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GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and I investigated the effect of lung cancer-related mutations in the GAIN domain of the Latrophilin 3 receptor

and the University of Michigan shaped his scientific curiosity, particularly around G protein-coupled receptors His research centers on the beta-2 adrenergic receptor and GPR65 , a proton-sensing receptor with promising therapeutic potential of GPR65, especially in the context of cancer immunotherapy, and how understanding receptor My research has looked at the trafficking and signaling of adrenergic and proton-sensing receptors, with

Jean-Philippe Pin Jean-Philippe Pin participated in the discovery of metabotropic glutamate receptors been studying the allosteric modulation and activation mechanism of this family of G protein-coupled receptors His studies led to new concepts in the GPCR field, such as the activation of cell surface receptors by

doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

basis of GPCR pharmacology through structure determination of the β1-adrenoceptor and adenosine A2A receptor Structures have been determined by X-ray crystallography of receptors coupled to either mini-Gs or mini-Go , and also by electron cryo-microscopy of receptors coupled to mini G protein bound to βγ subunits. a GPCR bound to a biased agonist and coupled to arrestin and also the first structure of a Class D receptor

signaling pathways and trafficking Localization of putative ligands for adhesion G protein-coupled receptors Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr. These cleaved fragments join to form the heteromeric ADGRG6 receptor complex.

Sponsors GPCR Retreat Program < Back to schedule A positive Allosteric Modulator of M1 Acetylcholine Receptors Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased receptors The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor

Today he and his team are working on understanding receptor signaling in specialized cellular environments to gain a better grasp of receptor function in pathophysiological settings with a special interest in His favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety

In my PhD, I studied the nanoscale spatial organization of G protein-coupled receptors (GPCRs) at the Importantly, my work revealed heterogeneous spatial patterns of receptor density and activation, that Alice Ting developing programmable receptors for molecular sensing and controlling cellular behaviour

GPCRs, Receptors of Infinite Variety When asked about his favorite GPCR, Nicoli refused to pick. .” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present an incredible Modeling the Invisible: Olfactory Receptors Nicoli’s work centers on predicting ligand binding and receptor – Alessandro Nicoli He shared a detailed case study of working on a specific odorant receptor (R5VK1) His research focuses on a group of 400 transmembrane proteins known as olfactory receptors, which mediate

for different families of GPCRs, including adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors By quantifying ligand–receptor interactions directly in intact cells, HCS allows researchers to observe For GPCR-focused programs, the ability to visualize receptor localization, internalization kinetics, GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud “These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize

eventually founding in vitro pharmacology departments, Sokhom always stayed anchored to G protein-coupled receptors Sokhom recalls how binding assays at BMS introduced him to the depth and complexity of receptor pharmacology There’s allosterism, receptor desensitization… it opened a whole new world.” PhD entirely in the industry setting—efficient, targeted, and rooted in real-world projects like CGRP receptor He blends classical receptor pharmacology with biosensor technology, always adapting to new tools and

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand concentrations, her work highlights why receptor localization and protein complex assembly matter high-throughput GPCR screens. ⸻ Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector Why receptor localization and scaffolding dramatically shift functional readouts in disease models. The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity.

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics, Receptor Plenary Lecture Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Read More 2:00 PM Complimentary Lunch Read More 3:00 PM More Jinpeng Sun Identification and Functional Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Bill Huang Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN

his research program focuses on the molecular and cellular mechanisms regulating G protein-coupled receptor (GPCR) responses, a class of receptors involved in many, if not all, physiological responses, with the He has developed innovative methods for in-cellulo measurement of protein-protein interactions, receptor

focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr.

Sensor Approach for Drug Discovery for Human Adhesion GPCRs Stephanie Häfner Abstract "G Protein-coupled receptors (GPCRs) are common drug targets, yet no approved drugs exist for the Adhesion G Protein-coupled receptors The NRS fuses the extracellular region of any given aGPCR with a cleavage module from a Notch receptor in vivo by targeting the latrophilin-type aGPCR Cirl/ADGRL in Drosophila, revealing NTF release and receptor This tailored system aims to expedite the identification of drugs targeting the unique aGPCR receptor

These extraordinary receptors, about which there was not much known other than that they are huge and with the vast unknown biochemical and pharmacological territory that would be helpful to study orphan receptors Her postdoctoral work leads her to investigate a whole family of orphan receptors: adhesion GPCRs. With the little knowledge on these receptors available, there were multiple questions to tackle.

for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors