Search Results

receptor-ligand complexes: Impact of ligand type and receptor activation state G protein-coupled receptors (GPCR Their abundance and role in nearly all physiological systems make GPCR the largest protein family targeted provided broadly generalizable performance expectations for docking into experimentally-characterized GPCR Simulations were performed using 37 experimental structures of 11 Class A GPCR crystallized in multiple Therefore, docking performance against GPCR targets can be estimated in advance based on docking target

#DrugDiscovery #MassSpec #Award #massspectrometry" Read more at the source #DrGPCR #GPCR #IndustryNews

Ho, ho, ho, GPCR elves! GPCR ecosystem! Best, Yamina & the Dr. and TPD Structural Biology Platforms GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Jobs GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist

bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array of biological

GPCR Podcast, she shares how her background in medicinal chemistry paved the way to co-founding Celtarys , a company now shaping the future of GPCR assay tools. Over time, she developed a fascination with how molecules influence biology and how that chemistry could drug discovery , GPCR research community , medicinal chemistry , Dr. GPCR ecosystem , GPCR online course , GPCR scientist network

a startup delivering tools for GPCR drug discovery. specialization in pharmaceutical chemistry, a degree that allowed her to see the full picture from synthesis to biology GPCR on the company page . _______________ Keyword Cloud:   GPCR scientist network , career development , fluorescent ligands , GPCR training program , Dr. GPCR ecosystem , GPCR podcast

Electron cryo-microscopy (cryo-EM) is a powerful technique for the structural characterization of biological cryo-EM has enabled insights into important drug target families such as G protein-coupled receptors (GPCRs Structural characterization of biologics, such as vaccines, viral vectors, and gene therapy agents, has

pharmaceutical chemist, Alessandro never imagined himself working at the cutting edge of computational GPCR began their mission: to computationally study olfactory GPCRs , a massively under-characterized group With hundreds of subtypes and limited ligand data, olfactory GPCRs represent a high-risk, high-reward —Alessandro Nicoli Want to explore computational GPCR science yourself? Explore the   GPCR University  or enroll in Terry's Corner for GPCR Courses led by Dr.

innovation #traitements #addiction #cannabis #Trisomie21 #Downsyndrome" Read more at the source #DrGPCR #GPCR

Yamina’s Corner delivers GPCR consulting that cuts through the noise, designing assay cascades, setting With a biology-first strategy, embedded execution, and scalable systems, it turns scattered data into Read The Full Article GPCR Publication Highlights   Chemokine–GPCR Selectivity Unveiled Sequence- and Distinct Ligand Activation in NMBR Simulations show how two ligands differently activate class A GPCR GPCR Team Join Our Newsletter!

G protein-coupled receptors (GPCRs) are integral to cellular signaling, influencing a wide array of physiological advancements in transcriptomic profiling have provided new insights into the expression patterns of GPCRs The study reports that human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 to 206, while platelets exhibit a distinct profile with 69 GPCR mRNAs. abundant and rare GPCR transcripts.

Significant advancements in the cellular biology of G protein-coupled receptors (GPCRs) about a novel This study, published in Nature Chemical Biology, highlights the role of the chaperone protein DNAJC13 fluorescence serves as a readout for the activity of APEX2 and, by extension, the trafficking of the GPCR The implications of this research extend beyond basic science ; understanding the role of DNAJC13 in GPCR field continues to evolve, this study represents a crucial step toward unraveling the understanding of GPCR

G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular

GPCR tools and key moves in the biotech world. Dr. GPCR Updates   We want your feedback - Help shape the future of Dr. GPCR.   Your voice matters. GPCR Ambassador - Share & refer with Dr. GPCR.   Help grow the GPCR community by joining the Dr. GPCR affiliate program. GPCR Team

“So I had to understand the biology myself.” researchers needs to start from lived experience, not just literature. _________________ Keyword Cloud: GPCR research community , chronic pain , GPCR drug discovery , GPCR scientist network , pain neuroscience

GPCR Colleagues & Curiosity-Driven Minds, We’re starting with exciting Dr. GPCR Symposia  – On-demand talks from GPCR trailblazers   Watch anytime. Learn from the best. Explore the Symposia GPCR Publication Highlights     Arrestin recognizes GPCRs independently of the receptor G(z)ESTY as an optimized cell-based assay for initial steps in GPCR deorphanization .   GPCR Team

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up In a field like GPCR research (where data complexity and failure rates are high), scientific rigor thrives GPCR ecosystem , GPCR research community , GPCR podcast , GPCR data platform , GPCR training program

GPCR ecosystem members!  GPCR ecosystem.  few years ago by some former colleagues and their description of the company was very intriguing: a biology Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery GPCR

Hello GPCR Innovators ,   We’re preparing to launch Terry’s Corner, a new knowledge hub shaped by Dr. Terry Kenakin’s decades of GPCR insight. delivers selective pain relief in preclinical models Dr.GPCR Updates Terry’s Corner  – Build Better GPCR Stay curious, stay connected, because the future of GPCR science is being written pathway by pathway. GPCR Team

GPCR Ecosystem Member, you've been with us as we've laid the groundwork for something truly special. GPCR Ecosystem, we're giving Dr. GPCR Premium Members a significantly reduced access  to Terry's Corner for a limited time.   GPCR Team & Terry’s Desk

Watch Episode 172 The Bigger Picture: GPCR Science Meets Public Health At its core, Catherine Demery’ For scientists, this means rethinking how we study GPCR-mediated respiratory depression. Why This Research Matters Beyond the Lab Catherine’s findings bridge the gap between basic receptor biology In other words, this is GPCR science with immediate, life-or-death consequences. They’re rewriting the biology of overdose.

. _________________ Keyword Cloud: GPCR training program , GPCR scientist network , GPCR drug discovery , G protein-coupled receptors , GPCR online course

Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4 WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified in WHIM syndrome patients, the functional effect of these mutations are not fully understood. Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and compare the properties of S339fs5 with wild type CXCR4 and a previously identified WHIM syndrome mutant, R334X. The S339fs5 and R334X mutants exhibited significantly increased signaling compared to wild type CXCR4 including agonist-promoted calcium flux and extracellular signal-regulated kinase activation. This increase is at least partially due to a significant decrease in agonist-promoted phosphorylation, β-arrestin binding, and endocytosis of S339fs5 and R334X compared to wild type CXCR4. Interestingly, there were also significant differences in receptor degradation, with S339fs5 having a very high basal level of degradation compared to that of R334X and wild type CXCR4. In contrast to wild type CXCR4, both R334X and S339fs5 were largely insensitive to CXCL12-promoted degradation. Moreover, while basal and agonist-promoted degradation of wild type CXCR4 was effectively inhibited by the CXCR4 antagonist TE-14016, this had no effect on the degradation of the WHIM mutants. Taken together, these studies identify a new WHIM syndrome mutant, CXCR4-S339fs5, that promotes enhanced signaling, reduced phosphorylation, β-arrestin binding and endocytosis, and a very high basal rate of degradation that is not protected by antagonist treatment. Read full article

This allows him to see how inflammation, cognition, and pain circuits overlap , and how GPCRs might serve And it challenges the GPCR community to use its tools not just to explain, but to intervene. the case for building pain research from the clinic down, not the bench up. ________ Keyword Cloud: GPCR podcast , pain modeling , GPCR online course , translational research , neuroimmune signaling .

Neuropeptides and their specific receptors (primarily G protein-coupled receptors, GPCRs) regulate multiple biological functions in insects and represent promising next-generation pest management strategy. A total of 41 neuropeptide GPCR genes belonging to three classes were also identified. These GPCRs and their probable ligands were predicted. to determine physiological functions and pharmacological characterization of neuropeptides and their GPCRs

There were several sections, among them one specific for GPCRs. Sometimes when you’re in the field you forget the importance GPCRs holds in drug development as a whole Session 4 on Wednesday was dedicated to GPCRs. The talks given targeted both traditional GPCRs such as the serotoninergic receptor 5HT1A, but also newer

. _________________ Keyword Cloud: GPCR online course, early-career scientists, imposter syndrome, GPCR podcast, neuroma model

Information exchange and interpretation is essential in biology and understanding how cells integrate information-coding molecules into complex orchestrated responses is a major challenge for modern cell biology The G protein-coupled receptors (GPCRs) are the largest family of membrane receptors, with nearly 800 The recognition that GPCRs may physically interact with each other has led to the hypothesis that their new ideas about the physiological role played by receptor homo- and hetero-oligomerization in cell biology

. _________________ Keyword Cloud: GPCR scientist network, GPCR training program, mentorship in science

G protein-coupled receptors (GPCRs) are major drug targets, yet their complex and dynamic structures By using machine learning, AF2 can accurately predict the 3D structures of GPCRs with atomic-level accuracy The AlphaFold database encompasses over 200 million proteins, aiding structural biology, protein design Furthermore, AI's role in structural biology and drug design is set to spark innovation in automated