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Minor offsets may occur. 00:00 Introduction and Dr. Dr. Elva Zhao on the web LinkedIn Monash University Pubmed Twitter Dr. GPCR Ecosystem Unlock the Full Dr. discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr

Your One-Stop-Shop for GPCR Drug Discovery and Development Researchers developing GPCR-targeted therapeutics need a reliable, comprehensive partner that spans discovery, optimization, and regulatory submission. Eurofins DiscoverX leads GPCR research innovation with 25+ years of expertise and provides you with product solutions including cell-based assays for basic research through therapeutic discovery and development. The assays are validated and accepted by industry and the scientific community, with thousands of peer-reviewed publications and billions of data points screened. These industry-standard assays, designed for regulatory submissions, are backed by partnerships with leading pharma and biotech companies worldwide. GPCR Product Solutions Determine rank-order hits, evaluate ligand bias or allostery, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors, and more Perform target identification and validation, high-throughput screening (HTS), lead optimization, safety assessment, and regulatory potency testing for commercial release Access a complete toolkit for GPCR solutions: cell line assay kits, cell lines, ready-to-use assays, detection kits, custom products, and more Comprehensive Coverage >1500 Human GPCRs products, including: 90% Target coverage Orphan receptors Ortholog variants Multiple cell line backgrounds Multiple Mechanisms of Actions (MOA) cAMP accumulation β-Arrestin recruitment Receptor internalization Ligand binding Calcium flux Pharmaco Chaperone discovery Numerous Product Types Cell line assay kits Cell lines Qualified bioassays eXpress assay kits Membrane preps Detection kits Custom products Services Flexible Formats for Every Research Need Eurofins DiscoverX understands that different research stages require different tools. This comprehensive portfolio offers multiple product formats to match your exact needs, whether you're conducting exploratory screens or regulatory-compliant potency testing. Assay Principle of Eurofins DiscoverX Cell-based Assays Whether you are developing small-molecule or biologic therapeutic drugs, Eurofins DiscoverX provides you with a variety of drug discovery and development products with multiple assay types and applications to meet your specific GPCR research needs. Access Product Solutions and Key Resources GPCR Functional Cell-Based Assays - Assessing Biased Signaling of Agonist Access White Paper Discover Your GPCR Solution - Find The Assay for Your Target of Interest Find Your Solutions The Human GPCRome - Obtain Your FREE Wall Poster for Your Laboratory Obtain Wall Poster Access GPCR Cell Line Assays, Ready-to-Use Kits, Mem Preps, & More Shop Products Supporting GPCR-focused Obesity and Diabetes Research Eurofins DiscoverX supports the ongoing obesity/diabetes revolution with the most comprehensive, validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors, and more. Browse products related to your obesity/diabetes target of interest: CALCRL and RAMP (AMs) GIPR GLP-1R GLP-2R GCGR GPR75 MC4R NPY2R (PYY) SSTR5 Activins CALCR and RAMPs (AMYs) Apelin (APJ/AGTRL1) View representative data: GLP-1R multi-MOA profiling Eurofins DiscoverX's GLP-1 receptor (GLP-1R) assay portfolio illustrates a comprehensive approach to obesity research, with complete MOA coverage for a single target: GLP-1. These assays enable complete pharmacological profiling across cAMP, β-arrestin, and internalization. GLP-1R representative assay results (dose-response curves) for exendin-4, tirzepatide, and retatrutide. A. cAMP dose–response; B. β-arrestin recruitment showing ligand bias; and C. Internalization profiles distinguishing highly versus weakly internalizing agonists. Together, these datasets exemplify the depth of pharmacological insight enabled by Eurofins DiscoverX platforms. This multi-dimensional characterization extends across our full obesity and diabetes product portfolio, including GIPR, GCGR, AMY receptors, MC4R, and beyond. Access GPCR Obesity and Diabetes Solutions and Key Resources Discover GPCR Obesity and Diabetes Product Solutions Find Your Solution Review GIP Product Solutions to Support Obesity/Diabetes View GIP Solutions Explore GLP-1 Product Solutions to Support Obesity/Diabetes See GLP-1 Solutions Accelerating Obesity Therapeutics Development Download App Note Beyond Eurofins DiscoverX Products: The Full Power of Eurofins Discovery Eurofins DiscoverX cell lines, assays, kits, and custom product solutions represent the foundation of tools for GPCR research and drug discovery and development. When these product solutions are combined with Calixar GPCR membrane proteins and Eurofins Discovery GPCR services, the benefits from integration provide the most comprehensive GPCR research and drug discovery platform spanning the entire discovery and development continuum. Eurofins Discovery GPCR services provides the industry's most extensive collection of validated GPCR assays with hundreds of binding and functional assays, available individually or in panels. These assays use the same platform as the Eurofins DiscoverX assays and beyond. Calixar GPCR membrane proteins , as a service, provides a wide array of GPCRs from various species, purified to the highest standards to ensure purity, integrity, and biological activity. These GPCRs are excellent for use in functional, structural, or identification assays. Let us Help You Get Started! Contact us Visit GPCR Product Solutions

Genemode on the web Website Jacob Lee on LinkedIn Jacob Lee on Dr. GPCR Ecosystem Jin Choe on LinkedIn Jin Choe on Dr. GPCR Ecosystem Unlock the Full Dr. discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr

Blanco-Redondo; icebreaker 01:15 - Career path: from Spain to Germany, and the decision to go further 05:57 - Dr Unlock the Full Dr. discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr

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Eleonora Comeo on the web LinkedIn ResearchGate Pubmed Google Scholar Dr. GPCR Ecosystem Unlock the Full Dr. discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr

serves as the direct point of contact for GPCR researchers requesting free antibody samples through the Dr Alexander Ball, on recombinant monoclonal antibodies Unlock the Full Dr. discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr

< Back This is a Title 03 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

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< Back This is a Title 01 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

< Back This is a Title 02 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next Articles News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

. 🚀 Develop New GPCR Skills Join Dr. Tune in to Ep.160 of the Dr.

🎓 Kicking Off Today: Dr. Watch Dr. Kenakin as he introduces the key concepts of this brand-new course.

The Practical Assessment of Signaling Bias Dr. Terry Kenakin < Back Workshop Summary Join Dr. Dr. Dr. Dr. Terry Kenakin’s workshop offers a fresh perspective on drug discovery .

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