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Want to know what’s buzzing in the world of GPCRs?  under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zhou , Chungong Yu , Haicang Zhang , Dongbo Bu 🤩 Seriously, why would you want to miss out on all the awesomeness that comes with a DrGPCR Premium terminating CEO and other execs amid strategic review Trevena Reports Third Quarter 2024 Results and Provides Business

Burning Cash Isn’t the Problem. Burning Alignment Is. You track the burn rate. You watch the runway shrink. You delay hires. Your business team optimizes for traction. It connects to business outcomes. They have strong early data and an even stronger burn rate. Everyone’s busy. No one’s clear.

It was about what we could build together, recalls Michelle Halls. That meant no one could build a fiefdom — and everyone had to talk. Culture as Infrastructure: How Trust Was Built Collaboration at this scale doesn’t happen by chance. Michelle’s story shows what happens when an ecosystem is built deliberately, not accidentally.  together or build smaller.

This year, we focused on building for sustainability  — strengthening operations, expanding partnerships Looking Ahead As we move into 2026, our focus remains simple: keep building with purpose — strengthening

This reactive approach, driven by a "go fast" mindset, burns through precious capital and time, leaving This belief that we don't have time to build better systems is a costly miscalculation. We believe we don't have time to build better systems, but in reality, our most brilliant and expensive I’ve lived this firsthand, not just in theory, but by building these systems from the ground up. Our Chief Brainstorm Officer, Attila Foris , is building a system so transparent that anyone joining

Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up The Challenge: Build a Team. Build a Lab. Build the R in R&D. He was tasked with building an in vitro pharmacology group from scratch , including infrastructure, hiring attitude and team fit , not just credentials He designed lab workflows that encouraged curiosity without burnout Sokhom knew this instinctively and built a system to support it.

Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall webworm Hyphantria

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Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

Dear GPCR Enthusiasts! Get ready to save the dates! Dr. GPCR University offers two live courses this fall that you won’t want to miss. Before the new semester kicks off, dive into our premium on-demand courses! With your membership, you’ll access over 500 minutes of top-notch content from Drs. Kenakin and Hoare on '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Choose between our monthly or yearly plans (with a 5-day free trial) to enjoy these courses and snag 25% off early bird discounts on upcoming classes. Check out what’s coming in September and October: Sign up for both courses now and score a 25% early bird discount with a premium membership! Course Details: When:  Thursdays at 10 AM EST Format:  Engaging Online Lectures with access to pre-read materials. Perks Include: In-depth Reading Materials Access to a Private Community Certificate of Participation for each course Don’t miss out—grab this special offer today! s Check out the details of each course below: Open to the Public: Enrollment is Now Available! Hurry and secure your spot TODAY! Dates:  September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic activity of ligands (affinity, efficacy, co-operativity) Determining mechanisms of action for new GPCR ligands Key elements of a comprehensive and effective GPCR discovery strategy Exclusive 25% Early Bird Discount for Dr. GPCR Ecosysme Premium members. Secure your spot before public enrollment opens! Dates:  October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays to analyze GPCR ligand behavior Predicting activity and in vivo target coverage with real-time kinetics Discovering new ligands and unique GPCR behaviors for innovative drug profiles GPCR Event Highlight  11th Adhesion GPCR Workshop    Location : Mexico City Dates : October 23-25, 2024 Join us in the vibrant heart of Mexico City to connect with fellow scientists and delve into the latest advances in adhesion GPCR biology. Logo Contest : Let your creativity shine! Submit your design for our Logo Contest by August 15, 2024 (Yes, it's TODAY)! Sponsorship Opportunities : Elevate your brand’s visibility at this prestigious event. Contact us at Hello@DrGPCR.com to explore sponsorship options. Your participation is eagerly awaited! This week's highlight includes congrats to: Miles Thompson ,   Alexander Hauser ,   Caroline Gorvin ,   et al.   for their work on GPCR pharmacogenomics  Let’s dive into the   Classified GPCR News  from August 5th to 11th, 2024 GPCR Activation and Signaling Pharmacological characterization of the zebrafish Hrh2a histamine H2 receptor Revealing the graded activation mechanism of neurotensin receptor 1 Intracellular pathways of calcitonin gene-related peptide-induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP Olanzapine manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders, Drugs, and more Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors GPCRs in Neuroscience In-silico predicted mouse melanopsins with blue spectral shifts deliver efficient subcellular signaling Striatal serotonin release signals reward value Ciliary length variations impact cilia-mediated signaling and biological responses The receptor tyrosine kinase IGF1R and its associated GPCRs are co-regulated by the noncoding RNA NEAT1 in Alzheimer's disease Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans Calcium-sensing receptor regulates Kv7 channels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like neurons Methods & Updates in GPCR Research G protein-coupled receptor (GPCR) pharmacogenomics Visualization of endogenous G proteins on endosomes and other organelles Reviews, GPCRs, and more Phytocannabinoids in neuromodulation: From omics to epigenetics The impact of nanobodies on GPCR structural biology and their potential as therapeutic agents Industry News Nxera Pharma Operational Highlights and Consolidated Results for the Second Quarter and First Half 2024 Cracking Codes in Cellular Communication Neurocrine Biosciences to Present at the Canaccord Genuity 44th Annual Growth Conference GPCR drugs make up a third of the market! GPCRs and mRNA antigens enable drug discovery and development Mapping GPCR-RAMP complexes with MolBoolean Screening GPR75 Modulators Using Medium-Throughput Reporter Gene Assay GPCR Therapeutics Optimizes the Joint Development of New Drugs Using Intralinks’ Virtual Data Room   GPCR Events, Meetings, and Webinars NEW September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October 23 - 25, 2024 | 11th Adhesion GPCR Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Senior or Lead Researcher   Senior Scientist, Cryo-Electron Microscopy   Postdoctoral Research Associate Become a Premium Member! 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They track burn rate, but not decision reversibility. they can clearly explain their burn rate. The problem is that burn rate measures spending, not freedom. When building quietly turns into surviving 👉 At a certain point, many biotech founders  believe they are still building the company, while in reality, they have already shifted into survival mode.

It is building a team that cannot operate when answers are incomplete. ✅ This is where survival is decided It is about building a team that can operate when clarity is missing. It also changes what questions matter when building the team. Built for growth means building a biotech team that can learn, adapt, and move forward together as the The goal is to build a team that can operate while uncertainty is present. 👉 Skills matter.

Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined the company as VP Business Carola Weiss’ professional career brings deep expertise in business development, marketing & sales, licensing

Law, our newly named Chief Business Officer.

August 2022 "CHESTERBROOK, Pa., Aug. 11, 2022 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq:TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today reported its financial results for the second quarter ended June 30, 2022 and provided an overview of its recent operational highlights." Read more at the source #DrGPCR #GPCR #IndustryNews

Terry Kenakin, monthly live AMAs, and a growing on-demand library built for scientists who need clarity

Teams feel busy, but outcomes feel less decisive. Leadership conversations take longer. In biotech, disciplined decisions today build strategic focus, execution clarity, and stronger biotech simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building

The organization feels busy, yet something subtle shifts. No single milestone clearly dominates. Milestones no longer build toward a single dominant value inflection point. And constraint feels uncomfortable in an environment built on discovery. simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building

GPCR operates as a membership-based, nonprofit initiative — built to strengthen the GPCR field through GPCR Premium — Build Your Structured Advantage ➤

“They offer more than assays—they build true scientific partnerships that help teams get the most from

Terry’s Pharmacology Corner is built around that reality.

Strong GPCR drug discovery decisions are built on structure, early risk awareness, and focused signal publications: D2 receptor constitutively active mutants; β2AR allosteric SERS assay; CXCR4 inhibitor burixafor Terry Kenakin walks through the core early assays that protect your chemistry, budget, and timeline.

. 👉 This is why strong biotech startups often appear busiest right before they lose momentum. simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building

which early assays are truly non-negotiable, which mechanisms demand immediate attention, and how to build

Ecosystem: sharper programming, deeper expertise, and renewed momentum across everything we publish and build Community presence  — from conferences to collaborative initiatives built in public. 👉 Email us to chat

Teams stay busy. How Rational Decisions Accumulate Into Drift 👉 Every biotech startup is built on decisions that make patterns: Incremental scope expansion that feels strategic Delayed commitments are justified as prudent Busy simply feeling stuck, this session will help you get unstuck quickly. 👉 Book a 1:1 consult and start building

Terry Kenakin, monthly AMAs, and a growing on-demand library built around pharmacology's most important

Business development conversations feel inconsistent, even when the company and the science have not not easier 3️⃣ Partner discussions sound positive, but rarely convert into concrete next steps 4️⃣ Business Investors, partners, and business development teams are not evaluating scientific merit in isolation. This puts the burden of synthesis on the listener , who may not share the same context or priorities. This clarity removes a hidden burden from founders. 👉 They no longer carry the responsibility of making

Budgets are locked. Teams are committed. Assumptions feel too costly to challenge. Business pushes speed. Operations push stability. Execution feels busy but not effective. Teams mistake motion for progress . And it is built far earlier than most teams realize, at the moment when strategic decision-making still earlier through strategic decision-making , when direction is still flexible, and alignment is easy to build