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In fact, her early decisions were based on curiosity, instinct, and a surprising love of cooking (yes GPCR x Celtarys partnership , she’s extending those insights to researchers worldwide. 👉 Explore Celtarys

From Patient to Researcher Alex wasn’t always planning to be a scientist. changed when his recurring pain — and the rigid protocols around opioid prescription — forced him to search school, Serafini aims to follow the physician-scientist path: part-time clinical work, mostly lab-based research journey proves how personal pain can lead to professional purpose — and why the next generation of pain researchers needs to start from lived experience, not just literature. _________________ Keyword Cloud: GPCR research

and infectious diseases (Proudfoot 2002), and in recent years attention has increasingly focused on cancer The involvement of chemokines and their receptors in several aspects of cancer biology, represents a inhibitor of the CCR5 used in HIV therapy; and the small molecule plerixafor, a CXCR4 antagonist used in cancer A lot of effort has been put forward to target CKRs especially in cancer, nevertheless, targeting this receptors redundancy and the fact that different chemokine receptors are overexpressed and promote cancer

Our access program for researchers in developing countries  continues as well: eligible scientists can They go beyond sponsorship to bring tools and technologies directly to the researchers who use them , Our partnerships with Celtarys Research  and Revvity are great examples — uniting innovation and application to advance GPCR research worldwide. a global platform dedicated to connecting GPCR scientists, industry experts, and innovators through research

At one point, he even questioned whether research was the right career for him. Still, early research internships were rocky. Discovering Modeling (and GPCRs) by Accident That interest led him to pursue a thesis at Scripps Research For Carlsson, this marked a shift in how his lab approached GPCR research. He came to see that effective GPCR research requires true interdisciplinary integration.

If you’ve felt the pace of GPCR research accelerating—and the signal getting harder to separate from Career opportunities:  In vitro Pharmacology Research Assistant—Geneva. drug hunters, and decision-makers stay grounded in fundamentals while keeping pace with modern GPCR research inputs, members get a coherent view of the GPCR landscape—connecting fundamentals to application, and research Premium Edition here ➤ From the Community “Great initiative—clear guidance on career paths, choosing research

But at Monash Institute of Pharmaceutical Sciences, a different idea took root: what if collaboration Why This Matters GPCR research demands integration — pharmacology, structural biology, signaling pathways

If you work in GPCR research, clarity is leverage. week’s issue focuses on structure, early safety strategy, and the next wave of signal transduction research Must-read publications: D2 receptor constitutively active mutants; β2AR allosteric SERS assay; CXCR4 You can now search courses by level, topic, or instructor. Submissions are welcome across formats including Original Research, Reviews, Methods, Perspectives, Hypothesis

, This week's breakthroughs are crucial for staying ahead in the rapidly evolving landscape of GPCR research Career opportunities:  Explore a selection of high-level job openings in high-throughput screening, research Catherine’s research, blending GPCR signaling studies with public health data, offers critical insights Competitive Edge:  Stay informed on emerging public health threats and the scientific research aimed Shape the next generation of cellular biochemistry research.

The research team, led by Brandon Novy and colleagues, utilized an innovative APEX2/AUR biosensor that By employing this biosensor, the research team identified 492 genes that significantly influence DOR After the labeling reaction, the researchers purified and biotinylated proteins (those that have been As the opioid crisis continues to challenge public health, insights gained from this research could inform The implications of this research extend beyond basic science ; understanding the role of DNAJC13 in

For most researchers, that’s a dead end. For Alessandro Nicoli, it’s an opportunity. —Alessandro Nicoli For the first time, researchers had a reliable set of predicted structures to work —Alessandro Nicoli A New Era of GPCR Research AlphaFold didn’t just fill a gap—it shifted the focus of

of Heydenreich et al. (2023) will be analysed to demonstrate how mutagenesis can be employed in GPCR research Through an in-depth mutational analysis of β2AR, the researchers identified specific residues that influence This case study underscores the critical importance of mutagenesis in GPCR research. Rational Drug Design One immediate application of this research lies in rational drug design . By identifying key β2AR residues that influence efficacy and potency, pharmaceutical researchers can

environment, paired with a supportive supervisor, laid the foundation for a fulfilling and productive research Supervisors not only guide your research but also shape your academic and professional growth. These mini "journal clubs" kept me informed about the latest research and sharpened my critical thinking choose a lab and mentor that align with your values and goals, embrace the discipline of structured research challenges will test your resolve, but every small victory along the way shapes you into a stronger researcher

A Career Built on Consistency From CGRP receptor antagonists at BMS to opioid receptor research at Alkermes drug discovery , G protein-coupled receptors , GPCR webinar series , GPCR scientist network , GPCR research

highlight: Congrats to our partner GPCR Therapeutics, on their expansion into fibrosis with their new research -like dopamine receptor in the promotion of feeding and related behaviors Methods & Updates in GPCR Research Scientist In Vitro Biologist/Molecular Pharmacologist Senior Vice President, Oncology Clinical Research Scientist (level I or II) Research Fellow Research Technician II - Surgery Post-Doc Research Associate Research Technician Explore Dr.

Revnity’s partnership with Durham (chemistry) and the Institute of Functional Genomics in Montpellier behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research

As researchers, we all understand the importance of data in driving meaningful discoveries  and advancing guide us in tailoring resources , tools , and content to meet your needs better and help fuel your research Pharmacological Society Vane Medal and switching on the Christmas lights at the University of Glasgow Advanced Research Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research differential endoplasmic reticulum environment amongst neuronal subtypes Methods & Updates in GPCR Research

His work spans deep academic research, startup life, and the application of machine learning and pharmacology There, Ajay expanded his understanding of neurobiology and translational research models, further refining He emphasizes that building a startup is not simply a continuation of research — it requires a mindset Advice for Young Scientists For early-career researchers, Ajay’s journey offers a powerful blueprint. addiction, or another unmet need, keeping the real-world impact in focus can clarify career decisions and research

The Hidden Lever in GPCR Research In GPCR pharmacology, the conversation often centers on ligand properties—affinity By reducing receptor density, researchers can transform full agonists into partial ones—allowing comparative With extreme overexpression, constitutive activity emerges, exposing inverse agonism.  That’s constitutive activity—and it’s what lets us see inverse agonism when we crank the system up. What role does constitutive activity play in uncovering inverse agonists , and how can you exploit this

ubiquitously expressed ORs, although there are highly increased in prostate tissue, especially in prostate cancer modulated by this tight mechanism with transcriptomic analysis revealing that while the majority of cancer and OR51E2, initially assumed to be GPCRs only expressed in prostate tissue, play a role in prostate cancer epithelial cells proliferation via activation by β-ionone which initiates prostate cancer cell cycle In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and

compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice Methods & Updates in GPCR Research Project Ambrosia lands $16m to ‘improve on existing GLP-1 drugs’ Opening Ceremony of Xuzhou Zhongshu Research Europe   July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Research Associate Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Become a Premium Member!

everyone, Take a moment to explore our latest coverage of GPCRs this week, which includes 7 insightful research Stay informed with the most recent developments in GPCR research and industry news. Present Your Research: Submit your abstract by June 24th for priority consideration or by July 22nd for receptor-mediated synaptic depression in dorsolateral striatum of adult male mice Methods & Updates in GPCR Research Scientist, In vitro pharmacology Senior Scientist - Receptor Pharmacology Postdoctoral Scientist Senior Research

Tissue expression levels of β-Arrestins and their implications in cancer In addition to molecular interactions expression data in healthy tissues from the Genotype-Tissue Expression (GTEx) database with data from cancer samples in The Cancer Genome Atlas (TCGA) through the Gene Expression Profiling Interactive Analysis (GEPIA) tool, it is evident that β-arrestin expression is dysregulated in many cancer types. In certain cancer types, only one β-arrestin isoform's expression may be altered, while the other remains

. 👉 Discover the pHSense™ Reagents + Listen to the podcast ➤ Celtarys Research – Optimizing HTRF with A new contributor article from our friends at Celtrays Research outlines how dual-labeled fluorescent decision-makers. 🚀 Join Premium Today & Enjoy ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers

Katharina Grotsch, Bryan L Roth, Valery V Fokin  et al. for their research on Virtual Screening of a If you have any research you would like to showcase to our community, you can submit a poster presentation Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Join Dr.

Career opportunities:  Roles spanning research associates to principal scientists across membrane proteins From Bench Frustrations to Breakthrough Design For decades, GPCR trafficking research relied on overexpression chemistry can shift the entire GPCR toolkit. 👉 Go behind the scenes with Revvity’s R&D team ➤ Celtarys Research Because they give researchers something rare in CNS work: clarity in complexity. start here 🚀 Join Premium Today & Enjoy ➤ 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research

With collaborations across medicinal chemistry and neuropathic pain research, Ben is bridging molecule Start learning with our GPCR University today. _______________ Keyword Cloud: GPCR research community

latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity Norton Cheng, JoAnn Trejo, et al. for their research Submit a few slides for a poster presentation to showcase your research and network with our community Fellow Postdoc Position Principal Scientist, In vitro pharmacology Senior Associate Scientist - Global Research Technologies Novo Nordisk Scientist I - Global Research Technologies Novo Nordisk Postdoctoral Associate Research Technologist I Senior Scientist- Internal Medicine Research Unit Postdoctoral Scholar – Synaptic

scientists tools to study receptors in their native, unmodified state—unlocking new questions about constitutive Changed After This Data: Trinquet pushed pHSense toward rapid commercialization—pivoting it from a research behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research

in the chemokine system can also contribute to various diseases, such as inflammatory conditions and cancer CCR1 is constitutively phosphorylated, constitutively interacts with β-arrestin2, and constitutively