Search Results

Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Read More 2:00 PM Complimentary Lunch Read More 3:00 PM More Jinpeng Sun Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Bill Huang Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand concentrations, her work highlights why receptor localization and protein complex assembly matter Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector complexes Why receptor localization and scaffolding dramatically shift functional readouts in disease models. The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity.

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Sensor Approach for Drug Discovery for Human Adhesion GPCRs Stephanie Häfner Abstract "G Protein-coupled receptors (GPCRs) are common drug targets, yet no approved drugs exist for the Adhesion G Protein-coupled receptors The NRS fuses the extracellular region of any given aGPCR with a cleavage module from a Notch receptor in vivo by targeting the latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor This tailored system aims to expedite the identification of drugs targeting the unique aGPCR receptor

Duvall discusses her lab’s work dissecting how GPCRs—especially neuropeptide Y (NPY) receptors—regulate and functional behavioral assays, including high-throughput and video-based methods, to reveal these receptors Why the study of conserved receptor pathways enables the development of broadly effective, species-independent How dissecting receptor function in non-neuronal tissues uncovers new parallels to human gut-brain communication If you often translate receptor mechanism findings from model organisms to human systems.

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor

, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors , and more Comprehensive Coverage >1500 Human GPCRs products, including: 90% Target coverage Orphan receptors cell line backgrounds Multiple Mechanisms of Actions (MOA) cAMP accumulation β-Arrestin recruitment Receptor validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors Apelin (APJ/AGTRL1) View representative data: GLP-1R multi-MOA profiling Eurofins DiscoverX's GLP-1 receptor

Sokhom recalls how binding assays at BMS introduced him to the depth and complexity of receptor pharmacology There’s allosterism, receptor desensitization… it opened a whole new world.” PhD entirely in the industry setting—efficient, targeted, and rooted in real-world projects like CGRP receptor He blends classical receptor pharmacology with biosensor technology, always adapting to new tools and About Sokhom Pin Sokhom Pin is a receptor pharmacologist with over 20 years of drug discovery research

student visa was in the work, during which time I thoroughly reviewed the literature on the melanocortin receptor first project where I demonstrated that MRAP2 regulates the signaling of multiple G protein-coupled receptors contributed to an In-vivo project that showed that MRAP2 regulates the growth hormone secretagogue receptor necessary modification leading to a structural change granting the arrestins access to the core of the receptor Cone was the first to clone the melanocortin receptors (the GPCRs that led to the discovery of MRAP2)

These extraordinary receptors, about which there was not much known other than that they are huge and with the vast unknown biochemical and pharmacological territory that would be helpful to study orphan receptors Her postdoctoral work leads her to investigate a whole family of orphan receptors: adhesion GPCRs. With the little knowledge on these receptors available, there were multiple questions to tackle.

for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and also discussed the re-emergence of interest in certain programs, the importance of connections across receptor They also discussed their own research on chemokine receptors and the importance of understanding the They also delved into the different signaling of Class B receptors and the potential for modulation at

Samuel Hoare Sam completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors life science, and academic scientists in the development of new therapeutics and the understanding of receptor about his love for GPCRs, kinetics, and decorticate the complexities of GPCR function to better target receptors

Professor Pfleger has developed extensive expertise in profiling receptor binding and function at the globally-recognized expertise in bioluminescence resonance energy transfer (BRET) technology, including his patented Receptor-Heteromer Investigation Technology (Receptor-HIT) for studying heteromers.

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the

degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors They also discussed the challenges of studying metabolites and their receptors, the relationship between Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They also explored the potential for better tools to understand and discover new metabolites or receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

Research (IMSR) of the University of Birmingham and Co-Director of the Centre of Membrane Proteins and Receptors physicists, engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor that GPCRs are not only active at the plasma membrane but also at intracellular sites and that these receptors

explore the development of powerful multiplex tools designed to map GPCR-RAMP interactions across the receptor That curiosity laid the foundation for a broader investigation into receptor activity-modifying proteins The lab’s early partnership with students like Emily Lorenzen catalyzed a transition from single-receptor From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors Instead of focusing on a single receptor, students now gravitate toward platforms , biosensors , and

Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor

long-standing track record in identifying molecular mechanisms that regulate the function of G protein-coupled receptors signaling architecture both at the cell surface and within the nucleus, providing insight into how receptor

endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors

Blanco Redondo Abstract "The Drosophila genome contains five loci encoding adhesion G-protein coupled receptors remoulade (remo) gene is a homologue of the vertebrate aGPCR ADGRA family, sharing the same overall receptor We found that the receptor is cleaved despite the lack of a consensus GPS sequence. Langenhan where I am studying and characterizing newly generated adhesion GPCR receptors in Drosophila