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  • What's Going On with GPCRs?! Find Out in This Week's Update! ⦿ Nov 4 - 10, 2024

    Want to know what’s buzzing in the world of GPCRs?  under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zhou , Chungong Yu , Haicang Zhang , Dongbo Bu 🤩 Seriously, why would you want to miss out on all the awesomeness that comes with a DrGPCR Premium terminating CEO and other execs amid strategic review Trevena Reports Third Quarter 2024 Results and Provides Business

  • Is Your GPCR Drug Discovery Program Built for Breakthroughs or Breakdowns?

    This reactive approach, driven by a "go fast" mindset, burns through precious capital and time, leaving This belief that we don't have time to build better systems is a costly miscalculation. We believe we don't have time to build better systems, but in reality, our most brilliant and expensive I’ve lived this firsthand, not just in theory, but by building these systems from the ground up. Our Chief Brainstorm Officer, Attila Foris , is building a system so transparent that anyone joining

  • Building Backwards: Why Top-Down Models Could Revolutionize Pain Research

    Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____

  • Lab Leadership Without Ego: How Sokhom Pin Built the Happiest Team at Alkermes

    At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up The Challenge: Build a Team. Build a Lab. Build the R in R&D. He was tasked with building an in vitro pharmacology group from scratch , including infrastructure, hiring attitude and team fit , not just credentials He designed lab workflows that encouraged curiosity without burnout Sokhom knew this instinctively and built a system to support it.

  • Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...

    Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall webworm Hyphantria

  • GPCR Buzz of the Week | Sep 23 - 29, 2024

    . 🔥 Why You Should Enroll Now: Budget-Friendly & Distinctive Educational Experience Affordable courses

  • 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024

    Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

  • 📰 GPCR Buzz: August 5-11, 2024 | Top Highlights from DrGPCR University!

    Dear GPCR Enthusiasts! Get ready to save the dates! Dr. GPCR University offers two live courses this fall that you won’t want to miss. Before the new semester kicks off, dive into our premium on-demand courses! With your membership, you’ll access over 500 minutes of top-notch content from Drs. Kenakin and Hoare on '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Choose between our monthly or yearly plans (with a 5-day free trial) to enjoy these courses and snag 25% off early bird discounts on upcoming classes. Check out what’s coming in September and October: Sign up for both courses now and score a 25% early bird discount with a premium membership! Course Details: When:  Thursdays at 10 AM EST Format:  Engaging Online Lectures with access to pre-read materials. Perks Include: In-depth Reading Materials Access to a Private Community Certificate of Participation for each course Don’t miss out—grab this special offer today! s Check out the details of each course below: Open to the Public: Enrollment is Now Available! Hurry and secure your spot TODAY! Dates:  September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic activity of ligands (affinity, efficacy, co-operativity) Determining mechanisms of action for new GPCR ligands Key elements of a comprehensive and effective GPCR discovery strategy Exclusive 25% Early Bird Discount for Dr. GPCR Ecosysme Premium members. Secure your spot before public enrollment opens! Dates:  October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time kinetics Discovering new ligands and unique GPCR behaviors for innovative drug profiles GPCR Event Highlight  11th Adhesion GPCR Workshop    Location : Mexico City Dates : October 23-25, 2024 Join us in the vibrant heart of Mexico City to connect with fellow scientists and delve into the latest advances in adhesion GPCR biology. Logo Contest : Let your creativity shine! Submit your design for our Logo Contest by August 15, 2024 (Yes, it's TODAY)! Sponsorship Opportunities : Elevate your brand’s visibility at this prestigious event. Contact us at Hello@DrGPCR.com to explore sponsorship options. Your participation is eagerly awaited! This week's highlight includes congrats to: Miles Thompson ,   Alexander Hauser ,   Caroline Gorvin ,   et al.   for their work on GPCR pharmacogenomics  Let’s dive into the   Classified GPCR News  from August 5th to 11th, 2024 GPCR Activation and Signaling Pharmacological characterization of the zebrafish Hrh2a histamine H2 receptor Revealing the graded activation mechanism of neurotensin receptor 1 Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP Olanzapine manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders, Drugs, and more Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors GPCRs in Neuroscience In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling Striatal serotonin release signals reward value Ciliary length variations impact cilia-mediated signaling and biological responses The receptor tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research G protein-coupled receptor (GPCR) pharmacogenomics Visualization of endogenous G proteins on endosomes and other organelles Reviews, GPCRs, and more Phytocannabinoids in neuromodulation: From omics to epigenetics The impact of nanobodies on GPCR structural biology and their potential as therapeutic agents Industry News Nxera Pharma Operational Highlights and Consolidated Results for the Second Quarter and First Half 2024 Cracking Codes in Cellular Communication Neurocrine Biosciences to Present at the Canaccord Genuity 44th Annual Growth Conference GPCR drugs make up a third of the market! GPCRs and mRNA antigens enable drug discovery and development Mapping GPCR-RAMP complexes with MolBoolean Screening GPR75 Modulators Using Medium-Throughput Reporter Gene Assay GPCR Therapeutics Optimizes the Joint Development of New Drugs Using Intralinks’ Virtual Data Room   GPCR Events, Meetings, and Webinars NEW September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October 23 - 25, 2024 | 11th Adhesion GPCR Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Become a Premium Member! Get your 5-day free trial TODAY!

  • Carola Weiss joins InterAx Biotech AG as VP Business Development

    Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined the company as VP Business Carola Weiss’ professional career brings deep expertise in business development, marketing & sales, licensing

  • Trevena Reports Second Quarter 2022 Results and Provides Business Update

    August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today reported its financial results for the second quarter ended June 30, 2022 and provided an overview of its recent operational highlights." Read more at the source #DrGPCR #GPCR #IndustryNews

  • The Hidden Driver of GPCR Drug Success: Why Target Residence Time Matters More Than You Think

    for GPCR scientists and translational teams, Premium keeps you informed on the science, careers, and business

  • From Pharmacy Crisis to Scientific Calling: Catherine Demery’s Unfiltered Path into Opioid Research

    It was here that the disciplined structure of industry science helped her re-find purpose and build confidence alcoholism and opioid addiction—a decision that would reshape her academic ambitions. “...I had a light bulb A career pivot is not a failure—it’s a refined strategy Industry can build skills that academia often

  • Exclusive Access: Terry's Corner is LIVE + Your Premium Member Discount!

    This isn't just another lecture series; it's a practical tool designed to help you recognize and build

  • Maria’s Travel Blogs: ACSMEDI-EFMC Medicinal Chemistry Frontiers 2025

    She has a lot of experience working for bigger businesses which she now shares as an advisor for startups

  • The Imprecision Problem: Why Your GPCR Drug Discovery Program Is Off-Track Before It Even Starts

    They’re hired for science, not for building operational scaffolding. Every two-week delay in a DMTA cycle can burn through hundreds of thousands in salaries and overhead. Build Precision Systems for GPCR Drug Discovery The only way out for GPCR drug discovery programs isn And if your systems aren’t built for precision, you’ll run out fast. 👉 In Part 2, we’ll expose exactly Let’s build the systems now, before the next delay burns another half a million. 🚀 Book your free 30

  • Target Residence Time: The Hidden Driver of In Vivo Efficacy

    Redefine Your Pipeline If your development program is built around potency alone, you may be leaving

  • From Student to Mentor: What Alessandro Nicoli Learned About Leading in Science

    As the lab grew, so did his responsibilities: from building computational models of GPCRs to guiding

  • Competitive vs Non-Competitive GPCR Antagonists: How to Interpret Pharmacology Data with Confidence

    Sharpen your discovery decisions ➤ Yamina's Consulting Corner - Building Your GPCR Program for Breakthroughs Solve the problem of a fragmented approach by learning how to build a unified system where every scientific Three takeaways from this week’s feature: Stop firefighting:  Learn why solving isolated problems burns Build predictable success:  Use a repeatable improvement framework to turn operational chaos into precision

  • Misread the Curve, Misjudge the Drug: Rethinking Antagonism in GPCR Pharmacology

    Terry’s Corner  is built to help you avoid those traps. Why now:  GPCR research is accelerating—and the projects that succeed will be those built on clear, accurate

  • GPCR Allosteric Modulation: Why Allostery is the Engine of Drug Discovery

    hours—not minutes—to equilibrate  ✅ A framework for designing or troubleshooting allosteric modulators with built-in Ask-Me-Anything sessions A growing, curated on-demand library Opportunities to shape future topics Built

  • Why Intracellular Drugs May Hold the Key to GPCR Therapeutics

    If your pipeline is built only around extracellular engagement, you might be leaving opportunities untapped

  • How Fast Does a Drug Work?

    Outdated Models Slow Your Next Program The analytical tools that shaped traditional affinity assays were built

  • Are You Guessing or Forecasting? Master GPCR Pharmacologic Models Before It’s Too Late

    🔹 Elevate your strategy → Building clarity in GPCR drug discovery Even the strongest GPCR programs stall—not from bad data, but from buried decisions; Yamina's Corner helps teams cut through the noise and build clarity that drives action 🔹 Innovate faster → Celtarys’s newest GPCR tools Explore new screening tools purpose-built for

  • Your GPCR Program Decisions Depend on Good Data Interpretation

    : A Model for R&D Success Scientific rigor doesn’t thrive in cultures defined by micromanagement or burnout At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture

  • GPCR Allostery: Unlock Hidden Mechanisms and Make Smarter Drug Decisions

    Your work belongs in the core conversation—not buried in supplementary files.

  • How Understanding Intracellular Drug Access Can Transform Your GPCR Drug Discovery Program

    Expand your computational toolkit ➤ Call for Papers: GPCRs: Signal Transduction, Volume II Building on

  • From Venice to Virtual Molecules: Alessandro Nicoli’s Unexpected Journey into Computational Chemistry

    While fascinated by organic chemistry and the idea of “building molecules,” he didn’t see the big picture—until Within weeks, he moved to Germany and became her first PhD student—helping build a lab from the ground limited ligand data, olfactory GPCRs represent a high-risk, high-reward challenge —perfect for a PhD built

  • When Pain Becomes a Catalyst: How Personal Experience Redefined One Scientist’s Mission

    Born in California and raised in Silicon Valley, his early interests were in finance and business. Building a Career from the Inside Out Now back in med school, Serafini aims to follow the physician-scientist

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