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September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte

Why there is no standalone amylin receptor Amylin, also known as islet amyloid polypeptide, is co-secreted No gene encodes a dedicated amylin receptor. agonists, dual amylin and calcitonin receptor agonists (DACRAs), and GLP-1/amylin co-agonists. That picture also has to extend beyond amylin alone. portfolio, from profiling to potency Once an amylin receptor line reports real amylin pharmacology instead

Here, we provide evidence that distal carboxyl-terminal tail (C-tail), but not proximal, phosphorylation site-directed mutagenesis and bioluminescence resonance energy transfer approaches that distal, not proximal, C-tail In addition, we show that GPCRs that have similarly positioned C-tail phosphoresidues are also able to However, although necessary for some GPCRs, we found that distal C-tail sites might not be sufficient In conclusion, this study provides evidence that distal C-tail phosphorylation sites specify GRK-βarrestin-mediated

Aylin Hanyaloglu About Dr. Aylin Hanyaloglu Dr. Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. Hanyaloglu undertook her postdoctoral training at the University of California, San Francisco with Professor Aylin Hanyaloglu on the web LinkedIn Researchgate Twitter Imperial College London Elsevier Loop Dr.

Aylin Hanyaloglu Dr. Aylin Hanyaloglu has been a Principal Investigator at Imperial College London since 2007. Hanyaloglu undertook her postdoctoral training at the University of California, San Francisco with Professor Aylin Hanyaloglu on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College

investigated regulatory mechanisms of GPCR action, namely dimerization and membrane trafficking, in Dr Aylin Hanyaloglu 's lab at Imperial College London. currently funded by a postdoctoral fellowship from Wellcome Trust, working on a collaborative project (Dr Hanyaloglu's