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About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Dopamine-Mediated Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. My addiction for dopamine led me to the Ottawa Hospital Research Institute (then the Moses and Rose Loeb (DA) receptors.

Committee Sponsors GPCR Retreat Program < Back to schedule A journey from Duke to McGill along the dopamine the INSERM Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

establishing a role for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors (D2R) functions. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug classes can engage overlapping

Salahpour worked on Dopamine Transporter and its role on regulating dopamine transmission and homeostasis the Department of Pharmacology and Toxicology at University of Toronto and has continued working on dopamine transmission and homeostasis and the role of several of key modulators of the dopamine system, including the dopamine transporter (DAT), the Vesicular Monoamine Transporter 2 (VMAT2), Tyrosine Hydroxylase (TH) and Trace Amine Associate Receptor 1 (TAAR1)."

During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors GPCR Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors scaffolding proteins synapse-associated protein 102 and post-synaptic density 95, and the du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

establishing a role for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors (D2R) functions. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug classes can engage overlapping

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Latrophilin 3 receptor. free energy landscape analysis to understand the signaling pathways and activation mechanisms of the Dopamine D3 receptor and the CXCR4-CXCL12 complex.

same university in 2005 by investigating the molecular mechanisms involved in the angiotensin type 2 receptor She identified the molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors She identified the structural determinant controlling biased signaling of melatonin type 2 receptors Award, she investigated biased and compartmentalized G protein signaling by the vasopressin type 2 receptor understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded chemokine US28 receptor

retired at the end of 2014 and since then has been writing papers on his final major project at Lilly, a dopamine doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

Samuel Hoare Sam completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors life science, and academic scientists in the development of new therapeutics and the understanding of receptor about his love for GPCRs, kinetics, and decorticate the complexities of GPCR function to better target receptors

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

the INSERM Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes.

have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine, dopamine , serotonin, cannabinoid and muscarinic receptors. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud “These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize GPCR Expertise Specialized knowledge in adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors

Every receptor tells a story but GPCRs speak a language of organization. Dr. Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction. Home → Flash News → Every receptor tells a story Every receptor tells a story Published on November 11 , 2025 Category Dr.GPCR Podcast Every receptor tells a story — but GPCRs speak a language of organization Michelle Halls unpacks how GPCR signaling isn’t just about ligand–receptor interaction.

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance GPCR Podcast Strategic Partners Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode , Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in real tissues is essential for Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor redundancy. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor bias. 🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor bias. 🔗 Read the full paper in Biochemistry : Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors

Home → Flash News → Did you know that A2B adenosine receptor-triggered calcium mobilization varies by Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi metabolism #obesity Published on March 10, 2025 Category GPCR Weekly News Did you know that A2B adenosine receptor-triggered /a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi

Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/mechanisms-of-constitutive-and-agonist-induced Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe to the Dr ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type -1-receptor #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → How does a superagonist activate M2 muscarinic receptors? www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics Published on March 31, 2025 Category GPCR Weekly News How does a superagonist activate M2 muscarinic receptors www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/visualizing-agonist-induced-m2-receptor-activation-regulated-by-aromatic-ring-dynamics

Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling /high-resolution-deep-mutational-scanning-of-the-melanocortin-4-receptor-enables-target-characterization-for-drug-discovery

Understanding receptor-specific nuances, like the role of NTF cleavage, is crucial for decoding their www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3 Understanding receptor-specific nuances, like the role of NTF cleavage, is crucial for decoding their www.ecosystem.drgpcr.com/adhesion-gpcrs/n-terminal-fragment-shedding-contributes-to-signaling-of-the-full-length-adhesion-receptor-adgrl3

➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization ️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization

pharmacological assays, and NMR to reveal the molecular mechanism of biased activation at the vasopressin V2 receptor pharmacological assays, and NMR to reveal the molecular mechanism of biased activation at the vasopressin V2 receptor ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/high-affinity-elr%2B-chemokine-ligands-show-g-protein-bias-over -%CE%B2-arrestin-recruitment-and-receptor-internalization-in-cxcr1-signalling #gpcr #drgpcr Previous

Home → Flash News → A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function Category GPCR Weekly News A new study from the Hudson Lab at the University of Glasgow shows that the FFA receptor www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/inverse-agonism-of-the-ffa4-free-fatty-acid-receptor-controls-both-adipogenesis-and-mature-adipocyte-function

Sponsors GPCR Retreat Program < Back to schedule A positive Allosteric Modulator of M1 Acetylcholine Receptors Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

Home → Flash News → Adenosine A3 receptor has been proposed to have significant roles in metabolism and /buff.ly/42b6ra3 #gpcr #drgpcr Published on January 16, 2025 Category GPCR Weekly News Adenosine A3 receptor Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling