Search Results

Share your thoughts and help shape the future of the Dr. GPCR Ecosystem. Your feedback guides improvements, new features, and community resources. Dr. GPCR Community Survey Help us build the next evolution of the GPCR Ecosystem — together. Every opinion counts. Whether you’ve joined our University sessions, explored our Job Board, or attended a Happy Hour, your feedback shapes what comes next. Let’s make Dr. GPCR more useful, connected, and inspiring for everyone in the field. 👉 Take the Survey Now Why Your Feedback Matters? We’re growing — and your input helps us grow in the right direction. By sharing your thoughts, you directly influence how we design new features, events, and educational programs. Your responses help us: Improve the Dr. GPCR University curriculum and resources. Make Retreats and Happy Hours more valuable and accessible. Build stronger connections between academia and industry. Develop new tools, training programs, and mentorship programs tailored to your specific needs. Your Voice Shapes Our Future Dr. GPCR was founded to bring the GPCR community together — and every survey response helps us strengthen that mission. This isn’t just a form — it’s how you influence the next generation of education, collaboration, and discovery. 💡 Start the Survey What We’d Love to Learn? We’ve grouped the questions into three sections so your feedback can make a real impact: 1. Your Experience How often do you use the Dr. GPCR platform? Which programs do you engage with most? (University, Retreat, Job Board, Newsletter, etc.) What has been your favorite experience so far? 2. Your Needs What topics or training modules would you like us to add next? What challenges do you face most in your research or biotech journey? How can we facilitate easier collaboration within the community? 3. Your Feedback How likely are you to recommend Dr. GPCR to a colleague? (1–10) What would make your experience even better? Any ideas, suggestions, or features you’d love to see in 2026? Survey 🙏 Thank You for Being Part of the Ecosystem Your feedback helps us: Keep events free or affordable Expand our shared knowledge base Support students and researchers entering the field Together, we’re building a home for everyone passionate about GPCR research and innovation.

Submit your partnership request with our easy-to-use online form. Join Dr. GPCR Ecosystem and collaborate with us to make a positive impact. Strategic Partners Back to Partners List Submit Thanks for submitting! We'll get back to you to set up a meeting.

Discover the mission, vision, and people behind the Dr. GPCR Ecosystem: uniting scientists, biotech, and innovators to advance GPCR research worldwide. Who We Are We are a global network of scientists, biotech innovators, pharma professionals, CRO leaders, and vendors—united by one mission: to make working on GPCRs easier, faster, and more collaborative. Dr. GPCR is both expert-led and community-first. We’re building together, with input from across the field. About Dr. GPCR Ecosystem We unite the GPCR Community to advance drug discovery Where GPCR Experts Move Science Forward Join the global community accelerating GPCR drug discovery through trusted insights, expert tools, and powerful connections. Join Free & Get Our Weekly News See Why it Matters 6,600+ followers 200+ Research Labs 1,500+ Scientists 50+ Biotech Companies Built by Scientists. Driven by Impact. Dr. GPCR began as a podcast. Now, it's a global ecosystem of scientists, biotech teams, CRO leaders, and trainees working to move GPCR science forward—together. We created this space to make trusted knowledge and collaborations easier to access—without noise, fluff, or hype. What We Believe The Ecosystem was built with five key beliefs: Scientific rigor first This is a space for data-driven work, not hype. Usefulness over flash Every piece of content and feature must be practical. Transparency builds trust We're open about who we are and what we do. Collaboration is key Progress in GPCR science requires a collective effort. Inclusion matters We welcome diverse voices, experiences, and expertise. We designed the Ecosystem to support your work —no matter where you are in your GPCR journey. Our Journey (So Far) From the first podcast episode to a global platform, it's all built by and for the GPCR community. 2020 First Podcast Episode Launched our podcast to share expert insights with the scientific community. 2021 2nd Annual Summit Increased our reach and impact with the GPCR Community 2022 Community Platform Expanded beyond content to create a dedicated space for GPCR scientists to connect. 2023 First Symposium Inaugural Dr. GPCR Symposium with over 100 attendees 2024 GPCR University Launched comprehensive courses and expert talks to deepen scientific understanding. 2025 Terry's Corner & Consulting Launched our exclusive program with Dr. Kenakin and offered to CROs consulting services See Full Timeline The Field Is Growing—but Fragmented As GPCR scientists, we know the problem: too much noise, too little time, and nowhere to connect that's built for us. We built Dr. GPCR to: Curate relevant data—not overwhelm you with it Connect researchers with CROs, peers, and biotech leaders Provide high-quality tools and expert insights on demand Whether you're in a lab, launching a startup, or prepping for due diligence, we built this for you. The GPCR Challenge Scientists waste an average of 12 hours per week searching for relevant GPCR research and connections. Our ecosystem cuts that time by 80%. You'll Be in Good Company From PhDs to CRO execs to rising biotech founders—this is a vetted, mission-aligned community built to help you move faster. Premium Members Include: ✔ Drug hunters at early-stage biotechs ✔ CRO leaders building assays and tools ✔ Academic researchers moving into translational work ✔ Teams preparing for fundraising or due diligence Expert Contributors Include: ✔ Terry Kenakin, with his exclusive series on GPCR pharmacology ✔ Sam Hoare, simplifying GPCR data analysis ✔ Global CROs and biotech leaders, contributing behind-the-scenes tools and insight What Makes the Ecosystem Different Built for Drug Discovery Designed by scientists in the GPCR space to accelerate your research goals Collaborative by Design Connects researchers, CROs, and biotech teams—not just profiles, real relationships. Results-Driven Every tool and content block is built to help you make a decision or move forward. ✔ GPCR-specific content ✔ Expert curation ✔ Vetted community What Joining the Ecosystem Looks Like 1 Join Free Sign up in seconds. You'll instantly receive the GPCR Weekly News (free version). 2 Get Verified We manually review each profile to ensure trust and scientific relevance. 3 Start Exploring Browse free content, community updates, and learn what's available. 4 Upgrade Anytime Premium unlocks exclusive courses, community features, and deeper insights. Start Your Journey Today Meet the Leadership Founder & Director Yamina Berchiche Get in Touch Board Member Anne M. Quinn Get in Touch Board Member Maria Waldhoer Get in Touch Co-Founder Attila Foris Get in Touch Board Member JoAnn Trejo Get in Touch Chief Matchmaker Mark Schmeizl Get in Touch Why Upgrade to Premium Everyone who joins receives the free Weekly News. Premium gives you everything else—the full toolbox for moving science forward. Free Membership Includes: ✔ Free version of GPCR Weekly News - straight to your inbox! ✔ Select news and content ✔ Ecosystem and podcast updates Premium Members Unlock: ✔ Full Weekly News access – All GPCR papers, events, jobs + expert commentary ✔ Dr. GPCR University – 5 on-demand GPCR courses, 1 project management course, 200+ expert talks ✔ Community tools – Member directories, messaging, and forums Partners Who Drive our Mission Partner Benefits Visibility to GPCR experts Direct connections Industry insights Explore Partnership Opportunities Ready to Join the Movement? Start free. Upgrade when you're ready. Dr. GPCR helps you stay ahead of the curve in science and strategy. Unlock Premium Access Join Free Now

Expert support, trusted CROs, and ready-to-use tools to accelerate GPCR drug discovery, reduce risk, and advance your discovery-stage projects. Dr. GPCR Foundry: Accelerate GPCR Drug Discovery Move from idea to insight—faster, smarter, and with confidence. Partner with our nonprofit team for expert guidance, trusted CRO collaborations, and field-tested tools that de-risk your GPCR programs and keep momentum strong. 👉 Book a Free 30-min Strategy Call Select your Challenge... ↑ Pick your challenge to see tailored solutions. Yamina's Corner Expert strategic and scientific consultancy for GPCR-focused biotechs, VCs, and CROs. From pipeline acceleration and investment de-risking to CRO differentiation — turning GPCR complexity into clear, actionable direction. Book Your Free Strategy Call GPCR University Team Membership Dr. GPCR University for your whole organization. Unified access to the full course library, live masterclasses, and community — so your team builds from the same expert-led foundation and compounds knowledge. Get Team Access TC Team Membership The team tier of Terry's Corner. Give every scientist on your team access to Dr. Kenakin's weekly insights and AMAs — building shared language around GPCR data and pharmacological decisions. Get Team Access GPCR University Expert-led courses spanning GPCR drug discovery — from receptor biology to translational pharmacology. Includes live masterclasses, a full course library, and community access. Built for working scientists. Explore the University Terry's Pharmacology Corner Weekly expert content and live AMAs led by Dr. Terry Kenakin. Translates complex GPCR pharmacology into practical understanding you can apply to data interpretation, lead optimization, and candidate selection. Explore Terry's Corner Timeline Strategy Strategic workshops that replace trial-and-error with proven frameworks for biotech growth. Real-world case studies and data-driven models for pipeline prioritization, resource allocation, and milestone planning. Explore Timeline Strategy Strategic Media Partnership A premium, limited partnership (12 spots/year) that positions your company as a leader within the Dr. GPCR ecosystem. Gated content, launch campaigns, and strategic co-creation — a mission-aligned collaboration, not a media buy. Apply for a Partnership Spot CRO Bank A curated directory of GPCR-specialized CROs and technology partners. Find the right service provider for your assay, screening, or discovery needs — without wading through generic directories. Explore CRO Bank Our Core Support Areas Discovery Consulting & Strategy Expert guidance to de-risk projects, refine strategy, and drive scientific progress. Visibility for Solution Providers Strategic media partnerships that connect your company with biotech innovators and showcase your expertise Training & Upskilling Specialized, insight-packed courses designed for discovery-phase GPCR teams. Tools & Resources Ready-to-use frameworks and resources tailored to the realities of discovery-stage GPCR work Our Partners Join these innovative organizations already benefiting from the DrGPCR Foundry. Book Plan Your Next Move in GPCR Discovery Meet directly with Dr. Yamina Berchiche for a focused strategy conversation to align your goals, uncover opportunities, and map your next steps. Let's move your GPCR discovery program forward. Wherever you are in your discovery journey, the Foundry helps GPCR biotech companies move faster and reduce risk. Let's discuss your next step.

Monitor GPCR internalization in real time with pHSense™ – no-wash, TR-FRET reagents from Revvity. Fast, clear, live-cell receptor trafficking detection. Unlock microscopy-free real-time GPCR internalization with pHSense pHSense™ probes are optimized reagents for plate readers, specifically designed to study internalization using time-resolved fluorescence (TRF) detection. They offer high-sensitivity, no-wash detection of internalization events in a scalable, plate-based format. This technology supports robust analysis even at low endogenous receptor expression levels. Suitable for basal/constitutive and agonist-induced GPCR internalization Compatible with TRF plate readers No-wash protocol simplifies workflow Formats available for modified GPCR cell lines or unmodified primary cells Explore pHSense Products Powered by Revvity’s legacy of innovation in translational science. Dr. GPCR Ecosystem Partner Visit Website Precision Tools for Translational Science Revvity is a global leader in life science innovation, delivering tools and technologies that bridge the gap between discovery and real-world impact. With decades of expertise and an unwavering focus on precision, Revvity empowers scientists to simplify complex workflows, accelerate discovery, and drive breakthroughs in drug development, diagnostics, and disease biology. Whether you’re decoding signaling pathways or designing the next generation of therapeutics, Revvity isn’t just a provider—they’re your partner in discovery. Discover pHSense™ portfolio From binding to signaling to internalization: Cell-based fluorescence assays for complete GPCR characterization The principle of pHSense™ relies on the pH-dependent fluorescence activation of a europium-labeled antibody to monitor receptor internalization in live cells. Neutral pH = low signal: The probe is minimally fluorescent at extracellular neutral pH (≥7), which means it doesn't emit a strong signal when bound to the surface. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the probe is internalized into acidic intracellular compartments (like early/late endosomes and lysosomes). The europium complex becomes increasingly fluorescent as the pH drops, enabling dynamic tracking of internalization. Time-Resolved Fluorescence (TRF) = High Signal-to-Background: Europium’s long-lived fluorescence allows TRF detection, which effectively filters out short-lived background signals. This results in high sensitivity and specificity in no-wash, plate-based live-cell assays. pHSense™ Eu Anti-FLAG Designed for the detection of FLAG-tagged receptor and membrane protein internalization. View Product pHSense Eu SNAP Labeling Reagent Can be used to label receptors and membrane proteins carrying an extracellular SNAP sequence with a pHSense probe to monitor their internalization View Product pHSense Fab Anti-Human or Anti-Mouse IgG Fab fragments for monitoring GPCR and antibody internalization in unmodified cells The Fab Anti-Human IgG Eu-conjugate can be used in combination with a neutral anti-GPCR to address unmodified receptors in primary cells View Product The Fab Anti-Mouse IgG2 Eu-conjugate is suited to study mouse biologics targeting GPCR and confirm their internalization effects on receptors. View Product The pHSense™ Advantage Clarity. Consistency. Compatibility. Purpose-Built for Live-Cell Internalization Assays The pHSense™ family of europium-labeled, pH-sensitive reagents is designed to simplify and accelerate the study of GPCR and membrane protein internalization in live cells. These reagents are fully compatible with plate-based, no-wash workflows and use time-resolved fluorescence (TRF) to eliminate background noise—delivering clear, quantifiable signals as targets move into acidic intracellular compartments. What Sets pHSense™ Apart ✅ Time-resolved detection minimizes background noise, which enhances detection sensitivity. ✅ No-wash protocol preserves cell integrity and kinetic detection. ✅ High-throughput ready: faster time-to-results and streamlined data acquisition. ✅ Comprehensive validation: validated for GPCRs, but also antibodies and ADCs. ✅ Versatility across suspension and adherent cells The Full GPCR Toolkit by Revvity Every step of the signaling cascade. One trusted source. GPCRs are among the most powerful and complex targets in biomedical research. Revvity offers a comprehensive reagent portfolio to match that complexity—supporting every stage of the signaling pathway, from ligand binding and G-protein activation to intracellular signaling readouts. With formats including TR-FRET, radioligand binding, cAMP, IP-One, and phospho-protein assays (ERK, AKT, CREB, MEK), this toolkit is built for speed, reproducibility, and translational insight. Proprietary no-wash technologies help reduce hands-on time while maintaining exceptional data quality—so you can move fast without compromise. View Reagents Explore Revvity’s GPCR Assay Technologies Tools designed to illuminate every step of GPCR signaling—from binding to downstream response. Ligand binding Measure receptor engagement with high sensitivity using TR-FRET, radioligand, and Fluorescent Tag-lite® formats. G-Protein Activation Quantify Gs, Gi, and Gq activation in real time with cAMP, GTP, and IP-One assays. Arrestin Recruitment Detect β-arrestin recruitment with TR-FRET and luminescence assays tailored for biased signaling studies. Intracellular Signaling Track key downstream events like ERK, AKT, and CREB phosphorylation with high-throughput precision. Build Your GPCR Assay Workflow Meet the Team behind pHSense™ Eric TRINQUET Sr Director Life Sciences Reagents, Revvity Eric Trinquet is a recognized expert in the field of immunoassays and fluorescence technologies. He currently leads Revvity's Research and Development activities, focusing on biochemical and cellular assay platforms related to Life Sciences Reagents. Before joining Revvity, Eric worked for Cisbio Bioassays first as Director of Technological Development and then as R&D Director. His career is marked by significant contributions, from introducing HTRF technology in the field of high-throughput screening to developing innovative solutions such as the IP-One kit for studying G Protein-Coupled Receptors (GPCRs) and the Tag-lite platform. Elodie DUPUIS R&D Senior project manager, team leader. Elodie Dupuis earned her Master’s degree in biology and biotechnology engineering from the University of Sciences of Nîmes and the Ecole des Mines engineering school (France) in 2009. She then joined Cisbio Bioassays, and later Revvity, as project leader and team manager in the Research & Development department, leading her team on the development of innovative HTRF™ and AlphaLISA™ kits for pharma, biotech, and academic partners. Through her research contributions, she has co-authored numerous scientific publications and holds several patents as an inventor. She has been leading collaborative projects with public research institutes and pharmaceutical companies, most notably the joint Revvity/Institute of Functional Genomics team, EIDOS. In 2020, together with her team, she initiated a long-term research effort that enabled the creation of a new and innovative portfolio for GPCRs, antibody drug conjugates, and several other applications: pHSense™. 2025 marked the commercial launch of the first pHSense products by Revvity. Mathis LAFFENETRE Product Manager, Immunoassay Reagents. Mathis holds a biotechnology engineering degree from the National School of Biomolecule Technology of Bordeaux and an MS in biomedical business management from the Grenoble School of Management. He joined Revvity (then Cisbio) in 2016 as part of the scientific marketing effort to build brand recognition for the HTRF technology and accelerate the company’s reagents use in academic labs, biotech companies, and pharma. In the following years, he held several marketing and strategic positions in France and the US, primarily related to the Immunoassay portfolio. As of 2025, he is part of the Immunoassay & Imaging Reagents Portfolio group as a product manager for the GPCRs, and is responsible for supporting the adoption and expansion of the reagent portfolio into the hands of scientists and researchers. Inside the Science: A Conversation with Revvity's Dr. Eric Trinquet From Rare Earth Probes to Internalization Assays: The pH Sense Story If you’ve ever used HTRF or wondered what goes into making a product worthy of your next experiment, this is your backstage pass. More about this conversation Our Partnership Dr. GPCR Spotlights Revvity’s pHSense™ Reagents for Real-Time GPCR Internalization A new reagent family designed to unlock high-throughput internalization workflows—now featured across the Dr. GPCR Ecosystem Boston, MA – September 2025 — Dr. GPCR, the global nonprofit platform dedicated to advancing GPCR research and drug discovery, is proud to spotlight the launch of pHSense™, a new reagent family from Revvity designed to bring unprecedented clarity, speed, and scalability to the study of receptor internalization. Internalization is a core—but often overlooked—dimension of GPCR biology. Traditionally, studying it has meant long workflows, low throughput, or expensive imaging platforms. pHSense™ changes that by combining europium-based, pH-sensitive probes with no-wash, live-cell protocols and TRF-based detection—making it possible to monitor internalization in real time, in standard plate-based assays. “When we saw dose-dependent internalization in endogenous GLP1R cells—without microscopy—that was the turning point,” said Dr. Eric Trinquet, Director of Research and Development at Revvity. “We knew pHSense could offer something truly new to the GPCR field.” A Tool Designed for Real Research Needs Built on more than two decades of GPCR assay innovation, pHSense™ was developed to overcome three persistent barriers in internalization studies: Complexity of imaging-based workflows Lack of scalability for high-throughput screening Difficulty detecting endogenous receptor activity With pHSense™, scientists can finally move beyond proxy readouts and track GPCR internalization as it happens—even at physiological expression levels. All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and are compatible with HTRF plate readers already used in most labs. Related Articles How Breakthroughs Happen: Eric Trinquet on Innovation, Serendipity & GPCRs Discover how Dr. Eric Trinquet, creator of HTRF and IP-One assays, turned failure into breakthrough tools for GPCR science. Learn why play, serendipity, and partnerships fuel innovation—and how this mindset can transform your research and biotech career. Dr. GPCR Podcast Oct 16, 2025 4 min read The Truth About GPCR Product Launches: Years in the Making What it really takes to launch a GPCR product—years of failure, science, and strategy. Go behind the scenes of pH-Sense with Revity’s Dr. Eric Trinquet. Dr. GPCR Podcast Oct 8, 2025 4 min read Innovative Data-Driven Solutions: The pHSense Revolution A powerful new tool tracks GPCR internalization in native cells—no imaging, no overexpression. Learn how pH Sense changes the game for drug discovery. Dr. GPCR Podcast Sep 26, 2025 3 min read Dr. GPCR Ecosystem Partner Contact Revvity

Find answers to all your questions about the Dr. GPCR Ecosystem: courses, podcasts, memberships, events, and more. Frequently asked questions Webinar University Vault Premium Pricing GPCR Masterclass YC-Biotech YC-VC YC-CRO Terrys Corner Media Partner General University Dr.GPCR Podcast What are GPCR webinars? GPCR webinars are live online scientific sessions focused on G protein-coupled receptor (GPCR) biology, pharmacology, signaling, and drug discovery. Each session explores mechanistic models, translational challenges, and real-world therapeutic implications. These webinars are designed for scientists who want deep, data-driven discussion rather than surface-level overviews. Who should attend these GPCR pharmacology webinars? These webinars are ideal for: • GPCR pharmacologists • Medicinal chemists working on receptor targets • Structural biologists • Translational scientists • Biotech and pharmaceutical researchers • Postdoctoral fellows and graduate researchers entering drug discovery If you work directly with receptor systems, ligand design, efficacy modeling, or signaling pathways, these sessions are built for you. Are these GPCR webinars suitable for industry scientists? Yes. The content is highly relevant for biotech and pharmaceutical scientists. Topics frequently address: • Receptor efficacy and bias • Allosteric modulation • PK/PD relationships • Irreversible binding and safety considerations • Translational pharmacology challenges The discussions are grounded in practical drug discovery, not just academic theory. How are these different from academic seminars or conferences? Most academic seminars focus on a single dataset or publication. These GPCR webinars focus on conceptual frameworks, models, and translational insight that apply across programs. Unlike large conferences, the live format allows direct interaction, questions, and scientific debate in real time. The goal is not presentation — it is scientific advancement. Are the webinars live or pre-recorded? The sessions are delivered live to allow direct Q&A with the speaker. Live participation gives you the opportunity to ask technical questions and engage in discussion with other scientists in the GPCR community. Selected recordings may be available afterward through the Dr. GPCR platform. Do I need prior knowledge of GPCR pharmacology? These webinars are designed for scientists with foundational knowledge in receptor pharmacology, signaling, or drug discovery. While some sessions may introduce key concepts, the overall level is advanced and assumes familiarity with pharmacological models and terminology. What topics are typically covered in GPCR webinars? Topics may include: • Receptor efficacy and operational models • Allosteric modulators (PAMs and NAMs) • Biased agonism • Dose–response modeling • Calcium and signaling assays • Drug–receptor kinetics • Translational pharmacology strategies • GPCR structure–function relationships Each session focuses on mechanistic clarity and practical application. Are these GPCR webinars free? Yes. All live GPCR webinars are free to attend. To receive early notifications, event reminders, and priority updates, you can join the Dr. GPCR Ecosystem as a free member. If you would like to go deeper beyond the live sessions, you can explore the full GPCR educational library inside Dr. GPCR University.(https://www.ecosystem.drgpcr.com/gpcr-university) Will attending help with continuing education or professional development? Yes. These webinars are designed to support ongoing scientific development in GPCR pharmacology and drug discovery. They provide exposure to current thinking, advanced modeling approaches, and expert interpretation of complex receptor behavior. For researchers working in biotech, pharma, or academia, this type of continuing education can strengthen both technical expertise and strategic thinking. How often are new GPCR webinars added? New live GPCR webinars are added regularly as part of the Dr. GPCR Ecosystem’s ongoing educational initiative. Upcoming sessions are announced in advance and updated on this page. Where can I find advanced GPCR training online? Dr. GPCR provides live GPCR webinars, masterclasses, and in-depth educational resources focused specifically on receptor pharmacology and drug discovery. These programs are designed for scientists seeking advanced, mechanism-focused training in GPCR biology.

Fast-track your biotech investments with VC Insights. Access expert guidance, vetted CROs, and data-driven strategies to invest smarter and move faster in GPCR drug discovery. Home About Services News Get in Touch Welcome VC Insights Fast Track Your Next Biotech Bet Get decision-grade data, vetted CROs, and expert guidance—so you move fast and invest smarter. I help you avoid costly delays, choose the right experiments, and unlock clear timelines that drive confident investment. Fast Track My Discovery The wrong CRO—or wrong experiments—can burn months and millions You're not here to fund academic detours. You're backing science that needs to move fast. But too often I hear: “We thought the experiments made sense—until the data didn’t help us decide.” “The CRO promised timelines they couldn’t hit.” “The team’s updates sound polished, but we can’t tell if they’re on track.” If you’ve said any of those, you’re not alone. That's where I come in : to pressure-test the science, align the strategy, and make sure every experiment earns its place. How I Drive Value Prioritize the Right Experiments Avoid noise. I help identify the experiments that truly matter—aligned to your milestones and inflection points. Translate project strategy into clear decision-driving assays Eliminate “nice to have” tests that stall timelines without payoff Match experiments to the specific phase and risk tolerance of the asset De-risk Your CRO Strategy I evaluate, select, and manage CROs that are fit-for-purpose—saving you time, cost, and rework. Audit and compare CRO options based on speed, quality, and fit Clarify deliverables and oversight to prevent rework and misfires Serve as a scientific bridge between VC, team, and CRO Move With Clarity and Speed Every week counts. I bring structure, decision frameworks, and momentum so your team stays on track. Build plans aligned to go/no-go moments, not busywork Drive regular check-ins that produce clear, actionable updates Anticipate delays and adapt quickly with contingency-ready paths " Yamina brings scientific clarity, leadership, and precision execution to complex pharmacological programs. I’ve worked with her on several discovery programs; in fragmented programs, she brought clarity and decision points that produced much better candidate progression. I am always delighted to work with Yamina as it always leads to an overall better and harmonious discovery program." - Terry Kenakin, PhD - UNC Chappel Hill Frequently Asked Questions 01 How quickly can you get started? I begin with a 30-minute call to understand your goals. From there, I deliver a roadmap or assessment within 1–2 weeks. 02 Do you only work post-investment? No—many VCs engage me before investing to assess targets, pressure-test science, or evaluate CRO readiness. 03 What if we already have a team? Perfect. I plug in as a strategic partner—complementing internal talent to bring execution clarity and scientific rigor. Let's turn complexity into confidence—with the data you need to move forward. Chat about My Discovery Send me a message First name* Last name Company name* Email* How Can I Help?* Send Message or Book My Call Menu Home Services About Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

Join the Dr. GPCR Affiliate Program and earn commissions by helping connect the global GPCR community. Share our ecosystem, courses, and events to advance drug discovery together. Dr. GPCR Affiliate Program Earn by Empowering the GPCR Ecosystem Help us connect scientists, founders, and innovators while earning commissions for every member, partner, or course you bring into the Dr. GPCR community. Become our Brand Ambassador Our vision is to build the best platform for the GPCR community and help you the scientists and business owners to share their experiences with others, get help, and find the perfect tools, colleagues, build their strategy and advance our field. As an ambassador, with the Affiliate Program, you'll earn a commission whenever your referral link is used and a qualified purchase has been made by your friends, colleagues, or followers who are also part of the GPCR field. Become our Brand Ambassador About Dr. GPCR Ecosystem We aspire to provide opportunities to connect, grow, and thrive together as a dynamic group. The goal is to better understand and exploit the druggability of GPCRs, together. The Dr. GPCR Ecosystem members have the opportunity to solve problems, find answers to their questions, identify the perfect service provider, and, most importantly, boost their GPCR project with just a few clicks. The Ecosystem is designed for all GPCR professionals to have an affordable and highly effective way to showcase their knowledge, connect, and advance the field, together. About the Dr. GPCR brand ambassador affiliate program Who can be a Dr. GPCR ambassador? Scientists and trainees with a strong GPCR background who like and want to create content by writing articles about their favorite GPCR topics and sharing these on social media platforms such as LinkedIn and other options listed at the end of this page. Who is eligible for the Dr. GPCR affiliate program? A GPCR background is mandatory independent of your current position and industry. You also must be an individual Dr. GPCR Ecosystem membership holder. For full details on eligibility, please read our Affiliate Policy . How do I apply for the affiliate program? To become an affiliate, you must create an account here . How does the Dr. GPCR affiliate program work? After becoming a member of the affiliate program, you'll get your personalized link where you can send your potential clients. After every qualified sale, you will earn a commission of $50. How does the commission work? Each qualifying sale earns a commission (excluding sale cancellations). Does it cost me anything to become an affiliate? The program is free to join; there are no monthly charges and no minimum sales requirements. However, the number of ambassador members is limited. Dr. GPCR reserves the right to remove the least active members from the program. Can I invite someone to participate? Yes! You can invite anyone to participate, and we welcome anyone if they are qualified. Do I need to sign a contract? There's no contract to sign when joining our program. You will be required to agree to our Terms and Conditions and our Affiliates Policy when you sign up on Ecosystem.DrGPCR.com. You can leave the program at any time by contacting us. Dr. GPCR may also remove affiliates from the program at any time. Is there an exclusivity agreement when joining? There's no exclusivity agreement. You can take part in other affiliate programs as well as be part of ours. Are affiliates outside of the U.S. eligible for the Affiliate Program? Yes, you may join the affiliate program as long as you have a verified PayPal account. What type of channels, tools, and techniques can I use to promote Dr. GPCR Ecosystem? OK to use: - Writing, blogging, guest blogging, - Podcast, video, vlog - Social media sharing, - YouTube & TikTok channels, - Business Page and website, - Informational and fan sharing, - Presentations and meetups. Not OK to use: Advertising Spam Anything misleading or annoying Social media bios Paying or offering intensives for the use of your link How do I track my earning? We use a third-party provider, GoAffPro.com , where you'll create your own account and through your dashboard, you can track all your activities. When will I receive my affiliate commissions? Affiliate payments are processed and sent directly to your PayPal in 7 to 30 days. We could hold payments up to 30 days to allow for processing, chargebacks, etc. Good Faith We introduce programs such as the Dr. GPCR Ambassador, in good faith and expect the same good faith in return. Please note that we may withhold awards where we believe customers are acting in bad faith or otherwise acting contrary to the intent of this program. To be clear, commercializing, advertising, publishing, mass distributing, selling, or paying for the use of referral links is not appropriate, and we will not honor such links. We cannot cover every nefarious scenario, nor will we attempt to, but we do promise to be fair and reasonable. Closure We are so excited about the Dr. GPCR Ambassador program. It will be a remarkable journey and fun to build together the "next-generation" platform for the B2B industry. With your help, we can create a world where the living experience is joyful and worry-free. Are you ready? Sign up , explore, and connect with us. Become our Brand Ambassador

Turn GPCR discovery chaos into clarity—Yamina’s Corner offers expert GPCR strategy, CRO guidance, and tailored scientific support to accelerate your pipeline. Home About News Get in Touch Welcome Turn GPCR Chaos Into Insights Expert strategic and scientific consultancy to accelerate your pipeline Book My Consultation Critical Bottlenecks in Your GPCR Pipeline ❌ Overwhelming pharmacology Data ❌ Suboptimal CRO Partnerships ❌ Stalled Pipeline Progression ❌ Uncertainty in GPCR Investments Advisory Focus Areas Expert support for Biotech innovators, VC investors and CRO partners Biotech Pipeline Acceleration For Biotech Leaders & Scientists Actionable Data Insights: Translate complex GPCR pharmacology into clear decisions for lead optimization and candidate selection. Accelerated Program Progression: Design robust assay cascades and establish key go/no-go points to speed up your pipeline. Optimized CRO Collaboration: Streamline internal R&D and external CRO workflows to prevent delays and ensure preclinical success. Fuel Discovery VC Due Diligence & De-risking For Venture Capital Firms De-risk GPCR Investments: Identify critical scientific red flags and technical gaps in GPCR assets before committing capital. Actionable Scientific Validation: Ensure target companies execute the right GPCR pharmacology experiments to generate robust, decision-making data. Clear Platform Assessment: Gain rapid, independent insight into GPCR platform risks and true therapeutic potential to inform investment strategy. Fast-Track Discovery CRO Partnership & Optimization For Contract Research Organizations Elevate Scientific Offerings: Refine and optimize your GPCR assay platforms and in vitro models to deliver superior data quality and results. Enhance Client Project Delivery: Streamline workflows and improve scientific execution to increase client satisfaction and secure repeat business. Differentiate Your Market Position: Showcase your specialized GPCR expertise to stand out from competitors and attract high-value biotech and pharma partners. Power Discovery How We Work: Your Path to GPCR Success 1 Initial Strategic Alignment We begin with a focused discussion of your current GPCR program and critical challenges, identifying precise areas for collaboration. 2 Define Actionable Objectives Together, we clarify specific, measurable goals, from target validation and assay development to CRO selection or portfolio strategy, ensuring a tailored approach. 3 Collaborative Execution & Impact I integrate directly into your discovery process to remove roadblocks, enhance execution, and generate actionable scientific data, driving confident decisions and sustained preclinical progress. Advance My Discovery My Approach: Precision Guidance for GPCR Programs I provide the focused, scientific expertise that accelerates complex GPCR discovery programs, ensuring clarity and de-risking your path from target to candidate. I integrate seamlessly with biotech, VC, and CRO teams as a trusted, objective partner. Integrated Strategic Partnership We collaborate directly with your scientific and leadership teams. This partnership prevents bottlenecks and optimizes resource allocation, ensuring every strategic decision efficiently propels your program forward and aligns with critical business objectives. Biology-First, Data-Driven Solutions Every recommendation is rooted in GPCR biology, pharmacology experience. This provides evidence-based strategies leveraging deep GPCR expertise to overcome specific scientific challenges and maximize your program's potential. Accelerated Preclinical Progression I streamline critical operational processes, from advanced assay design and CRO management to rapid go/no-go decision-making. This focused execution accelerates preclinical milestones and maximizes the efficiency and return on your R&D investment. Core Values: The Foundation of Every Successful Partnership My advisory is built on principles that ensure clarity, minimize risk, and drive enduring results in GPCR drug discovery. Scientific Integrity Every recommendation is rigorously evidence-based, not reliant on assumptions. This ensures robust, defensible decisions that de-risk your program from early discovery to regulatory milestones. Operational Discipline I instill structure and consistency across every phase of your discovery process. This approach eliminates inefficiencies and standardizes workflows, accelerating your path to a preclinical candidate. Collaborative Partnership I operate as an embedded, invested partner with your team. Your program's success is my priority, fostering a transparent, results-driven environment that maximizes collective expertise and accelerates progress. About Yamina A. Berchiche I'm Yamina A. Berchiche, and I understand the intricate challenges of GPCR drug discovery. Small missteps can derail entire programs: underperforming assays, off-track CROs, and data that fails to drive decisions. That's precisely where my expertise becomes your strategic advantage. With over two decades dedicated to GPCR pharmacology across biotech, academia, and the non-profit sector, I bring unparalleled scientific depth and operational precision to every project. My work focuses on integrating directly with your team as a strategic partner. Whether it's optimizing CRO selection, building robust internal capabilities, or translating complex data into decisive program advancements, I help you eliminate friction, align efforts, and accelerate your path to success. As the founder of Dr. GPCR, I also offer a unique, broad perspective and trusted relationships within the field. This allows me to connect you with critical insights and key collaborators, further accelerating your progress in GPCR drug discovery. Let's Talk Discovery What Partners Say Here’s what it’s like to work together — from people I’ve supported on both sides of the bench. Anne Marie Quinn, CEO Montana Molecular As a CRO, we were delivering high-quality data across complex biotech programs, but translating that data into aligned, timely decisions across stakeholders wasn’t always straightforward. After partnering with her, communication became clearer, deliverables were better defined, and collaboration across teams ran more smoothly. She helped streamline complex projects and made the CRO–client relationship more effective and productive. Terry Kenakin, PhD UNC Chappel Hill In complex pharmacological discovery programs, scientific ambiguity and fragmented execution can quietly erode progress. Yamina brings the clarity, rigor, and structured decision-making that keeps programs on track. Across multiple discovery efforts, she established clear decision gates and alignment across teams, materially strengthening candidate progression and prioritization. Her involvement consistently elevates both the scientific discipline and the quality of portfolio-level decisions. Murat Tunaboylu, CEO Antiverse Before engaging Yamina, our team faced hurdles navigating complex early discovery decisions. We had critical program choices ahead and needed clearer direction. Bringing her in marked a meaningful shift. We made confident progress on a pivotal program and gained clarity on our next strategic focus. Yamina was instrumental in unifying our scientific and operational teams, strengthening alignment and driving momentum across execution. Abishek Iyer, CEO Ashta Therapeutics Before working with Yamina, we had solid internal momentum but needed to better align our biology, assay priorities, and compound strategy into a cohesive, decision-driven plan. Her input helped us structure the screening funnel, define clear go/no-go criteria, and integrate ADME and mechanistic assays in a way that reflected both biological rationale and operational realities. She has been a true thought partner — not only on tactical execution, but on pressure-testing hypotheses, challenging assumptions, and maintaining disciplined forward progress. Book Book My 30 Minutes Strategy Call Menu Home Services About News Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

Discover CRO Bank Packages with Dr. GPCR Ecosystem. List your services and your brand on the world's first GPCR CRO Bank. Reach a targeted scientific audience and showcase your organization in the GPCR community. Be Discoverable When GPCR Teams Are Actively Evaluating Services and Tools The GPCR CRO Bank is designed to help service providers and tool companies get found, evaluated, and contacted — not just recognized. Companies present their services in a structured format so GPCR discovery teams can quickly identify relevant capabilities. Curated for quality Reach 1,400+ GPCR researchers Partner with us Today! Who the GPCR CRO Bank is For? Your structured home within the ecosystem The GPCR CRO Bank is a strong fit for companies that want to: Make their services or products easily discoverable within the GPCR ecosystem Present clear, structured product and service offerings in one trusted location Support inbound inquiries from teams actively evaluating CROs, platforms, or tools Use ecosystem visibility to support commercial conversations and decision-making If your primary goal is brand credibility and long-term recognition across high-traffic ecosystem pages, a Strategic Media Partnership may be a better fit. "Dr. GPCR is the world's largest nonprofit community focused on GPCRs. We are building the world's first CRO Service-focused GPCR bank. As a CRO partner, you'll gain trusted access to an engaged audience of biotech teams and drug discovery innovators — without having to fight for attention." Why Partner with Dr. GPCR? Featured across our nonprofit platform, trusted by thousands As a CRO partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. Reach Qualified Researchers Connect with scientists who are actively looking for tools like yours, without the noise of general platforms. Build Trust Develop content that speaks their language and establishes your credibility in the GPCR research community. Join a Curated Ecosystem Become part of a collaborative, curated ecosystem — not just another name on a crowded vendor list. What You Get as a CRO Partner? Built for discovery and evaluation These channels are used to support discovery and evaluation — helping teams understand what you offer and how to engage with you. Premium Licenses 10 Scientists Premium Accounts and 3 Non-Scientists Premium Accounts for your team. Custom Company Page Permanent company profile on the Dr. GPCR Ecosystem with your logo, branding, mission description, contact links, and key highlights. Featured Podcast Episode Be the guest on a dedicated Dr. GPCR Podcast episode. Feature up to 3 team members. Distributed across podcast platforms and social media. Blog Contributions Contribute to blog posts as a valued partner. Share insights on product launches, scientific discoveries, or customer stories. Product or Service Pages Individual pages for each product or service. Educate researchers and showcase technical value. Provide downloadable resources or use cases. Newsletter Visibility Featured in our highly read weekly newsletter. Tell your story with context, clarity, and purpose. Bonus: mentioned in podcast intros/outros. Social Media Promotion Engaging posts about your organization targeted to GPCR researchers and biotech professionals. Shared on LinkedIn and X (Twitter). Co-Branded Events & Training Collaborate on webinars and virtual training sessions to showcase your expertise and engage directly with the GPCR research community. Previous Partners Join these leading organizations Join these leading organizations in the GPCR research ecosystem. Book Ready to share your CRO company with the GPCR world? Book a 30-minute Strategy Call with Yamina to explore whether your capabilities fit within the GPCR CRO Bank.

< Back Fresh, Fresh, GPCR News ❇ Feb 17 - 23, 2025 Hi friends! Welcome to our weekly update! This week's GPCR roll-up includes the latest insights, research discoveries, and advancements. We'll also preview upcoming courses designed for both experienced researchers and newcomers. 🚀 Develop New GPCR Skills Join Dr. Terry Kenakin’s unique course, Development of GPCR Ligands as Therapeutic Drugs , and gain essential insights into: 🔹 Drug Development Basics – PK-PD insights, absorption, and drug properties 🔹 Clearance & Metabolism – Distribution, renal/hepatic pathways, and elimination 🔹 Safety First – Identifying toxicity risks and drug-drug interactions ⏳ Availability is limited. Register now and shape the future of drug discovery! Premium Members enjoy a 25% discount Secure Your Spot Today! Tune in to Ep.160 of the Dr. GPCR Podcast 🎧 Join Remi Janicot as he shares his educational journey, passion for basketball and science, and career decisions. He discusses biased signaling in GPCR research, developing biosensors for G protein activity, networking, mentorship, PhD resilience, COVID-19 challenges, and his aspiration to transition into biotechnology investment opportunities. Highlights of the week Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity Zhangsong Wu , Chen Qiu , Geng Chen , et al. Single-Molecule Insights into GPCR Conformational Landscapes Rajan Lamichhane Discovery of CCR8 Antagonist IDOR-1136-5177 for the Treatment of Cancer Stefan Diethelm , Luboš Remeň , Olivier Corminboeuf , et al. Classified GPCR News Let’s dive into the Classified GPCR News from February 17th to 23rd, 2025 Industry News Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist Revolutionizing Protein-Ligand Simulations: OpenMMDL's Open-Source Approach The Rapid Push into Radiopharmaceuticals in Oncology and What’s Next Call for GPCR Papers Special Issue on Adhesion GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite - Online March 17 - 21, 2025 | 2nd GPCR signaling and drug discovery Symposium & Workshop - Brazil NEW April 1 - 3, 2025 | 2nd Peptide-Based Therapeutics Summit - USA April 2 - 3, 2025 | New therapeutic modalities: Transforming receptor pharmacology - UK April 3 - 6, 2025 | ASPET 2025 - USA NEW April 14 - 17, 2025 | 20th Drug Discovery Chemistry 2025 - USA April 24 - 27, 2025 | American Physiology Summit 2025 - USA April 25 - 30, 2025 | AACR Annual Meeting 2025 - USA NEW May 1 - 2, 2025 | 5th Ace Drug Discovery Summit 2025 - USA NEW May 12 - 15, 2025 | ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025 - USA May 12 - 15, 2025 | PEGS 2025 - USA May 15 - 17, 2025 | 23rd GPCR Retreat 2025 - USA May 20 - 22, 2025 | SLAS Europe 2025 - Germany May 20 - 22, 2025 |4th GPCRs-Targeted Drug Discovery Summit - USA June 22 - 26, 2025 | G Protein-coupled Receptor Kinases and Arrestins - USA December 16 - 18, 2025 |Pharmacology 2025 - UK July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology - Australia GPCR Jobs NEW Open Postdoctoral position - Stanford University Structural Biologist - Confo Therapeutics Associate Director/Director, Platform & Hit-ID Chemistry Lead - Septerna Junior associate position and a PhD/post-doc level position - Eli Lilly and Company Postdoctoral Posit ion And PhD Position - Autonomous University of Barcelona GPCR Molecular Pharmacologist - Schrödinger Scientist - Biology - Superluminal Medicines Scientist I Cell Biology - Tectonic Therapeutic Adhesion GPCRs A force-sensitive adhesion GPCR is required for equilibrioception GPCR Activation and Signaling Extensive location bias of the GPCR-dependent translatome via site-selective activation of mTOR Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin Diapause hormone receptor affects larval growth and embryonic development in the multivoltine strain of Bombyx more Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe GPCRs in Cardiology, Endocrinology, and Taste Immunolocalization and quantification of the phoenixin and GPR173 in the gastrointestinal tract of Holstein-Friesian bulls Derivation of hiPSC line (ICADRB2i007-A-3) from an individual with osteoporosis linked to ADRB2: c.46G > A GPCRs in Neuroscience Cortical astrocyte activation triggers meningeal nociception and migraine-like pain GPCRs in Oncology and Immunology Spatial analysis of a complete DIPG-infiltrated brainstem reveals novel ligand-receptor mediators of tumour-to-TME crosstalk Discovery of CCR8 Antagonist IDOR-1136-5177 for the Treatment of Cancer The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts Methods & Updates in GPCR Research Histamine-modulated wettability switching in G-protein-coupled receptor inspired nanochannel for potential drug screening and biosensing Reviews, GPCRs, and more Single-Molecule Insights into GPCR Conformational Landscapes Covalent functionalization of G protein-coupled receptors by small molecular probes A deadly taste: linking bitter taste receptors and apoptosis Molecular roles in membrane receptor signaling pathways and cascade reactions in chondrocytes: a review Is GCR1 the GPR157 of plants? Structural and Molecular Insights into GPCR Function Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor 🔎 GPCR KEYWORDS GPCR , structural biology , biased signaling , metabolism , Chondrocytes , Signaling pathway , Integrin , Taste family 2 receptors , Calcium , Cell death , Mitochondria , macrolide antibiotics , motilin receptor , azithromycin , Extraoral taste receptors . < Previous Next >

< Back Your GPCR Order Has Arrived! ❇ Feb 10 - 16, 2025 🚀 GPCR Pals, Get Ready to Elevate Your Expertise! Welcome back to your exclusive GPCR Weekly Newsletter! We’re thrilled to unveil our ever-expanding course roster—designed to help you stay at the cutting edge of GPCR research. New topics, expert-led sessions, and hands-on learning opportunities await! 🎓 Kicking Off Today: Dr. Terry Kenakin ’s hands-on workshop, The Practical Assessment of Signaling Bias . Didn’t sign up? Don’t worry— registrations are NOW OPEN for the 2025 Dr.GPCR University Courses! This is your chance to learn directly from our world-renowned experts. Come back regularly as we are adding courses each month. Email us if you'd like to teach or if you'd like to learn more about any particular topic. 🗓️ Upcoming 4-Week Course: Development of GPCR Ligands as Therapeutic Drugs starting March 20 – April 10, 2025 (Thursdays, 10:00 AM–12:00 PM EST). Watch Dr. Kenakin as he introduces the key concepts of this brand-new course. During these four sessions, you'll dive into: Advanced pharmacokinetic modeling The Druglike Quality of Chemical Entities Drug Absorption 💡 Looking for workshops? We’ve got you covered! ✅ Practical Quantification of Allosteric Modulation – May 1, 2025 ✅ Applying the Black/Leff Operational Model to Predict Agonism – October 2, 2025 Premium Members save 25% on enrollment. Reserve Your Spot Now! 🔗 Register Today . 🔥 Act Fast – Only 25 Spots Available! ⚡ Don’t miss out! Premium Members save 25% on enrollment! Secure your spot today! Highlights of the Week How Ligands Achieve Biased Signaling toward Arrestins Stéphanie Gaillard , Neha Verma , Leisha A Emens , et. al. A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam Zech , Victoria Most , René Staritzbichler , et. al. A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Qin Wang , Wenwen Hao , Jing Li , et. al. Classified GPCR News Let’s dive into the Classified GPCR News from February 10th to 16th, 2025 Industry News Pain targets in ion channel pathways: an Innovation Distillery spotlight ‘It’s not for the faint of heart.’ How 3 CEOs took their biotechs public Aikium's AI-Driven mRNA Engine Looks to Address Undruggable Disordered Proteins Tectonic Therapeutic Secures Massive $185M PIPE Financing for Clinical Programs Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist Call for GPCR Papers NEW Special Issue on Adhesion GPCRs GPCR Events, Meetings, and Webinars March 19, 2025 | Advancing obesity drug discovery: Cell-based assays for GLP-1 and the G-Suite March 17 - 21, 2025 | 2nd GPCR signaling and drug discovery Symposium & Workshop NEW April 2 - 3, 2025 | New therapeutic modalities: Transforming receptor pharmacology April 3 - 6, 2025 | ASPET 2025 April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 15 - 17, 2025 | 23rd GPCR Retreat 2025 May 20 - 22, 2025 | SLAS Europe 2025 NEW May 20 - 22, 2025 |4th GPCRs-Targeted Drug Discovery Summit June 22 - 26, 2025 | G Protein-coupled Receptor Kinases and Arrestins NEW December 16 - 18, 2025 |Pharmacology 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Structural Biologist Associate Director/Director, Platform & Hit-ID Chemistry Lead Junior associate position and a PhD/post-doc level position Postdoctoral Position And PhD Position GPCR Molecular Pharmacologist Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing GPCR Activation and Signaling Lineage-Specific Class-A GPCR Dynamics Reflect Diverse Chemosensory Adaptations in Lophotrochozoa β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice fermentation extract A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C GPCRs in Cardiology, Endocrinology, and Taste N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation GPR180 Reduces Adiposity by Inhibiting Lipogenesis and Fatty Acid Uptake in Adipocytes Derivation of hiPSC line (ICADRB2i007-A-3) from an individual with osteoporosis linked to ADRB2: c.46G > A GPCRs in Neuroscience Effects of chemogenetic virus injection and clozapine administration in spinal cord injury GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption Reviews, GPCRs, and more How Ligands Achieve Biased Signaling toward Arrestins Structural and Molecular Insights into GPCR Function A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate 🔎 GPCR KEYWORDS Class-A G protein-coupled receptors , Lophotrochozoa , echinoderms , Arrestins , ILK , directional migration , epidermis , keratinocytes , scaffold proteins , β-arrestin , Hippo pathway , IMFRE gels , Regenerative healing , Skin repair , Wound healing , A2B adenosine receptor , Calcium , G protein , GPCR , Gi , Gq , Gs , N-homocysteinylation , Adiposity , Fatty Acid Uptake , Lipogenesis , Induced pluripotent stem cells , Osteoporosis , Reprogramming , AAV5-hSyn-hM3Dq-eYFP , Clozapine , DREADDs , Gq signaling pathway , Neuroregeneration , EPSC , GLT-1 , GPR37L1 , SPM , astrocytes , maresin 1 , microglia , nerve injury , neuropathic pain , spinal cord dorsal horn , OPN3 , cAMP signalin g , MC4R , docking , opioid , peptide ligand design , protein design , Ca2+ oscillation , GPCRs , basal activity , purinergic receptor , substrate stiffness < Previous Next >

Discover top GPCR Courses for your educational journey. Explore a curated list of GPCR Courses to enhance your knowledge and career. Stay at the Forefront of GPCR Drug Discovery Gain insider methods from the pioneers shaping biased signaling, assay design, and pharmacology—skills you won't find in any textbook or paper. ⧖ 20+ Hours of Expert Training ↓ Downloadable Resources ◕ New Courses added Quarterly Get Access to GPCR Courses Learn in 3 Simple Steps Free trailers coming soon Preview every masterclass before joining Unlock full access Get Premium for complete library access Learn anytime, anywhere Access on-demand from any device Join Premium Today Unlock Insider Access to GPCR Science! Free updates, exclusive previews, and highlights from our Masterclasses and Vault. First name Last name Email* Join Our Mailing List Count me in! * Explore the Masterclasses Trailers are free. Full classes require Premium. Filter by Category Filter by Level Filter by Instructor Watch Now INSTRUCTOR Heading 5 I'm a paragraph. Click here to add your own text and edit me. It's easy. Read More INSTRUCTOR Heading 5 I'm a paragraph. Click here to add your own text and edit me. It's easy. Read More INSTRUCTOR Heading 5 I'm a paragraph. Click here to add your own text and edit me. It's easy. 1 2 3 4 5 1 ... 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 ... 100 Learn directly from world leaders in GPCR research Access exclusive training from the scientists shaping the future of GPCR drug discovery Dr. Terry Kenakin Terry's Corner Author of 'A Pharmacology Primer', the definitive GPCR reference used by labs worldwide. Former GSK principal research investigator with 40+ years of industry experience. Dr. Sam Hoare Pharmechanics GPCR signaling & biased agonism expert regularly consulted by top pharma companies for assay design strategies. Pioneer in quantitative pharmacology methods. Dr. Yamina Berchiche Dr. GPCR Community builder for scientists with expertise in GPCR project strategy and translational applications. Unlock All 20+ GPCR Masterclasses – Save 95% Individual courses cost $300–600 each. With Premium, you get everything for just $249.99/year (less than $1/day). 20+ Hours of GPCR Masterclasses Downloadable Resources & Q&A Replays Weekly GPCR Insights (papers, jobs, events) Networking with a global scientist community One failed assay can cost $10,000+ in reagents and months of time. Think of Premium as insurance against wasted experiments and failed drug leads. Best Value Premium Yearly $249.99 $ 249.99 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Now 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. What Scientists Are Saying Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere Anonymous Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field Anonymous The content had enough depth to satisfy the hunger for theory while being full of practical knowledge Anonymous The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology Anonymous Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him Anonymous Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. Anonymous What are the benefits of becoming a member of Dr.GPCR? As a member, you can access: Dr.GPCR Podcast videos Live GPCR events Weekly classified GPCR news Contributor articles As a premium member, you can access all the free features plus: GPCR courses with a 25% discount Private groups 30+ Symposia recorded talks GPCR Job listings GPCR Event listings Direct access to members of the GPCR community How do I sign up for a membership? To sign up, click the 'Log In/Sign Up' button at the top of the homepage and fill out the registration form. Once your registration is complete, you will receive a confirmation email. Why do I need to fill out a form and wait for approval? We carefully screen anyone signing up to the Ecosystem to ensure they are real humans working on GPCRs. We want to keep our community exclusive to the field, so we need as much information as possible to verify your identity. How long will the Sign-Up process take? We could take up to two (2) business days. I’m just a student starting in the field. Can I sign up to the Ecosystem? Yes, everyone interested in the field is welcome to join. Please let us know about this while filling out the registration form. Why are personnel from US governmental agencies excluded from the free membership? Employees of any branch or department within the US government are not eligible for the free membership. Verification methods can vary but might require a work email address, an official ID, or other employment documentation during the sign-up process to confirm whether the individual is employed by a US governmental agency. If there's any uncertainty about eligibility, the best action is to contact us at hello@drgpcr.com. How much does the premium membership cost? The premium membership is priced at $249.99 per year. We have a 90% discount for people who live and work in developing countries and a 15% discount for team memberships, a minimum of 5 seats. You can also access a 25% discount on our Dr.GPCR University courses as a premium member. Can I upgrade from a standard membership to a premium membership? Yes, you can upgrade at any time. Log into your account, go to the Pricing section, and select the option you’d like to choose. Your premium benefits will be activated immediately. Is there a free trial for the premium membership? Yes, we offer a 30-day free trial for new premium members. You can sign up for the trial on the premium membership page. If you choose not to continue, you can cancel anytime before the trial ends without being charged. How do I cancel my membership? You can cancel your membership by following these steps: Go to My Account. Select the tab My Subscriptions. Select the membership you want to cancel and click Cancel Subscription. If you are a premium member, your access will remain active until the end of the current billing cycle. Will my membership renew automatically? If you choose the yearly payment option, your membership will renew automatically to ensure uninterrupted access. What should I do if I forget my password? Click on the 'Forgot Password' link on the login page, and follow the instructions to reset your password. You will receive an email with a link to create a new password. Who can I contact for more help with my membership? If you need further assistance, please email our support team at hello@drgpcr.com. We are here to help! The GPCR Field Is Advancing Fast – Don't Fall Behind Stay ahead in drug discovery with insights from the world's top GPCR experts. Get Access Today!

The Practical Assessment of Signaling Bias Dr. Terry Kenakin < Back Workshop Summary Join Dr. Terry Kenakin , a leading expert in pharmacology, as he unpacks the fascinating world of signaling bias in drug development! 🚀 This workshop will explore how different ligands (compounds) can stabilize unique receptor conformations, leading to distinct signaling outcomes—even when binding to the same receptor. Dr. Kenakin will explain that bias is not an exception but a fundamental principle of pharmacology, occurring whether or not researchers actively seek it. Through an engaging discussion, you'll explore: 🔹 What signaling bias is and why it matters 🔹 How receptor dynamics shape drug responses 🔹 Cutting-edge methods for quantifying bias 📊 🔹 Strategies to harness bias for better drug design —maximizing efficacy while minimizing side effects The session wraps up with a lively Q&A , allowing attendees to explore this game-changing topic in greater depth. Don't miss this opportunity to refine your understanding of bias as a tool, not an obstacle, in pharmacology! Key Highlights 🔍 Bias is Everywhere : Signaling bias naturally occurs in pharmacology—whether we look for it or not! 🧬 Receptor Flexibility : Ligands stabilize different receptor states, creating unique signaling pathways. 📏 Measuring Bias : New techniques allow us to quantify bias and compare drug efficacy more precisely. 💊 Therapeutic Potential : Understanding bias enables researchers to design drugs that target specific effects while avoiding unwanted side effects. 🗣️ Interactive Q&A : The discussion wraps up with an insightful Q&A, tackling real-world drug development challenges. Deep Dives & Insights 📌 Bias is Not an Anomaly—It’s a Feature! 🔹 Instead of avoiding bias, researchers can embrace it to refine drug responses. Dr. Kenakin challenges the traditional approach and encourages leveraging bias for better therapeutic outcomes. 📌 Receptors are Dynamic Players 🔹 Different ligands trigger unique receptor states, meaning the same receptor can signal in entirely different ways depending on what binds to it. Understanding these shifts can revolutionize drug development! 📌 Measuring Bias: A Quantitative Approach 🔹 The operational model provides a structured way to measure bias, combining affinity and efficacy. This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌 Bridging the Gap: Lab to Clinic 🔹 While measuring bias in a lab is relatively straightforward, translating these findings to clinical applications remains a challenge . The talk explores how to navigate this crucial gap. 📌 The Future of Drug Development 🚀 🔹 By integrating bias into drug design , researchers can craft more selective, effective, and safer therapies. This approach is shaping the next generation of precision medicine! Dr. Terry Kenakin’s workshop offers a fresh perspective on drug discovery . It shows that bias isn’t something to avoid—it’s something to utilize ! Whether you're a researcher, student, or industry professional, this session is packed with insights that will make you rethink your approach to pharmacology . Ready to explore the future of biased drug design? Let’s dive in! 🔬✨ AI Summary - May contain inaccuracies Materials: BIAS_WORKSHOP_PRINT .pdf Download PDF • 9.11MB BIAS_EXERCISE .pdf Download PDF • 721KB What would you like to learn today?

Awkward... This page isn’t available. Go Home

Awkward... This page isn’t available. Go Home

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back