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This gap is due to their unique autoproteolytic cleavage in the GAIN domain, creating a heterodimer of identify novel pharmacological targets and contribute to the development of innovative treatments for a range

end, her lab uses several computational structural biology tools and rational drug design approaches, ranging

identified physiological hormones of such under characterized ‘orphan’ receptors and functional probes for a range

In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped

During these four sessions, you'll dive into: Advanced pharmacokinetic modeling The Druglike Quality calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Qin Wang

Michelle Halls This structure: Multiplied research capacity Attracted talent and funding Created a durable As Terry shared during the AMA: “This is a labor of love. depletion vs. replenishment dynamics — how offset rates control exposure windows, shape therapeutic durability Get it right, and you unlock durable efficacy with leaner dosing strategies. But during a summer internship in protein purification, he faced a harsh reality: lab work wasn’t his

currently an Associate Professor in Medicine & Cell Biology in the Division of Cardiovascular Medicine, Duke Lefkowitz (Nobel Laureate, 2012) at Duke University. Dr. Sudha Shenoy on the web Duke University Personal Reflections and Words of Wisdom: Story From Dr.

During my PhD studies in Martin Lohse lab at the Max Delbrueck Center in Berlin, I consolidated my knowledge

with Piketa and how he found a job in Seda's lab at Cambridge, where he could immediately contribute due

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s Duke Professor until his death.

Trained initially as a biotechnology engineer, Jens discovered his true calling during an internship

Whitney Foundation fellowship to support his post-doctoral work with Robert Lefkowitz and Marc Caron at Duke In 1999, obtained an independent faculty position at Duke in Gastroenterology, where he remained until heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during

The discussion also covered the challenges they face in studying GPCRs due to their low expression levels Mike also spoke about his initial struggles during his Ph.D., such as a difficult model system and a G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161 as a potential drug target due Mike expressed his initial reluctance due to a lack of confidence and fear of not being ready. They also discussed the challenges they face in studying GPCRs due to their low expression levels and

During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the

Get it right, and you unlock durable efficacy with leaner dosing strategies.

trained as a medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during

During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships presentation, I will walk you through my various career experiences and include the skills I learned during

Unlike reversible ligands, their impact can persist long after the compound is gone — creating durable

During our time together, Aaron and I discussed how using Twist Bioscience’s proprietary technology to

Genova, Italy (2008-2016) and an Associate Research Professor in the Department of Cell Biology at Duke Before joining the Department of Cell Biology in 1996 as a postdoc and becoming faculty at Duke in 2000

During this period David has made a significant contribution to the understanding of agonist/ antagonist

During four years of postdoctoral research at ETH Zurich and the Paul Scherrer Institute in Switzerland They highlighted that while there was a time when biology lagged due to the lack of appropriate tools consideration to work on targets other than GPCRs, to which Aurelien Rizk explained that they chose GPCRs due They highlighted the strategic importance of planning in the biotech sector due to limited funds and They also discussed plans to offer a course with Terry, due to high interest.

biochemistry of GPCR and the crucial role of the lipidic environment on their structure and function during

Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled

During dinner with colleagues and Alfred Gillman , co-recipient of the 1994 Nobel Prize in Physiology

Caron and his family moved to Durham, NC in 1977, following receipt of his BSc in Chemistry from Laval He joined the faculty of Laval University School of Medicine in 1975 and then returned to join Duke’s Duke Professor until his death.

.” – Ben Clements His pivot into neuroscience and pharmacology during grad school at the University of The Cryo-EM Challenge One bottleneck in Ben’s work is visualizing binding sites of PAMs via cryo-EM , due

During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry During his last year of studies, Timo performed research in the biopharmaceutical company Argen X and During his Ph.D., Timo, together with Dr. During his Ph.D., he used these nanobodies as research tools, to investigate different GPCR conformations

Caron received a BS in Biology and BA in Philosophy at Emory University and a PhD at Duke University Caron at Duke University. Dr. advocate for trainees at all levels, she served as Service Chairperson and Interim President of the Duke

During her doctoral studies, she spent one year as a predoctoral visiting student at the CIQUS Research