beginning to close the gap KEY INSIGHTS FROM THE CONVERSATION The cell you screen in determines the biology agonist where none had been reported - constitutive beta-arrestin coupling at FFA2 Gilchrist's lab entered activates it naturally, and getting therapeutic results, suggests the field does not always need the full biology trajectory - from medical school intent to Pfizer, PhD in immunology, and an accidental entry into GPCR biology "As much as it's been wonderful to get crystal structures and use molecular dynamics, there are still

fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts in GPCR biology We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each If you’re working on exciting GPCR-related research — from structural biology to drug discovery — we’ to connect, exchange, and collaborate to improve human health through a better understanding of GPCR biology

received a prestigious Gates Cambridge Scholarship to study for a Ph.D. at the MRC Laboratory of Molecular Biology His Ph.D. work has been focused on understanding the structure and activation of Class D fungal GPCRs developed novel tools and methodologies to study fungal GPCRs which allowed the determination of the first structures

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Premont obtained his B.S. in Biology and Chemistry at the California Institute of Technology in 1985, In our work, we utilize methods including structural biology and proteomics, molecular biology and biochemical

Lauren Slosky About Irfan Dhanidina "My interest in oncology research led me to pursue a BSc in Biology Eldridge Distinguished Professor and Chair of the Department of Cell Biology & Physiology at The University Caron received a BS in Biology and BA in Philosophy at Emory University and a PhD at Duke University Cancer Center Twitter Google Scholar ORCID ResearchGate Dr. Integrating GPCR biology, behavioral pharmacology, and systems neuroscience approaches, the Slosky Lab

encompassing functional assay development, GPCR internalization research, and both small molecule and biologic Teams expanding into antibody or biologic modalities for challenging GPCR targets. Pharmacology group in the Diabetes, Obesity and Complications Therapeutic Area at Lilly's Seaport Innovation Center His scientific training included a PhD at the International Center for Genetic Engineering and Biotechnology Awarded patents and a proven record in both target and pathway identification, his drive centers on integrating

She has been at InterAx since 2017, where she leads the development of a computational systems biology Scientific Themes of the Conversation Kinetic versus endpoint characterization of GPCR ligands Systems biology descriptors Ligand residence time as a driver of drug action AI combined with functional, not only structural scale, and decisions from above 09:58 — InterAx's pivot from arrestin biosensors to kinetic systems biology She earned her M.Sc. in Zoology and Neurobiology before completing a Ph.D. in Biology and Pharmacology

The overall goal of her research program is to obtain rigorous mechanistic insights into the structure To this end, her lab uses several computational structural biology tools and rational drug design approaches

Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue He then joined the Internal Medicine Residency training program at Duke University Medical Center. that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

How an integrated training and lab structure at Monash Institute of Pharmaceutical Sciences fosters innovation Tried to map signaling heterogeneity in disease-relevant models, Built assays that need to work in real biology—not Michelle Halls is an Associate Professor at Monash University and Deputy Theme Leader of Drug Discovery Biology Michelle earned her PhD in Molecular Pharmacology at Monash University, then trained in single-cell biology

Sudha Shenoy is currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke University Medical Center.

Sri Kosuri Sri is a biologist that has helped build technologies, labs, and companies in synthetic biology He is passionate about developing more rational ways to understand and engineer biology. empirically exploring questions in protein biochemistry, human genetic variation, gene regulation, chemical biology , synthetic biology, and functional genomics. He is a Searle Scholar (2015), NIH New Innovator (2014), and received his ScD in Biological Engineering

Duvall emphasizes the value of model systems and cross-species discoveries in GPCR biology. considering novel ways to connect molecular pharmacology with organismal phenotype, especially in vector biology About Laura Duvall Laura Duvall trained in biochemistry and behavioral biology at the University of Pennsylvania Duvall established her laboratory at Columbia University, where she is part of the Department of Biological Her research is consistently motivated by uncovering new biological connections that can bridge basic

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

allosteric modulation and biased agonism, and incorporates computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models & Toxicology’, and in 2021 also named him a Highly Cited Researcher in the additional category of ‘Biology the relocation of some university labs to facilitate collaboration and overcome the siloed department structure Additionally, they explored the unique culture and structure of their Institute, highlighting its translational

to podcast list Strategic Partner(s) Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists It’s about enabling biology.” — Maria Majellaro Through its partnership with Dr. Together, we’re combining chemistry, biology, and business insight to empower the GPCR research community During her doctoral studies, she spent one year as a predoctoral visiting student at the CIQUS Research Center—Campus

technology platform deciphering cell signaling pathways combined with AI-based approaches to elucidate structure He also worked on creating novel methods for systems biology using temporal logic specifications while Integrating Mathematical Models and Biology: A Fascinating Discussion Yamina and Aurelien Rizk had a conversation about the importance of merging mathematical models and biology. and relevance of mathematical models in systems biology and pharmacology.

Pfleger on NanoBRET live-cell assays, receptor complex pharmacology, and what it took to move GPCR biology Those platforms have been applied across arrestin biology, receptor complex pharmacology, and the angiotensin The conversation also covers what it means when cell biology reaches the clinic. Endpoint Assays Can Miss the Biology Entirely A single measurement at a fixed time point collapses all That cell biology eventually became a clinical hypothesis, then a compound, then a trial result.

Institute of Metabolism and Systems Research (IMSR) of the University of Birmingham and Co-Director of the Centre and 2017, he was a Group Leader at the Institute of Pharmacology and Toxicology and Rudolf Virchow Center He leads a multidisciplinary research team comprising biologists, chemists, physicists, engineers and journals such as Nature, Cell, New England Journal of Medicine, Journal of Clinical Investigation, PLoS Biology

Why this matters How a chemist with zero biology training became a leader in GPCR probe design. Who should listen If you’ve ever: Navigated a project where the biology refused to match the textbook Collaborated across chemistry and biology and felt the translation gap firsthand… …this episode will his interest in ion channels, GPCR pharmacology, and the chemical strategies needed to probe complex biology His lab integrates synthetic chemistry, theoretical chemistry, cell biology, and imaging to understand

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

Listeners will gain perspective on how asking broader questions about receptor biology can reshape drug His research spans four decades of GPCR signaling, from cyclic AMP and adrenergic receptor biology to intersects with cancer, immunology, and systems biology. mutation paradigm 25:05 AI, in silico screening, and the limits of computational drug discovery without structures Paul Insel was at the FASEB experimental biology meeting in Atlantic City.

His research centers on the beta-2 adrenergic receptor and GPR65 , a proton-sensing receptor with promising implications in cancer biology.

Council of Australia Senior Principal Research Fellow, and Director of the Australian Research Council Centre More recently, his team has been at the forefront of the application of cryo-EM to elucidate of the structure 2021 Clarivate Analytics Highly Cited Researcher in two disciplines: Pharmacology & Toxicology and Biology

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced at the MRC Human Reproductive Sciences Centre, Edinburgh, a move to Perth, Australia resulted in her Her research focuses on understanding the fundamental cell biological mechanisms regulating GPCR activity Her work is currently funded by Biotechnology and Biological Sciences Research Council (BBSRC), Diabetes

During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry

optogenetics redefines the questions the field can ask KEY INSIGHTS FROM THE CONVERSATION mGlu2 Sits at the Center made the shift to optogenetics and genetically defined neuronal populations specifically because the biology A circuit-level argument 33:12 Advice for junior scientists: let the biology lead the method 35:28 Diversity at Vanderbilt University before continuing her training as a postdoctoral fellow at the Vanderbilt Center