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About this episode Dr. Dr. Kari Johnson on the web LinkedIn Google Scholar Research Gate USU Twitter Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

Dr. Dr. Brian Arey on the web LinkedIn ResearchGate Pubmed Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

Eleonora Comeo on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

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< Back This is a Title 01 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

< Back This is a Title 02 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

< Back This is a Title 03 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

Dr. Dr. David E. web LinkedIn ResearchGate Twitter Google Scholar Computation Receptor Biology- Gloriam Group GPCRdb Dr GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

Minor offsets may occur. 00:00 Introduction and Dr. Dr. Elva Zhao on the web LinkedIn Monash University Pubmed Twitter Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

Genemode on the web Website Jacob Lee on LinkedIn Jacob Lee on Dr. GPCR Ecosystem Jin Choe on LinkedIn Jin Choe on Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Enjoying the Dr

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Explore how subcellular location and temporal dynamics revolutionize GPCR signaling through nanodomains, endosomal compartments, and phase separation mechanisms. < Back The Spatiotemporal Revolution in GPCR Biology May 21, 2026 10:00 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction Classical GPCR signaling models assumed uniform receptor distribution and immediate signal termination upon ligand dissociation. Contemporary research reveals that subcellular location and temporal dynamics fundamentally determine signaling outcomes. This session examines how receptor nanodomains, endosomal signaling compartments, and biomolecular condensates create distinct signaling environments that prevent crosstalk and enable pathway specificity. The discussion spans location bias mechanisms that drive differential G protein versus arrestin activation, advanced imaging techniques that visualize these spatiotemporal processes, and the emerging role of liquid-liquid phase separation in organizing signaling complexes. Designed for structural pharmacologists, cell biologists, and drug discovery scientists working on GPCR systems where spatial organization influences therapeutic outcomes. Instructor Sudarshan Rajagopal is Associate Professor of Medicine in the Division of Cardiology at Duke University School of Medicine and Co-Director of the Duke Pulmonary Vascular Disease Center. His research has fundamentally advanced understanding of receptor regulatory mechanisms underlying cardiovascular and inflammatory diseases, particularly pulmonary hypertension. Since establishing his independent laboratory, his group has made defining contributions to biased agonism mechanisms and chemokine system signaling, with particular expertise in how spatial organization influences GPCR function in disease contexts. His work on spatiotemporal GPCR regulation directly informs the mechanistic framework addressed in this Masterclass. Upcoming Live Sessions

🎓 Kicking Off Today: Dr. Watch Dr. Kenakin as he introduces the key concepts of this brand-new course.

Strategic approaches to building GPCR research programs that translate fundamental discoveries into clinical impact and drug development. < Back How to Build Breakthrough GPCR Programs June 4, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction Building GPCR research programs that achieve both fundamental discovery and clinical translation requires strategic thinking from day one. This session addresses the structural and strategic decisions that determine whether breakthrough science reaches patients: securing funding aligned with translational potential, defining research directions that balance risk and impact, identifying discoveries worth pursuing to clinical endpoints, and navigating the pathway from academic research to drug development and spin-out companies. Andrew Tobin draws from his experience leading translational GPCR programs and co-founding Keltic Pharma to illustrate each strategic element. Intended for GPCR scientists, postdocs, and research leaders planning translational research programs. Instructor Andrew Tobin directs translational GPCR research focused on generating new medicines for brain disorders, severe asthma, and inflammatory gut disease. As co-founder and CEO of Keltic Pharma Therapeutics, he leads a biotechnology company developing a novel drug-discovery platform and working toward a radical cure for malaria. He also serves as Director of the Advanced Research Centre at the University of Glasgow, a £130M collaborative initiative housing over 550 researchers designed to redefine interdisciplinary research. His recent work on muscarinic acetylcholine receptor modulation and structure-guided design of M1 receptor agonists exemplifies the strategic approach to translational GPCR science that defines this Masterclass session. Upcoming Live Sessions

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