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About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Dopamine-Mediated Marc Caron, where I cloned the dopamine D5 receptor gene and investigated the regulation of dopaminergic and adrenergic receptors. My addiction for dopamine led me to the Ottawa Hospital Research Institute (then the Moses and Rose Loeb (DA) receptors.

Committee Sponsors GPCR Retreat Program < Back to schedule A journey from Duke to McGill along the dopamine the INSERM Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

establishing a role for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors (D2R) functions. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug classes can engage overlapping

Salahpour worked on Dopamine Transporter and its role on regulating dopamine transmission and homeostasis the Department of Pharmacology and Toxicology at University of Toronto and has continued working on dopamine transmission and homeostasis and the role of several of key modulators of the dopamine system, including the dopamine transporter (DAT), the Vesicular Monoamine Transporter 2 (VMAT2), Tyrosine Hydroxylase (TH) and Trace Amine Associate Receptor 1 (TAAR1)."

During his graduate studies, Emile is interested in characterizing novel G protein-coupled receptors GPCR Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine D1 Receptor Signaling About Bassam Albraidy "My thesis focus on studying the interaction of dopamine D1 receptors scaffolding proteins synapse-associated protein 102 and post-synaptic density 95, and the du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

establishing a role for Beta-arrestin signaling in the brain in vivo and has established its importance in D2 dopamine receptors (D2R) functions. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus providing a framework to understand how different drug classes can engage overlapping

GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the Latrophilin 3 receptor. free energy landscape analysis to understand the signaling pathways and activation mechanisms of the Dopamine D3 receptor and the CXCR4-CXCL12 complex.

Sponsors GPCR Retreat Program < Back to schedule Atypical Structure and Function of Typical Chemokine Receptors of the principal efforts of our laboratory is to understand the physiological consequences of NMDA receptor The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and Our laboratory is interested in the role of NMDA receptors not only on neurons, but also on other cells Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

same university in 2005 by investigating the molecular mechanisms involved in the angiotensin type 2 receptor She identified the molecular mechanisms involved in the opposite regulation of dopamine D1 and D5 receptors She identified the structural determinant controlling biased signaling of melatonin type 2 receptors Award, she investigated biased and compartmentalized G protein signaling by the vasopressin type 2 receptor understanding the role of compartmentalized Gq signaling by the cytomegalovirus-encoded chemokine US28 receptor

retired at the end of 2014 and since then has been writing papers on his final major project at Lilly, a dopamine doctoral dissertation was the first large-scale study of structure-activity relationships for adenosine receptors postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor He then joined WL/PD, where his lab demonstrated the existence of two subtypes of the adenosine A2 receptor In 1988, he joined Lilly as a receptor biologist in charge of a high-throughput screening lab.

have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine, dopamine , serotonin, cannabinoid and muscarinic receptors. NanoBRET® competitive binding assay enables real-time quantification of ligand–receptor interactions GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud GPCR Expertise Specialized knowledge in adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors

Samuel Hoare Sam completed his Ph.D. in biochemistry, studying allosteric modulation of dopamine receptors life science, and academic scientists in the development of new therapeutics and the understanding of receptor about his love for GPCRs, kinetics, and decorticate the complexities of GPCR function to better target receptors

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Complex Allosteric Cannabinoid Receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

David Hodson on visualizing GLP-1 and GIP receptors in pancreatic islets and brain circuits to advance therapies for diabetes and obesity. << Back to podcast list Strategic Partner(s) Visualizing GLP-1 & GIP Receptors in Islets and Brain In this episode, Professor David Hodson discusses how GLP-1 and GIP receptors regulate metabolism across the pancreas and brain, and why visualizing receptor localization and signaling in Why this matters How receptor distribution in islets and brain circuits shapes incretin hormone drug

Since 2013, he has been elected Chair of the subcommittee for the Dopamine receptors of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification

the INSERM Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes.

. << Back to podcast list Strategic Partner(s) Scaling GLP 1 Receptor Tools Through Academia Industry access aren’t planned from the start Why fluorescence-based assays outperform antibodies for studying receptor combining fluorophore design, ligand chemistry, and pharmacology, his work enables precise visualization of receptor His research focuses on class B GPCRs, including the GLP-1 and GIP receptors, with an emphasis on understanding how these receptors operate within complex tissues such as the pancreas and brain.

GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

Sponsors GPCR Retreat Program < Back to schedule A positive Allosteric Modulator of M1 Acetylcholine Receptors Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling During my post-doctoral research, I was part of a study that identified the receptors of a novel human In this study, I discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. My long-term plan is to conduct research in the field of receptor biology, with a focus on GPCRs.

Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Biased agonism at the GLP-1 receptor GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec

The team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 In particular, FB contributed to the discovery that CXCL12 is the ligand for the CXCR4 receptor and can FB’ team has identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves that are categorized into a large subgroup of G protein–coupled (GPCR) leukocyte chemotactic receptors (including CXCR4), and a smaller subgroup of atypical chemokine receptors (including the CXCR7/ACKR3

Explore GPCR lipid rafts, bitter taste receptor pharmacology, and data integration in this expert interview construction of an open-access GPCR-lipid raft database and reviews key findings from his research on D1 receptor When you’re mapping receptor localization and need to understand the mechanistic role of microdomains There, under Professor Mario Tiberi, he focused on G protein-coupled receptors and D1 receptor regulation—work that sparked his ongoing engagement with receptor signaling and microdomain biology.

GPCR webinars are live online scientific sessions focused on G protein-coupled receptor (GPCR) biology These webinars are ideal for: • GPCR pharmacologists • Medicinal chemists working on receptor targets Topics frequently address: • Receptor efficacy and bias • Allosteric modulation • PK/PD relationships Topics may include: • Receptor efficacy and operational models • Allosteric modulators (PAMs and NAMs ) • Biased agonism • Dose–response modeling • Calcium and signaling assays • Drug–receptor kinetics •

Gunnar Schulte Gunnar Schulte is a Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. University, Melbourne Australia, GPCR pharmacology; 2006) before starting his independent research team "Receptor Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction , the relevance of receptor dynamics, and receptor complex composition for signal initiation and specification

Strosberg AD in France, where he worked on the regulation of ß-adrenergic receptors. He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing He showed the formation of melatonin receptor heteromers in vitro and in vivo and their importance in He established the concept of ligand-independent functions of orphan receptors in heterodimers with other He discovered multiple rare and loss-of-function variants of the MT2 melatonin receptors that are associated

contributed to multiple projects exploring the underlying mechanisms of biased signaling at chemokine receptor signaling profile of CXCR3’s three endogenous biased ligands, elucidating the role of site-specific receptor biased agonists, and demonstrating the ligand specificity behind GRK recruitment to endosomes upon receptor identifying the non-canonical signaling effectors involved in the activation of Atypical Chemokine Receptor 3 (ACKR3), a receptor which does not couple to G protein and has been shown to maintain its activation

GIPR Imaging: From Cell Assays to In Vivo Systems Fluorescent tools for imaging endogenous incretin receptors across biological systems Interrogating Incretin Receptor Biology Across Biological Complexity GLP-1 and GIP receptors have emerged as central targets in metabolic medicine, yet their precise localization and dynamics in native contexts — without relying on receptor overexpression or genetic modification Enable simultaneous visualization of endogenous receptor localization and nanodomain organization in

🚀 This workshop will explore how different ligands (compounds) can stabilize unique receptor conformations , leading to distinct signaling outcomes—even when binding to the same receptor. 🧬 Receptor Flexibility : Ligands stabilize different receptor states, creating unique signaling pathways are Dynamic Players 🔹 Different ligands trigger unique receptor states, meaning the same receptor can This allows for a side-by-side comparison of how different compounds influence receptor signaling. 📌