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deal of scientific and business interest in solving this problem, and the last two years have seen the emergence

You can always adjust your email preferences in your account settings Below is your Classified GPCR News Reviews, GPCRs, and more Olfactory Receptors as an Emerging Chemical Sensing Scaffold.

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GPCR dimers are therefore emerging drug targets in different therapeutic areas including depression,

orthosteric agonists such as alkylpyrimidine‐4,6‐diol derivatives (Liu et al., 2016; Zhang et al., 2016) and embelin (2,5‐dihydroxy‐3‐undecyl‐1,4‐benzoquinone) which is a natural product derived from the plant Embelia

Incidentally, phosphorylation is a key regulatory mechanism employed in the GPCR-mediated signal transduction G protein-dependent signaling is the most well-known mechanism employed in GPCRs mediated signal transduction Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field

accelerating importance: transducer biosensors measuring receptor-coupling and selectivity, with an emphasis

likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic

This review delivers a concise overview of the role of β-arrestins with a primary emphasis on the signaling

Employing GRK knockout cells and β-arrestins lacking the finger-loop-region, we show that the two isoforms

degradation machinery, mitochondrial respiration genes, solute transporters, and the ER membrane complex (EMC We also showed that the EMC promotes surface expression of C3aR, likely explaining its identification

This emphasizes the importance of the Gi/o (pertussis toxin-sensitive G proteins, whose βγ subunits activate

This assay was applied to various target classes, with particular emphasis on those for which protein-based

, exocytosis, transcriptional regulation, and more, PKA signaling regulates cellular metabolism and emotional

extensively studied as model receptors for decades, new complexities in their regulation continue to emerge

Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets

Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor- κ B "Emerging

In this study, we generated and characterized human embryonic kidney 293A (HEK293A) cell lines devoid of conventional or novel PKC isozymes (ΔcPKC and ΔnPKC) and employ these to investigate the contribution

The molecular mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal

depending on where the GPCRs and their associated signaling machinery are localized in these cells with an emphasis

Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both Particular emphasis is given to findings from the past decade and a half that highlight the emerging

Here, molecular dynamics simulations are employed to explore the implied mechanism of the enhanced sensitivity

PAR4 emerges as a potent oncogene, capable of inducing tumor generation.

recent developments in single-molecule counting with a focus on photobleaching step counting and the emerging technique of quantitative single-molecule localization microscopy-with a particular emphasis on the

We will discuss recent evidence as well as what we consider as emerging areas to explore; from the signalling

A special emphasis is placed on knowledge gaps, challenges, and limitations to evaluate the underpinnings

Emerging evidence suggests adenosine G protein-coupled receptors (GPCRs) are promising therapeutic targets