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For drug hunters working at the GPCR interface, the difference between a successful lead and a dead-end For GPCR drug discovery, those hidden details can determine whether a compound advances or stalls. The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity By reducing receptor density, researchers can transform full agonists into partial ones—allowing comparative In an era of accelerated GPCR-targeting innovation, these advantages define which programs advance and

Research Middle-Down Mass Spectrometry Reveals Activity-Modifying Phosphorylation Barcode in a Class 1A Receptor Microenvironment Industry News Addex and Indivior Extend Research Term Of Substance Use Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

Exploring the intracellular allosteric site GPCRs represent one of the largest and most vital families For this reason, GPCRs have been a focus of drug development for decades due to their role in regulating GPCR activity, enabling greater specificity and fewer side effects. Recent advances in structural biology have allowed researchers to visualize the binding of allosteric allosteric site common in class A and class B GPCRs, particularly in chemokine receptors.

15 insightful research papers and industry updates. Stay informed with the most recent developments in GPCR research and industry news. Join the global GPCR community to present your research—submit your abstract using this form. Research ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate pharmacology Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate

This Thursday, explore the latest content on GPCRs, which includes 29 informative research papers and Stay informed about the most recent developments in GPCR research and industry updates. Rajagopal, Robert Lefkowitz, Howard Rockman for their review G Protein-Coupled Receptors: A Century of Research pharmacology NEW Post-Doctoral Scientist- Molecular Pharmacology (FDE) NEW Research Assistant Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research Associate/Associate Scientist

Terry’s Corner: GPCR Binding Affinity Experiments That Hold Up Orthosteric GPCR binding affinity experiments GPCR Podcast: When GPCR Tools Scale Even the most elegant tools only matter when they scale beyond a In Episode 3 of 3  of our series with Celtarys Research , leaders from academia and biotech unpack what GPCR offers a clear signal of where the field is heading. GPCR Premium Member And Lock in The Current Rate➤ https://www.ecosystem.drgpcr.com/gpcr-university-pricing

This week, we have a comprehensive coverage of 12 GPCR research papers. Submit a few slides for a poster presentation to showcase your research and network with our community Target in Ovarian Cancer Methods & Updates in GPCR Research Alared: Solvatochromic and Fluorogenic Red I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging

Welcome back GPCR fans, If your drug discovery strategy still relies on static GPCR models, you’re already Upcoming events:  GPCR-UK Network Meeting, neuroGPCR symposium, and Transatlantic ECI GPCR event—where Position your research for maximum visibility.   GPCR Podcast Listener Why Dr. GPCR Premium 🔹 What’s included?

GPCR Activation and Signaling Molecular Mechanisms of PTH/PTHrP class B GPCR Signaling and Pharmacological Methods & Updates in GPCR Research 3,4-Bis(hydroxymethyl)hexane-1,6-diol-based Maltosides (HDMs) for Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

moments that changed everything. 👉 Discover the pHSense™ Reagents + Listen to the podcast ➤ Celtarys Research A new contributor article from our friends at Celtrays Research outlines how dual-labeled fluorescent GPCR innovation is accelerating. University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

2026 GPCR Pharmacology AMA: Receptor Theory, Biased Signaling & Assay Interpretation The first GPCR Pharmacology objective is straightforward: Make mechanistic pharmacology easier to access, revisit, and apply across research as new videos are released: ▶️ https://www.youtube.com/@TerryPharmacologyCorner New White Paper on GPCR School of Medicine, has authored a new white paper in collaboration with Eurofins DiscoverX: Assess GPCR ) Systematic comparison of biased agonists using modern functional assays For scientists working in GPCR

Welcome aboard, GPCR Crew! pharmacology and apply it to their research in academia and industry. Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology mechanosensing   Postdoctoral Position Postdoctoral research position Adhesion GPCRs The G Protein-Coupled Research Simultaneous spectral illumination of microplates for high-throughput optogenetics and photobiology

The newest GPCR research is hot off the press! G protein-coupled receptor Methods & Updates in GPCR Research RediscMol: Benchmarking Molecular Generation Morgan Healthcare Conference Isomorphic Labs Announces Strategic Multi-Target Research Collaboration With Novartis Salipro Biotech announces multi-target research collaboration with an additional Top5 crop World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoctoral Fellow NEW Research

research. GPCR University 🎥 Access to the recorded classes of GPCR Courses and talks from Symposia 💲 Discounted GPCR courses GPCR Forum Initiate a vibrant conversation or seek assistance GPCR Events to keep you mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Oncology and Immunology GPR56: GPCR as a guardian against ferroptosis Methods & Updates in GPCR Research

GPCR podcast is now available! Our guest is Mark Schmeizl! Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

GPCR Ecosystem paid membership with extra benefits? 🔬Join the #GPCR movement today! ➡️ https://www.ecosystem.drgpcr.com/plans-pricing #gpcr #drgpcr

The latest and greatest in GPCR research is here, this week we’ve curated 14 GPCR papers, 7 industry Ross Cheloha's research involves semi-synthetic nanobody-ligand conjugates with enhanced transcriptional Research Phosphorylation Sites of the Gastric Inhibitory Polypeptide Receptor (GIPR) Revealed by Trapped-Ion-Mobility Lab NEW Junior Research Scientist Postdoctoral Fellow Post-Doc Research Associate Assistant/Associate GPCR Ecosystem

August 2022 "GPCRs modulate a plethora of physiological processes and mediate the effects of one-third The guidelines will aid consistency and clarity, as the basic receptor research and drug discovery communities Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR podcast is now available! Our guest is Dr. Adriano Marchese! Learn about his remarkable career and research in #GPCR signaling and trafficking. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

July 2022 Confo Therapeutics receives €1.7 million VLAIO grant for further research on GPCR modulators The grant should help expand Confo Therapeutic’s research on G protein-coupled receptor (GPCR) drug candidates . " Read more at the source #DrGPCR #GPCR #IndustryNews

Join us and learn how to quantify your kinetic GPCR signaling from the expert himself: Dr. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

👋 Take a look at the latest and greatest in GPCR research. Methods & Updates in GPCR Research Solvent accessibility of a GPCR transmembrane domain probed by in-membrane Researcher Director - Targeted Oncology Senior Scientist - Antibody Engineering Scientist—Immuno-Oncology Convergent Research - Senior Scientist, Cell-Based Assay Development Post Doctoral Fellow Research associate in protein production Vice President, Oncology Clinical Research Explore Dr.

GPCR activation typically occurs through the binding of agonists which stabilize receptor conformations GPCR targeting drugs: orthosteric vs allosteric sites Most of the drugs targeting GPCRs bind to the orthosteric GPCRs functional selectivity Recent research has revealed a more intricate understanding of GPCR behavior Agonist binding to GPCRs doesn't always trigger all associated events sequentially. selectively activate specific cellular outcomes linked to that GPCR.

May 2022 "Seoul, South Korea, 28 April 2022 – GPCR therapeutics, Inc., a venture-backed clinical stage company with an innovative approach to drug discovery based on targeting G Protein Coupled Receptors (GPCR Jon Wigginton will provide scientific expertise to support the company’s research and clinical development GPCR just had a very successful first meeting including all the Scientific Advisory Board." Read more at the source #DrGPCR #GPCR #IndustryNews

GPCR Latrophilin1 in neurons. Autoimmune Skin Diseases: from Basic Research to Clinical Trials. Methods & Updates in GPCR Research CPGL: Prediction of Compound-Protein Interaction by Integrating Graph GPCR Signal Transduction. GPCR Ecosystem

August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location Here we will discuss recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells. Read more at the source #DrGPCR #GPCR #IndustryNews

Rho1 signaling is activated by G-protein-coupled receptor (GPCR) signaling at the cell surface. During Drosophila embryonic salivary gland (SG) invagination, the GPCR ligand Folded gastrulation (Fog Here, we reveal that the Smog GPCR transduces Fog signal to regulate Rho kinase accumulation and myosin Read more at the source #DrGPCR #GPCR #IndustryNews

GPCRs in Neuroscience Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology. Methods & Updates in GPCR Research Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking Papers GPCRs: Signal Transduction. GPCR Events, Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. GPCR Ecosystem

of how residence time—not potency—predicts therapeutic coverage ✅ Insight into cryptic intracellular GPCR evaluating scaffold permeability using modern, cost-effective pharmacokinetic assays   Why Intracellular GPCR Drugs Change the Game For decades, drug design has treated GPCRs as surface targets. GPCRs now have validated intracellular  allosteric sites. Subscribe to The Kenakin Brief today  ➤ #GPCRs #IntracellularDrugs #DiffusionBarriers #DrugResidenceTime

We have gathered 24 new research papers on GPCRs and updates on industry news related to GPCRs. Kawthar Belkacemi, Philippe Rondard, Jean-Philippe Pin, and Laurent Prézeau, for their research on Heterodimers Research Protocol to visualize and quantify the COPII concentration and anterograde transport of nascent Scientist- Molecular Pharmacology (FDE) Research Assistant Senior Scientist - Receptor Pharmacology GPCR Ecosystem