Not More Data We'll define what matters, when to decide, and how to act—based on your biology guides program momentum Focus resources where they’ll change outcomes No More Strategy Swirl I build structure up clear deliverables across internal and CRO teams Keep cross-functional teams moving with shared structure

the GPCR research community — bridging wet-lab experimentation, open-access tools, and computational biology GPCR superfamily , building a digital and physical toolkit to systematically investigate GPCR-RAMP biology The system is modular and adaptable, opening doors for systems biology and context-specific interaction As the field advances, the computational layer — including AlphaFold and structural prediction tools Ilana uses chemical biology-based methods to study the regulation and protein-protein interactions of

AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain biology discovery, he later co-founded Superluminal Medicines, a company using machine learning to explore GPCR structure-function Ajay’s work sits at the intersection of GPCR biology, AI, and translational medicine.

biology to delineate mechanisms of action. The structure was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models Our mission is to understand the mechanism and structural bases for ligand binding and efficacy to help One example of our recent work surrounds a structure-based effort to develop ligands that specifically changes in G protein structure.

He earned his PhD at MIT in the laboratory of Lawrence Stern, where he studied structure-function relationships antibody motifs known to bind GPCRs and inserting them at the top of the heavy chain CDR3, the library enters skipping fragment-based screening and going directly to full bivalent IgG, the team hands functional biology He looks for target classes where existing platforms have already failed — not because the biology is He earned his Ph.D. at the Massachusetts Institute of Technology, where he studied MHC class II structure-function

Initially driven by a general passion for biology and a childhood dream of being an astronaut, he began “The goal is to smash all the amazing biology together and make a drug.” team aims to understand how and where these compounds interact with the receptor, paving the way for structure-based Structural Biology Roadblocks: The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding Still, by collaborating with structural biology teams and combining cryo-EM with NMR , his lab is narrowing

Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience Operational Discipline I instill structure and consistency across every phase of your discovery process Yamina brings the clarity, rigor, and structured decision-making that keeps programs on track. Therapeutics Before working with Yamina, we had solid internal momentum but needed to better align our biology Her input helped us structure the screening funnel, define clear go/no-go criteria, and integrate ADME

encompassing functional assay development, GPCR internalization research, and both small molecule and biologic Teams expanding into antibody or biologic modalities for challenging GPCR targets. Pharmacology group in the Diabetes, Obesity and Complications Therapeutic Area at Lilly's Seaport Innovation Center His scientific training included a PhD at the International Center for Genetic Engineering and Biotechnology Awarded patents and a proven record in both target and pathway identification, his drive centers on integrating

Biologist - Confo Therapeutics Associate Director/Director, Platform & Hit-ID Chemistry Lead - Septerna Position - Autonomous University of Barcelona GPCR Molecular Pharmacologist - Schrödinger Scientist - Biology - Superluminal Medicines Scientist I Cell Biology - Tectonic Therapeutic Adhesion GPCRs A force-sensitive Structural and Molecular Insights into GPCR Function Structural insights into prolactin-releasing peptide and biased signaling in the motilin receptor 🔎 GPCR KEYWORDS GPCR , structural biology , biased signaling

She developed expertise over the past two decades studying structure/function relationships of GPCRs Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Monserrat Avila Zozaya I did a PhD in cell biology at CINVESTAV, Mexico. About John Azietaku John Teye Azietaku,PhD is a trained pharmacist, holding a Ph.D. in Drug Discovery Biology

received a prestigious Gates Cambridge Scholarship to study for a Ph.D. at the MRC Laboratory of Molecular Biology His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs developed novel tools and methodologies to study fungal GPCRs which allowed the determination of the first structures

She developed expertise over the past two decades studying structure/function relationships of GPCRs me to shape a swiss start-up company from a scientifc idea to a thriving Biotech focusing on Systems Biology Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology network and biocomputing services, served on the Steering Committee of the San Diego Supercomputer Center

Sri Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology He is passionate about developing more rational ways to understand and engineer biology. empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical biology , synthetic biology, and functional genomics. He is a Searle Scholar (2015), NIH New Innovator (2014), and received his ScD in Biological Engineering

The overall goal of her research program is to obtain rigorous mechanistic insights into the structure To this end, her lab uses several computational structural biology tools and rational drug design approaches

Over 40 crystal structures of the A2A receptor alone have been deposited in the Protein Data Bank. across experimental systems Endogenous receptor expression in heterologous cell systems - how HEK cell biology The advice she offers to incoming PhD students centers not on technique but on disposition: stay curious affinity measurements shift depending on the assay 27:09 Synthesizing fluorescent ligands - from crystal structures "In chemistry, it's like when you finally see the NMR of your structure without anything but your compound

Since returning to Europe, her research has centered on receptor biology at the intersection of basic It is a small detail, but it marks something real about the state of adhesion GPCR biology in insects : these receptors exist in a space where the biology precedes the vocabulary. For receptor biology that requires iterative genetic manipulation - knocking out, tagging, rescuing, Some journals are beginning to accept negative data, and both agree this matters structurally.

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical