with receptors such as the μ-opioid and κ-opioid receptors, and how structural insights can guide the development interface of structural biology and drug discovery, where molecular structures inform the design and development One direction is to develop new tools using well-characterized receptors—the ones we understand well I can imagine myself in a biotech or pharmaceutical environment where I’m helping guide drug development Essentially serving as a bridge between the science and the development process. Dr.

His group developed BRET and NanoBRET-based live-cell platforms that capture protein-protein interactions He developed BRET and NanoBRET-based live-cell assay platforms now widely adopted across the GPCR field The development of NanoBRET - including live-cell ligand binding assays built on CRISPR-expressed receptors : science as a team sport 03:54 From Cambridge to Edinburgh - an accidental PhD and the origin of a career Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the

opioid / dynorphin link The unfinished GPCR frontier — PACAP, CGRP, and the persistent antibody problem Career Earlier work in her career showed that high-internalizing delta agonists drive receptor downregulation A single collaboration can redirect a career. Her next career step took her to AstraZeneca as a postdoctoral trainee, where she studied animal models Her career path-defining moment came from a third postdoctoral experience with Dr.

Insel's late-career pivot began with a deceptively simple question: are we studying the right GPCRs? A career redirected by a dinner and an empty schedule In 1975, Dr. That accidental assignment launched a career in GPCR signaling that has now spanned over four decades His own career has been shaped by reading broadly and importing ideas from other fields — a strategy medicine to molecular pharmacology 05:15 The origin story — dinner with Al Gilman and the start of a GPCR career

Stroke Foundation of Canada MacDonald Scholar (1998-2003) and Heart and Stroke Foundation of Ontario Career His research career has focused on the investigation of the regulation of G protein-coupled receptors

Stroke Foundation of Canada MacDonald Scholar (1998-2003) and Heart and Stroke Foundation of Ontario Career His research career has focused on the investigation of the regulation of G protein-coupled receptors

He argues that staying close to a hot topic feels safe but narrows a scientist's development, and that the moment you carry one field's questions into another is often the most productive window of a career From undruggable to promising Drug development veterans long treated large adhesive proteins as poor

mutagenesis Ectopic expression of taste and odorant receptors beyond their namesake tissues Persistence, career compounds that give beer its characteristic flavor — have shown anti-diabetic activity in clinical development medicinal chemist in Italy, followed by a Ph.D. in computational medicinal chemistry, during which she developed

SCIENTIFIC THEMES OF THE CONVERSATION The GPCR antibody reliability problem - how it developed, why it systematic characterization requires Immunogen selection as the critical upstream decision in GPCR antibody development Researcher-company collaboration as an active ingredient in antibody quality - not a support function Career crypts and implicated in several malignancies - was the target that made the difficulty of GPCR antibody development

Human ortholog connections, from fly adhesion GPCRs to vertebrate vascular and neurological disease Career Reconsidering a career is not the same as leaving science Blanco-Redondo describes a period after returning : GeneTex and Eurofins DiscoverX 00:29 - Introduction of Beatriz Blanco-Redondo; icebreaker 01:15 - Career neurological disease 22:58 - What first-contact receptor characterization actually looks like 26:02 - Career

Explore the fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each We aim to have engaging conversations about you as a scientist, your career, your work, and anything We'll then engage in a conversation centered around your career and how you got introduced to GPCRs.

She has been at InterAx since 2017, where she leads the development of a computational systems biology the animal 31:21 — Tools for the next decade: biosensors, tissues, high-throughput structure 38:43 — Career

the company's first GPCR antagonist antibody program from hit to an optimized lead, later declared a development day before the deadline - 07:26 Aptamers, SELEX, and chemokine receptors at GSK - 15:47 Doubting a career

receptor, and whether that regulatory layer contributes to the therapeutic window problem that GLP-1 drug development Zhao describes how the objective of biased agonism research at the GLP-1 receptor is to develop ligand Her mentor, Peter Chidiac, had consistently avoided steering her toward a predetermined career path,

chaperone, the Rho tag, and the Pluznick lab's Lucy tag — a cleavable leucine-rich signal sequence developed Pluznick's advice to early-career scientists is shaped by her own near-dismissal of an inconvenient microarray

Terry Kenakin's career tracks what happened when that picture came apart. phenotype - Translation: why bias is easy to measure and hard to carry into a body - Building a scientific career you - 51:10 Are GPCRs still good targets, after being declared mined out - 01:01:36 Advice for early career

Catherine, a PhD candidate at the University of Michigan, shares how personal loss and an unconventional career discovery scientists Respiratory pharmacologists Addiction researchers Public health professionals Early-career

Trained in electrical and computer engineering, he began his career at General Atomics building software GeneMode story starts with two teenagers in the same high-school classroom, different majors, different career Although both went to the same college, Jacob and Jin choose different career paths.

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supplies solutions, it does not remove them Most people treat biological complexity as a barrier to drug development He describes each such shift as adopting a new language, and is candid that the pattern is a career disadvantage

Shukla wasn't sure research would be his career. 15 From DNA quadruplexes to GPCR structural biology 06:32 The master's project that made research a career "I was not, to be honest, sure if research was what I wanted to take up as a career.

the Community Whether you’re a scientist, student, or just curious, you’ll hear about discoveries, career

am a postdoctoral research fellow endeavoring to build a productive, independent scientific research career

I then started my career at Evotec before moving to Domain Therapeutics (called Faust pharmaceutical

In his (future) independent research career, Aditya aims to work at the interface of GPCR molecular pharmacology

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

Beyond screening, our capabilities include custom assay development, deorphanization, biophysical characterization variant profiling Integrated Discovery Capabilities Deorphanization & translational pharmacology Assay development View Custom Assays & Deorphanization Custom assay development and deorphanization for challenging or with Eurofins DiscoverX products and Calixar membrane proteins, they span the entire discovery and development

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

scientific publications, he is most beloved as a mentor and his relentless encouragement that shaped the careers

The breadth of a scientific career is sometimes a temperament, not a strategy Hauser traces his integrative on pharmacogenomics findings 50:02 - Advice to junior scientists considering a GPCR or computational career