Eurofins DiscoverX scientists on physiological relevance, the GPCRs that refuse to work, and why obesity biology list Strategic Partner(s) Jane Lamerdin and Gaurav Agrawal: Building GPCR Assays That Reflect Real Biology Obesity and GLP-1 biology changed that, and the largest target class is once again at the front of drug Her background spans high-throughput, molecular, and systems biology research, which lets her speak to The easy readout drifts away from the biology researchers actually want to measure.

GPCR webinars are live online scientific sessions focused on G protein-coupled receptor (GPCR) biology These webinars are ideal for: GPCR pharmacologists Medicinal chemists working on receptor targets Structural biologists Translational scientists Biotech and pharmaceutical researchers Postdoctoral fellows and modeling Calcium and signaling assays Drug–receptor kinetics Translational pharmacology strategies GPCR structure–function These programs are designed for scientists seeking advanced, mechanism-focused training in GPCR biology

received a prestigious Gates Cambridge Scholarship to study for a Ph.D. at the MRC Laboratory of Molecular Biology His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs developed novel tools and methodologies to study fungal GPCRs which allowed the determination of the first structures

Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue He then joined the Internal Medicine Residency training program at Duke University Medical Center. that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

The overall goal of her research program is to obtain rigorous mechanistic insights into the structure To this end, her lab uses several computational structural biology tools and rational drug design approaches

Pradhan returns to often: that organisms in chronic pain are fundamentally different biological systems Professor of Psychiatry at the University of Illinois at Chicago, where her lab studies opioid receptor biology the same family produce opposite clinical outcomes Chronic disease states as fundamentally altered biological Pradhan turns to the structural weight carried by women and scientists of color in academia — the cumulative

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

She has been at InterAx since 2017, where she leads the development of a computational systems biology Scientific Themes of the Conversation Kinetic versus endpoint characterization of GPCR ligands Systems biology descriptors Ligand residence time as a driver of drug action AI combined with functional, not only structural scale, and decisions from above 09:58 — InterAx's pivot from arrestin biosensors to kinetic systems biology She earned her M.Sc. in Zoology and Neurobiology before completing a Ph.D. in Biology and Pharmacology

Lauren Slosky About Irfan Dhanidina "My interest in oncology research led me to pursue a BSc in Biology Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University Caron received a BS in Biology and BA in Philosophy at Emory University and a PhD at Duke University Cancer Center Twitter Google Scholar ORCID ResearchGate Dr. Integrating GPCR biology, behavioral pharmacology, and systems neuroscience approaches, the Slosky Lab

How an integrated training and lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation Tried to map signaling heterogeneity in disease-relevant models, Built assays that need to work in real biology—not Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader of Drug Discovery Biology Michelle earned her PhD in Molecular Pharmacology at Monash University, then trained in single-cell biology

beginning to close the gap KEY INSIGHTS FROM THE CONVERSATION The cell you screen in determines the biology agonist where none had been reported - constitutive beta-arrestin coupling at FFA2 Gilchrist's lab entered activates it naturally, and getting therapeutic results, suggests the field does not always need the full biology trajectory - from medical school intent to Pfizer, PhD in immunology, and an accidental entry into GPCR biology "As much as it's been wonderful to get crystal structures and use molecular dynamics, there are still

Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke University Medical Center.

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

Her group works at the intersection of neuropeptide signaling, behavioral genetics, and vector biology About Laura Duvall runs a research lab in the Department of Biological Sciences at Columbia University Instead, expression was almost exclusive to the mosquito rectum, a structure Duvall says she did not

Sri Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology He is passionate about developing more rational ways to understand and engineer biology. empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical biology , synthetic biology, and functional genomics. He is a Searle Scholar (2015), NIH New Innovator (2014), and received his ScD in Biological Engineering

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

to podcast list Strategic Partner(s) Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists It’s about enabling biology.” — Maria Majellaro Through its partnership with Dr. Together, we’re combining chemistry, biology, and business insight to empower the GPCR research community During her doctoral studies, she spent one year as a predoctoral visiting student at the CIQUS Research Center—Campus

technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure He also worked on creating novel methods for systems biology using temporal logic specifications while Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. and relevance of mathematical models in systems biology and pharmacology.

Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham and Co-Director of the Centre and 2017, he was a Group Leader at the Institute of Pharmacology and Toxicology and Rudolf Virchow Center He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and journals such as Nature, Cell, New England Journal of Medicine, Journal of Clinical Investigation, PLoS Biology

Pfleger on NanoBRET live-cell assays, receptor complex pharmacology, and what it took to move GPCR biology Those platforms have been applied across arrestin biology, receptor complex pharmacology, and the angiotensin The conversation also covers what it means when cell biology reaches the clinic. Endpoint Assays Can Miss the Biology Entirely A single measurement at a fixed time point collapses all That cell biology eventually became a clinical hypothesis, then a compound, then a trial result.

Council of Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure 2021 Clarivate Analytics Highly Cited Researcher in two disciplines: Pharmacology & Toxicology and Biology

His research centers on the beta-2 adrenergic receptor and GPR65 , a proton-sensing receptor with promising implications in cancer biology.

During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry

Why this matters How a chemist with zero biology training became a leader in GPCR probe design. Who should listen If you’ve ever: Navigated a project where the biology refused to match the textbook Collaborated across chemistry and biology and felt the translation gap firsthand… …this episode will his interest in ion channels, GPCR pharmacology, and the chemical strategies needed to probe complex biology His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand

Listeners will gain perspective on how asking broader questions about receptor biology can reshape drug His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to intersects with cancer, immunology, and systems biology. mutation paradigm 25:05 AI, in silico screening, and the limits of computational drug discovery without structures Paul Insel was at the FASEB experimental biology meeting in Atlantic City.

Introduction Conformational biosensors report the structural rearrangements of a GPCR as they happen She recently joined the High Throughput Biology team at Boehringer Ingelheim, where she supports the