Revolution in GPCR Biology <p class="font_8">Watch Now</p> Bryan Roth GPCR Molecular Glues: Biased Modulation Jacobson, Matteo Pavan Structure-Based Design of Modulators of Purinergic GPCRs <p class="font_8">Watch Programs <p class="font_8">Watch Now</p> Terry Hebert GPCR Signaling in iPSC-Derived Cardiac Disease Models Each session begins with a focused presentation from the guest expert, followed by moderated discussion

Gutkind a pre-built mental model for what to freeze, what to protect, and what to let continue.

constitutive activity, inverse agonism How volume control reveals essential properties of allosteric modulators Each session explores mechanistic models, translational challenges, and real-world therapeutic implications GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design

These residues may represent potential targets for allosteric modulators that reshape receptor signaling What were the main questions you were trying to answer? Dr. Nivedha: One of the main topics I worked on was allosteric communication in proteins. And now that I work with peptide drug modalities, I’m interested in peptide-binding GPCRs.

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and metabolic disease biology, with contributions to multiple clinical programs including preclinical models

Pierce | Midewestern University Introduction to GLP-1 pharmacology Translational Pharmacology & Disease Models including but not limited to pharmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation

All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

Her lab uses homology modeling, machine learning, and collaborative sensory experiments to predict bitterness Niv's lab is developing a recommendation system - trained on known receptor-ligand pairs and the structural

25 years of no regrets 22:10 Université de Sherbrooke's industry-integrated curriculum and what it modeled back 01:04:58 The black widow toxin discovery — two proteins, 15 years of prior research, one untested pair proteins expressed as various alternatively spliced isoforms thus potentially resulting in differential modulation

internalization, and recycling as design parameters for GLP1 agonists - Antibodies and aptamers as modalities Moving to a new modality means relearning the flowchart Shifting from small molecules to antibodies required

His main research group centers on the function, structure, and regulation of G protein-coupled receptors

GPCR About Ben Holland "Ben gained his masters in Engineering Science from Oxford, taking a specialisation

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During his last year of studies, Timo performed research in the biopharmaceutical company Argen X and gained

The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors

More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled However, the pursuit of allosteric modulators has gained attention as they have the potential to fine-tune

At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to

As a CRO partner, you'll gain trusted access to an engaged audience of biotech teams and drug discovery

Quickly get up to speed on new GPCR targets and mechanisms, and gain a competitive edge with our extensive

After bringing her in, we made confident progress on a key program and gained clarity around where to

As a strtegic partner, you'll gain trusted access to an engaged audience of academic researchers, biotech

At the time, NanoBiT was a prototype technology we gained access to by collaborating with Promega.

Claudia suggested possible next steps, including researching review articles or articles to gain a higher

Demet's research on the gain domain of adhesion GPCRs started during his postdoctoral studies and continued

Working in a lab allows scientists to gain amazing hard and soft skills, which opens the doors to several

.” – Ilana Kotliar The team developed two main assets: A web interface to visualize antibody validations

known to bind GPCRs and inserting them at the top of the heavy chain CDR3, the library enters each panning The design decision is the library's main differentiator.

software for military drones at General Atomics, and was stunned when he saw what his friend's lab was paying scheduled thirty-minute appointments on a postdoc's calendar to learn how to use a tool the lab had already paid And what surprised me even more was his lab was paying thousands of dollars for this legacy-looking software

Over the course of my graduate work, I gained experience with structural mass spectrometry and protein