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Mark your calendar for September and October 2024. Dr. Maria Waldhoer, JoAnn Trejo, and Anne Marie Quinn. Did you watch Episode #150 of the Dr. GPCR Matchmaking Mark Schmeizl, our Chief Matchmaker, can help you find your perfect match if you want Contact Mark today to get started. Dr. 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS

Our CSO, Maria, has recently traveled to the US to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers The venue was the UIC Student Center East, and Chicago is a great choice for a city, Maria found it very Wednesday was a key day for Maria, as she got to participate in a panel discussion alongside Dr. Maria alongside the other panelists during Wednesday's panel discussion. Session 8 on Thursday was Maria’s turn to give a talk.

“The beauty of multiplexing is that you can do many things with one pot of samples.” — Tom Sakmar Enter

Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis In this study, these results may provide a better understanding on the evolution of GPCRs, and expand

Learning the Lab, Learning Herself During her time at the contract research organization (CRO) in Ann I had a few friends who became addicted and, really sadly, many of whom actually passed away as a result

CNS disorders Predicting biological activity and design of 5-HT6 antagonists through assessment of ANN-QSAR

include chronic cough, in addition to the rights to develop certain retained compounds for Charcot-Marie-Tooth

efficacious in multiple neuroinflammatory disease models Discovery of a potent melatonin-based inhibitor of quinone

Let’s dive into the Classified GPCR News from May 27th to June 2nd, 2024. and neurotransmitter release GPCRs in Oncology and Immunology Neurotoxicity and accumulation of CPPD quinone

Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one

It’s about finding purpose through loss, choosing academia when many peers walk away, and designing science Like many young scientists, she explored different paths and gained industry experience before realizing Why Catherine Chose Academia At a time when many early-career scientists debate whether to stay in academia

In This Session, You’ll Gain: ✅ The ability to calculate how many replicates you really  need for 95% How Many Replicates Do You Really Need? The second trap is habit. Instead, you’ll calculate exactly how many replicates are needed to detect the differences that matter

Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting

Recently, AlphaFold2 has been developed to predict structure models of many functionally important proteins However, the predicted models and experimental structures were different in many aspects including the

Computational Biochemistry at Uppsala University and one of the strongest advocates for an approach that too many Closing the Trust Gap If collaboration is so effective, why do so many labs avoid it? Many startups chase elaborate simulations that look impressive on paper but do little to move drug discovery Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short

Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold Maria Majellaro Maria’s career didn’t start with a desire to launch a company. It began in Bari, Italy, with a love for science nurtured by her father and fueled by childhood cartoons The academic group Maria worked with had developed a technology that allowed for flexible, fast synthesis

Results show that for each of the 21 structures with bound ligands there exist many other GPCRs that These sites cluster at nine distinct locations, and each can be found in many different proteins.

Many such biosensors are based on the principle of Förster resonance energy transfer (FRET), and we have This methodology would be compatible with other mammalian species and with many biosensors.

splicing events account for hundreds, if not thousands, of potentially divergent isoforms throughout many This might not be a big deal for many, but in this new era of making sure that historically excluded Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds its way on many However, Reggaetón is a highly dynamic genre that attracts many here in Mexico, not to forget salsa music

👥We have many surprises in reserve for you at the next Dr.

The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs. However, thermal instability of the biosensor may pose a problem for in vivo studies.

April 2022 John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to treat pain without the negative side effects "Many people are familiar with cannabis, but John These compounds may be a novel way to treat pain without the negative side effects of cannabinoids or

“Choosing one specific receptor is difficult… they’re unique because they can bind many different molecules

Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling We hypothesized that somatic mutations in tumor samples may not be enriched within a single gene but rather that cognate mutations with similar effects on GPCR function are distributed across many receptors

G-protein-coupled receptors-an expansive class of transmembrane signaling proteins that participate in many

However, many studies over the past decade have reported that internalized membrane receptors can trigger

the importance of members of the GPCR superfamily as targets of a broad range of effective medicines many Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation

Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many

like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many

Although many cardiovascular GPCRs have been extensively studied as model receptors for decades, new We also discuss how advancing technologies to discover nanobodies with tailored specificities may expand