Alessandro Nicoli shares how he models olfactory GPCRs with AlphaFold, mentors students, and builds science Nicoli’s turning point came when he realized that molecules weren’t static—they could act , bind , and modulate Build predictive models to discover new ligands . water, membranes, ligands.” – Alessandro Nicoli He emphasized that MD allows researchers to observe allosteric About Alessandro Nicoli Alessandro Nicoli is currently a PhD student in the Molecular Modeling group

He is a leader in the study of GPCRs, biased agonism, and also on allosteric interactions between GPCRs

20th World Congress of Basic and Clinical Pharmacology - Australia GPCR Jobs NEW Open Postdoctoral position and a PhD/post-doc level position - Eli Lilly and Company Postdoctoral Posit ion And PhD Position - affects larval growth and embryonic development in the multivoltine strain of Bombyx more Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe GPCRs in Cardiology, Endocrinology, and Taste Immunolocalization β-arrestin-1/endothelin axis in human ovarian fibroblasts Methods & Updates in GPCR Research Histamine-modulated

keeps explaining what bias was supposed to δ-opioid receptor recycling from the lysosome — and why the post-internalization A quantitative model can turn an artifact into pharmacology. Early in her postdoc, Dr. The resolution came not from a new experiment but from a model — protean agonism, as Kenakin had just terpenes produce analgesic responses that pure compounds cannot — and whether the mechanism involves allosterism So that is why I got so into the models — in order to salvage my project."

There’s allosterism, receptor desensitization… it opened a whole new world.”

track including but not limited to pharmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation & kinetics, advanced quantitative approaches and innovation & strategic application Can I

During these four sessions, you'll dive into: Advanced pharmacokinetic modeling The Druglike Quality ✅ Practical Quantification of Allosteric Modulation – May 1, 2025 ✅ Applying the Black/Leff Operational Model to Predict Agonism – October 2, 2025 Premium Members save 25% on enrollment. Structural Biologist Associate Director/Director, Platform & Hit-ID Chemistry Lead Junior associate position and a PhD/post-doc level position Postdoctoral Position And PhD Position GPCR Molecular Pharmacologist

calling but by a Vietnam War draft assignment — the prevailing view held that receptors were at best allosteric His research established the beta-2 adrenergic receptor as the primary model system for understanding Beta-adrenergic receptors as a model system — Why the adrenergic system, with its rich pharmacological

Next steps • Mike will consider using Twitter to post job positions in his lab. Career Trajectory and Faculty Position Yamina and Mike discussed Mike's career trajectory and his decision to pursue a faculty position. GPCRs and Cancer Immune Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically They also touched upon the potential of GPCR modulation in stimulating the immune system to fight cancer

He then held a postdoctoral position at Forschungszentrum Jülich (Germany), where he worked on calculating postdoctoral role at the Polytechnic University of Turin (Italy), where he developed coarse-grained models Now in a tenure-track position, his research spans the development of computational methods such as structure-based models and enhanced sampling techniques, as well as their application to biomolecular systems, mainly

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

Real-world case studies and data-driven models for pipeline prioritization, resource allocation, and Explore Timeline Strategy Strategic Media Partnership A premium, limited partnership (12 spots/year) that positions Find the right collaboration model for your program.

The working model is that the nanobody anchors the conjugate at the receptor surface, positioning the Cheloha's position is that the standard assumption linking tighter binding to longer signaling is incomplete Every positive and negative control performed exactly as designed. The conjugate worked.

(biochemistry, cell biology, genetics) and experimental systems (purified proteins, cultured cells, model from postdoctoral research to leading his own lab, addressing the challenges of applying for academic positions

inherent affinity, and a cytoplasmic effector-binding pocket with its own independent affinity, both modulated Drug discovery needs modulators more than it needs hammers Arey's philosophy of drug discovery is grounded He argues for a therapeutic strategy built around modulators that can be combined, rather than single He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility

But we had to learn everything else—IP, market positioning, customer discovery.” — Maria Majellaro This scientific expertise is rooted in organic synthesis and medicinal chemistry, with a particular focus on GPCR modulators

Before focusing on the development of innovative mathematical modeling and simulation methods for drug Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. the strategic importance of planning in the biotech sector due to limited funds and the need to show positive and relevance of mathematical models in systems biology and pharmacology.

Choosing Mexico City as a Scientific Bet After postdoctoral and faculty positions at Stanford and UT 25 years of no regrets 22:10 Université de Sherbrooke's industry-integrated curriculum and what it modeled proteins expressed as various alternatively spliced isoforms thus potentially resulting in differential modulation

The conversation also touched on the challenges of applying for academic positions in the US, the importance Next steps • Yamina will share ideas on supporting John's new academic position after the recording stops John shared his experience of reaching out to and securing a position in Brian's lab. Academic Position Applications and Transition Preparation John and Yamina discussed the extensive process of applying for academic positions in the US.

a human ortholog linked to vascular malformations and blood-brain barrier dysfunction in vertebrate models completing her PhD in Germany and her postdoctoral work at Columbia University, where she worked on ALS models adhesion GPCR research in Drosophila, CRISPR, epitope tagging, and knockout strategies The logic of model That thread, from a behavioral assay in a fly larva to a clinical phenotype in mice, is what gives the model Thanks to Toby, that gave me a position here, and I could stay.

the transcriptional regulation of signaling components as an underappreciated axis of pharmacological modulation His position is that the drug problem has to be solved, or at least bounded, before the vaccine trial

Can models predict drug outcomes? Jens Carlsson shares how GPCR modeling is moving from explanation to real prediction in drug discovery . << Back to podcast list Strategic Partner(s) Model. Yamina Berchiche to share his unconventional journey from aspiring engineer to GPCR modeler. His team focuses on understanding how ligands modulate receptor function and how those insights can drive

GPCR Product Solutions Determine rank-order hits, evaluate ligand bias or allostery, study multiple targets

Previously, she held the position of Vice President of Cell Biology & Pharmacology, at Bristol-Myers Prior to this, she held the position of Vice President, at Medarex, Inc .

GPCR Ecosystem and collaborate with us to make a positive impact.

accelerate go/no-go calls & shorten timelines Your Science Stays Focused on What Matters We work together to position your CRO for growth • Refine your offering to match what biotech teams actually need • Position your

combines bioinformatic analysis of GPCR expression across human cancers with wet-lab validation in animal models It is a positive feedback loop that exploits the acidic environment tumors naturally create. 3. studied receptor function in human physiology, receptor molecular pharmacology in cells, and animal models