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- 📢 Early Bird Registration Ends Tomorrow! | Sep 16 - 22, 2024
Time is running out!
- đź“° GPCR Weekly News, February 27 to March 5, 2023
Methods & Updates in GPCR Research Time- and cost-efficient bacterial expression and purification of
- Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery
They can metabolize, inactivate, or transform your compound, sometimes into a toxic byproduct, other times
- đź“° GPCR Weekly News, March 13 to 19, 2023
There is still time.
- GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!
Understanding real-time kinetics to predict activity and in vivo target coverage.
- đź“° GPCR Weekly News
A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson's
- Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024
It’s time to mark your calendars and save the dates—let’s make some stellar memories together!
- High-Content Screening for GPCR Programs: Overcoming Assay Limitations with Fluorescent Ligands
Pilot experiments are essential to optimize: Cell density Fluorescent probe concentration Exposure times
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
The increase in active β-arrestin molecules and the time they spend diffusing on the plasma membrane
- Overview of adhesion GPCRs self-activation
However, at that time the structural conformation of the transmembrane (TM) region was not yet known.
- Decoding β-Arrestins: from Structure to function
M. et al. 2019), and hydrogen-deuterium exchange (HDX) mass spectrometry for time-dependent conformational
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
all of the other current GPCR discovery procedures, Orion’s approach does not require the onerous and time-consuming







