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There’s allosterism, receptor desensitization… it opened a whole new world.”

He then held a postdoctoral position at Forschungszentrum Jülich (Germany), where he worked on calculating postdoctoral role at the Polytechnic University of Turin (Italy), where he developed coarse-grained models Now in a tenure-track position, his research spans the development of computational methods such as structure-based models and enhanced sampling techniques, as well as their application to biomolecular systems, mainly

CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation out Ryk, required for Vangl2 function, protected synapses and preserved cognitive function in a mouse model Collectively, these data suggest that ADCs targeting CD97 impair tumor growth in preclinical GBM models Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation I then pursued a postdoctoral research position under the mentorship of Dr. Jonathan A.

Domain in a Holo-Adhesion GPCR Demet Araç Abstract "According to the Tethered Agonist (TA)-mediated model in which the conformation of the Extracellular Region (ECR) has a direct role in modulating the 7TM The TA peptide remains at its original position and is not involved in signaling. We utilize several genetically modified mouse models to investigate requirements for receptor activator and continuously work to identify novel chemical modulators of AGPCRs through assay development and

Can models predict drug outcomes? Jens Carlsson shares how GPCR modeling is moving from explanation to real prediction in drug discovery . << Back to podcast list Strategic Partner(s) Model. Yamina Berchiche to share his unconventional journey from aspiring engineer to GPCR modeler. His team focuses on understanding how ligands modulate receptor function and how those insights can drive

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

In 1992, he won a Helen Hay Whitney Foundation fellowship to support his post-doctoral work with Robert In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling post-translational including structural biology and proteomics, molecular biology and biochemical enzymology, primary and model cell culture, and transgenic, knockout, knock-in and conditional models of mouse physiology and behavior

Receptors Fabian Pohl Structural studies of the CELSR1 extracellular region reveal a compact multidomain module This compact module provides a plethora of potential ligand binding sites for the various adhesion domains within the structure and hints at a model where the compact module could be pulled apart by robust mechanical We assign the N-terminal CADH1-8 module as necessary for cell adhesion and we show the C-terminal CAHD9 -GAIN module regulates signaling.

GPCR Ecosystem and collaborate with us to make a positive impact.

The conversation also touched on the challenges of applying for academic positions in the US, the importance Next steps • Yamina will share ideas on supporting John's new academic position after the recording stops John shared his experience of reaching out to and securing a position in Brian's lab. Academic Position Applications and Transition Preparation John and Yamina discussed the extensive process of applying for academic positions in the US.

(biochemistry, cell biology, genetics) and experimental systems (purified proteins, cultured cells, model from postdoctoral research to leading his own lab, addressing the challenges of applying for academic positions

Before focusing on the development of innovative mathematical modeling and simulation methods for drug Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. the strategic importance of planning in the biotech sector due to limited funds and the need to show positive and relevance of mathematical models in systems biology and pharmacology.

I work with invertebrate animal models (mainly D. melanogaster) and in vitro techniques to pick apart adhesion GPCRs, and extends to the development of novel screening approaches to identify pharmacological modulators

the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic mouse models A fungal serine protease allergen with GPCR-modulating features was discovered as a new biomarker and

Previously, she held the position of Vice President of Cell Biology & Pharmacology, at Bristol-Myers Prior to this, she held the position of Vice President, at Medarex, Inc .

We sat down to chat about GPCRs, synthesizing labeled ligands, and her unique position that allows her

Alex Serafini shares why pain research must start with real-world behavior and models before drilling with RNA-seq and behavioral analysis, revealed nuanced roles of RGS4, RGS9, and RGSZ — not just as modulators Research Playbook Looking ahead, Serafini’s vision is bold: build a lab that develops translational models He's equally focused on sex differences in pain processing and the failure of "one-size-fits-all" models He aspires to become a physician-scientist, with a focus on translational in vitro and in vivo model

Lauren has a science background and is passionate about helping talented scientists find their dream position

accelerate go/no-go calls & shorten timelines Your Science Stays Focused on What Matters We work together to position your CRO for growth • Refine your offering to match what biotech teams actually need • Position your

became head of medicinal chemistry. 6 years ago I decided to take on a new challenge by taking the position

But we had to learn everything else—IP, market positioning, customer discovery.” — Maria Majellaro This scientific expertise is rooted in organic synthesis and medicinal chemistry, with a particular focus on GPCR modulators

Determine the Signaling Profile of Adhesion GPCR ADGRL1 / Latrophilin-1 Sheila Ribalta-Mena GPR110 modulates During my graduate studies, using various transgenic mouse models and expertise in intestinal and renal antibodies, and cancer-associated mutations at the GAIN-7TM interface, alter holoreceptor conformations, and modulate single-molecule perspective and investigating how the binding of extracellular transsynaptic ligands modulates " Cell Biology PhD student " Sheila Ribalta-Mena on the web CINVESTAV ResearchGate LinkedIn GPR110 modulates

been elected a Research Fellow at Gonville and Caius College, which is one of the most prestigious positions

He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility

He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility

GPCR Product Solutions Determine rank-order hits, evaluate ligand bias or allostery, study multiple targets

realities of using fluorescence-based assays, the challenge of translating in vitro pharmacology to in vivo models How integrating antibody-based modalities has expanded options for hard-to-drug GPCR targets. Teams expanding into antibody or biologic modalities for challenging GPCR targets.

GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models