Aylin Hanyaloglu, Caroline Gorvin, and Alejandra Tomas.

Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling Abigail Walker, Aylin Hanyaloglu, et al., for their study on Constitutive internalisation of EP2 differentially regulates

Why there is no standalone amylin receptor Amylin, also known as islet amyloid polypeptide, is co-secreted No gene encodes a dedicated amylin receptor. agonists, dual amylin and calcitonin receptor agonists (DACRAs), and GLP-1/amylin co-agonists. That picture also has to extend beyond amylin alone. portfolio, from profiling to potency Once an amylin receptor line reports real amylin pharmacology instead

Meanwhile, incretin and amylin-based therapies are reshaping the obesity drug landscape. Eli Lilly’s next moves with Orforglipron and its amylin analog are highly anticipated.  

Sexton et al. for their job on Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP Molecular insights into G protein coupling specificity at a class A GPCR Cryo-EM Structure of the Human Amylin

excretion of harmful substances via ABCB1 in keratinocytes GPCRs in Neuroscience Ventral tegmental area amylin

and β-arrestins, paving the way for capturing challenging protein complexes (Böttke, T., et al. 2020, Aydin