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Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue He then joined the Internal Medicine Residency training program at Duke University Medical Center. that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke University Medical Center.

constraint on pharmacological interpretation Equilibrium vs. dynamic frameworks for studying receptor biology An assay measures a specific thing - not the biology you assume it measures One of Livingston's most Academia and industry are structurally complementary - not competing versions of the same thing Academia Livingston argues these structural constraints make the two sectors dependent on each other - and notes moving - and then to flip it on its head again and say the receptor at the surface might not be the center

Radioligand binding and the first demonstration of GPCR structure — The methodological progression from The cloning race and the serendipity of the intronless gene — Competing against Genentech's molecular biology When Brian Kobilka proposed screening a genomic library, Merck's molecular biology collaborators called The discovery that it was structurally homologous to rhodopsin was a complete surprise. of Medicine and Professor of Biochemistry, Chemistry, and Pathology at the Duke University Medical Center

GPCR webinars are live online scientific sessions focused on G protein-coupled receptor (GPCR) biology These webinars are ideal for: GPCR pharmacologists Medicinal chemists working on receptor targets Structural biologists Translational scientists Biotech and pharmaceutical researchers Postdoctoral fellows and modeling Calcium and signaling assays Drug–receptor kinetics Translational pharmacology strategies GPCR structure–function These programs are designed for scientists seeking advanced, mechanism-focused training in GPCR biology

This conversation explores the biology, diversity, and unexpected reach of human taste GPCRs, beginning Niv describes how bitter taste receptors differ structurally from most other GPCRs - missing conserved matchmaking - applying recommendation system logic to the bitter taste receptor family Sweet taste receptor biology Bitter taste receptors are built to activate, not to be blocked Bitter taste GPCRs are structurally unusual consequences 41:58 - Taste GPCRs as drug targets - asthma, cardiac physiology, and early signals in cancer biology

Lauren Slosky About Irfan Dhanidina "My interest in oncology research led me to pursue a BSc in Biology Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University Caron received a BS in Biology and BA in Philosophy at Emory University and a PhD at Duke University Cancer Center Twitter Google Scholar ORCID ResearchGate Dr. Integrating GPCR biology, behavioral pharmacology, and systems neuroscience approaches, the Slosky Lab

What emerges is a quiet argument that the structural shifts the pandemic forced — project planning in Experimental planning under uncertainty — Structuring projects into self-contained blocks so a lab can Civic responsibility in returning to the bench — Deconfining a research center slowly, with planning research center closed again, the team would still have something to analyze, something to write. The research center was deconfining at 20% capacity the week of the recording. Dr.

Duvall emphasizes the value of model systems and cross-species discoveries in GPCR biology. considering novel ways to connect molecular pharmacology with organismal phenotype, especially in vector biology About Laura Duvall Laura Duvall trained in biochemistry and behavioral biology at the University of Pennsylvania Duvall established her laboratory at Columbia University, where she is part of the Department of Biological Her research is consistently motivated by uncovering new biological connections that can bridge basic

How an integrated training and lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation Tried to map signaling heterogeneity in disease-relevant models, Built assays that need to work in real biology—not Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader of Drug Discovery Biology Michelle earned her PhD in Molecular Pharmacology at Monash University, then trained in single-cell biology

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts in GPCR biology We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each If you’re working on exciting GPCR-related research — from structural biology to drug discovery — we’ to connect, exchange, and collaborate to improve human health through a better understanding of GPCR biology We'll then engage in a conversation centered around your career and how you got introduced to GPCRs.

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia resulted in her Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes

Why this matters How a chemist with zero biology training became a leader in GPCR probe design. Who should listen If you’ve ever: Navigated a project where the biology refused to match the textbook Collaborated across chemistry and biology and felt the translation gap firsthand… …this episode will his interest in ion channels, GPCR pharmacology, and the chemical strategies needed to probe complex biology His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand

signaling — one of the most fundamental pathways in vertebrate development, stem cell renewal, and tumor biology pharmacologically accessible binding pocket — a conclusion that was not obvious from the initial frizzled 4 crystal structure Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Biology is on Frizzled signaling and pharmacology aiming to understand the role of WNT/Frizzled signaling in biology

Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham and Co-Director of the Centre and 2017, he was a Group Leader at the Institute of Pharmacology and Toxicology and Rudolf Virchow Center He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and journals such as Nature, Cell, New England Journal of Medicine, Journal of Clinical Investigation, PLoS Biology

She has been at InterAx since 2017, where she leads the development of a computational systems biology Scientific Themes of the Conversation Kinetic versus endpoint characterization of GPCR ligands Systems biology descriptors Ligand residence time as a driver of drug action AI combined with functional, not only structural scale, and decisions from above 09:58 — InterAx's pivot from arrestin biosensors to kinetic systems biology She earned her M.Sc. in Zoology and Neurobiology before completing a Ph.D. in Biology and Pharmacology

His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors , cyclic AMP regulation, and receptor biology across tissue systems. Biology runs on opposing forces, and good pharmacology learns to see them. 07:40 Expanding the hypothesis — PAR1, PAR4, and upstream pathobiology 11:00 Gas pedals and brakes — biology's Paul Insel "Almost most biological systems are all about gas pedals and brakes.

Nikolaus Heveker's lab at the CHU Sainte-Justine Research Center on chemokine receptor structure–function Splice variants aren't just structural — they signal differently. career 06:30 An empty lab and the chemokine redundancy problem 09:00 A master's, old-school molecular biology During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships

technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure He also worked on creating novel methods for systems biology using temporal logic specifications while Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. and relevance of mathematical models in systems biology and pharmacology.

Council of Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure 2021 Clarivate Analytics Highly Cited Researcher in two disciplines: Pharmacology & Toxicology and Biology

During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry

His research centers on the beta-2 adrenergic receptor and GPR65 , a proton-sensing receptor with promising implications in cancer biology.

Pfleger on NanoBRET live-cell assays, receptor complex pharmacology, and what it took to move GPCR biology Those platforms have been applied across arrestin biology, receptor complex pharmacology, and the angiotensin The conversation also covers what it means when cell biology reaches the clinic. Endpoint Assays Can Miss the Biology Entirely A single measurement at a fixed time point collapses all That cell biology eventually became a clinical hypothesis, then a compound, then a trial result.

to podcast list Strategic Partner(s) Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists It’s about enabling biology.” — Maria Majellaro Through its partnership with Dr. Together, we’re combining chemistry, biology, and business insight to empower the GPCR research community During her doctoral studies, she spent one year as a predoctoral visiting student at the CIQUS Research Center—Campus

Approach <p class="font_8">Watch Now</p> Sudarshan Rajagopal The Spatiotemporal Revolution in GPCR Biology Jacobson, Matteo Pavan Structure-Based Design of Modulators of Purinergic GPCRs <p class="font_8">Watch Strategy Allosteric Modulation Allosteric Modulation & Kinetics Biased Signaling & Allosteric Modulation Structure-Based GPCR Masterclass is a live scientific discussion with a leading expert in GPCR pharmacology, receptor biology

Listeners will gain perspective on how asking broader questions about receptor biology can reshape drug His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to intersects with cancer, immunology, and systems biology. mutation paradigm 25:05 AI, in silico screening, and the limits of computational drug discovery without structures Paul Insel was at the FASEB experimental biology meeting in Atlantic City.

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

Simone Prömel Simone Prömel is currently a professor of cell biology at the Heinrich Heine University mechano-activation- activation scenario that forms the basis for her current projects that focus on the structural