Search Results

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor

pharmacology, and pharmacoepidemiology with innovative computational methods to gain novel insights into receptor identify human signaling systems and thereby discovered endogenous peptides activating several orphan receptors

Her research centers on developing nanobody-ligand conjugates to target GPCRs, with a focus on receptors Sachdev pursued Ph.D. in the same lab where she investigated the molecular pharmacology of cannabinoid receptors

sedative that prolongs exhalation and induces bradycardia—acting through alpha-2 adrenergic, not opioid, receptors investigates how fentanyl and xylazine shut down breathing through different mechanisms—work that blends receptor Listen now and see how one scientist is turning molecules into a mission, bridging the gap between receptor ecosystem , GPCR training program , GPCR podcast , opioid pharmacology , xylazine research , mu opioid receptor

focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential receptor He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

Hannes Schihada Following studies in Pharmacy in Regensburg, Germany, I joined the receptor pharmacology I spent 2 1/2 years in his lab and developed novel conformational sensors for these intriguing receptors

episode Fiona Marshall got fascinated with GPCRs after attending a lecture on how the beta-adrenergic receptor biology, Fiona published the first description of the cloning and structural requirements of the GABAB receptor

developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors

Ph.D. from Department of Pharmacology, University of Washington (1992, mentor Charley Chavkin , sigma receptors Focus on study of drugs and toxins on GPCR (opioid, cannabinoid receptor) and ion channel (K, Ca, TRP

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification

The result: a framework for designing ligands with altered receptor preferences. ♦️ Defines “public”

San Francisco under the guidance of Professor Shaun Coughlin where she worked on the newly discovered protease-activated program is to gain a thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer progression. Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over

years of experience in GPCR, primarily focused on drug discovery and developing new tools to study this receptor

Saraf " My research focuses on evaluating and targeting serotonin 1A receptors for therapeutic outcomes

The focus of his research is the molecular pharmacology of cannabinoids and cannabinoid receptors.

identification of RAMPs (solving some CGRP family issues) and the GABA B, carboxylic, and nicotinic acid receptors

Her work focuses on both sweet and bitter taste receptor GPCRs and her lab established the BitterDB .

She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing

the Vesicular Monoamine Transporter 2 (VMAT2), Tyrosine Hydroxylase (TH) and Trace Amine Associate Receptor

My expertise includes biochemical approaches, proteomics and transcriptomics to name a few. My main topics were protein biochemistry, Drosophila husbandry, and genetics.

That’s why a compound like phenoxybenzamine can knock down receptor populations after just a brief exposure beyond-clearance-the-strategic-power-of-irreversible-drug-binding #GPCR #DrGPCR #Pharmacology #DrugDiscovery #BindingKinetics #ReceptorPharmacology

career, the recurring theme in Kari’s work has been GPCRs and more specifically Metabotropic Glutamate Receptors

The majority of my research is concentrated on rhodopsin family with a few works on metabotropic receptor

Julia studies the mechanisms of 'biased signaling' at GPCRs, with a specific focus on the chemokine receptor

Today, Antonella has expanded her research to olfactory GPCRs and trace amine receptors.

Matters Computational models are moving beyond interpretation into real-world prediction of ligand-receptor His team focuses on understanding how ligands modulate receptor function and how those insights can drive

large compound libraries with the goal of finding new chemical matter to probe understudied and orphan receptors

In 2020, he was promoted to a Readership/Professor in Receptor Pharmacology and was elected a Fellow

His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors

During the past 2 decades, my research mainly focused on chemokine receptor structure/function relationships