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Order does not emerge naturally in biotech.

Red flags emerge when: 👉 Founders cannot articulate who might block market entry 👉 Competitive patents Several patterns are already emerging: 👉 IP discussions happen earlier in fundraising conversations

The CEO oscillates between fire-fighting and “let’s step back and think,” depending on emotional energy clear priorities. 👉 The CEO becomes the unofficial project manager , even if they believe they’re “empowering looks like: Predictable decision points (monthly, biweekly, quarterly) aligned with science cycles, not emotions

What emerged was more than a ligand — it was a tool that enabled reproducible, stable, and high-contrast The Human Reaction Behind a GPCR Imaging Milestone Scientists rarely talk about the emotional side of That same emotional imprint hit with the whole-islet image. This emotional spark carried the team through the next steps — validation, iteration, and expanding the

2️⃣ Dose selection logic: Is there a clear, mechanistic, and empirical rationale for how you plan to

The cannabinoid receptor type 2 (CB2R) has emerged as a compelling target across inflammation, immune Among 16 SCRAs evaluated, three compounds—AAN396, AAN397, and AAN405—emerged as nanomolar binders with

For JB, that moment was a cold email from a biologist he’d never met, asking if he could synthesize a Transformed GPCR Imaging and Outperformed Antibodies As JB continued exploring the biology, a major obstacle emerged JB emphasizes how much of their progress came from staying open, asking questions freely, and engaging

But without concrete context, they’re empty. Your listener doesn’t want to be impressed.

synthesize the key topics addressed during the AMA and highlight the GPCR pharmacology insights that emerged Its clinical utility emerged from the interplay between β₁-mediated inotropy and α-mediated vascular Kenakin  emphasized that the key advantage is not subtlety for its own sake—it’s bounded pharmacology EC₅₀ and Emax uncouple affinity and efficacy, making cross-agonist comparison unreliable. Dr. Kenakin  emphasized that only operational-model–derived ratios anchored to a benchmark partial agonist

. 👉 If your roadmap is full of scientific deliverables but empty of decision triggers, you’re burning

target to avoid adverse effects Why GPCR Imaging Tools Matter More Than Ever This tool could not have emerged

Emerging direction: Genetics + receptor-distribution mapping. Emerging direction: Multi-target GPCR + myostatin-pathway combinations. Emerging direction: Treatment sequencing + guided de-escalation. Emerging direction: Peptide–drug conjugates for precision targeting.

Kenakin emphasizes, “Schild plots don’t just confirm competition—they expose when competition is an illusion

The Accidental Beginning Michelle hadn’t mapped out a scientific empire. She emphasizes leadership not as titles but as creating spaces where science thrives . For innovators and biotech strategists, stories like Michelle’s reveal how scientific leadership emerges

From these efforts emerged the concept of privileged structures : chemical backbones that show repeat And occasionally, new chemistry emerges from an unexpected source: Side effects.

To tackle these, the lab employs molecular docking, molecular dynamics simulations, and ligand-based

Embracing Complexity and Failure Carlsson’s approach to modeling is rooted in scientific humility. He emphasizes that not every question can be answered computationally—and that saying “we don’t know” Still, he emphasizes that data limitations remain a major challenge, especially when it comes to small Until better datasets emerge, predictive modeling will continue to rely on creative integration of computational

Breakthroughs this week:  nanomedicines targeting PAR2 for sustained analgesia; Emerging Voices in GPCR

This innovation emerged from years of foundational work in photophysics and GPCR pharmacology.

Embark on this week’s thrilling updates in GPCR research, learning opportunities, and industry developments If you want to enhance your brand, email Hello@DrGPCR.com  for sponsorship opportunities. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and

These methods will provide scientists with direct access to emerging tools and insights. Tom Sakmar, Emily Lorenzen, and Ilana Kotliar about creating a multiplex system with DUET-tagged constructs GPR45 steps up: A previously orphan receptor emerges as a powerful target for appetite and obesity control

It emphasizes scaffold selection, linker optimization, and assay compatibility to enhance target binding

But those failures are where new paths emerge, often leading to transformative tools like the IP1 assay Instead of chasing linear progress, Eric encourages young scientists to stay playful longer—embracing Eric Trinquet Built to Fail, Built to Win: Inside the IP1 Assay Origin Story The IP-One assay didn’t emerge

From failing fast to embracing serendipity, Eric shares the mindset (and messy origin stories) that shaped

This lecture challenges scientists to move beyond binary inhibition data and embrace a systems-level

But a pattern emerged: some scaffolds showed dual responsiveness to pH through lifetime and brightness

With extreme overexpression, constitutive activity emerges, exposing inverse agonism.  Emerging drug hunters cannot afford to test compounds in default conditions alone. What emerges is not just more data—it’s the right data, positioned to inform strategic decision-making

a delay is introduced between the time of excitation of the donor and the readout of the acceptor’s emission distance between donor and acceptor is close enough, energy is transferred, and a second, short-lived emission Measuring emission at both donor (usually 620nm) and acceptor (typically 665nm) wavelengths allows for The delay introduced in HTRF between excitation and emission detection lets the background signals dissipate By using donor-acceptor pairs with different emission spectra that don’t overlap, researchers can design

Emerging GPCR Therapeutic Targets in CNS Drug Discovery GPCRs have been studied for decades, but there As mentioned in previous posts, CELT-335, one of our fluorescent compounds, was successfully employed

Once you do, the irregular potency vanishes, and the true profile emerges.