to pursue a postdoc as emerging from a straightforward observation: there was still a question she wanted to know more of how it's regulated, but I want to know more of upstream. I want to know how the G protein got activated. So receptor is a natural choice." "Keep the core to what is the question that you want to answer. run in the mountains, play with Tilly (a 9-year old retired greyhound), collecting mini shoes, and hang

advanced fluorescent probes developed specifically for working with endogenous GLP-1R and GIPR across a range Available across multiple spectral ranges for confocal, super-resolution, and intravital imaging. daLUXendin

end, her lab uses several computational structural biology tools and rational drug design approaches, ranging

To achieve this goal, we use a wide range of established approaches (biochemistry, cell biology, genetics

calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C Qin Wang

titles, with Yamina suggesting "Ancient Greek Chemistry and GPCRs"—a nod to Ian’s heritage and the wide-ranging

learning, with a particular focus on how chronic alcohol exposure disrupts those mechanisms across levels ranging It is also a complication: a receptor that modulates so many circuits will inevitably produce wanted circuits - and that has the potential to impact our understanding of how they influence a really wide range "Maybe the effect that I want to have by activating mGlu2 has the effects I want in a rodent brain, but But maybe there's another receptor there that will have the effect that we want in the human brain."

In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped

Drug Discovery (IDD) expertise, and a portfolio of over 2,750 assays, covering one of the broadest ranges

Quick recap Yamina and Claudia had a wide-ranging discussion about Claudia's work on metabolites and

They are involved in several pathologies, ranging from neurological, oncological, degenerative, metabolic

to translate scientific training into career options that are often invisible to bench scientists, ranging

That period of laborious, close-range data inspection became the conceptual foundation of his pan-GPCR

The discussion ranges across four decades of receptor pharmacology — from the era when the field debated

subtypes, A1, A2A, A2B, and A3, are expressed across virtually every tissue and implicated in conditions ranging

subfamilies in the GPCR superfamily - just 15 receptor genes - yet they govern a disproportionately wide range

active consent and recruit selected populations that do not represent a country's full demographic range

group was large enough to require it - acting on advice from mentors who recognized that funding panels wanted identified physiological hormones of such under characterized ‘orphan’ receptors and functional probes for a range

Inside a company, you understand the full range of decisions - immunogen design, host selection, production