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- 📰 GPCR Weekly News, May 6 to 12, 2024
Mark your calendar for September and October 2024. Dr. Maria Waldhoer, JoAnn Trejo, and Anne Marie Quinn. Did you watch Episode #150 of the Dr. GPCR Matchmaking Mark Schmeizl, our Chief Matchmaker, can help you find your perfect match if you want Contact Mark today to get started. Dr. 13 - 17, 2024 | 20th Annual PEGS Boston Summit May 16 - 19, 2024 | ASPET 2024 May 27 - 29, 2024 | SLAS
- Maria’s Travel Blogs: ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025
Our CSO, Maria, has recently traveled to the US to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers The venue was the UIC Student Center East, and Chicago is a great choice for a city, Maria found it very Wednesday was a key day for Maria, as she got to participate in a panel discussion alongside Dr. Maria alongside the other panelists during Wednesday's panel discussion. Session 8 on Thursday was Maria’s turn to give a talk.
- From One to Many: How a GPCR Curiosity Became a Field-Wide Toolkit
“The beauty of multiplexing is that you can do many things with one pot of samples.” — Tom Sakmar Enter
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea Here, we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis In this study, these results may provide a better understanding on the evolution of GPCRs, and expand
- Understanding the Journey: Catherine Demery's Path to Addiction Science
Learning the Lab, Learning Herself During her time at the contract research organization (CRO) in Ann I had a few friends who became addicted and, really sadly, many of whom actually passed away as a result
- GPCR Buzz of the Week | Sep 23 - 29, 2024
CNS disorders Predicting biological activity and design of 5-HT6 antagonists through assessment of ANN-QSAR
- Addex and Indivior Extend GABAB Positive Allosteric Modulator Research Collaboration for...
include chronic cough, in addition to the rights to develop certain retained compounds for Charcot-Marie-Tooth
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
efficacious in multiple neuroinflammatory disease models Discovery of a potent melatonin-based inhibitor of quinone
- 📰 GPCR Weekly News, May 27 to June 2, 2024
Let’s dive into the Classified GPCR News from May 27th to June 2nd, 2024. and neurotransmitter release GPCRs in Oncology and Immunology Neurotoxicity and accumulation of CPPD quinone
- From Multiplex to Models: Scaling Up GPCR Discovery in the Post-Silo Era
Kotliar sums it up best: “We went from one receptor to many… and now, from many, we can go back to one
- Purpose-Driven Opioid Research: Catherine Demery’s Academic Path
It’s about finding purpose through loss, choosing academia when many peers walk away, and designing science Like many young scientists, she explored different paths and gained industry experience before realizing Why Catherine Chose Academia At a time when many early-career scientists debate whether to stay in academia
- Curve Shifts Don’t Lie, But Your Eyes Might
In This Session, You’ll Gain: ✅ The ability to calculate how many replicates you really need for 95% How Many Replicates Do You Really Need? The second trap is habit. Instead, you’ll calculate exactly how many replicates are needed to detect the differences that matter
- Neurotransmitters: Potential Targets in Glioblastoma
Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting
- AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
Recently, AlphaFold2 has been developed to predict structure models of many functionally important proteins However, the predicted models and experimental structures were different in many aspects including the
- GPCR Collaboration: From Models to Medicine
Computational Biochemistry at Uppsala University and one of the strongest advocates for an approach that too many Closing the Trust Gap If collaboration is so effective, why do so many labs avoid it? Many startups chase elaborate simulations that look impressive on paper but do little to move drug discovery Structural biologists may capture snapshots of receptor conformations, but lack large-scale screening Overstating the precision of a model or the predictive power of an assay may look persuasive in the short
- From Lab Bench to Boardroom: The Unexpected Path of a Medicinal Chemist
Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold Maria Majellaro Maria’s career didn’t start with a desire to launch a company. It began in Bari, Italy, with a love for science nurtured by her father and fueled by childhood cartoons The academic group Maria worked with had developed a technology that allowed for flexible, fast synthesis
- Conservation of Allosteric Ligand Binding Sites in G-Protein Coupled Receptors
Results show that for each of the 21 structures with bound ligands there exist many other GPCRs that These sites cluster at nine distinct locations, and each can be found in many different proteins.
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Many such biosensors are based on the principle of Förster resonance energy transfer (FRET), and we have This methodology would be compatible with other mammalian species and with many biosensors.
- Adhesion GPCR Consortium Newsletter - May 2024
splicing events account for hundreds, if not thousands, of potentially divergent isoforms throughout many This might not be a big deal for many, but in this new era of making sure that historically excluded Pyramids: although it is very touristy, it is just a hop away from Mexico City and finds its way on many However, Reggaetón is a highly dynamic genre that attracts many here in Mexico, not to forget salsa music
- Dr. GPCR Summit 2022 is coming!
👥We have many surprises in reserve for you at the next Dr.
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
The second messenger cyclic adenosine monophosphate (cAMP) is a key mediator in many GPCR signaling pathways The GloSensor™ cAMP assay enables real-time monitoring of signaling downstream of many GPCRs. However, thermal instability of the biosensor may pose a problem for in vivo studies.
- John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to ...
April 2022 John Streicher talks about his work on terpenes found in cannabis as these may be a novel way to treat pain without the negative side effects "Many people are familiar with cannabis, but John These compounds may be a novel way to treat pain without the negative side effects of cannabinoids or
- From Venice to Virtual Molecules: Alessandro Nicoli’s Unexpected Journey into Computational Chemistry
“Choosing one specific receptor is difficult… they’re unique because they can bind many different molecules
- Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled ...
Because there are many more GPCRs than effectors, mutations in different receptors could perturb signaling We hypothesized that somatic mutations in tumor samples may not be enriched within a single gene but rather that cognate mutations with similar effects on GPCR function are distributed across many receptors
- Single-molecule counting applied to the study of GPCR oligomerization
G-protein-coupled receptors-an expansive class of transmembrane signaling proteins that participate in many
- Posttranslational modifications in GPCR internalization
However, many studies over the past decade have reported that internalized membrane receptors can trigger
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
the importance of members of the GPCR superfamily as targets of a broad range of effective medicines many Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation
- Location bias contributes to functionally selective responses of biased CXCR3 agonists
Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many
- Search for safer pain relief advances with new engineered compounds
like morphine and other drugs, provide relief via activation of opioid receptors, but without inducing many
- Nanobodies as Probes and Modulators of Cardiovascular G Protein-Coupled Receptors
Although many cardiovascular GPCRs have been extensively studied as model receptors for decades, new We also discuss how advancing technologies to discover nanobodies with tailored specificities may expand













