With a deep focus on structure-based drug design, Jens discusses how his lab bridges simulation and experiment—and molecules to leveraging AlphaFold for structure prediction, Jens shares the cutting-edge tools his lab at the intersection of computation and pharmacology, often in close collaboration with experimental labs

One evening running analyses alone in the lab, a pattern appeared. Before that I was doing my postdoc in California in the lab of Dr. My PhD was in Georgia in the lab of Dr. Vaidehi’s lab and that’s when you were first exposed to GPCRs. One Friday evening I was alone in the lab running analyses.

With my background in neuroscience, the lab of Dr. Overall, the lab works on diverse models and diseases, and has developed a wide array of tools to dissect

To this end, her lab uses several computational structural biology tools and rational drug design approaches Marta Filizola on the web Icahn School of Medicine at Mount Sinai Filizola Lab Wikipedia Twitter Linkedin

collaboration with: GeneTex Recombinant Antibodies for GPCRs: A Challenge to the Community Test them in your lab When feasible, GeneTex uses VirDTM-GPCR arrays (CDI Labs, Mayagüez, PR), which present a nearly comprehensive The challenge: test them in your lab This is the goal of the Dr. GPCR x GeneTex partnership.

to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff Benovic’s laboratory In 2016 he decided to move his lab to the Medical College of Wisconsin in Milwaukee, WI. His laboratory is interested in understanding the mechanisms that govern spatial and temporal regulation His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged

Her lab investigates how GPCRs modulate synaptic transmission in brain circuits involved in reinforcement Alcohol Disrupts mGlu2 - But a PAM Can Restore It Johnson's lab demonstrated that adolescent alcohol Johnson's lab has extended this using conditional knockout mice that allow selective deletion of mGlu2 Johnson's lab uses this framework to ask whether activating mGlu2 in specific corticostriatal circuits Introduction 01:27 Johnson's career path - from Vanderbilt drug discovery to NIH postdoc to independent lab

He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

For postdoctoral training, he joined the laboratory of Dr. His laboratory is currently located at the Institute Cochin – Inserm (Paris, France). His laboratory was among the first to demonstrate the oligomerization of GPCRs. His lab was among the first to discover mitochondrial functions of GPCRs. Ralf Jockers on the web Jockers Lab WGDR-3545 Pubmed Dr. GPCR Ecosystem Unlock the Full Dr.

Then I pursued my education in the lab of Dr. I followed my interest in allergy and GPCRs by joining the lab of Dr.

Avila Zozaya & Yamina Berchiche About Inês Pinheiro PharmD by training and Ph.D. candidate in Hartley's lab Monserrat Avila Zozaya on the web Antony Boucard Lab Dr. GPCR Ecosystem About Yamina Berchiche Dr.

She subsequently joined Professor Mark Connor's laboratory at Macquarie University in Australia. Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid Inês Pinheiro PharmD by training and Ph.D. candidate in Hartley's lab at the University of Geneva. Monserrat Avila Zozaya on the web LinkedIn Antony Boucard Lab Dr.

Receptor Tools Through Academia Industry Collaboration How do GPCR tools move from individual academic labs surgeon, he conducted postdoctoral research at the CNRS in Montpellier before establishing independent laboratories The Web Maria Majellaro LinkedIn ResearchGate Ecosystem Johannes Broichhagen LinkedIn Google Scholar Lab for Molecular Pharmacology (FMP) Profile David Hodson Radcliffe Department of Medicine Islet Biology Lab

Cone’s lab was a clear choice for a postdoc. Dr. the first to clone the melanocortin receptors (the GPCRs that led to the discovery of MRAP2), and his lab Since I joined the lab, I became proficient in many In-vivo techniques, I adapted my arrestin recruitment

Oct 2020 — Presented at ERNEST with Beyond the Lab . Nov 2020 — Invited to the 9th GDR Meeting with Beyond the Lab . 2021 Expanding the Conversation Podcast Mar 2022 — Featured at ERNEST with Beyond the Lab .

Using radioligand binding assays developed for the beta-adrenergic receptor system, his lab purified, His lab developed the GRK (G protein-coupled receptor kinase) family and discovered the beta-arrestins Lefkowitz's lab was getting nowhere screening plasmid libraries. Kobilka had applied to Duke without ever meeting him, had joined the lab without an interview, and had Adrenaline-Fueled Adventures of an Accidental Scientist Duke University Wikipedia Nobel Prize HHMI Lefkowitz Lab

Conformational biosensors for GPCR activation: FRET, BRET, and single-color sensor design, site-specific labeling labeling efficiency. Trained as a pharmacist, she earned her doctorate in Biomedicine in Martin Lohse's laboratory, where As a Scientist in Madan Babu's lab at St. She is a postdoctoral researcher in Brian Kobilka's lab at Stanford University.

health and disease, fascinated her so much that she continued working on them when she started her own lab Simone Prömel on the web Prömel Lab Pubmed Researchgate Twitter Dr. GPCR Ecosystem About Dr.

Throughout the episode, Ian reflects on the value of a supportive lab culture , the need for better experimental About Ian Chronis I recently finished my PhD in the lab of Dr.

Work by the Beaulieu Lab has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar Working in collaboration with geneticists, the Beaulieu-Lab has identified interactions between cellular

ABOUT THE GUEST Chris Tate is a group leader at the MRC Laboratory of Molecular Biology in Cambridge, afternoon and a paper on an unrelated protein The thermostabilization insight did not come from the lab Science is brutal, things fail for months, and the only way through is genuine passion for being in the lab screen, and a synchrotron SELECTED QUOTES "None of my best ideas have ever arisen from being in the lab Because when you're in the lab, you're thinking about what's in front of you."

How an integrated training and lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation She leads the Spatial Organisation of Signalling Laboratory, where her team investigates how GPCRs orchestrate She established her lab in 2011, and today she is a Viertel Senior Medical Research Fellow.

field has lived with a quiet, persistent problem: antibodies that pass catalog-level QC, ship to a lab For Ball, the stakes became concrete years before GeneTex - in a research lab where the reliability of The Most Expensive Thing a Lab Can Waste Is Not Money Ball's most direct recommendation to researchers Introducing Lin and Ball - roles and context at GeneTex 03:25 GeneTex history - from a Texas research lab

The conversation traces her path from neurobiology in Salzburg through academic labs in Vienna, Copenhagen training began in zoology and neurobiology in Salzburg, followed by a PhD on GPCRs in Michael Freissmuth's lab Schwartz’s lab in Copenhagen where she completed her postdoctoral training.

membrane protein structural biology can be particularly appealing. 18:00 — Choosing a postdoctoral lab So Joe, tell me a little bit about how you ended up working on GPCRs in Ashish’s lab. And that realization eventually led me to Ashish’s lab. Dr. Joseph Kim: It actually came from discussions with Ashish when I first joined the lab. The reason I was able to transition successfully into GPCR structural biology was because I joined a lab

company that started with the development of technologies combining mathematical methods and a wet lab the interdisciplinary nature of his company, which includes mathematics, signaling pathways, a wet lab company, which started with the development of technologies combining mathematical methods and a wet lab

computational medicinal chemistry before spending a formative period in Gerhard Klebe's structural biology lab Her postdoctoral training in Masha Niv's lab in Israel marked her first work on GPCRs, specifically the Masha Niv's lab .

decisions in academic science, uncertainty, reentry, and the conditions that keep scientists in the lab describes a period after returning from New York when she was genuinely uncertain about continuing in the lab Drosophila 13:57 - Naming Remulate, ketchup, and mayo; why Remulate became the primary focus 15:47 - Lab

current work extends that logic into signaling kinetics: the time dimension in GPCR signaling that labs After a PhD on allosteric modulation of dopamine receptors in Philip Strange's UK lab and a postdoc at Yet that is precisely how most labs treat time-course signaling data — collecting it, plotting it, and

practical knowledge, and say instructors understand both the technical and the human challenges of lab mention most Expert instructors who are also gifted communicators Depth of theory paired with practical, lab-ready attendee The course was very practical and easily translatable to experiments that we could do in our own labs