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As Chief Matchmaker, I recently had the pleasure of speaking with Beth Fleck, Director of In Vitro Pharmacology Mark:  “Beth, why did you decide to join Crinetics?” Beth:  “Yes.  There are a lot of learning opportunities at Crinetics.  Mark:  “Beth, why would someone want you as their boss?” Beth:  “Well, I enjoy training and mentoring team members. 

Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology

Our Chief Matchmaker, Mark Schmeizl, had a great conversation about this position with Beth Fleck, Director

Marshall About this episode Fiona Marshall got fascinated with GPCRs after attending a lecture on how the beta-adrenergic receptor in the heart is activated by adrenaline, during her undergraduate studies at Bath University

biased agonism, with the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased signal transduction mechanisms of GPCRs, such as the formation of complexes between G proteins and beta-arrestins

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and proteins can act as allosteric modulators of D2R signaling and explores the potential usefulness of beta-arrestins