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- Visualizing GPCRs in their native environment changes everything | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling. | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- How GPCR Collaboration Built an Innovation Engine | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- irreversible drugs post 1 | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- Media Partner Packages | Dr. GPCR Ecosystem
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- We’re excited to announce our strategic partnership with Celtarys Research, a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- irreversible drugs post 3 | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can reveal | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free! ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- ep 175 with jens carlsson clip 1 | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- ama session sept 18 post 1 | Dr. GPCR Ecosystem
affinity experiments are interpreted—and how those interpretations quietly shape SAR, lead selection, and development
- GPCR Retreat Schedule 2023
Vulnerability in Ovarian Cancer Robert Rottapel University of Toronto Read More Friday, November 3rd / 4:20 PM Developing
- Dr. GPCR Summit 2022 Live Talks Schedule
High throughput GPCR screening technologies enable deciphering host-microbiome communication and the development
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- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
are conserved adhesion G protein-coupled receptors; they are essential for embryogenesis and neural development
- Yamina's Corner | Dr. GPCR Ecosystem
Actionable Objectives Together, we clarify specific, measurable goals, from target validation and assay development
- Smells Like GPCR Spirit: Cracking Olfactory Codes with Alessandro Nicoli | Dr. GPCR Ecosystem
Alessandro PhD work aims to fill these gaps by leveraging computational structure-based tools and develop
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- Trademark Policy | Dr. GPCR Ecosystem
GPCR development of Dr. GPCR Buttons. By using a Dr. GPCR button, Publishers give Dr.
- Content and Conduct Policy | Dr. GPCR Ecosystem
Please note that the definition of spam on Ecosystem.DrGPCR.com may develop and change over time, and
- Your GPCR Order Has Arrived! ❇ Feb 10 - 16, 2025 | Dr. GPCR Ecosystem
. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April
- The Practical Assessment of Signaling Bias | Dr. GPCR Ecosystem
Kenakin , a leading expert in pharmacology, as he unpacks the fascinating world of signaling bias in drug development effects. 🗣️ Interactive Q&A : The discussion wraps up with an insightful Q&A, tackling real-world drug development Understanding these shifts can revolutionize drug development! The talk explores how to navigate this crucial gap. 📌 The Future of Drug Development 🚀 🔹 By integrating
