After running her own academic group in Graz, she spent six and a half years at Novo Nordisk in early Scientists starting companies need experienced operators around them, and the honesty to know when to the animal 31:21 — Tools for the next decade: biosensors, tissues, high-throughput structure 38:43 — Career advice for scientists eyeing industry or biotech 42:35 — On starting a GPCR company: why not too early Leave a quick review to help more scientists find the show—and help us keep improving every episode.

For Gloriam, this work began with a grandmother's cancer diagnosis and an early determination to develop This shift places data scientists and computational biologists in a newly central role - not as support moments, work-life balance, and advice for junior scientists SELECTED QUOTES "Whereas data generation Join me a learn more about David’s work, his career trajectory, and GPCRdb. Dr. David E. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Kim’s scientific trajectory. 52:00 — Advice for young scientists The importance of curiosity, persistence I’m really curious about your career trajectory. Dr. Joseph Kim: Sure. That constant questioning felt more aligned with being a scientist than being a physician. Dr. your trajectory as a scientist? And finally, what advice would you give to young scientists who want to enter the GPCR field? Dr.

Rosie Dawaliby "I’m an expert in early-stage drug discovery, targeting membrane proteins, especially as a synthesis of the different knowledge, experiences, and know-how from the different stages of my career Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific Leave a quick review to help more scientists find the show—and help us keep improving every episode.

He also reflected on his journey from his early involvement in a university chemistry lab to his current Industry: Career Progression Discussion Yamina and John had a detailed discussion about the prospects Yamina agreed and sought advice from John on career progression in academia. John then reflected on his career, sharing key moments of realization in his scientific work and his Leave a quick review to help more scientists find the show—and help us keep improving every episode.

The question has been central to Johnson's career since long before the tools to answer it properly existed She trained in high-throughput drug discovery at Vanderbilt - contributing to early functional assay formative constraint she navigated across her entire training: drawn to circuit-level questions that her early A circuit-level argument 33:12 Advice for junior scientists: let the biology lead the method 35:28 Diversity Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Chia-Yi Lin and Alexander Ball, both scientists-turned-industry professionals at GeneTex, trace how the ABOUT THE GUESTS Alexander Ball is a senior scientist at GeneTex who joined the company in 2012 after His dual perspective - having depended on antibodies as a bench scientist and now helping produce them Researcher-company collaboration as an active ingredient in antibody quality - not a support function Career Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Early focus-formation assays using muscarinic receptors and carbachol produced transforming efficiencies Nearly 93% of uveal melanomas carry a single GαQ Q209 activating mutation that blocks GTPase activity Episode Timeline 00:00 Introduction 02:09 From Buenos Aires to NIH: a career that followed the science problem 45:31 Two "what the heck" moments that became Nature and Cell papers 50:48 Advice for young scientists Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Career Trajectory and Faculty Position Yamina and Mike discussed Mike's career trajectory and his decision Science Journeys and Career Advice Yamina and Mike discussed their experiences in the field of science Mike advised junior scientists to focus on projects they are passionate about, emphasizing that ownership Mike reflected on his early years as a postdoc, admitting that he lacked focus and didn't see the direct Leave a quick review to help more scientists find the show—and help us keep improving every episode.

type 2 diabetes, and muscarinic receptors, her lab screens in disease-relevant cell lines and looks early mini-gene origin and finding an inverse agonist where none had been reported SELECTED QUOTES "Being a scientist Join me and learn more about Annette’s career, our common love for chemokines, and how you can use your training as a scientist in so many different ways. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

The importance of collaboration, conferences, and stepping outside research silos. 48:20 — Career Reflections At that time, I wasn’t sure what career direction I wanted, so I started contacting computational research One of the challenges I faced early in my PhD was collecting data on previously published chimeric GPCR What advice would you give to scientists entering computational GPCR research? Computational scientists can easily become isolated.

discovery by sharing the latest research and technology advances in the field and providing exposure to scientists Sachdev is an early career researcher in the National Institute of Diabetes and Digestive and Kidney Given her expertise in GPCR pharmacology and scientific communication, she is poised to make valuable Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific Leave a quick review to help more scientists find the show—and help us keep improving every episode.

GPCR AI Summary Quick recap Yamina and Arthur discussed Arthur's career journey in pharmacology, including Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career Arthur shared his career journey, including his collaboration with Patrick Sexton and Jim Burch, and They reviewed significant early papers related to the topic, including work by Brian Roth, Terry Kenakin Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Paul Insel did something unusual for a working lab scientist: he stopped pipetting, and started writing His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors Early in the pandemic, senior clinicians were stopping their own ACE inhibitors and ARBs based on hypothesis-driven — a lens that has quietly shaped how he reads both disease mechanism and drug targets across a long career Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Career Dr. Yamina Berchiche: If you were not a scientist, what would you be doing? Dr. Yamina Berchiche: How did you become a scientist? Dr. Yamina Berchiche: What advice would you give to young scientists? Dr. Bengtsson: Young scientists often follow instructions without asking why.

Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology For most of the 1990s and early study by crystallography, and the question of how to solve that became the organizing problem of his career Science requires a skin like a rhino Tate's advice to young scientists is not procedural - it is temperamental Unpublished: a Class D GPCR dimer - one PhD student, 18 months, a Nature paper 49:05 Advice for young scientists Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Working alongside structural biologists, computational pharmacologists, and receptor scientists working Her mentor, Peter Chidiac, had consistently avoided steering her toward a predetermined career path, nodding along when a supervisor is speaking and nothing has been understood - a pattern Zhao describes as nearly it are layered: language barriers, cultural conditioning around deference, the general insecurity of early-stage Leave a quick review to help more scientists find the show—and help us keep improving every episode.

A single collaboration can redirect a career. She treats this as a generalizable lesson for junior scientists: openness to collaboration is not decorative Pradhan turns to the structural weight carried by women and scientists of color in academia — the cumulative ligand-directed signaling at delta-opioid receptors, and it is their collaboration with a headache physician-scientist Leave a quick review to help more scientists find the show—and help us keep improving every episode.

With decades of expertise and an unwavering focus on precision, Revvity empowers scientists to simplify receptor-mediated endocytosis, the probe is internalized into acidic intracellular compartments (like early is responsible for supporting the adoption and expansion of the reagent portfolio into the hands of scientists scalability for high-throughput screening Difficulty detecting endogenous receptor activity With pHSense™, scientists serendipity, and partnerships fuel innovation—and how this mindset can transform your research and biotech career

At this point in my career, I am creating connections with biomedical industry, assessing professional opportunities, and seriously weighing strengths of career options across sectors; however, academia I want to connect more trainees with diverse career resources to support professional decision-making endeavors, will inform my future career decisions." Leave a quick review to help more scientists find the show—and help us keep improving every episode.

discovery by sharing the latest research and technology advances in the field and providing exposure to scientists My experience in basic research at several universities worldwide and early R&D at Novo Nordisk A/S allowed In 1994, they became a Bioinformatics Scientist at CuraGen Corporation. From 2002 to 2006, they were a Senior Application Scientist at Accelrys, where they were the technical Leave a quick review to help more scientists find the show—and help us keep improving every episode.

diabetic kidney disease - and watching protein levels fall in patients' urine is, for him, the reason most scientists Scientific Themes of the Conversation Real-time vs. endpoint assays - why kinetics change the pharmacological Pfleger describes profiles where the peak of a response occurs early and then subsides - and where an : science as a team sport 03:54 From Cambridge to Edinburgh - an accidental PhD and the origin of a career Leave a quick review to help more scientists find the show—and help us keep improving every episode.

<< Back to podcast list Strategic Partner(s) The Scientist's Compass: From Academia to Entrepreneurship Networking & Career Growth – Overcoming introversion, the importance of talking to people, and how networking Tune in to hear how Dmitry navigated his career, the challenges of studying GPCRs, and why talking to MRC Laboratory of Molecular Biology in Cambridge, UK as a postdoctoral fellow and later as a staff scientist Leave a quick review to help more scientists find the show—and help us keep improving every episode.

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Young scientists are hungry for alternate career paths. is the heart of scientific innovation Who Should Listen PhD students and postdocs exploring biotech careers GPCR scientists interested in translational innovation Biotech investors and strategic leaders seeking Ajay Yekkirala is a molecular pharmacologist, biotech founder, and scientist whose career has been defined Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Two Eurofins DiscoverX scientists on physiological relevance, the GPCRs that refuse to work, and why In this conversation, two Eurofins DiscoverX scientists reflect on what nearly three decades of building For Agrawal it is personal: he spent his PhD on four GPCRs and now stewards 289, carrying those early Scientists first, vendor second. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar This conversation is especially valuable for scientists developing functional assays, fluorescence-based What early cyclic AMP assays revealed about spatial signaling long before high-content technologies existed Join a global GPCR community of scientists and biotech leaders. 👉 Join now Unlock the Full Dr. Leave a quick review to help more scientists find the show—and help us keep improving every episode.

preserving original work, the value of international conferences, and the dynamics between junior and senior scientists Ferns', the importance of maintaining team culture, and the potential health issues among well-known scientists The conversation also touched upon Arthur's career decisions, his scientific achievements, and the importance Lastly, they deliberated on involving junior scientists and postdocs in their podcast and the possibility Leave a quick review to help more scientists find the show—and help us keep improving every episode.

preserving original work, the value of international conferences, and the dynamics between junior and senior scientists Ferns', the importance of maintaining team culture, and the potential health issues among well-known scientists The conversation also touched upon Arthur's career decisions, his scientific achievements, and the importance Lastly, they deliberated on involving junior scientists and postdocs in their podcast and the possibility Leave a quick review to help more scientists find the show—and help us keep improving every episode.

Trained in electrical and computer engineering, he began his career at General Atomics building software Excel is the default research tool because no one built a better one for scientists. GeneMode story starts with two teenagers in the same high-school classroom, different majors, different career Although both went to the same college, Jacob and Jin choose different career paths. Today, Genemod has built a freezer management tool and a project management tool where scientists can