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including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

unstructured regions ♦️ Includes a web tool + viral chemokine engineering demo This is a must-read for GPCR modelers

the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells (LECs), a cellular model

Cancer Research, 2014) and GPCRs (Feigin, et al., PNAS, 2014) in breast cancer pathogenesis, using mouse models Mike also spoke about his initial struggles during his Ph.D., such as a difficult model system and a age and his desire to gain more knowledge about cancer biology led him to transition into using mouse models asked about his move from in vitro to in vivo work, and Mike explained that he wanted to use better models Yamina proposed further exploration of dosage and length of treatment in a mouse model and suggested

The model behind the data 💡 Terry Kenakin shows how experimental snapshots can reveal much more—and drug discovery. 🟢 Built for pharmacologists building stronger pipelines and those rethinking legacy models

Why receptor localization and scaffolding dramatically shift functional readouts in disease models. validation under real experimental constraints, Tried to map signaling heterogeneity in disease-relevant models

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

University in Australia, one of the pioneers in the medicinal chemistry, computational and mathematical modelling scientists working in the arenas of structure and signaling, neuroscience, cancer, translational and model

Through live Q&A, targeted modules, and short, focused lessons, Terry’s Corner gives discovery teams Rethink outdated models. Translate early data into better decisions.

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models

My initial focus was on creating an automated chimeric homology modeling pipeline for GPCRs and since

California in San Francisco to continue his training as a postdoctoral researcher where he used structural models

Signaling Trafficking Metabolism Structure and Bioinformatics Health and Disease Immunology Nervous system Model

His research group uses a combination of pharmacological investigations and mathematical modeling to

transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models

He adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled

Overall, the lab works on diverse models and diseases, and has developed a wide array of tools to dissect

computational structural biology tools and rational drug design approaches, ranging from molecular modeling

His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems,

the understanding of how an orphan GPCR exerts its effects both in vitro (cell culture and ex vivo models

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule A positive Allosteric Modulator

I work with invertebrate animal models (mainly D. melanogaster) and in vitro techniques to pick apart adhesion GPCRs, and extends to the development of novel screening approaches to identify pharmacological modulators

the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse models A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and

laboratory is to understand the physiological consequences of NMDA receptor deficiency using genetic mouse models neurotransmitter receptor that regulates the formation and maintenance of synaptic connections between neurons It plays an important role in the way that neurons wire together and change the strength of synaptic Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells

These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models

steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models Slosky characterized a new class of β-arrestin biased allosteric modulators (BAMs) for the neurotensin Critically, these ligands reduce addiction-associated behaviors in animal models without the side effects