Premium Members Include: ✔ Drug hunters at early-stage biotechs ✔ CRO leaders building assays and tools

their understanding of the GPCRs through various approaches, including structural biology and signaling assays

Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal assay

molecular dynamics, and virtual screening — tightly integrated with experimental mutagenesis and functional assays

on a project involving receptor kinases and collaborating with other postdocs in the lab to develop assays

Insel has long argued that purifying receptors, depleting GTP, and stabilizing conformations through

Receptor signaling assays showed efficacy shifts in the spinal cord and tolerance attenuation in the

exploration of dosage and length of treatment in a mouse model and suggested using a biosensor-based assay

Cell context, assay choice, and receptor conformational heterogeneity all contribute to outcomes.

sequence-based phylogeny, database mining for tissue expression, virtual screening, pharmacological assay

in 19 Wnt ligands is currently available in a biologically active, tagged form suitable for binding assays

She trained in high-throughput drug discovery at Vanderbilt - contributing to early functional assay

on receptors but on G protein cycle regulation - RGS proteins, GoLoco proteins, and the kinetics of GTP

Using radioligand binding assays developed for the beta-adrenergic receptor system, his lab purified,

Computational Methods Complement Experimental Pharmacology Experimental assays measure pathway activation

the Forefront of GPCR Drug Discovery Gain insider methods from the pioneers shaping biased signaling, assay Pharmechanics GPCR signaling & biased agonism expert regularly consulted by top pharma companies for assay Weekly GPCR Insights (papers, jobs, events) Networking with a global scientist community One failed assay

GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays

GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays