. << Back to podcast list Strategic Partner(s) Anita Nivedha: Computational Dynamics of Ligand Bias in GPCR Signaling Scientific Abstract G protein–coupled receptors (GPCRs) transmit extracellular signals Communication routes toward G proteins differed from those toward arrestins. The result is activation of intracellular signaling partners like G proteins or β-arrestins. Then we compared pathways leading to G proteins versus β-arrestins.

. << Back to podcast list Strategic Partner(s) Robert J. His lab developed the GRK (G protein-coupled receptor kinase) family and discovered the beta-arrestins , proteins now understood as central mediators of receptor desensitization and G protein-independent Lefkowitz was awarded the Nobel Prize in Chemistry, shared with Brian Kobilka, for studies of G protein-coupled Functional analogies between the two systems had been recognized — both were G protein-coupled — but

. << Back to podcast list Strategic Partner(s) Arun Shukla: How Two Arrestins Regulate 800 GPCRs The so-called non-canonical GPCRs — receptors once dismissed as non-functional because they don't couple to G Receptors like CXCR7, C5L2, and TQIP6 were long dismissed as non-canonical because they don't couple to G Biased agonism is harder than the opioid story suggested The neat bifurcation between G-protein and beta-arrestin

. << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology interface sits on helix 1, involves a domain-swapped N-terminus and helix 7, is twice the area of the G In 2016 mini-G proteins were developed as a tool for the structure determination of GPCRs in the fully coupled to either mini-Gs or mini-Go, and also by electron cryo-microscopy of receptors coupled to mini G

<< Back to podcast list Strategic Partner(s) Dr. Michael Feigin About Dr. Michael Feigin "Dr. Craig Malbon at SUNY Stony Brook studying the role of G-protein coupled receptors (GPCRs) and their regulators They also discussed his research on cell polarity and its role in cancer progression, his work on G-protein He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161

<< Back to podcast list Strategic Partner(s) Dr. Jean Martin Beaulieu About Dr. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular

<< Back to podcast list Strategic Partner(s) Dr. Josephine (Pina) Cardarelli About Dr. mission is to discover and develop highly effective cancer therapeutics by targeting heteromers of G

. << Back to podcast list Strategic Partner(s) Signals, pH, and Discovery : Cracking GPCR Mysteries with University of Chicago and the University of Michigan shaped his scientific curiosity, particularly around G

<< Back to podcast list Strategic Partner(s) Dr. Demet Araç About Dr. backgrounds, academic backgrounds, and career paths, with a focus on their experiences in the field of GPCR (G Advice for Junior Scientists Demet and Yamina discussed the progress of their research in the GPCR (G

<< Back to podcast list Strategic Partner(s) Dr. Thomas P. Sakmar About Dr. Thomas P. on to discover a “counterion switch” in visual pigments and to develop strategies to assay receptor-G-protein

He discusses biased signaling in GPCR research, developing biosensors for G protein activity, networking Highlights of the week Structural insights into prolactin-releasing peptide receptor signaling and G-protein and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite 2025 - Germany May 20 - 22, 2025 |4th GPCRs-Targeted Drug Discovery Summit - USA June 22 - 26, 2025 | G and more Single-Molecule Insights into GPCR Conformational Landscapes Covalent functionalization of G

<< Back to podcast list Strategic Partner(s) Dr. GPCR Board About Dr. Yamina Berchiche "Dr. GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors My experience in basic research at several universities worldwide and early R&D at Novo Nordisk A/S allowed

. << Back to podcast list Strategic Partner(s) GPCR Pharmacology, Career Twists & Serendipity with Sokhom Novartis, and eventually founding in vitro pharmacology departments, Sokhom always stayed anchored to G

. << Back to podcast list Strategic Partner(s) Eleonora Comeo: Fluorescent Ligands and the Pharmacology It is also a matter of G protein coupling, tissue context, and the signaling assay used to measure affinity that make receptor behavior visible Adenosine receptor subtype pharmacology - the four subtypes, their G

. << Back to podcast list Strategic Partner(s) Graciela Piñeyro: Partial Agonism, Receptor Recycling, If the right ligand could engage G-protein signaling while sparing β-arrestin, pain relief might finally Piñeyro's lab systematically compared G-protein and β-arrestin recruitment across 25 compounds — standard

. << Back to podcast list Strategic Partner(s) Ross Cheloha: Nanobody-GPCR Conjugates and the Engineering the stabilization of GPCR ligands using non-natural amino acids Receptor conformation selectivity: G-protein Conformation selectivity changes the duration of the signal PTH receptor exists in G-protein coupled

<< Back to podcast list Strategic Partner(s) Dr. GPCR Team About Dr. Yamina Berchiche Dr. Yamina A. GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors

<< Back to podcast list Strategic Partner(s) Dr. Alix A. J. Rouault About Dr. Alix A. J. then undertook my first project where I demonstrated that MRAP2 regulates the signaling of multiple G

. << Back to podcast list Strategic Partner(s) Michel Bouvier: BRET, Biased Agonism, and the Tools That Changed GPCR Pharmacology G-protein-coupled receptors were once described through a simple model: a of BRET - dimerization controversy, marine bioluminescence, and a reviewer's demand 25:51 Building G-protein

<< Back to podcast list Strategic Partner(s) Dr. Claudia Stäubert About Dr. "I received my degree in biochemistry from Leipzig University (Germany) being already fascinated by G

. << Back to podcast list Strategic Partner(s) Qing Fan: Inside the Architecture of Class C GPCRs Class the agonist binding site; the GABA-B2 subunit is required for trafficking to the cell surface and for G illustration of what pathway-selective drug design can achieve: a compound that confers analgesia through G

November 2-4, 2023 We are pleased to welcome you at Le Château Montebello, the 22nd Annual Great Lakes G activity-modifying proteins or RAMPs regulate GPCR function, is confirmed as Plenary Speaker of the inaugural Marc G. Additionally, there will be a Marc G.

. << Back to podcast list Strategic Partner(s) Charlotte Crauwels: Designing Hybrid GPCRs with Computational Protein Engineering Scientific Abstract G protein–coupled receptors (GPCRs) are among the most extensively These hybrid receptors enable researchers to probe receptor signaling, investigate G protein coupling

. << Back to podcast list Strategic Partner(s) GPCRs and the Science Behind Pain and Recovery with Dr specialist, Serafini found himself repeatedly drawn to them, or more precisely, to RGS (Regulators of G

. << Back to podcast list Strategic Partner(s) When to Walk, When to Run: Lessons from the GPCR Trenches His journey highlights the transition from general drug development to a deep dive into G protein-coupled

. << Back to podcast list Strategic Partner(s) GPCR Assay Strategy, Bias, and Translational Drug Discovery Keeping GLP1 receptors at the membrane can shape the therapeutic profile Building on work from Stephen

<< Back to podcast list Strategic Partner(s) Dr. Stephane Angers About Dr. Stephane Angers Dr. Stephane Angers on the web Angers Lab The Donnelly Centre Twitter Dr.

. << Back to podcast list Strategic Partner(s) Maria Waldhoer: Pharmacological Fingerprints and the Limits ten to fifteen pharmacological parameters — internalization rates, recycling and degradation rates, G

<< Back to podcast list Strategic Partner(s) A Brief History of allosteric modulation with Dr. They discussed various modulatory elements, such as RAMPs, G proteins, and GRKs, with Arthur recounting

<< Back to podcast list Strategic Partner(s) Self-Learning, Collaboration, and Delegation in Science Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination