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Want to know what’s buzzing in the world of GPCRs?  under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zhou , Chungong Yu , Haicang Zhang , Dongbo Bu 🤩 Seriously, why would you want to miss out on all the awesomeness that comes with a DrGPCR Premium terminating CEO and other execs amid strategic review Trevena Reports Third Quarter 2024 Results and Provides Business

Burning Cash Isn’t the Problem. Burning Alignment Is. You track the burn rate. You watch the runway shrink. You delay hires. Your business team optimizes for traction. It connects to business outcomes. They have strong early data and an even stronger burn rate. Everyone’s busy. No one’s clear.

It was about what we could build together, recalls Michelle Halls. That meant no one could build a fiefdom — and everyone had to talk. Culture as Infrastructure: How Trust Was Built Collaboration at this scale doesn’t happen by chance. Michelle’s story shows what happens when an ecosystem is built deliberately, not accidentally.  together or build smaller.

This year, we focused on building for sustainability  — strengthening operations, expanding partnerships Looking Ahead As we move into 2026, our focus remains simple: keep building with purpose — strengthening

This reactive approach, driven by a "go fast" mindset, burns through precious capital and time, leaving This belief that we don't have time to build better systems is a costly miscalculation. We believe we don't have time to build better systems, but in reality, our most brilliant and expensive I’ve lived this firsthand, not just in theory, but by building these systems from the ground up. Our Chief Brainstorm Officer, Attila Foris , is building a system so transparent that anyone joining

Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up The Challenge: Build a Team. Build a Lab. Build the R in R&D. He was tasked with building an in vitro pharmacology group from scratch , including infrastructure, hiring attitude and team fit , not just credentials He designed lab workflows that encouraged curiosity without burnout Sokhom knew this instinctively and built a system to support it.

Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall webworm Hyphantria

. 🔥 Why You Should Enroll Now: Budget-Friendly & Distinctive Educational Experience Affordable courses

Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

Dear GPCR Enthusiasts! Get ready to save the dates! Dr. GPCR University offers two live courses this fall that you won’t want to miss. Before the new semester kicks off, dive into our premium on-demand courses! With your membership, you’ll access over 500 minutes of top-notch content from Drs. Kenakin and Hoare on '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Choose between our monthly or yearly plans (with a 5-day free trial) to enjoy these courses and snag 25% off early bird discounts on upcoming classes. Check out what’s coming in September and October: Sign up for both courses now and score a 25% early bird discount with a premium membership! Course Details: When:  Thursdays at 10 AM EST Format:  Engaging Online Lectures with access to pre-read materials. Perks Include: In-depth Reading Materials Access to a Private Community Certificate of Participation for each course Don’t miss out—grab this special offer today! s Check out the details of each course below: Open to the Public: Enrollment is Now Available! Hurry and secure your spot TODAY! Dates:  September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic activity of ligands (affinity, efficacy, co-operativity) Determining mechanisms of action for new GPCR ligands Key elements of a comprehensive and effective GPCR discovery strategy Exclusive 25% Early Bird Discount for Dr. GPCR Ecosysme Premium members. Secure your spot before public enrollment opens! Dates:  October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time kinetics Discovering new ligands and unique GPCR behaviors for innovative drug profiles GPCR Event Highlight  11th Adhesion GPCR Workshop    Location : Mexico City Dates : October 23-25, 2024 Join us in the vibrant heart of Mexico City to connect with fellow scientists and delve into the latest advances in adhesion GPCR biology. Logo Contest : Let your creativity shine! Submit your design for our Logo Contest by August 15, 2024 (Yes, it's TODAY)! Sponsorship Opportunities : Elevate your brand’s visibility at this prestigious event. Contact us at Hello@DrGPCR.com to explore sponsorship options. Your participation is eagerly awaited! This week's highlight includes congrats to: Miles Thompson ,   Alexander Hauser ,   Caroline Gorvin ,   et al.   for their work on GPCR pharmacogenomics  Let’s dive into the   Classified GPCR News  from August 5th to 11th, 2024 GPCR Activation and Signaling Pharmacological characterization of the zebrafish Hrh2a histamine H2 receptor Revealing the graded activation mechanism of neurotensin receptor 1 Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP Olanzapine manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders, Drugs, and more Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors GPCRs in Neuroscience In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling Striatal serotonin release signals reward value Ciliary length variations impact cilia-mediated signaling and biological responses The receptor tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research G protein-coupled receptor (GPCR) pharmacogenomics Visualization of endogenous G proteins on endosomes and other organelles Reviews, GPCRs, and more Phytocannabinoids in neuromodulation: From omics to epigenetics The impact of nanobodies on GPCR structural biology and their potential as therapeutic agents Industry News Nxera Pharma Operational Highlights and Consolidated Results for the Second Quarter and First Half 2024 Cracking Codes in Cellular Communication Neurocrine Biosciences to Present at the Canaccord Genuity 44th Annual Growth Conference GPCR drugs make up a third of the market! GPCRs and mRNA antigens enable drug discovery and development Mapping GPCR-RAMP complexes with MolBoolean Screening GPR75 Modulators Using Medium-Throughput Reporter Gene Assay GPCR Therapeutics Optimizes the Joint Development of New Drugs Using Intralinks’ Virtual Data Room   GPCR Events, Meetings, and Webinars NEW September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October 23 - 25, 2024 | 11th Adhesion GPCR Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Become a Premium Member! 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Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined the company as VP Business Carola Weiss’ professional career brings deep expertise in business development, marketing & sales, licensing

Law, our newly named Chief Business Officer.

August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today reported its financial results for the second quarter ended June 30, 2022 and provided an overview of its recent operational highlights." Read more at the source #DrGPCR #GPCR #IndustryNews

Reverse Engineering Your Path to FDA Approval Most biotech development plans are built forward : start It's the test of how well you built it. Building FDA-Ready Thinking into Your Strategy Regulatory success is not a function. If you can’t see them too, you’re not building strategy, you’re building surprises. Because by the time they do, your timelines will stretch, your budgets will strain, and your confidence

observed at higher concentrations, consistent with competitive displacement  These visual layers act as built-in

What followed — a trip to London, confocal imaging marathons, and a partnership built on trust and curiosity Together, they built the first generation of GLP-1R fluorescent ligands — probes precise enough to visualize To build tools that performed consistently, JB and collaborators shifted toward a more rigorous parallelized chemists, theorists, biochemists, toxicologists, and cell biologists — all working toward the same goal: building

But HCS only works when assays are built with rigor and powered by the right fluorescent ligands. It’s a system-aware resource built for researchers who need clarity fast—reinforcing system-level GPCR

. ✅ Start with relevance, not results. 2️⃣ Using buzzwords instead of clarity Words like “platform”, It’s about strategic clarity. ✅ When your pitch follows this logic, it respects the listener’s time, builds It communicates that you know who you’re building for, why now is the right time, and how your solution , or simply feeling stuck, this session will get you unstuck, fast. 👉 Book a 1:1 consult and start building

They fail because a molecule behaved exactly as the underlying system allowed—amplified, buffered, redirected utility emerged from the interplay between β₁-mediated inotropy and α-mediated vascular effects that buffered

The future of discovery will belong to scientists who know how to build the right partnerships and stay Instead of forcing antibodies to do what they weren’t built for, JB’s group engineered fluorescent ligands when the cryo-EM data arrived — a structure solved through the same collaborative network that had built It’s about trust — the kind of trust built when collaborators confirm your data, replicate your results Here’s where the biggest opportunities will emerge: Building receptor-specific delivery systems for gene

Key limitations of radioligand assays include:  • No spatial information  — signals are measured in bulk

The literature was buzzing. Labs were competing.

Meanwhile, researchers in the building across the way turned off the lights at 6 PM.

Schild analysis turns receptor pharmacology into detective work, spotlighting mechanistic fingerprints buried Built for pharmacologists refining tools, discovery teams solving bottlenecks, and leaders seeking credible

Listen to the episode ➤ Quick Links Assess GPCR Biased Signaling of Agonist How GPCR Collaboration Built

Your scientific thinking built the foundation, but leadership is what scales it. waiting too long for certainty can destroy your momentum . 👉 Biotech founders often delay critical business But in business, decisions must be made under uncertainty . Clarity doesn’t precede action; it follows it.   2️⃣ “Eliminate error at all costs” Labs are built around or simply feeling stuck, this session will get you unstuck — fast. 👉 Book a 1:1 consult and start building

That’s not a story about nostalgia — it’s a snapshot of how GPCR research was built, on technique at of GPCR research today — from high-throughput ligand screens to real-time signaling readouts — are built The Evolution of GPCR Research Every generation of GPCR scientists inherits the tools of the last and builds What started as hand-built assays on ice has become integrated platforms for drug discovery, systems

For innovators building tools, platforms, or therapeutics, these origin moments are where tomorrow’s She built on chance moments with deliberate moves—grants pursued, labs chosen, collaborations built. Built to Inspire The story of Michelle Halls isn’t just about a career; it’s about a pattern.

. • Training Builds Innovation : Her lab model at Monash is shaping the next generation of GPCR scientists . 👉 Dive into spatial pharmacology ➤ A Note From Yamina: Building the Next Chapter of Dr.