GPCR podcast is now available! Our guest is Dr. Listen where you get your podcasts. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr #drgpcr #

September 2022 "Class A (rhodopsin-like) G protein-coupled receptors (GPCRs) are constitutive phospholipid scrambling is not detectable in the resting plasma membrane of mammalian cells that is replete with GPCRs considered whether cholesterol, a prominent component of the plasma membrane, limits the ability of GPCRs This mechanism may explain the inability of GPCRs to scramble lipids at the plasma membrane." Read more at the source #DrGPCR #GPCR #IndustryNews

This week, we've curated 12 GPCR papers. GPCR Symposium for the year, which will focus on GPCRs in Immunology and Oncology. GPCR Newsletter with Dr. Kathleen Caron, as our video guest, subscribe now! for high-throughput gpcrs antibody discovery Reviews, GPCRs, and more Current strategic trends in drug GPCR Ecosystem

Good day, GPCR folks! Take advantage of our GPCR highlights of the week. Dr. GPCR Symposium for the year on GPCRs in Immunology and Oncology! GPCR Newsletter for exclusive content, check out our latest video featuring Dr. Kathleen Caron. Check out the weekly Classified GPCR News from October 30 to November 4, 2023. GPCR Ecosystem

GPCR podcast is now available! Our guest is Dr. Tim De Groof! It’s not often when you get the best of both worlds - nano-bodies and #GPCRs. Listen where you get your podcasts https://www.ecosystem.drgpcr.com/dr-gpcr-podcast #gpcr #drgpcr #podcast

🧠Do you want to share your #GPCR knowledge? Come to Dr. GPCR Ecosystem and create a course on your favorite #GPCR research, technique and more… Available for GPCR Ecosystem paid memberships ➡️https://bit.ly/3R8ZZbo #gpcr #drgpcr

GPCR Summit 2022 held between Oct. 10 - 16, it's FREE! Join the #GPCR movement by signing up now! ➡️ https://bit.ly/3cKMXlw #gpcr #drgpcr

Hello GPCR enthusiasts! Join us for our weekly GPCR round-up. This week's highlights: Drs. Matthew Eddy and lab research on GPCR signaling mechanisms using NMR spectroscopy with labeled receptors GPCR Symposia? GPCR Newsletter! GPCR Ecosystem

GPCR event of the year is the 3rd edition of the Summit. Come join us from October 10 to 16 to hear about exciting #GPCR research from amazing speakers. GPCR Ecosystem site member to attend the Summit, it’s free! ➡️ https://bit.ly/3SUkB8D #gpcr #drgpcr

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization We investigated the influence of specific inhibitors of G protein-coupled receptors (GPCR), endocytosis The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA Overall, phagocytosis, CME, GPCR, ERK signaling, and S2R/TMEM97 are involved in the internalization of Read more at the source #DrGPCR #GPCR #IndustryNews

Stay informed with our GPCR roundup. GPCR Symposium on 'GPCRs as Therapeutic Modalities' Showcase your project with a 1-minute abstract video in Neuroscience System-wide mapping of peptide-GPCR interactions in C. elegans GPCR interactions involving Papers NEW opnMe GPCR Route 66+ project. GPCR Ecosystem

components of the intracellular signaling pathways that mediate the effects of G protein-coupled receptors (GPCRs Upon activation, GPCRs have conformational changes that allow the coupling and subsequent activation Role of RGS proteins in regulating GPCR signaling: Recent studies have revealed that the interaction The interaction between RGS proteins and GPCRs is highly specific and tightly regulated; mutations in and amplitude of GPCR signaling.

GPCR podcast is here! 🎧Hear Dr. GPCR Ecosystem membership or listen wherever you get your podcast for free.

GPCR podcast! Give it a listen to hear from Dr. Thomas P. Sakmar on how the molecular studies of rhodopsin paved the way to understanding #GPCRs Be sure to subscribe https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ #drgpcr #gpcr #podcast

Greetings, GPCR fellows! Prepare for the latest GPCR updates. This week's highlights: Dr. GPCR Symposium on 'GPCRs as Therapeutic Modalities' is set for September 22nd. GPCR Newsletter for confirmed speaker announcements. Adhesion GPCRs Functional partnerships between GPI-anchored proteins and adhesion GPCRs GPCR Activation GPCR Ecosystem

October 2022 Membrane Lipids Are an Integral Part of Transmembrane Allosteric Sites in GPCRs: A Case Negative Allosteric Modulator, ORG27569, and Analogs "A growing number of G-protein-coupled receptor (GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases, but few therapies have been directed against GPCRs in the field of cancer, partly because of the lack Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered activation mechanism "The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

Welcome, GPCR fellows! Get excited about the latest GPCR news! GPCR Symposium on GPCRs as Therapeutic Modalities is on September 22nd. GPCR Symposium on Structural and Molecular Insights on GPCR Activation are available for premium members GPCR Activation and Signaling Endosome positioning coordinates spatially selective GPCR signaling. GPCR Ecosystem

GPCR Podcast, we have Dr. Pina Cardarelli, CSO of GPCR Therapeutics. ecosystem.drgpcr.com/dr-gpcr-podcast/ #gpcr#drgpcr #podcast

But what are the conformation changes that drive GPCR dimerization? How dynamic are GPCRs dimer interfaces? GPCRs constantly bind to form dimers and dissociate to form monomers. But how can we target GPCR dimers? via%3Dihub #GPCR #DrGPCR#Ecosystem

Welcome, GPCR fellows! Get ready for the latest GPCR news. This week's highlighted papers: Dr. GPCR Symposium on Structural and Molecular Insights on GPCR Activation was a success! GPCR Symposium on GPCRs as Therapeutic Modalities on September 22nd. GPCR Newsletter! GPCR Ecosystem

September 2022 "Adhesion G protein-coupled receptors (aGPCRs) are cell-surface proteins with large extracellular Modulating a single function of a specific aGPCR isoform while affecting no other function and no other Here, we engineered an antibody, termed LK30, that binds to the extracellular region of the aGPCR ADGRL3 Our work provides proof of concept for the modulation of isoform- and ligand specific aGPCR functions therapeutics" Read more at the source #DrGPCR #GPCR #IndustryNews

September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formation "The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent Read more at the source #DrGPCR #GPCR #IndustryNews

2022 Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR simulation was conducted to elucidate binding mechanisms of a middle-sized flexible molecule, bosentan, to a GPCR Read more at the source #DrGPCR #GPCR #IndustryNews

G protein-coupled receptors (GPCRs) are integral membrane proteins crucial for sensing extracellular Central to GPCR function are G proteins, comprising subfamilies such as Gs, Gi/o, Gq/11, and G12/13, In conclusion, FRET and BRET-based sensors have transformed the landscape of GPCR research, offering unprecedented insights into the intricacies of GPCR signaling. Zhou, Y., et al., Multiple GPCR Functional Assays Based on Resonance Energy Transfer Sensors. 

Hello GPCR friends👋, Stay informed with the latest developments in GPCR research and industry news! GPCR Symposium is coming up on July 21st on Structural and Molecular Insights on GPCR Activation. Reviews, GPCRs, and more Advancements in G protein-coupled receptor biosensors to study GPCR-G protein GPCR Events, Meetings, and Webinars FREE Symposium - IPI Surfacing (June 15, 2023) GPCRs in drug discovery GPCR Ecosystem

Joe Clayton from BioTek Instruments talk about automated micro-plate-based methods for quantifying #GPCR activation. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #drgpcr #gpcr #virtualcafe