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Results found for "Brigitte Kieffer"
- Dr. Amynah Pradhan | Dr. GPCR Ecosystem
Brigitte Kieffer , where she studied ligand-directed signaling at the delta-opioid receptor. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send
- Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://buff.ly/42b6ra3 #gpcr #drgpcr | Dr. GPCR Ecosystem
a3ar-antagonism-mitigates-metabolic-dysfunction-associated-steatotic-liver-disease-by-exploiting-monocyte-derived-kupffer-cell-necroptosis-and-inflammation-resolution
- From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet | Dr. GPCR Ecosystem
Episode How Eric and his team reimagined rare earth complexes to develop pH-sensitive probes with tunable brightness It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send
- Exploring Career Paths in GPCR Research with Dr. Jacek Mokrosiński | Dr. GPCR Ecosystem
Schwartz, and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of Quick Recap Yamina and Jacek discussed their experiences with name mispronunciations, cultural differences Summary Embracing Cultural Differences and Collaboration Yamina and Jacek shared their experiences with name mispronunciations and variations and discussed the importance of embracing cultural differences It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send
- What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments! ✅ Tune in: https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast | Dr. GPCR Ecosystem
in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different
- “Research is all about knowing when to walk and when to run.” –Ben Clements In Ep. 166 of the Dr.GPCR Podcast, hear how a postdoc is reshaping the conversation on opioid use, imposter syndrome, and the power of collaborative science. Why early-career voices are critical in GPCR drug discovery —and how lab culture makes all the difference. 🎧 Watch here: https://buff.ly/Kr3qKud #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Why early-career voices are critical in GPCR drug discovery —and how lab culture makes all the difference Why early-career voices are critical in GPCR drug discovery —and how lab culture makes all the difference
- This new study reveals how the conformation of parathyroid hormone (PTH) and the C-terminal helix α5 of Gα regulate the selective coupling of PTH1R to Gs or Gq. Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration, and strength. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/allosteric-mechanism-in-the-distinctive-coupling-of-gq-and-gs-to-the-parathyroid-hormone-type-1-receptor #gpcr #drgpcr | Dr. GPCR Ecosystem
Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration Through Cryo-EM and single-cell experiments, the authors show differences in binding affinity, duration
- 🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! 🎙️ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast ✅ Tune in today! | Dr. GPCR Ecosystem
Home → Flash News → 🎧 Why Does GPCR Location Make All the Difference? GPCR Podcast 🎧 Why Does GPCR Location Make All the Difference?
- Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system
- Did you know that A2B adenosine receptor-triggered calcium mobilization varies by cell type? A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ signaling, revealing a more complex regulation than previously thought. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺ A recent study explores how Gi, Gq, Gs proteins, and PKC contribute differently to intracellular Ca²⁺
- GPCR activation is well-known to be a multi-step process. However, current molecular structures only capture the fully activated complex. Check out this paper to see how scientists combine different techniques to elucidate the intermediate GPCR-mini-Gαsβγ complex at 2.6 Å. Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structure-and-function-of-a-near-fully-activated-intermediate-gpcr-g%CE%B1%CE%B2%CE%B3-complex #gpcr #drgpcr | Dr. GPCR Ecosystem
Check out this paper to see how scientists combine different techniques to elucidate the intermediate Check out this paper to see how scientists combine different techniques to elucidate the intermediate
- Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking. 📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias. 🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides | Dr. GPCR Ecosystem
. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor CGRP receptor family, challenging the long-held assumption of redundancy. 🔬 A closer look reveals differences
