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- Check out the new optical BRET-based biosensor, GÎąi bONE-GO! In neuronal cell lines, the use of GÎąi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! âĄď¸https://buff.ly/e6gAlBv #gpcr#drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Check out the new optical BRET-based biosensor, GÎąi bONE-GO! In neuronal cell lines, the use of GÎąi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! âĄď¸https://buff.ly/e6gAlBv #gpcr#drgpcr Published on April 21, 2025 Category GPCR Weekly News Check out the new optical BRET-based biosensor, GÎąi bONE-GO! In neuronal cell lines, the use of GÎąi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! âĄď¸ https:// buff.ly/e6gAlBv #gpcr#drgpcr Recent Articles Previous Next
- In Ep.163 of the Dr. GPCR Podcast, Dr. Dmitry Veprintsev discusses the importance of asking the right GPCR question. Itâs not just about learning the techniques; itâs about curiosity! đ Do you remember any question that changed your perspective completely? đĄÂ âłď¸Visit https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry-  #DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #GPCRScience | Dr. GPCR Ecosystem
Home â Flash News â In Ep.163 of the Dr. GPCR Podcast, Dr. Dmitry Veprintsev discusses the importance of asking the right GPCR question. Itâs not just about learning the techniques; itâs about curiosity! đ Do you remember any question that changed your perspective completely? đĄ âłď¸Visit https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry- #DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #GPCRScience Published on April 8, 2025 Category Dr. GPCR Podcast In Ep.163 of the Dr. GPCR Podcast, Dr. Dmitry Veprintsev discusses the importance of asking the right GPCR question. Itâs not just about learning the techniques; itâs about curiosity! đ Do you remember any question that changed your perspective completely? đĄ âłď¸Visit https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry- #DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #GPCRScience Recent Articles Previous Next
- Science isn't always about eureka momentsâsometimes it's about steady progress. In our latest Dr. GPCR Podcast episode, Ian Chronis shares his top aha moments, from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling. â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology | Dr. GPCR Ecosystem
Home â Flash News â Science isn't always about eureka momentsâsometimes it's about steady progress. In our latest Dr. GPCR Podcast episode, Ian Chronis shares his top aha moments, from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling. â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology Published on April 22, 2025 Category Dr. GPCR Podcast Science isn't always about eureka momentsâsometimes it's about steady progress. In our latest Dr. GPCR Podcast episode, Ian Chronis shares his top aha moments, from learning the hard way about gel electrophoresis to discovering the hidden complexities of GPCR signaling. â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology Recent Articles Previous Next
- Dr. Maria Majellaro perfected her focaccia recipe. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. Itâs not just culinary precision, itâs a metaphor for drug discovery done right. In Ep. 168, she shares how Celtarys went from a thesis idea to a biotech reality. Meet Dr.GPCRâs new partner: Celtarys đ đ See what theyâre cooking up now: Ep 168 with Dr. Maria Majellaro from Celtarys #GPCRresearchCommunity #DrGPCR #StartupScience #BiotechFounders #GPCRscientistNetwork | Dr. GPCR Ecosystem
Home â Flash News â Dr. Maria Majellaro perfected her focaccia recipe. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. Itâs not just culinary precision, itâs a metaphor for drug discovery done right. In Ep. 168, she shares how Celtarys went from a thesis idea to a biotech reality. Meet Dr.GPCRâs new partner: Celtarys đ đ See what theyâre cooking up now: Ep 168 with Dr. Maria Majellaro from Celtarys #GPCRresearchCommunity #DrGPCR #StartupScience #BiotechFounders #GPCRscientistNetwork Published on June 12, 2025 Category Dr. GPCR Podcast Dr. Maria Majellaro perfected her focaccia recipe. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. Itâs not just culinary precision, itâs a metaphor for drug discovery done right. In Ep. 168, she shares how Celtarys went from a thesis idea to a biotech reality. Meet Dr.GPCRâs new partner: Celtarys đ đ See what theyâre cooking up now: Ep 168 with Dr. Maria Majellaro from Celtarys #GPCRresearchCommunity #DrGPCR #StartupScience #BiotechFounders #GPCRscientistNetwork Recent Articles Previous Next
- Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRsâ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! | Dr. GPCR Ecosystem
Home â Flash News â Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRsâ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! Published on October 29, 2024 Category GPCR Weekly News Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRsâ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! âĄď¸ https://www.ecosystem.drgpcr.com/methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6-and-cxcr1 Recent Articles Previous Next
- Behind every great discovery is a great question đ Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode. If youâre passionate about GPCRs and drug discovery, this episode is a must-listen! âłď¸Listen at Ep 163 with Dr. Dmitry Veprintsev #DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience | Dr. GPCR Ecosystem
Home â Flash News â Behind every great discovery is a great question đ Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode. If youâre passionate about GPCRs and drug discovery, this episode is a must-listen! âłď¸Listen at Ep 163 with Dr. Dmitry Veprintsev #DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience Published on April 10, 2025 Category Dr. GPCR Podcast Behind every great discovery is a great question đ Dr. Dmitry Veprintsev shares how asking the right GPCR questions and dreaming big have shaped his work, in the latest Dr. GPCR podcast episode. If youâre passionate about GPCRs and drug discovery, this episode is a must-listen! âłď¸Listen at Ep 163 with Dr. Dmitry Veprintsev #DrGPCR #GPCRPodcast #Biotech #Pharmacology #GPCRScience Recent Articles Previous Next
- Whatâs one key piece of advice from Ian Chronis in Ep.164 of the Dr.GPCR Podcast?Listen to other scientistsâ researchâitâs a great way to stay motivated and inspired đ Donât miss this insightful conversation on GPCRs, pharmacology, and scientific discovery! â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology #CancerResearch | Dr. GPCR Ecosystem
Home â Flash News â Whatâs one key piece of advice from Ian Chronis in Ep.164 of the Dr.GPCR Podcast?Listen to other scientistsâ researchâitâs a great way to stay motivated and inspired đ Donât miss this insightful conversation on GPCRs, pharmacology, and scientific discovery! â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology #CancerResearch Published on April 24, 2025 Category Dr. GPCR Podcast Whatâs one key piece of advice from Ian Chronis in Ep.164 of the Dr.GPCR Podcast?Listen to other scientistsâ researchâitâs a great way to stay motivated and inspired đ Donât miss this insightful conversation on GPCRs, pharmacology, and scientific discovery! â https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast #Pharmacology #CancerResearch Recent Articles Beyond Clearance: The Strategic Power of Irreversible Drug Binding This session unpacks how persistent binding can either accelerate your programâor quietly kill it. Thatâs the power (and the peril) of irreversible drugs. These arenât just âstronger binders.â Theyâre kinetic game-changersâcompounds that rewrite the relationship between ligand, receptor, and physiologic outcome. Understanding how persistent binding affects receptor turnover, tissue penetration, and PK/PD relationships can give your team a strategic edge. 11 hours ago How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovationâand how this mindset can transform your research and biotech career. 5 days ago Understanding Enzyme Inhibition In GPCR Discovery Programs Every drug you design will meet an enzyme before it meets its receptor. If you want your molecules to survive first contact with biologyâand with the FDAâenzyme inhibition must be part of your core playbook. This weekâs feature breaks down exactly how to think about inhibitors with rigor and speed, so you can make better decisions earlier in the pipeline. Breakthroughs this week: Potentiation of GPCR signaling by ATP and sugar monophosphates; Pharmacology 2025; Nxera Pharma 5 days ago Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives long enough to act. Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacologyâthe framework that connects molecular survival to clinical success. Oct 14 Assay Volume Control: Your GPCR Drug Discovery Power Lever If you want cleaner decisions, start with the systemâthen the ligand. This weekâs lead feature unlocks a deceptively simple lever that separates signal from storytelling, moving programs forward with fewer surprises. Thatâs precisely what Terryâs Corner delivers: practical tools from Dr. Terry Kenakin to elevate your science and sharpe Itâs a curated toolkit designed to help GPCR professionals move faster, with more confidence. Premium Members count on this every weekâand t Oct 9 Previous Next
- A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr | Dr. GPCR Ecosystem
Home â Flash News â A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr Published on March 17, 2025 Category GPCR Weekly News A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸ https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr Recent Articles Previous Next
- Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism and cell growth âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism and cell growth âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos #gpcr #drgpcr Published on February 4, 2025 Category GPCR Weekly News Check out the latest GPCR news in the Ecosystem today! Youâll need to register but donât worry, itâs Free! Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism and cell growth âĄď¸ https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos #gpcr #drgpcr Recent Articles Previous Next
- đ§ Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: đŹ How GPCR trafficking shapes signaling outcomes đ Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! đď¸ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast â Tune in today! | Dr. GPCR Ecosystem
Home â Flash News â đ§ Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: đŹ How GPCR trafficking shapes signaling outcomes đ Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! đď¸ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast â Tune in today! Published on March 18, 2025 Category Dr. GPCR Podcast đ§ Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: đŹ How GPCR trafficking shapes signaling outcomes đ Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! đď¸ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast â Tune in today! Recent Articles Previous Next
- Interested in learning more about signaling bias? Youâre in the right place! đ Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants đ âłď¸ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Interested in learning more about signaling bias? Youâre in the right place! đ Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants đ âłď¸ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Published on February 10, 2025 Category Dr. GPCR Courses Interested in learning more about signaling bias? Youâre in the right place! đ Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants đ âłď¸ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Recent Articles Previous Next
- terrys corner predict drug behavior | Dr. GPCR Ecosystem
Home â Flash News â terrys corner predict drug behavior Published on July 12, 2025 Category Terry's Corner Linear, linkage, or probability? Dive into the logic of drug modeling with Terry Kenakin. In his latest lesson, he breaks down the essential models shaping modern pharmacology. Learn to âextend your eyesâ and predict complex drug behaviors. đ˘ Browse the full catalog (and expect a new course every week!) âłď¸ https://www.terrykenakin.com #pharmacology #drugmechanism #kenakin #GPCR #DrGPCR Recent Articles Previous Next
- A well-updated profile opens doors to collaborations and exciting GPCR projects đ Donât miss outâupdate yours now! | Dr. GPCR Ecosystem
Home â Flash News â A well-updated profile opens doors to collaborations and exciting GPCR projects đ Donât miss outâupdate yours now! Published on December 4, 2024 Category Dr. GPCR Profiles A well-updated profile opens doors to collaborations and exciting GPCR projects đ Donât miss outâupdate yours now! âłď¸ Go to https://www.ecosystem.drgpcr.com/account/my-account and meet all the fantastic scientists that are part of our community đ #gpcr #drgpcr Recent Articles Previous Next
- đ Ready to dive into the world of GPCR drug development? Join Dr. Terry Kenakin for the 4-week course âDevelopment of GPCR Ligands as Therapeutic Drugsâ! Get exclusive access to expert lectures, recordings, reading materials, and even a private call with Dr. Kenakin himself! Donât miss this chance to level up your knowledge. đš Spots are limitedâsave yours now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research | Dr. GPCR Ecosystem
Home â Flash News â đ Ready to dive into the world of GPCR drug development? Join Dr. Terry Kenakin for the 4-week course âDevelopment of GPCR Ligands as Therapeutic Drugsâ! Get exclusive access to expert lectures, recordings, reading materials, and even a private call with Dr. Kenakin himself! Donât miss this chance to level up your knowledge. đš Spots are limitedâsave yours now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Published on February 26, 2025 Category Dr. GPCR Courses đ Ready to dive into the world of GPCR drug development? Join Dr. Terry Kenakin for the 4-week course âDevelopment of GPCR Ligands as Therapeutic Drugsâ! Get exclusive access to expert lectures, recordings, reading materials, and even a private call with Dr. Kenakin himself! Donât miss this chance to level up your knowledge. đš Spots are limitedâsave yours now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Recent Articles Previous Next
- Ready to stand out in the GPCR world? Take advantage of a platform where you can network within your field! đ Showcase your expertise by keeping your profile up-to-date on Dr. GPCR. | Dr. GPCR Ecosystem
Home â Flash News â Ready to stand out in the GPCR world? Take advantage of a platform where you can network within your field! đ Showcase your expertise by keeping your profile up-to-date on Dr. GPCR. Published on December 11, 2024 Category Dr. GPCR Profiles Ready to stand out in the GPCR world? Take advantage of a platform where you can network within your field! đ Showcase your expertise by keeping your profile up-to-date on Dr. GPCR. âłď¸Start today at https://www.ecosystem.drgpcr.com/account/my-account #gpcr #drgpcr Recent Articles Previous Next
- How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr | Dr. GPCR Ecosystem
Home â Flash News â How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! âĄď¸https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr Published on May 26, 2025 Category GPCR Weekly News How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! âĄď¸ https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr Recent Articles Previous Next
- Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin đand save your spot soon! Remember Premium Members get a 25% discount đ âłď¸Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin đand save your spot soon! Remember Premium Members get a 25% discount đ âłď¸Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr Published on February 18, 2025 Category GPCR Weekly News Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin đand save your spot soon! Remember Premium Members get a 25% discount đ âłď¸ Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr Recent Articles Previous Next
- How does nanoscale GPCR organization shape signaling? đ¤ We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, hereâs the answer đ â Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â How does nanoscale GPCR organization shape signaling? đ¤ We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, hereâs the answer đ â Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr Published on March 20, 2025 Category Dr. GPCR Podcast How does nanoscale GPCR organization shape signaling? đ¤ We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, hereâs the answer đ â Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr Recent Articles Previous Next
- âResearch is all about knowing when to walk and when to run.â âBen Clements In Ep. 166 of the Dr.GPCR Podcast, hear how a postdoc is reshaping the conversation on opioid use, imposter syndrome, and the power of collaborative science. Why early-career voices are critical in GPCR drug discovery âand how lab culture makes all the difference. đ§ Watch here: https://buff.ly/Kr3qKud #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Home â Flash News â âResearch is all about knowing when to walk and when to run.â âBen Clements In Ep. 166 of the Dr.GPCR Podcast, hear how a postdoc is reshaping the conversation on opioid use, imposter syndrome, and the power of collaborative science. Why early-career voices are critical in GPCR drug discovery âand how lab culture makes all the difference. đ§ Watch here: https://buff.ly/Kr3qKud #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery Published on May 20, 2025 Category Dr. GPCR Podcast âResearch is all about knowing when to walk and when to run.â âBen Clements In Ep. 166 of the Dr.GPCR Podcast, hear how a postdoc is reshaping the conversation on opioid use, imposter syndrome, and the power of collaborative science. Why early-career voices are critical in GPCR drug discovery âand how lab culture makes all the difference. đ§ Watch here: https://buff.ly/Kr3qKud #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery Recent Articles Previous Next
- What do mission-driven teams and world-class science have in common? â Integrity â Systems that last â The right people In this episode, Joe & Chuck from Company Launch Partners share what it means to build something that endures. đ§ Catch the full episode: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Home â Flash News â What do mission-driven teams and world-class science have in common? â Integrity â Systems that last â The right people In this episode, Joe & Chuck from Company Launch Partners share what it means to build something that endures. đ§ Catch the full episode: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Published on May 6, 2025 Category Dr. GPCR Podcast What do mission-driven teams and world-class science have in common? â Integrity â Systems that last â The right people In this episode, Joe & Chuck from Company Launch Partners share what it means to build something that endures. đ§ Catch the full episode: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Recent Articles Previous Next
- đĽ New Course Alert! âDevelopment of GPCR Ligands as Therapeutic Drugsâ with Dr. Terry Kenakin is here! Spots are filling up fastâPremium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so donât miss your chance to learn from the best. đš Secure your spot now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research | Dr. GPCR Ecosystem
Home â Flash News â đĽ New Course Alert! âDevelopment of GPCR Ligands as Therapeutic Drugsâ with Dr. Terry Kenakin is here! Spots are filling up fastâPremium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so donât miss your chance to learn from the best. đš Secure your spot now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Published on February 24, 2025 Category Dr. GPCR Courses đĽ New Course Alert! âDevelopment of GPCR Ligands as Therapeutic Drugsâ with Dr. Terry Kenakin is here! Spots are filling up fastâPremium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so donât miss your chance to learn from the best. đš Secure your spot now! đ https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Recent Articles Previous Next
- New strategic partnership alert! đ Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. đ§Ş âWe donât just deliver compounds. We solve assay problems.â â Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner đ âłď¸ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys   #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment | Dr. GPCR Ecosystem
Home â Flash News â New strategic partnership alert! đ Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. đ§Ş âWe donât just deliver compounds. We solve assay problems.â â Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner đ âłď¸ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment Published on June 10, 2025 Category Dr. GPCR Podcast New strategic partnership alert! đ Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. đ§Ş âWe donât just deliver compounds. We solve assay problems.â â Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner đ âłď¸ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment Recent Articles Previous Next
- Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸https://buff.ly/42b6ra3 #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸https://buff.ly/42b6ra3 #gpcr #drgpcr Published on January 16, 2025 Category GPCR Weekly News Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox âĄď¸https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a3ar-antagonism-mitigates-metabolic-dysfunction-associated-steatotic-liver-disease-by-exploiting-monocyte-derived-kupffer-cell-necroptosis-and-inflammation-resolution #gpcr #drgpcr Recent Articles Beyond Clearance: The Strategic Power of Irreversible Drug Binding This session unpacks how persistent binding can either accelerate your programâor quietly kill it. Thatâs the power (and the peril) of irreversible drugs. These arenât just âstronger binders.â Theyâre kinetic game-changersâcompounds that rewrite the relationship between ligand, receptor, and physiologic outcome. Understanding how persistent binding affects receptor turnover, tissue penetration, and PK/PD relationships can give your team a strategic edge. 11 hours ago How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovationâand how this mindset can transform your research and biotech career. 5 days ago Understanding Enzyme Inhibition In GPCR Discovery Programs Every drug you design will meet an enzyme before it meets its receptor. If you want your molecules to survive first contact with biologyâand with the FDAâenzyme inhibition must be part of your core playbook. This weekâs feature breaks down exactly how to think about inhibitors with rigor and speed, so you can make better decisions earlier in the pipeline. Breakthroughs this week: Potentiation of GPCR signaling by ATP and sugar monophosphates; Pharmacology 2025; Nxera Pharma 5 days ago Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives long enough to act. Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacologyâthe framework that connects molecular survival to clinical success. Oct 14 Assay Volume Control: Your GPCR Drug Discovery Power Lever If you want cleaner decisions, start with the systemâthen the ligand. This weekâs lead feature unlocks a deceptively simple lever that separates signal from storytelling, moving programs forward with fewer surprises. Thatâs precisely what Terryâs Corner delivers: practical tools from Dr. Terry Kenakin to elevate your science and sharpe Itâs a curated toolkit designed to help GPCR professionals move faster, with more confidence. Premium Members count on this every weekâand t Oct 9 Previous Next
- Seeking to gain more knowledge on signaling bias? Weâve got the perfect opportunity for you đ Registrations open until February 14th â ď¸ Last spots available for âThe Practical Assessment of Signaling Biasâ with Dr. Terry Kenakin âłď¸Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Seeking to gain more knowledge on signaling bias? Weâve got the perfect opportunity for you đ Registrations open until February 14th â ď¸ Last spots available for âThe Practical Assessment of Signaling Biasâ with Dr. Terry Kenakin âłď¸Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Published on February 8, 2025 Category Dr. GPCR Courses Seeking to gain more knowledge on signaling bias? Weâve got the perfect opportunity for you đ Registrations open until February 14th â ď¸ Last spots available for âThe Practical Assessment of Signaling Biasâ with Dr. Terry Kenakin âłď¸Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Recent Articles Beyond Clearance: The Strategic Power of Irreversible Drug Binding This session unpacks how persistent binding can either accelerate your programâor quietly kill it. Thatâs the power (and the peril) of irreversible drugs. These arenât just âstronger binders.â Theyâre kinetic game-changersâcompounds that rewrite the relationship between ligand, receptor, and physiologic outcome. Understanding how persistent binding affects receptor turnover, tissue penetration, and PK/PD relationships can give your team a strategic edge. 11 hours ago How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovationâand how this mindset can transform your research and biotech career. 5 days ago Understanding Enzyme Inhibition In GPCR Discovery Programs Every drug you design will meet an enzyme before it meets its receptor. If you want your molecules to survive first contact with biologyâand with the FDAâenzyme inhibition must be part of your core playbook. This weekâs feature breaks down exactly how to think about inhibitors with rigor and speed, so you can make better decisions earlier in the pipeline. Breakthroughs this week: Potentiation of GPCR signaling by ATP and sugar monophosphates; Pharmacology 2025; Nxera Pharma 5 days ago Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives long enough to act. Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacologyâthe framework that connects molecular survival to clinical success. Oct 14 Assay Volume Control: Your GPCR Drug Discovery Power Lever If you want cleaner decisions, start with the systemâthen the ligand. This weekâs lead feature unlocks a deceptively simple lever that separates signal from storytelling, moving programs forward with fewer surprises. Thatâs precisely what Terryâs Corner delivers: practical tools from Dr. Terry Kenakin to elevate your science and sharpe Itâs a curated toolkit designed to help GPCR professionals move faster, with more confidence. Premium Members count on this every weekâand t Oct 9 Previous Next
- master gpcr pharmacologic models before its too late | Dr. GPCR Ecosystem
Home â Flash News â master gpcr pharmacologic models before its too late Published on July 11, 2025 Category GPCR Weekly News Most GPCR teams arenât failing because of bad science. Theyâre stalling because of slow decisions, misapplied models, and buried priorities. This weekâs GPCR Weekly News helps you fix that. Terryâs Corner breaks down the 4 pharmacologic models that separate forecasting from guessing. Dr. Sokhom S. Pin shares how he built high-output, low-burnout teamsâand earned his PhD while working full time. Yaminaâs Corner exposes the silent drift killing GPCR programs (and how to reverse it). đĄPlus: New tools from Celtarys Research . Biotech strategy moves from Catalio Capital Management . And your voice in our survey. If your competitors are already applying these insights⌠can you afford to skip this weekâs update? âłď¸ Read the Weekly News â https://www.ecosystem.drgpcr.com/post/crush-data-confusion-conquer-gpcr-drug-discovery?utm_content=bufferd9b30&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer #GPCR #Pharmacology #DrugDiscovery #ScientificLeadership #DrGPCR Recent Articles Beyond Clearance: The Strategic Power of Irreversible Drug Binding This session unpacks how persistent binding can either accelerate your programâor quietly kill it. Thatâs the power (and the peril) of irreversible drugs. These arenât just âstronger binders.â Theyâre kinetic game-changersâcompounds that rewrite the relationship between ligand, receptor, and physiologic outcome. Understanding how persistent binding affects receptor turnover, tissue penetration, and PK/PD relationships can give your team a strategic edge. 11 hours ago How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovationâand how this mindset can transform your research and biotech career. 5 days ago Understanding Enzyme Inhibition In GPCR Discovery Programs Every drug you design will meet an enzyme before it meets its receptor. If you want your molecules to survive first contact with biologyâand with the FDAâenzyme inhibition must be part of your core playbook. This weekâs feature breaks down exactly how to think about inhibitors with rigor and speed, so you can make better decisions earlier in the pipeline. Breakthroughs this week: Potentiation of GPCR signaling by ATP and sugar monophosphates; Pharmacology 2025; Nxera Pharma 5 days ago Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery Before your GPCR ligand ever meets its receptor, it meets the enzymes that determine whether it survives long enough to act. Recognizing, predicting, and leveraging these interactions is the essence of enzyme inhibition pharmacologyâthe framework that connects molecular survival to clinical success. Oct 14 Assay Volume Control: Your GPCR Drug Discovery Power Lever If you want cleaner decisions, start with the systemâthen the ligand. This weekâs lead feature unlocks a deceptively simple lever that separates signal from storytelling, moving programs forward with fewer surprises. Thatâs precisely what Terryâs Corner delivers: practical tools from Dr. Terry Kenakin to elevate your science and sharpe Itâs a curated toolkit designed to help GPCR professionals move faster, with more confidence. Premium Members count on this every weekâand t Oct 9 Previous Next
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- Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! âĄď¸https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr | Dr. GPCR Ecosystem
Home â Flash News â Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! âĄď¸https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe to the Dr. GPCR Newsletter đ° and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! âĄď¸ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Recent Articles Previous Next
- Autoantibodies that activate GPCRs? Wildâbut real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling in Ep.167 of the Dr.GPCR Podcast This episode is a must if you're thinking diagnostics. đ˛ Tap to listen: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRautoantibodies #GPCRdrugdiscovery #DrGPCR #Immunology | Dr. GPCR Ecosystem
Home â Flash News â Autoantibodies that activate GPCRs? Wildâbut real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling in Ep.167 of the Dr.GPCR Podcast This episode is a must if you're thinking diagnostics. đ˛ Tap to listen: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRautoantibodies #GPCRdrugdiscovery #DrGPCR #Immunology Published on June 3, 2025 Category Dr. GPCR Podcast Autoantibodies that activate GPCRs? Wildâbut real. Tom Sakmar & Ilana Kotliar break down the link between GPCR autoantibodies, long COVID, and disease signaling in Ep.167 of the Dr.GPCR Podcast This episode is a must if you're thinking diagnostics. đ˛ Tap to listen: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRautoantibodies #GPCRdrugdiscovery #DrGPCR #Immunology Recent Articles Previous Next
- "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners. Behind every successful research organization, there is a rock-solid operations team. Donât miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. âłď¸ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Home â Flash News â "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners. Behind every successful research organization, there is a rock-solid operations team. Donât miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. âłď¸ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Published on May 1, 2025 Category Dr. GPCR Podcast "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners.Behind every successful research organization, there is a rock-solid operations team. Donât miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. âłď¸ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Recent Articles Previous Next
- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? đ˛ Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
Home â Flash News â Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? đ˛ Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata Published on June 5, 2025 Category Dr. GPCR Podcast Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? đ˛ Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata Recent Articles Previous Next