discusses the compartmentalization of GPCR signaling in lipid rafts, including work linking G alpha subunit researchers draws on Richard Feynman's "pleasure of finding out" and Robert Lefkowitz's four keys to success

She brings more than twenty years of industry experience across diverse cell-based assays, supporting At Eurofins DiscoverX, Agrawal leads market development for the cell-based assay portfolio and supports The support inbox and community collaborations feed directly back into what gets built next. The Human Genome Project to pharmacology: Lamerdin's route 10:40 Why the largest target class still surprises

The discussion will examine how GLP-1 regulates insulin secretion, suppresses glucagon release, slows

What matters is whether office layout, mentorship practices, and daily behaviors support the claim. GPCR Summit preview 01:30 Meet Lauren Solano and Propel Careers 03:11 The path from bench science to worried or afraid or feel awkward reaching out to people for informational interviews because you are supposed

She recently joined the High Throughput Biology team at Boehringer Ingelheim, where she supports the

Class B GPCRs, RAMPs, and the Migraine Pharmacology Gap Class B GPCRs represent one of the smaller subfamilies in the GPCR superfamily - just 15 receptor genes - yet they govern a disproportionately wide range of The functional unit is the assembled complex at the cell surface, and that assembly is not predictable Their influence on receptor pharmacology appears to be primarily allosteric - subtly reshaping the GPCR binding site rather than contributing their own contact surface.

describes a decade of GABA-B receptor research at Columbia - from obligate heterodimerization and the inter-subunit carries the agonist binding site; the GABA-B2 subunit is required for trafficking to the cell surface Neither subunit functions without the other. - that she terms the inter-subunit latch. Her description of this trajectory is not frustration - it is the argument for sustained focus.

directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes vulnerability to chronic stress and depression and; 2) Understanding the role of phenotypically defined subpopulations

Ajay Yekkirala is a GPCR pharmacologist, biotech entrepreneur, and co-founder of Superluminal Medicines breakthrough GPCR research career The inside story behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein dynamics,” and how Superluminal is using it to predict Seeing the limits of traditional drug discovery, he later co-founded Superluminal Medicines, a company Ajay Yekkirala on the web Superluminal Medicines LinkedIn Tune in now to hear how asking “what if?”

Technical University of Delft in The Netherlands, I pursued a PhD at the University of Copenhagen under the supervision

A Mentor Who Worked at the Bench During a difficult stretch of his NIH postdoc, Hoare's supervisor Ted Early-Career Researchers Know More Than They Think Hoare makes an argument that surprised him when he pharmacology data analyst and the founder of Pharmechanics LLC , a consultancy and data analysis company supporting

Adhesion GPCRs represent one of the most architecturally complex and least understood branches of the GPCR superfamily For Boucard, adhesion GPCRs are not simply a research subject. cancer The structural bottleneck: what cryo-EM cannot yet capture about receptor dynamics at the cell surface observe the dynamics of receptor assembly, complex formation, and signaling in real time at the cell surface a Scientific Bet After postdoctoral and faculty positions at Stanford and UT Southwestern, Boucard surveyed

led a project that demonstrated the GPCR kinases (GRKs) can translocate to endosomes, and that the subcellular Last summer, Julia worked at as the first-ever summer intern at Septerna, the GPCR-based biotechnology

UNC-CH, where she was the first to discover the essential role of adrenomedullin peptide for embryonic survival Minnesota's MS and Ph.D. programs in Pharmacology, Graduate Program in Neuroscience, and Life Sciences Summer

of biased agonism at the μ-opioid receptor — and why partial agonism keeps explaining what bias was supposed the opposite, the advice is harder to take than it sounds — and, in her telling, the only thing that sustained

“I had two kids and realized I just couldn’t support a family on a technician’s salary.” Key Takeaway Sokhom Pin's journey is a masterclass in scientific persistence , non-traditional success

(MFI): a reliable, self-sustaining computational chemistry service provider, developing its own software I am now combining my training as a chemist and as an entrepreneur to grow a sustainable service and

Aditya is interested in understanding the role of the membrane microenvironment in the subcellular organization ) independent research career, Aditya aims to work at the interface of GPCR molecular pharmacology, subcellular

into the field began with a forensic toxicologist father who tested crime scene samples for controlled substances A readout that captures a downstream marker, a surrogate signal, or a population average can yield clean and industry are structurally complementary - not competing versions of the same thing Academia can sustain pieces are internalizing, moving - and then to flip it on its head again and say the receptor at the surface Working under the supervision of Dr.

Whether in academia or industry, success comes from curiosity, persistence, and knowing your values. Summary made with AI About Dmitry Veprintsev Dmitry is Professor of Molecular and Cellular Pharmacology postdoctoral fellow and later as a staff scientist, focusing on the biophysical studies of the tumour suppressor

What he found reframed how the field explains why closely related receptor subtypes produce different This conversation follows that thread into adhesion GPCRs, a subfamily of 33 human receptors with enormous Within a few years, dozens of labs were running similar studies across every GPCR subfamily. "Go for subfields where the seas are rough and the sky is dark and there are a lot of mysteries." be surprised."

Pathway Dials The promise of biased ligands — pulling one signaling arm while sparing another — only survives

He has received substantial, long-term support from international and national competitive, charitable GPCR AI Summary Quick recap Yamina and Arthur discussed Arthur's career journey in pharmacology, including Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career For their upcoming project, Yamina favored a conversational approach, while Arthur suggested a kickoff They highlighted the importance of fine-tuning the approach to suit different diseases and interdisciplinary

identifying ligands for orphan GPCRs by developing a powerful new computational tool for identifying ‘surrogate

are to understand the basic mechanism by which Ric-8 proteins fold all heterotrimeric G protein alpha subunits

mGlu2 can suppress drug seeking across four addictive substances - but its clinical results have never In alcohol use disorder and other substance addictions, one of the most consequential changes is the By suppressing glutamate release across circuits in the basal ganglia, mGlu2 is positioned to modulate by subsequent preclinical work following the disappointing schizophrenia trials. "We're really just beginning to scratch the surface of understanding how these receptors work in specific

A harder question surfaces underneath: how much of what we call a lab is its physical walls, and how contract between scientific leadership and trainees during crisis Communication infrastructure as a substitute Computational scientists suddenly had uninterrupted time at home with full data access and far fewer

Machine learning finds patterns in defined datasets; AI aims to substitute for human reasoning more broadly Tudor Oprea "If you only make big enough numbers, big enough networks, big enough algorithms, suddenly

These webinars are designed for scientists who want deep, data-driven discussion rather than surface-level Are these GPCR webinars suitable for industry scientists? Yes. These webinars are designed to support ongoing scientific development in GPCR pharmacology and drug discovery

International Research Network (IRN) i-GPCRnet of the CNRS, is chair of IUPHAR « Melatonin receptor » sub-committee