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<< Back to podcast list Strategic Partner(s) Chris Langmead Chris Langmead is Professor, Deputy Director Prior to joining Heptares, Chris was a neuroscience researcher at GlaxoSmithKline, UK (1998-2009). Chris serves on the editorial boards of the British Journal of Pharmacology, ACS Chemical Neuroscience

Chris Tate co-founded Heptares after reading one paper on a Friday afternoon. . << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology Chris Tate spent years working on membrane proteins that were simply too unstable to study by crystallography ABOUT THE GUEST Chris Tate is a group leader at the MRC Laboratory of Molecular Biology in Cambridge, Chris Tate obtained his Ph.D. from the University of Bristol in 1989 and then moved to the University

Timo De Groof About Dr. Timo De Groof Dr. Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in Timo De Groof on the web LinkedIn Researchgate Twitter Medical Imaging Group Google Scholar Dr.

Workshop 2024 , hosted in the vibrant heart of Mexico City at the prestigious venue, CINVESTAV - Centro de Investigación y de Estudios Avanzados del IPN (in English: Center for Research and Advanced Studies About the venue Cinvestav: Centro de investigación y de Estudios Avanzados del IPN Av.

Marshall walks through the decade when membrane proteins kept failing to crystallize in detergent, and how Chris Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal Chris Tate and Dr. Richard Henderson at the Laboratory of Molecular Biology in Cambridge, UK.

Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke Doctor of Philosophy (Ph.D.) in biochemistry under the supervision of Michel Bouvier at Université de

Bianca Plouffe obtained her B.Sc. in Biochemistry in 2003 from Université de Sherbrooke (Qc, Canada). In 2006, Bianca obtained a Doctoral Scholarship from the Fonds de Recherche du Québec en Santé. Institutes of Health Research in 2012, Bianca joined the research group of Prof Michel Bouvier at Université de

ABOUT THE GUEST Michel Bouvier is CEO of the Institut de Recherches Cliniques de Montreal (IRCM) and He completed his PhD under Jacques de Champlain, studying the role of presynaptic adrenergic receptors Bouvier returns to throughout his career, originally from Julie Axelrod via his PhD mentor Jacques de and a scholar of the Medical Research Council of Canada at the Faculty of Medicine of the Université de As some of you may know, Michel was one of my professors at the Universite de Montreal.

biochemists Celtarys empowers medicinal biochemists by providing innovative fluorescent probes that de-risk She then joined the University of Santiago de Compostela as a postdoctoral researcher in Prof. and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools Boston, MA and Santiago de Fluorescent Probes Innovative fluorescent probes that de-risk the pre-clinical drug discovery phase with Mestre Mateo 2, Santiago de Compostela, 15706, Spain Email Website LinkedIn

and risk 16:18 Turning down the medical school acceptance — 25 years of no regrets 22:10 Université de Gaetan Guillemette in the Pharmacology department at the Université de Sherbrooke. Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN). He also actively volunteers as an Associate Professor of the non-governmental organization Institut des Sciences, des Technologies et des Etudes Avancées d’Haïti (ISTEAH) to help consolidate higher education

with our nonprofit team for expert guidance, trusted CRO collaborations, and field-tested tools that de-risk From pipeline acceleration and investment de-risking to CRO differentiation — turning GPCR complexity Book a Strategy Call → Our Core Support Areas Discovery Consulting & Strategy Expert guidance to de-risk

Clarke and completed postdoctoral work at AstraZeneca, with Brigitte Kieffer in Strasbourg, and with Chris Chris Evans at UCLA.

Conference History The GPCR Retreat is an annual joint meeting with the Club des récepteurs à Sept Domaines The following year, the Great Lakes GPCR Retreat partnered with the annual symposium of the Club des Montebello, the 22nd Annual Great Lakes G Protein-Coupled Receptor Retreat held jointly with the Club des

The conversation covers the de-orphanization of GPR139 and GPR55, the unresolved promise of biased agonism His group contributed to the de-orphanization of GPR139 and GPR55, including the identification of sub-nanomolar GPCRDB as community infrastructure for integrating and accelerating GPCR research The interdisciplinary de-orphanization De-Orphanization Is a Full-Discipline Effort The process of characterizing an orphan receptor from protein sequence data 11:55 Orphan GPCRs - years spent chasing receptors with no known function or ligand 13:31 De-orphanizing

Fuel Discovery VC Due Diligence & De-risking For Venture Capital Firms De-risk GPCR Investments: Identify focused, scientific expertise that accelerates complex GPCR discovery programs, ensuring clarity and de-risking This ensures robust, defensible decisions that de-risk your program from early discovery to regulatory

an opioid receptor pharmacology group at the CHU Sainte-Justine Research Center and the Université de Research Center and a professor in the Department of Pharmacology and Physiology at the Université de She completed her PhD at McGill University with Claude de Montigny, working on serotonin and antidepressant mechanisms, and her postdoctoral training with Michel Bouvier at the Université de Montréal, where she

Brian Kobilka's lab at Stanford University and the SFMB laboratory at the Université Libre de Bruxelles

He obtained his Ph.D. from the Université de Montréal in 2002 under the guidance of Dr.

She began as a medicinal chemist in Italy, but a postdoc opportunity in Santiago de Compostela—and a predoctoral visiting student at the CIQUS Research Center—Campus of International Excellence—in Santiago de

From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors

stall timelines without payoff Match experiments to the specific phase and risk tolerance of the asset De-risk

receptors at the bench — training that spanned chemokine receptor conformational dynamics at the Université de She holds a PhD in Biochemistry from the Université de Montréal, where she trained in Dr.

His postdoctoral training included research at the École Polytechnique Fédérale de Lausanne (2015–2016

"My contribution to science began during the equivalent of U.S. masters training at the Université de

Scientific Officer and co-founder of Celtarys Research , a biotech spin-off from the University of Santiago de

Bender's work targets this gap directly - arguing that de-orphanizing a receptor biochemically and making

in mathematics, physics, and computer science at the French Grande École, École Normale Supérieure de

degree in biology and biotechnology engineering from the University of Sciences of Nîmes and the Ecole des