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<< Back to podcast list Strategic Partner(s) Developing new tools to uncover GPCR signaling patterns My particular projects revolve around developing new tools to study GPCR activity in ways that were not This research has led to a first-author Cell article on the development of a new biosensor platform called Overall, the lab works on diverse models and diseases, and has developed a wide array of tools to dissect

The question has been central to Johnson's career since long before the tools to answer it properly existed She trained in high-throughput drug discovery at Vanderbilt - contributing to early functional assay development transcript and may require manual verification after video editing. 00:00 Introduction 01:27 Johnson's career All through her career, the recurring theme in Kari’s work has been GPCRs and more specifically Metabotropic

Insel's late-career pivot began with a deceptively simple question: are we studying the right GPCRs? A career redirected by a dinner and an empty schedule In 1975, Dr. That accidental assignment launched a career in GPCR signaling that has now spanned over four decades His own career has been shaped by reading broadly and importing ideas from other fields — a strategy medicine to molecular pharmacology 05:15 The origin story — dinner with Al Gilman and the start of a GPCR career

His research career has centered on GPCR signaling — with particularly deep work on beta-adrenergic receptors — a lens that has quietly shaped how he reads both disease mechanism and drug targets across a long career a pandemic 25:00 Genetic determinants of severity — ACE1 isoforms and population data 28:40 Vaccine development

the Community Whether you’re a scientist, student, or just curious, you’ll hear about discoveries, career

In this conversation, Charlotte Crauwels discusses her work developing computational strategies to support Her research centers on developing computational pipelines that guide the design of hybrid or chimeric At that time, I wasn’t sure what career direction I wanted, so I started contacting computational research Eventually, I connected with my current supervisor and began developing GPCR-related research projects Charlotte Crauwels: The goal of my PhD was to develop a computational pipeline that supports the design

Human ortholog connections - from fly adhesion GPCRs to vertebrate vascular and neurological disease Career Reconsidering a career is not the same as leaving science Blanco-Redondo describes a period after returning : GeneTex and Eurofins DiscoverX 00:29 - Introduction of Beatriz Blanco-Redondo; icebreaker 01:15 - Career neurological disease 22:58 - What first-contact receptor characterization actually looks like 26:02 - Career

am a postdoctoral research fellow endeavoring to build a productive, independent scientific research career

His work focuses on developing novel β₂-adrenergic ligands that selectively engage signaling pathways Bengtsson began his research career studying brown adipose tissue under the mentorship of Dr. entrepreneur and founder of biotechnology companies translating GPCR pharmacology into therapeutic development therapeutics Key Insights from the Conversation A Childhood Physiological Experiment Sparked a Scientific Career Another company, Atrogi, is based on our research on β₂-adrenergic receptors and the development of new

Explore the fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each We aim to have engaging conversations about you as a scientist, your career, your work, and anything We'll then engage in a conversation centered around your career and how you got introduced to GPCRs.

I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical

Catherine, a PhD candidate at the University of Michigan, shares how personal loss and an unconventional career discovery scientists Respiratory pharmacologists Addiction researchers Public health professionals Early-career

In his (future) independent research career, Aditya aims to work at the interface of GPCR molecular pharmacology

His group developed BRET and NanoBRET-based live-cell platforms that capture protein-protein interactions He developed BRET and NanoBRET-based live-cell assay platforms now widely adopted across the GPCR field The development of NanoBRET - including live-cell ligand binding assays built on CRISPR-expressed receptors : science as a team sport 03:54 From Cambridge to Edinburgh - an accidental PhD and the origin of a career Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the

with receptors such as the μ-opioid and κ-opioid receptors, and how structural insights can guide the development interface of structural biology and drug discovery, where molecular structures inform the design and development One direction is to develop new tools using well-characterized receptors—the ones we understand well I can imagine myself in a biotech or pharmaceutical environment where I’m helping guide drug development Essentially serving as a bridge between the science and the development process. Dr.

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

Trained in electrical and computer engineering, he began his career at General Atomics building software GeneMode story starts with two teenagers in the same high-school classroom, different majors, different career Although both went to the same college, Jacob and Jin choose different career paths.

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

Shukla wasn't sure research would be his career. 15 From DNA quadruplexes to GPCR structural biology 06:32 The master's project that made research a career "I was not, to be honest, sure if research was what I wanted to take up as a career.

mutagenesis Ectopic expression of taste and odorant receptors beyond their namesake tissues Persistence, career compounds that give beer its characteristic flavor — have shown anti-diabetic activity in clinical development medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

She has been at InterAx since 2017, where she leads the development of a computational systems biology the animal 31:21 — Tools for the next decade: biosensors, tissues, high-throughput structure 38:43 — Career

receptor, and whether that regulatory layer contributes to the therapeutic window problem that GLP-1 drug development Zhao describes how the objective of biased agonism research at the GLP-1 receptor is to develop ligand Her mentor, Peter Chidiac, had consistently avoided steering her toward a predetermined career path,

chaperone, the Rho tag, and the Pluznick lab's Lucy tag — a cleavable leucine-rich signal sequence developed Pluznick's advice to early-career scientists is shaped by her own near-dismissal of an inconvenient microarray

His thesis work led to the development and application of light energy transfer methodology to study His research program is developed to understand the signaling mechanisms underlying the Wnt and Hedgehog families of growth factors and their signaling mechanisms in development, adult tissue homeostasis, His pioneer work led to the development of novel antibody molecules blocking and activating the Wnt pathway biotech companies, ModMab Therapeutics , and AntlerA Therapeutics , which are pursuing the clinical development

At Neurocrine, he initiated and led the effort to discover and develop orally active, nonpeptide GnRH Prior to Neurocrine, from 1995 to 1998, he co-founded ScienceMedia Inc. to develop eLearning solutions Between 1992 to 1995 he led contract research efforts at Biosym Technologies to develop and apply computational serves as board chair at Radionetics Oncology, a pharmaceutical company focused on the discovery and development

Discover how Celtarys Research is transforming GPCR assay development with fluorescent ligands in this At Celtarys, the focus is on enabling fast, customizable development of fluorescent ligands and chemical GPCR, Celtarys will bring those lessons to the broader community, providing insight into assay development Their approach is highly consultative—they don’t just sell ligands, they co-develop solutions. Whether you're designing assays, developing probes, or seeking better tools for GPCR drug discovery,

This webinar introduces two families of advanced fluorescent probes developed specifically for working His group focuses on the development of chemical tools — including fluorescent ligands and photopharmacological His research group develops and applies novel technologies to investigate GLP-1 and GIP receptors — two Organizers Celtarys Research Celtarys develops and commercializes fluorescent chemical tools and related Curated intelligence on GPCR drug discovery trends and developments Expert-led webinars and masterclasses

Your One-Stop-Shop for GPCR Drug Discovery and Development Researchers developing GPCR-targeted therapeutics product solutions including cell-based assays for basic research through therapeutic discovery and development Assay Principle of Eurofins DiscoverX Cell-based Assays Whether you are developing small-molecule or biologic therapeutic drugs, Eurofins DiscoverX provides you with a variety of drug discovery and development Product Solutions to Support Obesity/Diabetes See GLP-1 Solutions Accelerating Obesity Therapeutics Development

The company’s mission is to discover and develop highly effective cancer therapeutics by targeting heteromers Cardarelli is a drug development leader with extensive experience driving drug discovery teams in bringing biology, pharmacology, translational medicine, oncology, immuno-oncology, immunology, and clinical development While at BMS and Medarex, she led programs from target ID to clinical development that included, CXCL10 including anti-PD-1 patents, 22 EP patents, and greater than 100 global patents centered around therapeutic development